Natural killer cells as a therapeutic tool for infectious diseases - current status and future perspectives

  • Natural Killer (NK) cells are involved in the host immune response against infections due to viral, bacterial and fungal pathogens, all of which are a significant cause of morbidity and mortality in immunocompromised patients. Since the recovery of the immune system has a major impact on the outcome of an infectious complication, there is major interest in strengthening the host response in immunocompromised patients, either by using cytokines or growth factors or by adoptive cellular therapies transfusing immune cells such as granulocytes or pathogen-specific T-cells. To date, relatively little is known about the potential of adoptively transferring NK cells in immunocompromised patients with infectious complications, although the anti-cancer property of NK cells is already being investigated in the clinical setting. This review will focus on the antimicrobial properties of NK cells and the current standing and future perspectives of generating and using NK cells as immunotherapy in patients with infectious complications, an approach which is promising and might have an important clinical impact in the future.

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Author:Stanislaw Schmidt, Lars Tramsen, Bushra Rais, Evelyn UllrichORCiDGND, Thomas LehrnbecherORCiDGND
URN:urn:nbn:de:hebis:30:3-467473
DOI:https://doi.org/10.18632/oncotarget.25058
ISSN:1949-2553
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/29755697
Parent Title (English):OncoTarget
Publisher:Impact Journals LLC
Place of publication:[s. l.]
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/04/17
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2018/06/19
Tag:adoptive immunotherapy; bacterium; fungus; natural killer cell; virus
Volume:9
Issue:29
Page Number:17
First Page:20891
Last Page:20907
Note:
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
HeBIS-PPN:433827335
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universit├Ątspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung 3.0