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Year of publication
Document Type
- Preprint (2268) (remove)
Has Fulltext
- yes (2268)
Keywords
- Kollisionen schwerer Ionen (33)
- heavy ion collisions (27)
- Deutsch (23)
- Quark-Gluon-Plasma (14)
- equation of state (13)
- QGP (12)
- heavy-ion collisions (11)
- Kongress (10)
- Syntax (10)
- quark-gluon plasma (10)
Institute
- Physik (1377)
- Frankfurt Institute for Advanced Studies (FIAS) (962)
- Informatik (759)
- Medizin (176)
- Extern (82)
- Biowissenschaften (75)
- Ernst Strüngmann Institut (70)
- Mathematik (48)
- MPI für Hirnforschung (47)
- Psychologie (46)
Seed harvesting from wild plant populations is key for ecological restoration, but may threaten the persistence of source populations. Consequently, several countries have set guidelines limiting the proportions of harvestable seeds. Here, we use high-resolution data from 298 plant species to model the demographic consequences of seed harvesting. We find that the current guidelines only protect some species, but are insufficient or overly restrictive for others. We show that the maximum possible fraction of seed harvesting is strongly associated with harvesting frequency and generation time of the target species, ranging from 100% in long-lived species to <1% in the most annuals. Our results provide quantitative basis to guide seed harvesting legislation based on species’ generation time and harvesting regime.
Antimicrobial resistance is a major threat to global health and food security today. Scheduling cycling therapies by targeting phenotypic states associated to specific mutations can help us to eradicate pathogenic variants in chronic infections. In this paper, we introduce a logistic switching model in order to abstract mutation networks of collateral resistance. We found particular conditions for which unstable zero-equilibrium of the logistic maps can be stabilized through a switching signal. That is, persistent populations can be eradicated through tailored switching regimens.
Starting from an optimal-control formulation, the switching policies show their potential in the stabilization of the zero-equilibrium for dynamics governed by logistic maps. However, employing such switching strategies, deserve a specific characterization in terms of limit behaviour. Ultimately, we use evolutionary and control algorithms to find either optimal and sub-optimal switching policies. Simulations results show the applicability of Parrondo’s Paradox to design cycling therapies against drug resistance.
Hu, Haoyu ; Rai, Gautam ; Crippa, Lorenzo ; Herzog-Arbeitman, Jonah ; Călugăru, Dumitru ; Wehling, Tim O. ; Sangiovanni, Giorgio ; Valentí, Roser ; Tsvelik, Alexei M. ; Bernevig, B. Andrei
We use the topological heavy fermion (THF) model and its Kondo Lattice (KL) formulation to study the symmetric Kondo state in twisted bilayer graphene. Via a large-N approximation, we find a symmetric Kondo (SK) state in KL mode at fillings ν=0,±1,±2. In the SK state, all symmetries are preserved and the local moments are Kondo screened by the conduction electrons. At the mean-field level of the THF model at ν=0,±1,±2,±3, we also find a similar symmetric state. We study the stability of the symmetric state by comparing its energy with the ordered states and find the ordered states to have lower energy. However, moving away from integer fillings by doping holes to the light bands, we find the energy difference is reduced, which suggests the loss of ordering and a tendency towards Kondo screening. In order to include many-body effects beyond the mean-field approximation, we perform dynamical mean-field theory (DMFT) calculations on the THF model. We find the spin susceptibility follows a Curie behavior at ν=0,±1,±2 down to ∼2K where the onset of screening of the local moment becomes visible. This hints to very low Kondo temperatures at these fillings, in agreement with the outcome of our mean-field calculations. At non-integer filling ν=±0.5,±0.8,±1.2 DMFT shows deviations from a 1/T-susceptibility at much higher temperatures, suggesting a more effective screening of local moments with doping. Finally, we study the effect of a C3z-rotational-symmetry-breaking strain via mean-field approaches and find that a symmetric phase (that only breaks C3z symmetry) can be stabilized at sufficiently large strain at ν=0,±1,±2. Our results suggest that a symmetric Kondo phase is strongly suppressed at integer fillings, but could be stabilized either at non-integer fillings or by applying strain.
