Nasal IgE in subjects with allergic and non-allergic rhinitis
- Purpose: The prevalence of "ocal allergic rhinitis" within individuals suffering from perennial rhinitis remains uncertain, and patients usually are diagnosed with non-allergic rhinitis. The aim of this study was to evaluate the prevalence of a potential "local allergic rhinitis" in subjects suffering from non-allergic rhinitis in a non-selected group of young students. Methods: 131 students (age 25.0 ± 5.1 years) with a possible allergic rhinitis and 25 non-allergic controls without rhinitis symptoms (age 22.0 ± 2.0 years) were recruited by public postings. 97 of 131 students with rhinitis were tested positive (≥3 mm) to prick testing with 17 frequent allergens at visit 1. Twenty-four 24 subjects with a house dust mite allergy, 21 subjects with a non-allergic rhinitis, and 18 non-allergic controls were further investigated at visit 2. Blood samples were taken, and nasal secretion was examined. In addition, all groups performed a nasal provocation test with house dust mite (HDM). Results: In serum and nasal secretion, total IgE and house dust mite specific IgE significantly differed between HDM positive subjects and controls. However, no differences between non-allergic subjects and control subjects were quantifiable. Neither a nasal provocation test nor a nasal IgE to HDM allergens showed a measurable positive response in any of the non-allergic rhinitis subjects as well as the healthy controls, whilst being positive in 13 subjects with HDM allergy. Conclusions: Nasal IgE is present in subjects with HDM allergy, but not in non-allergic rhinitis. In the investigated non-selected population, exclusive local production of IgE is absent. By implication, therefore, our findings challenge the emerging concept of local allergic rhinitis. Study identifier at ClinicalTrials.gov: NCT 02810535.
Author: | Jonas Eckrich, Julia Hinkel, Anna Fischl, Eva HerrmannORCiDGND, Gabriele Holtappels, Claus Bachert, Stefan ZielenORCiDGND |
---|---|
URN: | urn:nbn:de:hebis:30:3-547386 |
DOI: | https://doi.org/10.1016/j.waojou.2020.100129 |
ISSN: | 1939-4551 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/32612737 |
Parent Title (English): | World Allergy Organization journal |
Publisher: | Wolters Kluwer Health Lippincott Williams & Wilkins |
Place of publication: | Hagerstown, Md. |
Document Type: | Article |
Language: | English |
Year of Completion: | 2020 |
Date of first Publication: | 2020/06/23 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2020/07/06 |
Tag: | Allergic rhinitis; House dust mite allergy; Local IgE; Local allergic rhinitis; Non-allergic-rhinitis |
Volume: | 13 |
Issue: | 6, Art. 100129 |
Page Number: | 12 |
First Page: | 1 |
Last Page: | 12 |
Note: | © 2020 The Authors. Published by Elsevier Inc. on behalf of World Allergy Organization. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
HeBIS-PPN: | 467707804 |
Institutes: | Medizin / Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |