Inflammatory serum markers up to 5 years after comprehensive periodontal therapy of aggressive and chronic periodontitis

  • Aim: The aim of the study is to assess the long-term effect of active periodontal therapy on serum inflammatory parameters in patients with aggressive (AgP) and chronic (ChP) periodontitis in a non-randomised clinical study. Methods: Twenty-five ChP and 17 AgP were examined clinically prior to (baseline), 12 weeks and 60 months after subgingival debridement of all pockets within 2 days. Systemic antibiotics were prescribed if Aggregatibacter actinomycetemcomitans was detected (10 AgP, 8 ChP), flap surgery was rendered if required. Neutrophil elastase (NE), C-reactive protein (CRP), lipopolysaccharide binding protein, interleukin 6, 8, and leukocyte counts were assessed at baseline, 12 weeks and 60 months. Results: Clinical parameters improved significantly in both groups from 12 weeks to 60 months. Eleven AgP and 18 ChP patients received surgical treatment after the 12 weeks examination. Only 3 patients in each group attended ≥ 2 supportive maintenance visits per year. NE and CRP were significantly higher in AgP than ChP at baseline and 60 months (p < 0.01). For leukocyte counts in ChP, significant changes were observed (baseline: 6.11 ± 1.44 nl−1; 12 weeks: 5.34 ± 1.40 nl−1; 60 months: 7.73 ± 2.89 nl−1; p < 0.05). Multiple regression analysis identified African origin, surgical treatment and female sex to correlate with better clinical improvement. Conclusion: Despite comprehensive periodontal treatment, AgP patients exhibit higher NE and CRP levels than ChP patients up to 5 years after therapy. Clinical relevance: Systemic inflammatory burden in AgP patients is higher than in ChP patients even 5 years after periodontal treatment.
Metadaten
Author:Tatjana Ramich, Anne Asendorf, Katrin Nickles, Maximilian Johannes Gerhard OremekORCiDGND, Ralf Schubert, Luigi Nibali, Martin Wohlfeil, Peter EickholzORCiDGND
URN:urn:nbn:de:hebis:30:3-502440
DOI:https://doi.org/10.1007/s00784-018-2398-x
ISSN:1436-3771
ISSN:1432-6981
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/29484548
Parent Title (English):Clinical oral investigations
Publisher:Springer
Place of publication:Berlin ; Heidelberg
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/02/27
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/05/13
Tag:Aggressive periodontitis; C-reactive protein; Chronic periodontiti; Interleukin-6; Leukocyte elastase; Lipopolysaccharide-binding protein
Volume:22
Issue:9
Page Number:11
First Page:3079
Last Page:3089
Note:
Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
HeBIS-PPN:453767427
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0