Sebastian Robert Ott, Niklaus Meier, Martin Kolditz, Torsten Thomas Bauer, Gernot Gerhard Ulrich Rohde, Elisabeth Presterl, Dirk Schürmann, Philipp Moritz Lepper, Felix Christian Ringshausen, Holger Flick, Stephen L. Leib, Mathias Wilhelm Rudolf Pletz
- Background: Pulmonary nocardiosis (PN) is an uncommon but potentially life-threatening infection. Most of our knowledge is derived from case reports or smaller case series. Recently, increasing PN incidence rates have been reported. We aim to describe the clinical course of and risk factors for PN in four Western European countries and to estimate population-based annual hospitalization rates.
Methods: Retrospective evaluation (1995 to 2011) of the clinical course of and risk factors for PN in patients from 11 hospitals in four European countries (Germany, Austria, Switzerland and The Netherlands). Calculation of population-based estimates of hospitalization rates of PN in Germany (2005 to 2011) using official German nationwide diagnosis-related groups (DRG) hospital statistics.
Results: Forty-three patients fulfilled stringent criteria for proven (n = 8) and probable (n = 35) PN; seven with extrapulmonary dissemination. Within the 43 patients, major PN risk factors were immunocompromising (83.7%) and/or pulmonary (58.1%; in 27.9% as only comorbidity) comorbidities. Median duration of PN targeted therapy was 12 weeks. Distinguished patterns of resistance were observed (imipenem susceptibility: N. farcinica 33.3%; N. asteroides 66.7%). Overall mortality rate was 18.9%; in disseminated PN 50%. Over time, annual PN hospitalization rates remained unchanged at around 0.04/100′000 with the highest rate among men aged 75–84 years (0.24/100′000).
Conclusion: PN is rare, but potentially life-threatening, and mainly affects immunocompromised elder males. Overall annual hospitalization rates remained stable between 2005 and 2011.
MetadatenAuthor: | Sebastian Robert Ott, Niklaus Meier, Martin KolditzORCiDGND, Torsten Thomas Bauer, Gernot Gerhard Ulrich RohdeORCiDGND, Elisabeth PresterlGND, Dirk Schürmann, Philipp Moritz LepperORCiDGND, Felix Christian RingshausenORCiDGND, Holger Flick, Stephen L. Leib, Mathias Wilhelm Rudolf PletzORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-488453 |
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DOI: | https://doi.org/10.1016/j.ijid.2018.12.010 |
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ISSN: | 1878-3511 |
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ISSN: | 1201-9712 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/30658169 |
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Parent Title (English): | International journal of infectious diseases |
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Publisher: | Elsevier |
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Place of publication: | Amsterdam [u.a.] |
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Document Type: | Article |
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Language: | English |
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Year of Completion: | 2019 |
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Date of first Publication: | 2019/01/15 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Contributing Corporation: | OPINION-study group |
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Release Date: | 2019/03/05 |
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Tag: | nocardia; nocardiosis; pulmonary nocardiosis |
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Volume: | 81 |
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Page Number: | 9 |
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First Page: | 140 |
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Last Page: | 148 |
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Note: | © 2019 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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HeBIS-PPN: | 448055945 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
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