Organizers and activators : Cytosolic Nox proteins impacting on vascular function

  • NADPH oxidases of the Nox family are important enzymatic sources of reactive oxygen species (ROS) in the cardiovascular system. Of the 7 members of the Nox family, at least three depend for their activation on specific cytosolic proteins. These are p47phox and its homologue NoxO1 and p67phox and its homologue NoxA1. Also the Rho-GTPase Rac is important but as this protein has many additional functions, it will not be covered here. The Nox1 enzyme is preferentially activated by the combination of NoxO1 with NoxA1, whereas Nox2 gains highest activity with p47phox together with p67phox. As p47phox, different to NoxO1 contains an auto inhibitory region it has to be phosphorylated prior to complex formation. In the cardio-vascular system, all cytosolic Nox proteins are expressed but the evidence for their contribution to ROS production is not well established. Most data have been collected for p47phox, whereas NoxA1 has basically not yet been studied. In this article the specific aspects of cytosolic Nox proteins in the cardiovascular system with respect to Nox activation, their expression and their importance will be reviewed. Finally, it will be discussed whether cytosolic Nox proteins are suitable pharmacological targets to tamper with vascular ROS production.

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Author:Katrin SchröderORCiDGND, Norbert Weißmann, Ralf Peter Louis BrandesORCiDGND
URN:urn:nbn:de:hebis:30:3-458906
DOI:https://doi.org/10.1016/j.freeradbiomed.2017.03.017
ISSN:1873-4596
ISSN:0891-5849
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/28336130
Parent Title (English):Free radical biology and medicine
Publisher:Elsevier
Place of publication:New York, NY [u. a.]
Document Type:Article
Language:English
Year of Completion:2017
Date of first Publication:2017/03/21
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/03/15
Tag:Activity control; NADPH oxidase; Nox; NoxA1; NoxO1; Oxygen-derived free radicals; Phosphorylation; p22phox; p47phox; p67phox
Volume:109
Page Number:11
First Page:22
Last Page:32
Note:
© 2017 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
HeBIS-PPN:431864969
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0