Long-term vaptan treatment of idiopathic SIADH in an octogenarian

  • Hyponatremia is the most common and by far underestimated electrolyte disorder in clinical practice. Especially in elderly patients, treatment of symptomatic hyponatremia is challenging. Herein we describe the case of an octogenarian with recurrent symptomatic hyponatremia due to idiopathic syndrome of inappropriate antidiuretic hormone release (SIADH). Fluid restriction was insufficient to prevent repeated episodes of hyponatremia complicated by falls and coma. After introduction of a low-dose therapy with tolvaptan, serum sodium levels as well as the clinical condition were stable under vaptan therapy, without any relapse for more than six years now. This case demonstrates that long-term tolvaptan treatment for hyponatremia caused by SIADH is safe and well tolerated, even in the elderly.

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Author:Stefan BüttnerORCiD, Jürgen Bachmann, Helmut GeigerGND, Nicholas ObermüllerGND
URN:urn:nbn:de:hebis:30:3-426345
DOI:https://doi.org/10.3390/jcm6030028
ISSN:2077-0383
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/28282848
Parent Title (English):Journal of Clinical Medicine
Publisher:MDPI
Place of publication:Basel
Contributor(s):Hemant Poudyal
Document Type:Article
Language:English
Date of Publication (online):2017/05/04
Date of first Publication:2017/03/08
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2017/05/04
Tag:SIADH; elderly; hyponatremia; tolvaptan
Volume:6
Issue:3, Art. 28
Page Number:6
First Page:1
Last Page:6
Note:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
HeBIS-PPN:423588877
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0