Non-linear relationship between BOLD activation and amplitude of beta oscillations in the supplementary motor area during rhythmic finger tapping and internal timing

  • Functional imaging studies using BOLD contrasts have consistently reported activation of the supplementary motor area (SMA) both during motor and internal timing tasks. Opposing findings, however, have been shown for the modulation of beta oscillations in the SMA. While movement suppresses beta oscillations in the SMA, motor and non-motor tasks that rely on internal timing increase the amplitude of beta oscillations in the SMA. These independent observations suggest that the relationship between beta oscillations and BOLD activation is more complex than previously thought. Here we set out to investigate this rapport by examining beta oscillations in the SMA during movement with varying degrees of internal timing demands. In a simultaneous EEG-fMRI experiment, 20 healthy right-handed subjects performed an auditory-paced finger-tapping task. Internal timing was operationalized by including conditions with taps on every fourth auditory beat, which necessitates generation of a slow internal rhythm, while tapping to every auditory beat reflected simple auditory-motor synchronization. In the SMA, BOLD activity increased and power in both the low and the high beta band decreased expectedly during each condition compared to baseline. Internal timing was associated with a reduced desynchronization of low beta oscillations compared to conditions without internal timing demands. In parallel with this relative beta power increase, internal timing activated the SMA more strongly in terms of BOLD. This documents a task-dependent non-linear relationship between BOLD and beta-oscillations in the SMA. We discuss different roles of beta synchronization and desynchronization in active processing within the same cortical region.

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Author:Florian Gompf, Anja Pflug, Helmut Laufs, Christian Alexander Kell
URN:urn:nbn:de:hebis:30:3-429141
DOI:https://doi.org/10.3389/fnhum.2017.00582
ISSN:1662-5161
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/29249950
Parent Title (English):Frontiers in human neuroscience
Publisher:Frontiers Research Foundation
Place of publication:Lausanne
Contributor(s):Srikantan S. Nagarajan
Document Type:Article
Language:English
Year of Completion:2017
Date of first Publication:2017/11/30
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/01/23
Tag:EEG-fMRI; internal time; predictive timing; premotor cortex; supplementary motor area (SMA)
Volume:11
Issue:Art. 582
Page Number:11
First Page:1
Last Page:11
Note:
Copyright © 2017 Gompf, Pflug, Laufs and Kell. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
HeBIS-PPN:427941679
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0