Philip Ferstl, Natalie Filmann, Eva-Maria Heilgenthal, Andreas Schnitzbauer, Wolf Otto Bechstein, Volkhard A. J. Kempf, David Villinger, Tilman Schultze, Michael Hogardt, Christoph Stephan, Haitham Mutlak, Nina Weiler, Marcus Maximilian Mücke, Jonel Trebicka, Stefan Zeuzem, Oliver Waidmann, Martin-Walter Welker
- Objectives: Rising prevalence of multidrug-resistant organisms (MDRO) is a major health problem in patients with liver cirrhosis. The impact of MDRO colonization in liver transplantation (LT) candidates and recipients on mortality has not been determined in detail.
Methods: Patients consecutively evaluated and listed for LT in a tertiary German liver transplant center from 2008 to 2018 underwent screening for MDRO colonization including methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant gram-negative bacteria (MDRGN), and vancomycin-resistant enterococci (VRE). MDRO colonization and infection status were obtained at LT evaluation, planned and unplanned hospitalization, three months upon graft allocation, or at last follow-up on the waiting list.
Results: In total, 351 patients were listed for LT, of whom 164 (47%) underwent LT after a median of 249 (range 0–1662) days. Incidence of MDRO colonization increased during waiting time for LT, and MRDO colonization was associated with increased mortality on the waiting list (HR = 2.57, p<0.0001. One patients was colonized with a carbapenem-resistant strain at listing, 9 patients acquired carbapenem-resistant gram-negative bacteria (CRGN) on the waiting list, and 4 more after LT. In total, 10 of these 14 patients died.
Conclusions: Colonization with MDRO is associated with increased mortality on the waiting list, but not in short-term follow-up after LT. Moreover, colonization with CRGN seems associated with high mortality in liver transplant candidates and recipients.
MetadatenAuthor: | Philip FerstlORCiDGND, Natalie FilmannORCiDGND, Eva-Maria Heilgenthal, Andreas SchnitzbauerORCiDGND, Wolf Otto BechsteinORCiDGND, Volkhard A. J. KempfORCiDGND, David VillingerGND, Tilman SchultzeORCiDGND, Michael HogardtORCiDGND, Christoph StephanORCiDGND, Haitham MutlakORCiDGND, Nina Weiler, Marcus Maximilian MückeORCiDGND, Jonel TrebickaORCiDGND, Stefan ZeuzemORCiDGND, Oliver WaidmannORCiDGND, Martin-Walter WelkerGND |
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URN: | urn:nbn:de:hebis:30:3-612465 |
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DOI: | https://doi.org/10.1371/journal.pone.0245091 |
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ISSN: | 1932-6203 |
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Parent Title (English): | PLOS ONE |
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Publisher: | Public Library of Science |
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Place of publication: | San Francisco |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2021/01/22 |
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Date of first Publication: | 2021/01/22 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2021/06/28 |
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Tag: | Methicillin-resistant Staphylococcus aureus; cirrhosis; death rates; enterobacter infections; pseudomonas aeruginosa; epidemiology; epidemiology; liver transplantation; medical risk factors; pseudomonas aeruginosa |
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Volume: | 16 |
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Issue: | 1, art. e0245091 |
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Page Number: | 13 |
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First Page: | 1 |
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Last Page: | 13 |
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HeBIS-PPN: | 483291358 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Open-Access-Publikationsfonds: | Medizin |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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