Jens Müller-von der Grün, Anne Ria Winkelmann, Franz Rödel, Sven Balster, Thomas Peter Michael Neumayer, Shahram Michael Ghanaati, Christian Hubertus Brandts, Iris Burck, Daniel Martin, Claus Rödel, Nikolina Kesar, Panagiotis Balermpas
- Background; Salivary gland carcinomas (SGC) cover a heterogeneous group of malignancies with a lack of data of high-level evidence.
Methods; Clinical data of 127 patients treated for SGC at a university cancer center between 2002 and 2017 were analyzed retrospectively. The association of clinicopathological characteristics, treatment modalities, adverse events, and outcome was assessed.
Results: Patients received surgery (n = 65), surgery followed by (chemo-)radiotherapy (n = 56), or primary (chemo-)radiotherapy (n = 6). Injury to the cranial nerves or their branches was the most frequent surgical complication affecting 40 patients (33.1%). Ten year overall and progression-free survival rates were 73.2% and 65.4%, respectively. Parotid tumor site, advanced tumor, and positive nodal stage remained independent negative prognostic factors for overall survival, loco-regional and distant tumor control in multivariate analysis.
Conclusions: Optimizing treatment strategies for SGC, depending on distinct clinicopathological factors, remains challenging due to the low incidence rates of the disease.
MetadatenAuthor: | Jens Müller-von der GrünORCiDGND, Anne Ria WinkelmannGND, Franz RödelORCiDGND, Sven BalsterGND, Thomas Peter Michael NeumayerGND, Shahram Michael GhanaatiORCiDGND, Christian Hubertus BrandtsORCiDGND, Iris BurckORCiDGND, Daniel MartinGND, Claus RödelORCiDGND, Nikolina KesarGND, Panagiotis BalermpasORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-637408 |
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DOI: | https://doi.org/10.1007/s00405-021-06652-5 |
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ISSN: | 1434-4726 |
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Parent Title (English): | European archives of oto-rhino-laryngology and head & neck |
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Publisher: | Springer |
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Place of publication: | Berlin ; Heidelberg |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2021/03/24 |
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Date of first Publication: | 2021/03/24 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2023/01/31 |
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Tag: | Head and neck cancer; Patterns of care; Radiotherapy; Salivary gland carcinoma; Surgery |
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Volume: | 278 |
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Issue: | 11 |
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Page Number: | 11 |
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First Page: | 4411 |
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Last Page: | 4421 |
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Note: | This work was supported by grants from the Else Kröner-Fresenius-Stiftung to Jens von der Grün. Open Access funding enabled and organized by Projekt DEAL. |
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HeBIS-PPN: | 507146093 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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