Repetitive magnetic stimulation induces plasticity of inhibitory synapses

  • Repetitive transcranial magnetic stimulation (rTMS) is used as a therapeutic tool in neurology and psychiatry. While repetitive magnetic stimulation (rMS) has been shown to induce plasticity of excitatory synapses, it is unclear whether rMS can also modify structural and functional properties of inhibitory inputs. Here we employed 10-Hz rMS of entorhinohippocampal slice cultures to study plasticity of inhibitory neurotransmission on CA1 pyramidal neurons. Our experiments reveal a rMS-induced reduction in GABAergic synaptic strength (2–4 h after stimulation), which is Ca2+-dependent and accompanied by the remodelling of postsynaptic gephyrin scaffolds. Furthermore, we present evidence that 10-Hz rMS predominantly acts on dendritic, but not somatic inhibition. Consistent with this finding, a reduction in clustered gephyrin is detected in CA1 stratum radiatum of rTMS-treated anaesthetized mice. These results disclose that rTMS induces coordinated Ca2+-dependent structural and functional changes of specific inhibitory postsynapses on principal neurons.

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Author:Maximilian Lenz, Christos Galanis, Florian Müller-Dahlhaus, Alexander Opitz, Corette Wierenga, Gábor Szabó, Ulf Ziemann, Thomas Deller, Klaus Funke, Andreas Vlachos
URN:urn:nbn:de:hebis:30:3-506414
DOI:https://doi.org/10.1038/ncomms10020
ISSN:2041-1723
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/26743822
Parent Title (English):Nature Communications
Publisher:Nature Publishing Group UK
Place of publication:[London]
Document Type:Article
Language:English
Year of Completion:2016
Date of first Publication:2016/01/08
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/07/11
Tag:Excitability; Synaptic plasticity; Therapeutics
Volume:7
Issue:Art. 10020
Page Number:13
First Page:1
Last Page:13
Note:
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
HeBIS-PPN:453520855
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0