The effect of primary urological cancers on survival in men with secondary prostate cancer

  • Background: To test the effect of urological primary cancers (bladder, kidney, testis, upper tract, penile, urethral) on overall mortality (OM) after secondary prostate cancer (PCa). Methods: Within the Surveillance, Epidemiology and End Results (SEER) database, patients with urological primary cancers and concomitant secondary PCa (diagnosed 2004-2016) were identified and were matched in 1:4 fashion with primary PCa controls. OM was compared between secondary and primary PCa patients and stratified according to primary urological cancer type, as well as to time interval between primary urological cancer versus secondary PCa diagnoses. Results: We identified 5,987 patients with primary urological and secondary PCa (bladder, n = 3,287; kidney, n = 2,127; testis, n = 391; upper tract, n = 125; penile, n = 47; urethral, n = 10) versus 531,732 primary PCa patients. Except for small proportions of Gleason grade group and age at diagnosis, PCa characteristics between secondary and primary PCa were comparable. Conversely, proportions of secondary PCa patients which received radical prostatectomy were smaller (29.0 vs. 33.5%), while no local treatment rates were higher (34.2 vs. 26.3%). After 1:4 matching, secondary PCa patients exhibited worse OM than primary PCa patients, except for primary testis cancer. Here, no OM differences were recorded. Finally, subgroup analyses showed that the survival disadvantage of secondary PCa patients decreased with longer time interval since primary cancer diagnosis. Conclusions: After detailed matching for PCa characteristics, secondary PCa patients exhibit worse survival, except for testis cancer patients. The survival disadvantage is attenuated, when secondary PCa diagnosis is made after longer time interval, since primary urological cancer diagnosis.

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Author:Mike WenzelORCiDGND, Christoph WürnschimmelORCiD, Luigi Nocera, Claudia Collà Ruvolo, Zhe Tian, Fred Saad, Alberto Briganti, Derya TilkiORCiDGND, Markus Graefen, Frederik RoosGND, Philipp Mandel, Felix ChunORCiDGND, Pierre I. Karakiewicz
URN:urn:nbn:de:hebis:30:3-644859
DOI:https://doi.org/10.1002/pros.24209
ISSN:1097-0045
Parent Title (English):The prostate
Publisher:Wiley-Liss
Place of publication:New York, NY
Document Type:Article
Language:English
Date of Publication (online):2021/08/16
Date of first Publication:2021/08/16
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/01/25
Tag:bladder cancer; kidney cancer; mortality; primary prostate cancer; urological cancer
Volume:81
Issue:15
Page Number:10
First Page:1149
Last Page:1158
Note:
Open access funding enabled and organized by Projekt DEAL.
HeBIS-PPN:491339305
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (English):License LogoCreative Commons - Namensnennung-Nicht kommerziell 4.0