Evelyn Klein, Dietmar Schlembach, Angela Ramoni, Elena Langer, Franz Bahlmann, Sabine Grill, Helene Schaffenrath, Reinhard van der Does, Diethelm Messinger, Wilma D. J. Verhagen-Kamerbeek, Manfred Reim, Martin Hund, Holger Stepan
- Objective: To evaluate the influence of the soluble fms-like tyrosine kinase 1/placental growth factor ratio in physicians’ decision making in pregnant women with signs and symptoms of preeclampsia in routine clinical practice.
Methods: A multicenter, prospective, open, non-interventional study enrolled pregnant women presenting with preeclampsia signs and symptoms in several European perinatal care centers. Before the soluble fms-like tyrosine kinase 1/placental growth factor ratio result was known, physicians documented intended clinical procedures using an iPad® application (data locked/time stamped). After the result was available, clinical decisions were confirmed or revised and documented. An independent adjudication committee evaluated the appropriateness of decisions based on maternal/fetal outcomes. Clinician decision making with regard to hospitalization was the primary outcome.
Results: In 16.9% of mothers (20/118) the hospitalization decision was changed after knowledge of the ratio. In 13 women (11.0%), the initial decision to hospitalize was changed to no hospitalization. In seven women (5.9%) the revised decision was hospitalization. All revised decisions were considered appropriate by the panel of adjudicators (McNemar test; p < 0.0001).
Conclusions: The use of the soluble fms-like tyrosine kinase 1/placental growth factor test influenced clinical decision making towards appropriate hospitalization in a considerable proportion of women with suspected preeclampsia. This is the first study to demonstrate the impact of angiogenic biomarkers on decision making in a routine clinical practice.
MetadatenAuthor: | Evelyn Klein, Dietmar Schlembach, Angela Ramoni, Elena Langer, Franz BahlmannGND, Sabine GrillGND, Helene Schaffenrath, Reinhard van der Does, Diethelm Messinger, Wilma D. J. Verhagen-Kamerbeek, Manfred Reim, Martin Hund, Holger Stepan |
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URN: | urn:nbn:de:hebis:30:3-457790 |
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DOI: | https://doi.org/10.1371/journal.pone.0156013 |
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ISSN: | 1932-6203 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/27243815 |
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Parent Title (English): | PLoS one |
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Publisher: | PLoS |
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Place of publication: | Lawrence, Kan. |
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Contributor(s): | Ana Claudia Zenclussen |
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Document Type: | Article |
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Language: | English |
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Year of Completion: | 2016 |
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Date of first Publication: | 2016/05/31 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2018/03/01 |
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Tag: | Decision making; Eclampsia; Hospitals; Physicians; Placental growth factor; Preeclampsia; Pregnancy; Tyrosine kinases |
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Volume: | 11 |
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Issue: | (5): e0156013 |
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Page Number: | 19 |
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First Page: | 1 |
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Last Page: | 19 |
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Note: | Copyright: © 2016 Klein et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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HeBIS-PPN: | 432099190 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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