Sphingosine 1-phosphate in renal diseases
- Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about the physiological and pathophysiological functions of S1P in this organ have been raised. In this review, we summarize the current state of knowledge about S1P-mediated functions in the kidney. A special focus is put on S1P modulated signal transduction in renal glomerular and tubular cells and consequences for the development and treatment of several kidney diseases, diabetic nephropathy, glomerulonephritis, ischemia-reperfusion injury, as well as for Wilms tumor progression.
| Author: | Alexander Koch, Josef PfeilschifterGND, Andrea HuwilerORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-316628 |
| DOI: | https://doi.org/10.1159/000350093 |
| ISSN: | 1421-9778 |
| ISSN: | 1015-8987 |
| Parent Title (English): | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology |
| Publisher: | Karger |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2013/05/31 |
| Date of first Publication: | 2013/05/31 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2013/09/23 |
| Tag: | Diabetic nephropathy; Glomerulonephritis; Ischemia-reperfusion injury; Kidney disease; Sphingosine 1-phosphate; Wilms tumor |
| Volume: | 31 |
| Issue: | 6 |
| Page Number: | 16 |
| First Page: | 745 |
| Last Page: | 760 |
| Note: | This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License (www.karger.com/OA-license), applicable to the online version of the article only. Distribution for non-commercial purposes only. |
| HeBIS-PPN: | 353220310 |
| Institutes: | Medizin / Medizin |
| Fachübergreifende Einrichtungen / Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit (ZAFES) | |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |
