Sphingosine 1-phosphate in renal diseases

  • Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about the physiological and pathophysiological functions of S1P in this organ have been raised. In this review, we summarize the current state of knowledge about S1P-mediated functions in the kidney. A special focus is put on S1P modulated signal transduction in renal glomerular and tubular cells and consequences for the development and treatment of several kidney diseases, diabetic nephropathy, glomerulonephritis, ischemia-reperfusion injury, as well as for Wilms tumor progression.

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Author:Alexander Koch, Josef PfeilschifterGND, Andrea HuwilerORCiDGND
Parent Title (English):Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology
Place of publication:Basel
Document Type:Article
Date of Publication (online):2013/05/31
Date of first Publication:2013/05/31
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/09/23
Tag:Diabetic nephropathy; Glomerulonephritis; Ischemia-reperfusion injury; Kidney disease; Sphingosine 1-phosphate; Wilms tumor
Page Number:16
First Page:745
Last Page:760
This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License (www.karger.com/OA-license), applicable to the online version of the article only. Distribution for non-commercial purposes only.
Institutes:Medizin / Medizin
Fachübergreifende Einrichtungen / Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0