High frequency of low-virulent microorganisms detected by sonication of implanted pulse generators: so what?
- Introduction: Deep brain stimulation (DBS) has become a well-established treatment modality for a variety of conditions over the last decades. Multiple surgeries are an essential part in the postoperative course of DBS patients if nonrechargeable implanted pulse generators (IPGs) are applied. So far, the rate of subclinical infections in this field is unknown. In this prospective cohort study, we used sonication to evaluate possible microbial colonization of IPGs from replacement surgery. Methods: All consecutive patients undergoing IPG replacement between May 1, 2019 and November 15, 2020 were evaluated. The removed hardware was investigated using sonication to detect biofilm-associated bacteria. Demographic and clinical data were analyzed. Results: A total of 71 patients with a mean (±SD) of 64.5 ± 15.3 years were evaluated. In 23 of these (i.e., 32.4%) patients, a positive sonication culture was found. In total, 25 microorganisms were detected. The most common isolated microorganisms were Cutibacterium acnes (formerly known as Propionibacterium acnes) (68%) and coagulase-negative Staphylococci (28%). Within the follow-up period (5.2 ± 4.3 months), none of the patients developed a clinical manifest infection. Discussions/Conclusions: Bacterial colonization of IPGs without clinical signs of infection is common but does not lead to manifest infection. Further larger studies are warranted to clarify the impact of low-virulent pathogens in clinically asymptomatic patients.
Author: | Philipp Spindler, Katharina Angela FaustORCiDGND, Tobias Finger, Gerd-Helge SchneiderORCiDGND, Simon Heinrich BayerlORCiDGND, Andrej Trampuz, Andrea A. Kühn, Peter VajkoczyORCiDGND, Vincent Matthias PrinzGND |
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URN: | urn:nbn:de:hebis:30:3-627939 |
DOI: | https://doi.org/10.1159/000517472 |
ISSN: | 1423-0372 |
Parent Title (English): | Stereotactic and functional neurosurgery |
Publisher: | Karger |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2021/09/06 |
Date of first Publication: | 2021/09/06 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2022/05/04 |
Tag: | Antimicrobial treatment; Biofilm; Complications; Deep brain stimulation; Low-virulent infection; Sonication |
Volume: | 100 |
Issue: | 1 |
Page Number: | 6 |
First Page: | 8 |
Last Page: | 13 |
Note: | We acknowledge support from the German Research Foundation (DFG) and the Open Access Publication Fund of Charité - Universitätsmedizin Berlin. |
HeBIS-PPN: | 496022865 |
Institutes: | Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung 4.0 |