Use of radiobiological modeling in treatment plan evaluation and optimization of prostate cancer radiotherapy

  • There are many tools available that are used to evaluate a radiotherapy treatment plan, such as isodose distribution charts, dose volume histograms (DVH), maximum, minimum and mean doses of the dose distributions as well as DVH point dose constraints. All the already mentioned evaluation tools are dosimetric only without taking into account the radiobiological characteristics of tumors or OARs. It has been demonstrated that although competing treatment plans might have similar mean, maximum or minimum doses they may have significantly different clinical outcomes (Mavroidis et al. 2001). For performing a more complete treatment plan evaluation and comparison the complication-free tumor control probability (P+) and the biologically effective uniform dose (D ) have been proposed (Källman et al. 1992a, Mavroidis et al. 2000). The D concept denotes that any two dose distributions within a target or OAR are equivalent if they produce the same probability for tumor control or normal tissue complication, respectively (Mavroidis et al. 2001)...

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Author:Panayiotis Mavroidis, Dimos Baltas, Bengt K. Lind, Nikos Papanikolaou
Parent Title (English):Prostate cancer - diagnostic and therapeutic advances
Place of publication:[Erscheinungsort nicht ermittelbar]
Editor:Philippe E. Spiess
Document Type:Part of a Book
Date of Publication (online):2011/11/25
Date of first Publication:2011/11/25
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/10/04
Page Number:24
First Page:237
Last Page:260
Published: under CC BY 3.0 license
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 3.0