Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies

  • The use of neutralizing antibodies is one of the most successful methods to interfere with receptor–ligand interactions in vivo. In particular blockade of soluble inflammatory mediators or their corresponding cellular receptors was proven an effective way to regulate inflammation and/or prevent its negative consequences. However, one problem that comes along with an effective neutralization of inflammatory mediators is the general systemic immunomodulatory effect. It is, therefore, important to design a treatment regimen in a way to strike at the right place and at the right time in order to achieve maximal effects with minimal duration of immunosuppression or hyperactivation. In this review, we reflect on two examples of how short time administration of such neutralizing antibodies can block two distinct inflammatory consequences of viral infection. First, we review recent findings that blockade of IL-10/IL-10R interaction can resolve chronic viral infection and second, we reflect on how neutralization of the chemokine CXCL10 can abrogate virus-induced type 1 diabetes.

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Author:Mette Ejrnaes, Matthias G. von Herrath, Urs Christen
URN:urn:nbn:de:hebis:30-68444
DOI:https://doi.org/10.1080/17402520600579028
ISSN:1740-2530
ISSN:1740-2522
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/16603445
Parent Title (English):Clinical & developmental immunology
Publisher:Hindawi
Place of publication:New York, NY
Document Type:Article
Language:English
Date of Publication (online):2009/08/19
Year of first Publication:2006
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2009/08/19
Tag:CXCR3; LCMV; autoimmune disease; chronic infection; dendritic cells; molecular mimicry
Volume:13
Issue:1
Page Number:11
First Page:67
Last Page:77
Note:
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Note:
Die Publikation wurde vom Verlag zurückgezogen. Vgl. dazu: Journal of Immunology Research, 2016, Art. 2747402, doi:10.1155/2016/2747402. Der korrekte Artikel ist erschienen in: Clinical & developmental immunology, 13.2006, Nr. 2-4, S. 337-347, doi:10.1080/17402520600800721
Source:Clinical & Developmental Immunology, March 2006; 13(1): 67–77 ; doi:10.1080/17402520600579028 ; http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16603445
HeBIS-PPN:215053060
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 3.0