Hematopoietic SCT in Europe 2013 : recent trends in the use of alternative donors showing more haploidentical donors but fewer cord blood transplants

  • A record number of 39 209 HSCT in 34 809 patients (14 950 allogeneic (43%) and 19 859 autologous (57%)) were reported by 658 centers in 48 countries to the 2013 survey. Trends include: more growth in allogeneic than in autologous HSCT, increasing use of sibling and unrelated donors and a pronounced increase in haploidentical family donors when compared with cord blood donors for those patients without a matched related or unrelated donor. Main indications were leukemias, 11 190 (32%; 96% allogeneic); lymphoid neoplasias, 19 958 (57%; 11% allogeneic); solid tumors, 1543 (4%; 4% allogeneic); and nonmalignant disorders, 1975 (6%; 91% allogeneic). In patients without a matched sibling or unrelated donor, alternative donors are used. Since 2010 there has been a marked increase of 96% in the number of transplants performed from haploidentical relatives (802 in 2010 to 1571 in 2013), whereas the number of unrelated cord blood transplants has slightly decreased (789 in 2010 to 666 in 2013). The use of donor type varies greatly throughout Europe.

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Author:Jakob R. Passweg, Helen Baldomero, Peter BaderORCiDGND, Chiara Bonini, Simone Cesaro, Peter Dreger, Rafael F. Duarte, Carlo Dufour, J. H. Frederik Falkenburg, Dominique Farge-Bancel, Andrew Gennery, Nicolaus Kröger, Francesco Lanza, Arnon Nagler, Anna Sureda, Mohamad Mohty
URN:urn:nbn:de:hebis:30:3-422160
URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387247
DOI:https://doi.org/10.1038/bmt.2014.312
ISSN:0268-3369
ISSN:0951-3078
ISSN:1476-5365
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/25642761
Parent Title (English):Bone marrow transplantation
Publisher:Nature Publishing Group
Place of publication:London
Document Type:Article
Language:English
Date of Publication (online):2016/12/01
Date of first Publication:2015/02/02
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Creating Corporation:European Society for Blood and Marrow Transplantation (EBMT)
Release Date:2016/12/01
Volume:50
Issue:4
Page Number:7
First Page:476
Last Page:482
Note:
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
HeBIS-PPN:428669921
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0