- Objectives: To assess tolerability and efficacy of lacosamide in adults with cerebrovascular epilepsy etiology (CVEE).
Materials and methods: Exploratory post hoc analyses of a double‐blind, initial monotherapy trial of lacosamide vs carbamazepine‐controlled release (carbamazepine‐CR) (SP0993; NCT01243177); a double‐blind conversion to lacosamide monotherapy trial (SP0902; NCT00520741); and an observational study of adjunctive lacosamide added to one antiepileptic drug (SP0973 VITOBA; NCT01098162). Patients with CVEE were identified based on epilepsy etiology recorded at baseline.
Results: In the initial monotherapy trial, 61 patients had CVEE (lacosamide: 27; carbamazepine‐CR: 34). 20 (74.1%) patients on lacosamide (27 [79.4%] on carbamazepine‐CR) reported treatment‐emergent adverse events (TEAEs), most commonly (≥10%) headache, dizziness, and fatigue (carbamazepine‐CR: headache, dizziness). A numerically higher proportion of patients on lacosamide than carbamazepine‐CR completed 6 months (22 [81.5%]; 20 [58.8%]) and 12 months (18 [66.7%]; 17 [50.0%]) treatment without seizure at last evaluated dose. In the conversion to monotherapy trial, 26/30 (86.7%) patients with CVEE reported TEAEs, most commonly (≥4 patients) dizziness, convulsion, fatigue, headache, somnolence, and cognitive disorder. During lacosamide monotherapy, 17 (56.7%) patients were 50% responders and six (20.0%) were seizure‐free. In the observational study, 36/83 (43.4%) patients with CVEE reported TEAEs, most commonly (≥5%) fatigue and dizziness. Effectiveness was assessed for 75 patients. During the last 3 months, 60 (80%) were 50% responders and 42 (56.0%) were seizure‐free.
Conclusions: These exploratory post hoc analyses suggested lacosamide was generally well tolerated and effective in patients with CVEE, with data from the initial monotherapy trial suggesting numerically better efficacy than carbamazepine‐CR.
MetadatenVerfasserangaben: | Felix RosenowORCiDGND, Christian BrandtORCiDGND, Ali Bozorg, Svetlana Dimova, Björn Steiniger‐Brach, Ying Zhang, Bruno Ferrò, Gregory L. Holmes, Reetta Kälviäinen |
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URN: | urn:nbn:de:hebis:30:3-564359 |
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DOI: | https://doi.org/10.1111/ane.13230 |
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ISSN: | 1600-0404 |
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Titel des übergeordneten Werkes (Englisch): | Acta Neurologica Scandinavica |
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Verlag: | Wiley-Blackwell |
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Verlagsort: | Oxford |
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Dokumentart: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Datum der Veröffentlichung (online): | 18.02.2020 |
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Datum der Erstveröffentlichung: | 18.02.2020 |
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Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Datum der Freischaltung: | 07.12.2020 |
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Freies Schlagwort / Tag: | antiepileptic drugs; elderly; epilepsy; lacosamide; seizures; stroke |
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Jahrgang: | 141 |
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Seitenzahl: | 10 |
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Erste Seite: | 473 |
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Letzte Seite: | 482 |
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HeBIS-PPN: | 475576195 |
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Institute: | Medizin / Medizin |
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DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Lizenz (Englisch): | Creative Commons - Namensnennung-Nicht kommerziell 4.0 |
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