ATXN2 and its neighbouring gene SH2B3 are associated with increased ALS risk in the Turkish population

  • Expansions of the polyglutamine (polyQ) domain (≥34) in Ataxin-2 (ATXN2) are the primary cause of spinocerebellar ataxia type 2 (SCA2). Recent studies reported that intermediate-length (27–33) expansions increase the risk of Amyotrophic Lateral Sclerosis (ALS) in 1–4% of cases in diverse populations. This study investigates the Turkish population with respect to ALS risk, genotyping 158 sporadic, 78 familial patients and 420 neurologically healthy controls. We re-assessed the effect of ATXN2 expansions and extended the analysis for the first time to cover the ATXN2 locus with 18 Single Nucleotide Polymorphisms (SNPs) and their haplotypes. In accordance with other studies, our results confirmed that 31–32 polyQ repeats in the ATXN2 gene are associated with risk of developing ALS in 1.7% of the Turkish ALS cohort (p = 0.0172). Additionally, a significant association of a 136 kb haplotype block across the ATXN2 and SH2B3 genes was found in 19.4% of a subset of our ALS cohort and in 10.1% of the controls (p = 0.0057, OR: 2.23). ATXN2 and SH2B3 encode proteins that both interact with growth receptor tyrosine kinases. Our novel observations suggest that genotyping of SNPs at this locus may be useful for the study of ALS risk in a high percentage of individuals and that ATXN2 and SH2B3 variants may interact in modulating the disease pathway.

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Metadaten
Author:Suna Lahut, Özgür Ömür, Özgün Uyan, Zeynep Sena Ağım, Aslihan Özoğuz, Yeşim Parman, Feza Deymeer, Piraye Oflazer, Filiz Koç, Hilmi Özçelik, Georg AuburgerORCiDGND, Ayşe Nazlı Başak
URN:urn:nbn:de:hebis:30:3-258578
DOI:https://doi.org/10.1371/journal.pone.0042956
ISSN:1932-6203
Parent Title (English):PLoS One
Publisher:PLoS
Place of publication:Lawrence, Kan.
Document Type:Article
Language:English
Date of Publication (online):2012/08/20
Date of first Publication:2012/08/20
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2012/08/24
Volume:7
Issue:(8):e42956
Page Number:6
HeBIS-PPN:357990366
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0