Martin Röhling, Kerstin Kempf, Winfried Banzer, Klaus Michael Braumann, Dagmar Führer, Martin Halle, David McCarthy, Stephan Martin, Jürgen Scholze, Hermann Toplak, Aloys Berg, Hans-Georg Predel
- Low-caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high-protein, low-glycemic but moderate-caloric formula diet. This post-hoc analysis of the Almased Concept against Overweight and Obesity and Related Health Risk- (ACOORH) trial investigated the impact of a lifestyle intervention combined with a formula diet (INT, n = 308) compared to a control group with lifestyle intervention alone (CON, n = 155) on hemodynamic parameters (systolic and diastolic blood pressure (SBP, DBP), resting heart rate (HR), and pulse wave velocity (PWV)) in high-risk individuals with prehypertension or hypertension. INT replaced meals during the first 6 months (1 week: 3 meals/day; 2–4 weeks: 2 meals/day; 5–26 weeks: 1 meal/day). Study duration was 12 months. From the starting cohort, 304 (68.3%, INT: n = 216; CON: n = 101) participants had a complete dataset. Compared to CON, INT significantly reduced more SBP (−7.3 mmHg 95% CI [−9.2; −5.3] vs. −3.3 mmHg [−5.9; −0.8], p < 0.049) and DBP (−3.7 mmHg [−4.9; −2.5] vs. −1.4 mmHg [−3.1; 0.2], p < 0.028) after 12 months. Compared to CON, INT showed a pronounced reduction in resting HR and PWV after 6 months but both lost significance after 12 months. Changes in SBP, DBP, and PWV were significantly associated positively with changes in body weight and fat mass (all p < 0.05) and resting HR correlated positively with fasting insulin (p < 0.001) after 12 months. Combining a lifestyle intervention with a high-protein and low-glycemic formula diet improves hemodynamic parameters to a greater extent than lifestyle intervention alone in high-risk individuals with overweight and obesity.
MetadatenAuthor: | Martin RöhlingORCiDGND, Kerstin KempfORCiDGND, Winfried BanzerGND, Klaus Michael BraumannORCiDGND, Dagmar FührerGND, Martin HalleORCiDGND, David McCarthyORCiD, Stephan MartinORCiDGND, Jürgen ScholzeGND, Hermann ToplakORCiDGND, Aloys BergORCiDGND, Hans-Georg PredelGND |
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URN: | urn:nbn:de:hebis:30:3-827165 |
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DOI: | https://doi.org/10.3390/nu14071443 |
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ISSN: | 2072-6643 |
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Parent Title (English): | Nutrients |
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Publisher: | MDPI |
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Place of publication: | Basel |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2022/03/30 |
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Date of first Publication: | 2022/03/30 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Contributing Corporation: | ACOORH Study Group |
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Release Date: | 2024/06/20 |
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Tag: | blood pressure; cardiac autonomic regulation; formula diet; heart rate; insulin; lifestyle intervention; pulse wave velocity |
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Volume: | 14 |
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Issue: | 7, art. 1443 |
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Article Number: | 1443 |
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Page Number: | 13 |
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First Page: | 1 |
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Last Page: | 13 |
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Note: | Funding: Almased-Wellness-GmbH. |
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HeBIS-PPN: | 521024137 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
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