Cellular stress responses: cell survival and cell death
- Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress as well as the cell type. Also, there is often the interplay between these responses that ultimately determines the fate of the stressed cell. The mechanism by which a cell dies (i.e., apoptosis, necrosis, pyroptosis, or autophagic cell death) depends on various exogenous factors as well as the cell's ability to handle the stress to which it is exposed. The implications of cellular stress responses to human physiology and diseases are manifold and will be discussed in this review in the context of some major world health issues such as diabetes, Parkinson's disease, myocardial infarction, and cancer.
| Author: | Simone FuldaORCiDGND, Adrienne M. Gorman, Osamu Hori, Afshin Samali |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-243636 |
| DOI: | https://doi.org/10.1155/2010/214074 |
| ISSN: | 1687-8884 |
| ISSN: | 1687-8876 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/20182529 |
| Parent Title (English): | International journal of cell biology |
| Publisher: | Hindawi |
| Place of publication: | New York, NY |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2012 |
| Year of first Publication: | 2010 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2012/05/23 |
| Volume: | 2010 |
| Issue: | Article ID 214074 |
| Page Number: | 23 |
| HeBIS-PPN: | 303960280 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 3.0 |
