The many roles of cell adhesion molecules in hepatic fibrosis

  • Fibrogenesis is a progressive scarring event resulting from disrupted regular wound healing due to repeated tissue injury and can end in organ failure, like in liver cirrhosis. The protagonists in this process, either liver-resident cells or patrolling leukocytes attracted to the site of tissue damage, interact with each other by soluble factors but also by direct cell-cell contact mediated by cell adhesion molecules. Since cell adhesion molecules also support binding to the extracellular matrix, they represent excellent biosensors, which allow cells to modulate their behavior based on changes in the surrounding microenvironment. In this review, we focus on selectins, cadherins, integrins and members of the immunoglobulin superfamily of adhesion molecules as well as some non-classical cell adhesion molecules in the context of hepatic fibrosis. We describe their liver-specific contributions to leukocyte recruitment, cell differentiation and survival, matrix remodeling or angiogenesis and touch on their suitability as targets in antifibrotic therapies.

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Author:Edith Hintermann, Urs Christen
URN:urn:nbn:de:hebis:30:3-526244
DOI:https://doi.org/10.3390/cells8121503
ISSN:2073-4409
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/31771248
Parent Title (English):Cells
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/11/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/12/30
Tag:antifibrotic therapy; cadherin; cell adhesion; immunoglobulin superfamily; integrin; junctional adhesion molecule; liver fibrosis; non-classical adhesion molecule; selectin
Volume:8
Issue:12, Art. 1503
Page Number:27
First Page:1
Last Page:27
Note:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
HeBIS-PPN:458137235
Institutes:Medizin / Medizin
Fachübergreifende Einrichtungen / Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung 4.0