Phytochemical analysis of Ficus carica L. active compounds possessing anticonvulsant activity
- The anticonvulsant potential of Ficus carica methanol-extract (Fc) has been studied. It was found that Fc most active fraction is rich in oligosaccharides (OFG). 1H, 13C NMR and Nano-ESI, MALDI MS, and LC-MS techniques proved that OFG contains alpha-glucopyranoside oligomer in high amounts. Both Fc and OFG reduced strychnine (STR) convulsion-action. Fc and OFG fully protected the experimental-animals from STR-lethality. The intracerebroventricular-administration (ICV) of Fc or OFG in combination with glycine in ethanol-treated mice caused a dose-dependent returning to a 2nd-loss of righting-reflex (LORR), and was antagonized by STR. FC and OFG ICV injection counteracted STR-inhibition, confirming that Fc/OFG anticonvulsant mechanism of action was mediated by potentiation of glycine receptor. These results support Fc and OFG potential anticonvulsant-activity with good safety-profile. Keywords: Ficus carica, Moraceae, Nano-ESI MS, MALDI MS, Intracerebroventricular, Anticonvulsant activity.
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| Author: | Karim RaafatORCiD, Mario WurglicsGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-544961 |
| DOI: | https://doi.org/10.1016/j.jtcme.2018.01.007 |
| ISSN: | 2225-4110 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/31453121 |
| Parent Title (English): | Journal of traditional and complementary medicine |
| Publisher: | Medknow Publ. |
| Place of publication: | Mumbai |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2018 |
| Date of first Publication: | 2018/09/28 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2020/04/20 |
| Tag: | Anticonvulsant activity; Ficus carica; Intracerebroventricular; MALDI MS; Moraceae; Nano-ESI MS |
| Volume: | 9 |
| Issue: | 4 |
| Page Number: | 8 |
| First Page: | 263 |
| Last Page: | 270 |
| Note: | © 2018 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| HeBIS-PPN: | 464888298 |
| Institutes: | Biochemie, Chemie und Pharmazie / Pharmazie |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 58 Pflanzen (Botanik) / 580 Pflanzen (Botanik) |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
