Olaf Eickmeier, Su Youn Kim, Eva Herrmann, Constanze Döring, Ruth Pia Dücker, Sandra Voss, Sibylle Wehner, Christoph Hölscher, Julia Pietzner, Stefan Zielen, Ralf Schubert
- Background: Ataxia telangiectasia (A-T) is a rare but devastating and progressive disorder characterized by cerebellar dysfunction, lymphoreticular malignancies and recurrent sinopulmonary infections. In A-T, disease of the respiratory system causes significant morbidity and is a frequent cause of death.
Methods: We used a self-limited murine model of hydrochloric acid-induced acute lung injury (ALI) to determine the inflammatory answer due to mucosal injury in Atm (A-T mutated)- deficient mice (Atm−/−).
Results: ATM deficiency increased peak lung inflammation as demonstrated by bronchoalveolar lavage fluid (BALF) neutrophils and lymphocytes and increased levels of BALF pro-inflammatory cytokines (e.g. IL-6, TNF). Furthermore, bronchial epithelial damage after ALI was increased in Atm−/− mice. ATM deficiency increased airway resistance and tissue compliance before ALI was performed.
Conclusions: Together, these findings indicate that ATM plays a key role in inflammatory response after airway mucosal injury.
MetadatenAuthor: | Olaf EickmeierORCiDGND, Su Youn Kim, Eva HerrmannORCiDGND, Constanze Döring, Ruth Pia DückerORCiDGND, Sandra Voss, Sibylle Wehner, Christoph Hölscher, Julia Pietzner, Stefan ZielenORCiDGND, Ralf SchubertORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-349851 |
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DOI: | https://doi.org/10.1186/1471-2466-14-93 |
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ISSN: | 1471-2466 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24884546 |
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Parent Title (English): | BMC pulmonary medicine |
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Publisher: | BioMed Central |
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Place of publication: | London |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2014/05/29 |
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Date of first Publication: | 2014/05/29 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2014/10/29 |
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Tag: | ATM; acute lung injury; ataxia telangiectasia; inflammation |
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Volume: | 14 |
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Issue: | 93 |
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Page Number: | 9 |
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Note: | Copyright © 2014 Eickmeier et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
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HeBIS-PPN: | 366630210 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 2.0 |
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