The prognostic relevance of the proliferation markers Ki-67 and Plk1 in early-stage ovarian cancer patients with serous, low-grade carcinoma based on mRNA and protein expression
- Since type and duration of an appropriate adjuvant chemotherapy in early-stage ovarian cancer (OC) are still being debated, novel markers for a better stratification of these patients are of utmost importance for the design of an improved chemotherapeutical strategy. In contrast to numerous cancer studies on cellular proliferation based on the immunohistochemistry-driven evaluation of protein expression, we compared mRNA and protein expression of two independent markers of cellular proliferation, Ki-67 and Plk1, in a large cohort of 243 early-stage OC and their relationship with clinicopathological features and survival. Based on marker expression we demonstrate that early-stage OC patients (stages I/II, low-grade, serous) with high expression (Ki-67, Plk1) had a significantly shorter progression-free survival (PFS) and overall survival (OS) compared to patients with low expression (Ki-67, Plk1). Remarkably, based on mRNA expression this significant difference got lost in advanced stages (III/IV): At least for PFS, high levels of Ki-67 and Plk1 correlate with moderately better survival compared to patients with low expressing tumors. Our data suggest that in addition to Ki-67, Plk1 is a novel marker for the stratification of early-stage OC patients to maximize therapeutic efforts. Both, Ki-67 and Plk1, seem to be better suited in early-stages (I/II) as therapeutical targets compared to advanced-stages (III/IV) OC.
Verfasserangaben: | Franz RödelORCiDGND, Shengtao Zhou, Balász Győrffy, Monika RaabORCiD, Mourad SanhajiORCiDGND, Ranadip MandalORCiDGND, Daniel MartinORCiD, Sven BeckerORCiDGND, Klaus StrebhardtORCiD |
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URN: | urn:nbn:de:hebis:30:3-571936 |
DOI: | https://doi.org/10.3389/fonc.2020.558932 |
ISSN: | 2234-943X |
Titel des übergeordneten Werkes (Englisch): | Frontiers in oncology |
Verlag: | Frontiers Media |
Verlagsort: | Lausanne |
Dokumentart: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Datum der Veröffentlichung (online): | 07.10.2020 |
Datum der Erstveröffentlichung: | 07.10.2020 |
Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Datum der Freischaltung: | 08.12.2020 |
Freies Schlagwort / Tag: | Ki-67/MIB1; mRNA and protein expression; ovarian cancer; polo-like kinase 1; prognosis |
Jahrgang: | 10 |
Ausgabe / Heft: | 558932 |
HeBIS-PPN: | 477518435 |
Institute: | Medizin / Medizin |
DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Lizenz (Deutsch): | ![]() |