Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind
- Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood. Therefore, the VEGF system serves as a promising therapeutic target for brain pathologies, but its simultaneous action on vascular cells paves the way for harmful side effects. To circumvent these deleterious effects, many studies have aimed to clarify whether VEGFs directly affect neural cells or if the effects are mediated secondarily via other cell types, like vascular cells. A great number of reports have shown the expression and function of VEGF receptors (VEGFRs), mainly VEGFR-1 and -2, in neural cells, where VEGFR-2 has been described as the major mediator of VEGF-A signals. This review aims to summarize and compare the divergent roles of VEGFR-1 and -2 during CNS development and homeostasis.
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| Verfasserangaben: | Ina M. Wittko-Schneider, Fabian T. Schneider, Karl PlateGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-291443 |
| DOI: | https://doi.org/10.1007/s00018-013-1279-3 |
| ISSN: | 1420-682X |
| ISSN: | 1420-9071 |
| Pubmed-Id: | https://pubmed.ncbi.nlm.nih.gov/23475067 |
| Titel des übergeordneten Werkes (Englisch): | Cellular and molecular life sciences |
| Verlag: | Birkhäuser |
| Verlagsort: | Basel |
| Dokumentart: | Wissenschaftlicher Artikel |
| Sprache: | Englisch |
| Datum der Veröffentlichung (online): | 12.03.2013 |
| Datum der Erstveröffentlichung: | 12.03.2013 |
| Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Datum der Freischaltung: | 13.03.2013 |
| Freies Schlagwort / Tag: | Brain development; Brain repair; Migration; Neural stem cells; Neurogenesis; VEGF receptors |
| Jahrgang: | 70 |
| Ausgabe / Heft: | 10 |
| Seitenzahl: | 21 |
| Erste Seite: | 1705 |
| Letzte Seite: | 1725 |
| Bemerkung: | Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| HeBIS-PPN: | 334239737 |
| Institute: | Medizin / Medizin |
| DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Lizenz (Deutsch): |  Creative Commons - Namensnennung 3.0 |
