Oxidative stress and epigenetic regulation in ageing and age-related diseases

  • Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. Mechanistically, it is well accepted that the accumulation of intracellular damage determined by reactive oxygen species (ROS) might orchestrate the progressive loss of control over biological homeostasis and the functional impairment typical of aged tissues. Here, we review how epigenetics takes part in the control of stress stimuli and the mechanisms of ageing physiology and physiopathology. Alteration of epigenetic enzyme activity, histone modifications and DNA-methylation is, in fact, typically associated with the ageing process. Specifically, ageing presents peculiar epigenetic markers that, taken altogether, form the still ill-defined “ageing epigenome”. The comprehension of mechanisms and pathways leading to epigenetic modifications associated with ageing may help the development of anti-ageing therapies.

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar
Author:Chiara Cencioni, Francesco Spallotta, Fabio Martelli, Sergio Valente, Antonello Mai, Andreas M. ZeiherORCiDGND, Carlo Gaetano
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/23989608
Parent Title (English):International journal of motorcycle studies : IJMS
Publisher:Nova Southeastern University
Place of publication:Fort Lauderdale, Fla.
Document Type:Article
Date of Publication (online):2013/08/28
Date of first Publication:2013/08/28
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/09/25
Tag:ageing; cardiac; cardiovascular; endothelial; epigenetics; oxidative stress
Page Number:21
First Page:17643
Last Page:17663
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 3.0