Chemotherapy and diffuse low-grade gliomas : a survey within the European Low-Grade Glioma Network

  • Background: Diffuse low-grade gliomas (DLGGs) are rare and incurable tumors. Whereas maximal safe, functional-based surgical resection is the first-line treatment, the timing and choice of further treatments (chemotherapy, radiation therapy, or combined treatments) remain controversial. Methods: An online survey on the management of DLGG patients was sent to 28 expert centers from the European Low-Grade Glioma Network (ELGGN) in May 2015. It contained 40 specific questions addressing the modalities of use of chemotherapy in these patients. Results: The survey demonstrated a significant heterogeneity in practice regarding the initial management of DLGG patients and the use of chemotherapy. Interestingly, radiation therapy combined with the procarbazine, CCNU (lomustine), and vincristine regimen has not imposed itself as the gold-standard treatment after surgery, despite the results of the Radiation Therapy Oncology Group 9802 study. Temozolomide is largely used as first-line treatment after surgical resection for high-risk DLGG patients, or at progression. Conclusions: The heterogeneity in the management of patients with DLGG demonstrates that many questions regarding the postoperative strategy and the use of chemotherapy remain unanswered. Our survey reveals a high recruitment potential within the ELGGN for retrospective or prospective studies to generate new data regarding these issues.

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Author:Amélie Darlix, Emmanuel Mandonnet, Christian Franz Freyschlag, Daniel Pinggera, Marie-Thérèse ForsterORCiDGND, Martin VoßORCiDGND, Joachim Peter SteinbachORCiDGND, Carmel Loughrey, John Goodden, Giuseppe Banna, Concetta Di Blasi, Nicolas Foroglou, Andreas F. Hottinger, Marie-Hélène Baron, Johan Pallud, Hugues Duffau, Geert-Jan Rutten, Fabien Almairac, Denys Fontaine, Luc Taillandier, Catarina Viegas, Luisa Albuquerque, Gord von Campe, Tadeja Urbanic Purkart, Marie Blonski
Pubmed Id:
Parent Title (English):Neuro-oncology practice
Publisher:Oxford Univ. Press
Place of publication:Oxford
Document Type:Article
Year of Completion:2018
Date of first Publication:2018/12/13
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/09/02
Tag:PCV; chemotherapy; clinical practice; diffuse low-grade glioma; temozolomide
Page Number:10
First Page:264
Last Page:273
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (English):License LogoCreative Commons - Namensnennung-Nicht kommerziell 4.0