Prospective evaluation of artemether-lumefantrine for the treatment of non-falciparum and mixed-species malaria in Gabon

  • Background: The recommendation of artemisinin combination therapy (ACT) as first-line treatment for uncomplicated falciparum malaria is supported by a plethora of high quality clinical trials. However, their recommendation for the treatment of mixed-species malaria and the large-scale use for the treatment of non-falciparum malaria in endemic regions is based on anecdotal rather than systematic clinical evidence. Methods: This study prospectively observed the efficacy of artemether-lumefantrine for the treatment of uncomplicated non-falciparum or mixed-species malaria in two routine district hospitals in the Central African country of Gabon. Results: Forty patients suffering from uncomplicated Plasmodium malariae, Plasmodium ovale or mixed-species malaria (including Plasmodium falciparum) presenting at the hospital received artemether-lumefantrine treatment and were followed up. All evaluable patients (n = 38) showed an adequate clinical and parasitological response on Day 28 after oral treatment with artemether-lumefantrine (95% confidence interval: 0.91,1). All adverse events were of mild to moderate intensity and completely resolved by the end of study. Conclusions: This first systematic assessment of artemether-lumefantrine treatment for P. malariae, P. ovale and mixed-species malaria demonstrated a high cure rate of 100% and a favourable tolerability profile, and thus lends support to the practice of treating non-falciparum or mixed-species malaria, or all cases of malaria without definite species differentiation, with artemether-lumefantrine in Gabon. Trial Registration: Identifier: NCT00725777

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Author:Ghyslain Mombo-Ngoma, Christian Kleine, Arti Basra, Heike Würbel, Daisy A. Diop, Mesküre Capan, Ayola A. Adegnika, Florian Michael KurthORCiDGND, Benjamin Gottlieb MordmüllerORCiDGND, Fanny Joanny, Peter G. Kremsner, Michael Ramharter, Sabine Bélard
Pubmed Id:
Parent Title (English):Malaria journal : published in collaboration with the Liverpool School of Tropical Medicine
Publisher:BioMed Central
Place of publication:London
Document Type:Article
Date of Publication (online):2012/07/10
Date of first Publication:2012/07/10
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/09/23
Tag:Artemether-lumefantrine; Artemisinin-combination-therapy; Malaria; Malariae; Non-falciparum; Ovale
Page Number:6
© 2012 Mombo-Ngoma et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 2.0