Yunlong Hou, Juan M. Adrian-Segarra, Manfred Richter, Natalia Kubin, Jaeyoung Shin, Isabella Werner, Thomas Walther, Markus Schönburg, Jochen Pöling, Henning Warnecke, Thomas Braun, Sawa Kostin, Thomas Kubin
- It is now accepted that heart failure (HF) is a complex multifunctional disease rather than simply a hemodynamic dysfunction. Despite its complexity, stressed cardiomyocytes often follow conserved patterns of structural remodelling in order to adapt, survive, and regenerate. When cardiac adaptations cannot cope with mechanical, ischemic, and metabolic loads efficiently or become chronically activated, as, for example, after infection, then the ongoing structural remodelling and dedifferentiation often lead to compromised pump function and patient death. It is, therefore, of major importance to understand key events in the progression from a compensatory left ventricular (LV) systolic dysfunction to a decompensatory LV systolic dysfunction and HF. To achieve this, various animal models in combination with an “omics” toolbox can be used. These approaches will ultimately lead to the identification of an arsenal of biomarkers and therapeutic targets which have the potential to shape the medicine of the future.
MetadatenAuthor: | Yunlong Hou, Juan M. Adrian-Segarra, Manfred Richter, Natalia Kubin, Jaeyoung Shin, Isabella Werner, Thomas WaltherGND, Markus Schönburg, Jochen Pöling, Henning Warnecke, Thomas BraunORCiDGND, Sawa KostinORCiD, Thomas Kubin |
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URN: | urn:nbn:de:hebis:30:3-393810 |
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DOI: | https://doi.org/10.1155/2015/212910 |
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ISSN: | 2314-6133 |
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Parent Title (English): | BioMed research international |
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Publisher: | Hindawi |
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Place of publication: | New York |
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Document Type: | Article |
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Language: | English |
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Year of Completion: | 2015 |
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Year of first Publication: | 2015 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2016/02/04 |
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Volume: | 2015 |
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Issue: | Article ID 212910 |
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Page Number: | 11 |
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First Page: | 1 |
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Last Page: | 10 |
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Note: | Copyright © 2015 Yunlong Hou et al. This is an open access article distributed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/ , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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HeBIS-PPN: | 377938785 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 3.0 |
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