Brief report – Telomere length is a poor biomarker to predict 1-year mortality or cardiovascular comorbidity in patients with transcatheter aortic valve replacement

  • Background: Transcatheter aortic valve replacement (TAVR) is a therapeutic option for patients with aortic valve stenosis at increased surgical risk. Telomeres are an established marker for cellular senescence and have served to evaluate cardiovascular diseases including severe aortic valve stenosis. In our study, we hypothesized that telomere length may be a predictor for outcome and associated with comorbidities in patients with TAVR. Methods and results: We analyzed leucocyte telomere length from 155 patients who underwent TAVR and correlated the results with 1-year mortality and severe comorbidities. The cohort was subdivided into 3 groups according to telomere length. Although a trend for a positive correlation of telomere length with a lower EuroSCORE could be found, telomere length was not associated with survival, aortic valve opening area or cardiovascular comorbidities (peripheral, coronary or cerebrovascular disease). Interestingly, long telomeres were significantly correlated to a reduced left ventricular ejection fraction (LVEF). Conclusion: In elderly patients with severe aortic valve stenosis, leucocyte telomere length did not predict post-procedural survival. The correlation between long telomere length and reduced LVEF in these patients deserves further attention.

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Author:Martin Steinmetz, Charlotte Schmitter, Tobias Radecke, Anja Stundl, Georg Nickenig, Christian Schaefer, Nadjib Schahab, Mariuca Vasa-Nicotera, Jan-Malte Sinning
URN:urn:nbn:de:hebis:30:3-485256
DOI:https://doi.org/10.1371/journal.pone.0213250
ISSN:1932-6203
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/30861019
Parent Title (English):PLoS one
Publisher:PLoS
Place of publication:Lawrence, Kan.
Contributor(s):Marc Wilhelm Merx
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/03/12
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/03/14
Tag:Aortic valve; Aortic valve replacement; Coronary heart disease; Ejection fraction; Stenosis; Telomere length; Telomeres; White blood cells
Volume:14
Issue:(3): e0213250
Page Number:6
First Page:1
Last Page:6
Note:
Copyright: © 2019 Steinmetz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
HeBIS-PPN:448042053
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0