The White-test helps to reduce biliary leakage in liver resection: a systematic review and meta-analysis
- Background. Bile leakage testing may help to detect and reduce the incidence of biliary leakage after hepatic resection. This review was performed to investigate the value of the White-test in identifying intraoperative biliary leakage and avoiding postoperative leakage. Material and methods. A systematic review and meta-analysis was performed. Two researchers performed literature research. Primary outcome measure was the incidence of post-hepatectomy biliary leakage; secondary outcome measure was the ability of detecting intraoperative biliary leakage with the help of the White-test. Results. A total of 4 publications (including original data from our center) were included in the analysis. Evidence levels of the included studies had medium quality of 2b (individual cohort studies including low quality randomized controlled trials). Use of the White-test led to a significant reduction of post-operative biliary leakage [OR: 0.3 (95% CI: 0.14, 0.63), p = 0.002] and led to a significant higher intraoperative detection of biliary leakages [OR: 0.03 (95%CI: 0.02, 0.07), p < 0.00001]. Conclusion. Existing evidence implicates the use of the White-test after hepatic resection to identify bile leaks intraoperatively and thus reduce incidence of post-operative biliary leakage. Nonetheless, there is a requirement for a high-quality randomized controlled trial with adequately powered sample-size to confirm findings from the above described studies and further increase evidence in this field.
Author: | Richard LinkeGND, Frank UlrichGND, Wolf Otto BechsteinORCiDGND, Andreas SchnitzbauerORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-771537 |
DOI: | https://doi.org/10.1016/S1665-2681(19)30777-X |
ISSN: | 1665-2681 |
Parent Title (English): | Annals of Hepatology |
Publisher: | Mexican Association of Hepatology |
Place of publication: | México |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2019/05/31 |
Year of first Publication: | 2015 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2023/10/04 |
Tag: | Diagnostic dye; Intraoperative test; Lipid solution |
Volume: | 14 |
Issue: | 2 |
Page Number: | 7 |
First Page: | 161 |
Last Page: | 167 |
HeBIS-PPN: | 513047689 |
Institutes: | Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |