Editorial : bad bugs in the XXIst century: resistance mediated by multi-drug efflux pumps in gram-negative bacteria
- The discovery of antibiotics represented a key milestone in the history of medicine. However, with the rise of these life-saving drugs came the awareness that bacteria deploy defense mechanisms to resist these antibiotics, and they are good at it. Today, we appear at a crossroads between discovery of new potent drugs and omni-resistant superbugs. Moreover, the misuse of antibiotics in different industries has increased the rate of resistance development by providing permanent selective pressure and, subsequently, enrichment of multidrug resistant pathogens. As a result, antimicrobial resistance has now become an urgent threat to public health worldwide (http:// www.who.int/drugresistance/documents/surveillancereport/en/). The development of multidrug resistance (MDR) in an increasing number of pathogens, including Pseudomonas, Acinetobacter, Klebsiella, Salmonella, Burkholderia, and other Gram-negative bacteria is a serious issue. Membrane efflux pump complexes of the Resistance-Nodulation-Division (RND) superfamily play a key role in the development of MDR in these bacteria. These pumps, together with other transporters, contribute to intrinsic and acquired resistance of bacteria toward most, if not all, of the compounds available in our antimicrobial arsenal. Given the enormous drug polyspecificity of MDR efflux pumps, studies on their mechanism of action are extremely challenging, and this has negatively impacted both on the development of new antibiotics that are able to evade these efflux pumps and on the design of pump inhibitors. The collection of articles in this eBook, published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy, aims to update the reader about the latest advances on the structure and function of RND efflux transporters, their roles in the overall multidrug resistance phenotype of Gram-negative pathogens, and on the strategies to inhibit their activities. ...
Author: | Attilio Vittorio Vargiu, Klaas Martinus PosORCiD, Keith Poole, Hiroshi Nikaido |
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URN: | urn:nbn:de:hebis:30:3-505976 |
DOI: | https://doi.org/10.3389/fmicb.2016.00833 |
ISSN: | 1664-302X |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/27303401 |
Parent Title (English): | Frontiers in microbiology |
Publisher: | Frontiers Media |
Place of publication: | Lausanne |
Contributor(s): | Kunihiko Nishino |
Document Type: | Article |
Language: | English |
Year of Completion: | 2016 |
Date of first Publication: | 2016/05/31 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2019/07/01 |
Tag: | antibiotic resistance; bacterial resistance mechanisms; efflux pumps; multi-drug-resistant pathogens; superbugs |
Volume: | 7 |
Issue: | Art. 833 |
Page Number: | 3 |
First Page: | 1 |
Last Page: | 3 |
Note: | Copyright © 2016 Vargiu, Pos, Poole and Nikaido. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
HeBIS-PPN: | 450769879 |
Institutes: | Biochemie, Chemie und Pharmazie / Biochemie und Chemie |
Exzellenzcluster / Exzellenzcluster Makromolekulare Komplexe | |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung 4.0 |