Nox4 maintains blood pressure during low sodium diet

  • The NADPH oxidase Nox4 is a hydrogen peroxide (H2O2)-producing enzyme, with the highest expression in the kidney. As the kidney is involved in volume and blood pressure control through sodium handling, we set out to determine the impact of a low sodium diet on these parameters in WT and Nox4-/- mice. Nox4 expression in the murine kidney was restricted to the proximal tubule. Nevertheless, low-sodium-induced weight loss and sodium sparing function was similar in WT and Nox4-/- mice, disputing an important function of renal Nox4 in sodium handling. In contrast, a low sodium diet resulted in a reduction in systolic blood pressure in Nox4-/- as compared to WT mice. This was associated with a selectively lower pressure to heart-rate ratio, as well as heart to body weight ratio. In general, a low sodium diet leads to activation of sympathetic tone and the renin angiotensin system, which subsequently increases peripheral resistance. Our observations suggest that the control by this system is attenuated in Nox4-/- mice, resulting in lower blood pressure in response to low sodium.

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Author:Flávia Figueiredo de Rezende FelipeORCiDGND, Pedro Felipe Malacarne, Niklas MüllerGND, Birgit Rathkolb, Martin Hrabě de Angelis, Katrin SchröderORCiDGND, Ralf BrandesORCiDGND
Parent Title (English):Antioxidants
Place of publication:Basel
Document Type:Article
Date of Publication (online):2021/07/10
Date of first Publication:2021/07/10
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/08/03
Tag:NADPH oxidase 4; proximal tubule cells; reactive oxygen species
Issue:7, art. 1103
Page Number:12
First Page:1
Last Page:12
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0