Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain

  • Mitochondrial maintenance crucially depends on the quality control of proteins by various chaperones, proteases and repair enzymes. While most of the involved components have been studied in some detail, little is known on the biological role of the CLPXP protease complex located in the mitochondrial matrix. Here we show that deletion of PaClpP, encoding the CLP protease proteolytic subunit CLPP, leads to an unexpected healthy phenotype and increased lifespan of the fungal ageing model organism Podospora anserina. This phenotype can be reverted by expression of human ClpP in the fungal deletion background, demonstrating functional conservation of human and fungal CLPP. Our results show that the biological role of eukaryotic CLP proteases can be studied in an experimentally accessible model organism.

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Metadaten
Author:Fabian Fischer, Andrea Weil, Andrea HamannORCiD, Heinz D. OsiewaczORCiDGND
URN:urn:nbn:de:hebis:30:3-263393
DOI:https://doi.org/10.1038/ncomms2397
ISSN:2041-1723
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/23360988
Parent Title (English):Nature Communications
Publisher:Nature Publishing Group
Place of publication:London
Document Type:Article
Language:English
Date of Publication (online):2013/01/29
Date of first Publication:2013/01/29
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2013/02/13
Volume:4
Issue:1397
Page Number:6
Note:
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
HeBIS-PPN:33136686X
Institutes:Biowissenschaften / Biowissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlungen:Universit├Ątspublikationen
Sammlung Biologie / Sondersammelgebiets-Volltexte
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0