SUMO : glue or solvent for phase-separated ribonucleoprotein complexes and molecular condensates?
- Spatial organization of cellular processes in membranous or membrane-less organelles (MLOs, alias molecular condensates) is a key concept for compartmentalizing biochemical pathways. Prime examples of MLOs are the nucleolus, PML nuclear bodies, nuclear splicing speckles or cytosolic stress granules. They all represent distinct sub- cellular structures typically enriched in intrinsically disordered proteins and/or RNA and are formed in a process driven by liquid-liquid phase separation. Several MLOs are critically involved in proteostasis and their formation, disassembly and composition are highly sensitive to proteotoxic insults. Changes in the dynamics of MLOs are a major driver of cell dysfunction and disease. There is growing evidence that post-translational modifications are critically involved in controlling the dynamics and composition of MLOs and recent evidence supports an important role of the ubiquitin-like SUMO system in regulating both the assembly and disassembly of these structures. Here we will review our current understanding of SUMO function in MLO dynamics under both normal and pathological conditions.
Author: | Jan Keiten-SchmitzORCiD, Linda Röder, Eran Hornstein, Michaela Müller-McNicollORCiDGND, Stefan MüllerORCiD |
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URN: | urn:nbn:de:hebis:30:3-612507 |
DOI: | https://doi.org/10.3389/fmolb.2021.673038 |
ISSN: | 2296-889X |
Parent Title (English): | Frontiers in molecular biosciences |
Publisher: | Frontiers in molecular biosciences |
Place of publication: | Lausanne |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2021/05/07 |
Date of first Publication: | 2021/05/07 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2021/06/30 |
Tag: | PML; RNF4; SUMO; membrane-less organelles; nucleolus; splicing; stress granules |
Volume: | 8 |
Issue: | art. 673038 |
Page Number: | 9 |
First Page: | 1 |
Last Page: | 9 |
Note: | Work in the Müller lab was funded by DFG collaborative research cebters SFB815 and SFB1177. MM-M and SM are part of the Cluster project ENABLE funded by the State of Hesse. Work in the Hornstein lab is supported by Mondry Family Professorial Chair, RADALA Foundation, Weizmann – Brazil Center for Research on Neurodegeneration and Minerva Foundation with funding from the Federal German Ministry for Education and Research. |
HeBIS-PPN: | 484966413 |
Institutes: | Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Open-Access-Publikationsfonds: | Medizin |
Licence (German): | Creative Commons - Namensnennung 4.0 |