BET inhibition as a new strategy for the treatment of gastric cancer

  • Gastric cancer is one of the most common malignancies and a leading cause of cancer death worldwide. The prognosis of stomach cancer is generally poor as this cancer is not very sensitive to commonly used chemotherapies. Epigenetic modifications play a key role in gastric cancer and contribute to the development and progression of this malignancy. In order to explore new treatment options in this target area we have screened a library of epigenetic inhibitors against gastric cancer cell lines and identified inhibitors for the BET family of bromodomains as potent inhibitors of gastric cancer cell proliferations. Here we show that both the pan-BET inhibitor (+)-JQ1 as well as a newly developed specific isoxazole inhibitor, PNZ5, showed potent inhibition of gastric cancer cell growth. Intriguingly, we found differences in the antiproliferative response between gastric cancer cells tested derived from Brazilian patients as compared to those from Asian patients, the latter being largely resistant to BET inhibition. As BET inhibitors are entering clinical trials these findings provide the first starting point for future therapies targeting gastric cancer.

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Author:Raquel Carvalho Montenegro, Peter G. K. Clark, Alison Howarth, Xiao Wan, Alessandro Ceroni, Paulina Siejka, Graciela A. Nunez-Alonso, Octovia Monteiro, Catherine Rogers, Vicki Gamble, Rommel Burbano, Paul E. Brennan, Cynthia Tallant, Daniel Ebner, Oleg Fedorov, Eric M. O’Neill, Stefan Knapp, Darren Dixon, Susanne Müller
URN:urn:nbn:de:hebis:30:3-453394
DOI:https://doi.org/10.18632/oncotarget.9766
ISSN:1949-2553
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/27259267
Parent Title (English):OncoTarget
Publisher:Impact Journals LLC
Place of publication:[s. l.]
Document Type:Article
Language:English
Year of Completion:2016
Date of first Publication:2016/06/01
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/01/16
Tag:BET inhibitors; bromodomain; cytotoxicity; epigenetic; gastric cancer
Volume:7
Issue:28
Page Number:16
First Page:43997
Last Page:44012
Note:
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
HeBIS-PPN:426121279
Institutes:Biochemie, Chemie und Pharmazie / Biochemie und Chemie
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0