Oncosuppressive functions of decorin

  • The extracellular matrix is rapidly emerging as a prominent contributor to various fundamental processes of tumorigenesis. In particular, decorin, a member of the small leucine-rich proteoglycan gene family, is assuming a central role as a potent soluble tumor repressor. Decorin binds and antagonizes various receptor tyrosine kinases and inhibits downstream oncogenic signaling in several solid tumors. Among other functions, decorin evokes cell cycle arrest, apoptosis, and antimetastatic, and antiangiogenic programs. Recent work has revealed a paradigmatic shift in our understanding of the molecular mechanisms underlying its tumoricidal properties. Decorin adversely compromises the genetic signature of the tumor microenvironment and induces endothelial cell autophagy downstream of VEGFR2. Moreover, decorin selectively evokes destruction of tumor cell mitochondria downstream of Met through mitophagy. Acting as a partial agonist, decorin signals via proautophagic receptors and triggers procatabolic processes that parallel the classical tumoricidal properties of this multifaceted proteoglycan.

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Author:Thomas NeillORCiD, Liliana SchäferORCiD, Renato V. IozzoORCiDGND
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/27308453
Parent Title (English):Molecular & cellular oncology
Publisher:Taylor & Francis
Place of publication:London
Document Type:Article
Year of Completion:2015
Date of first Publication:2015/02/25
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/07/11
Tag:Peg3; angiostasis; autophagy; mitophagy; mitostatin; proteoglycans
Page Number:12
First Page:e975645-1
Last Page:e975645-11
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell 3.0