LET's sponge : how the lncRNA PFL promotes cardiac fibrosis
- Compared to their protein-coding counterparts, almost nothing is known about the role of long noncoding RNAs (lncRNAs) in cardiac fibrosis. In the current report, Liang and Pan et al. characterized the pro-fibrotic lncRNA PFL in respect to cardiac fibrosis in mice. PFL was upregulated in the hearts of mice after myocardial infarction and in fibrotic cardiac fibroblasts. Moreover, PFL competitively sponged the cardio-protective miRNA let-7d in cardiac fibroblasts. Knockdown of platelet activating factor receptor (PTAFR) was shown to affect the pro-fibrotic collagen production mediated by PFL. PTAFR overexpression also led to collagen production and RNA abundance of PTAFR was also regulated by miRNA let-7d. Therefore, the PFL/PTAFR/let-7d-dependent gene regulatory mechanism proposed by the authors manifests the hypothesis of competing endogenous RNAs to cardiac fibrosis.
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| Author: | Matthias LeisegangORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-455707 |
| DOI: | https://doi.org/10.7150/thno.23364 |
| ISSN: | 1838-7640 |
| Parent Title (English): | Theranostics |
| Publisher: | Ivyspring |
| Place of publication: | Wyoming, NSW |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2018 |
| Date of first Publication: | 2018/01/01 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2018/02/01 |
| Tag: | Cardiac Fibrosis; LncRNA; PFL; ceRNA; miRNA |
| Volume: | 8 |
| Issue: | 4 |
| Page Number: | 4 |
| First Page: | 874 |
| Last Page: | 877 |
| Note: | © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
| HeBIS-PPN: | 432157824 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (English): |  Creative Commons - Namensnennung-Nicht kommerziell 4.0 |