Acharya, Shreyasi ; Adamová, Dagmar ; Adler, Alexander ; Aglieri Rinella, Gianluca ; Agnello, Michelangelo ; Agrawal, Neelima ; Ahammed, Zubayer ; Ahmad, Shakeel ; Ahn, Sang Un ; Ahuja, Ishaan ; Akindinov, Alexander ; Al-Turany, Mohammad ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alfanda, Haidar Mas’ud ; Alfaro Molina, Jose Ruben ; Ali, Bushra ; Alici, Andrea ; Alizadehvandchali, Negin ; Alkin, Anton ; Alme, Johan ; Alocco, Giacomo ; Alt, Torsten ; Altsybeev, Igor ; Anaam, Mustafa Naji ; Andrei, Cristian ; Andronic, Anton ; Anguelov, Venelin ; Antinori, Federico ; Antonioli, Pietro ; Apadula, Nicole ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arata, Carolina ; Arcelli, Silvia ; Aresti, Mauro ; Arnaldi, Roberta ; Arneiro, J.G. M.C. A. ; Arsene, Ionut Cristian ; Arslandok, Mesut ; Augustinus, Andre ; Averbeck, Ralf Peter ; Azmi, Mohd Danish ; Badalà, Angela ; Bae, Joonsuk ; Baek, Yong Wook ; Bai, X. ; Bailhache, Raphaëlle ; Bailung, Yoshini ; Balbino, Alessandro ; Baldisseri, Alberto ; Balis, Bartosz ; Banerjee, Debjani ; Banoo, Zarina ; Barbera, Roberto ; Barile, Francesco ; Barioglio, Luca ; Barlou, Maria ; Barnaföldi, Gergely Gábor ; Barnby, Lee Stuart ; Barret, Valerie ; Barreto, L. ; Bartels, Clara ; Barth, Klaus ; Bartsch, Esther ; Bastid, Nicole ; Basu, Sumit ; Batigne, Guillaume ; Battistini, Daniel ; Batyunya, Boris ; Bauri, Dibakar ; Bazo Alba, José Luis ; Bearden, Ian Gardner ; Beattie, Caitlin ; Becht, Pascal ; Behera, D. ; Belikov, Iouri ; Bell Hechavarria, Ailec de la Caridad ; Bellini, Francesca ; Bellwied, Rene ; Belokurova, Svetlana ; Belyaev, Vladimir ; Bencédi, Gyula ; Beolè, Stefania ; Bercuci, Alexandru ; Berdnikov, Yaroslav ; Berdnikova, Anastasia ; Bergmann, L. ; Besoiu, Mihaela Gabriela ; Betev, Latchezar ; Bhaduri, Partha Pratim ; Bhasin, Anju ; Bhat, Mohammad Asif ; Bhattacharjee, Buddhadeb ; Bianchi, Livio ; Bianchi, Nicola ; Bielčík, Jaroslav ; Bielčíková, Jana ; Biernat, Jacek ; Bigot, A.P. ; Bilandzic, Ante ; Biro, Gabor ; Biswas, Saikat ; Bizé, Nicolas ; Blair, Justin Thomas ; Blau, Dmitry S. ; Blidaru, Mihail-Bogdan ; Bluhme, N. ; Blume, Christoph ; Boca, Gianluigi ; Bock, Friederike ; Bodova, T. ; Bogdanov, Alexey A. ; Boi, Stefano ; Bok, Jeongsu ; Boldizsár, László ; Bombara, Marek ; Bond, Peter Matthew ; Bonomi, Germano ; Borel, Hervé ; Borissov, Alexander ; Borquez Carcamo, A.G. ; Bossi, Hannah ; Botta, Elena ; El Mard Bouziani, Youssef ; Bratrud, Lars ; Braun-Munzinger, Peter ; Bregant, Marco ; Broz, Michal ; Bruno, Giuseppe Eugenio ; Buckland, Matthew Daniel ; Budnikov, Dmitry ; Büsching, Henner ; Bufalino, Stefania ; Bühler, Paul ; Buthelezi, Edith Zinhle ; Bylinkin, Alexander ; Bysiak, Sebastian Adam ; Cai, M. ; Caines, Helen Louise ; Caliva, Alberto ; Calvo Villar, Ernesto ; Camacho, J.M. M. ; Camerini, Paolo ; Canedo, F.D. M. ; Carabas, M. ; Amatriain Carballo, Aitor ; Carnesecchi, Francesca ; Caron, Robin Albert Andre ; Carvalho, L.A. D. ; Castillo Castellanos, Javier Ernesto ; Catalano, Fabio ; Ceballos Sanchez, Cesar ; Chakaberia, Irakli ; Chakraborty, Pritam ; Chandra, Sinjini ; Chapeland, Sylvain ; Chartier, Marielle ; Chattopadhyay, S. ; Chattopadhyay, S. ; García Chávez, Tonatiuh ; Cheng, T. ; Cheshkov, Cvetan Valeriev ; Cheynis, Brigitte ; Chibante Barroso, Vasco Miguel ; Chinellato, David Dobrigkeit ; Chizzali, E.S. ; Cho, J. ; Cho, Soyeon ; Chochula, Peter ; Christakoglou, Panagiotis ; Christensen, Christian Holm ; Christiansen, Peter L. ; Chujo, Tatsuya ; Ciacco, M. ; Cicalò, Corrado ; Cindolo, Federico ; Ciupek, Michael Rudolf ; Clai, Giulia ; Colamaria, Fabio Filippo ; Colburn, Jonathan Samuel ; Colella, Domenico ; Colocci, Manuel ; Conesa Balbastre, Gustavo ; Conesa del Valle, Zaida ; Contin, Giacomo ; Contreras Nuno, Jesus Guillermo ; Coquet, Maurice Louis ; Cormier, Thomas Michael ; Cortese, Pietro ; Cosentino, Mauro Rogerio ; Costa, Filippo ; Costanza, Susanna ; Cot, C. ; Crkovská, Jana ; Crochet, Philippe ; Cruz Torres, Reynier ; Cui, Pengyao ; Dainese, Andrea ; Danisch, Meike Charlotte ; Danu, Andrea ; Das, Prottay ; Das, Prottay ; Das, Supriya ; Dash, A.R. ; Dash, Sadhana ; De Caro, Annalisa ; De Cataldo, Giacinto ; Cuveland, Jan de ; De Falco, Alessandro ; De Gruttola, Daniele ; De Marco, Nora ; De Martin, Chiara ; De Pasquale, Salvatore ; Deb, R. ; Deb, Suman ; Debski, R.J. ; Deja, Kamil Rafal ; Del Grande, R. ; Stritto, L.Dello ; Deng, W. ; Dhankher, Preeti ; Di Bari, Domenico ; Di Mauro, Antonio ; Arteche Díaz, Raúl ; Dietel, Thomas ; Ding, Yanchun ; Divià, Roberto ; Dixit, Dhruv Utpalkumar ; Djuvsland, Øystein ; Dmitrieva, Uliana ; Dobrin, Alexandru Florin ; Dönigus, Benjamin ; Dubinski, J.M. ; Dubla, Andrea ; Dudi, Sandeep ; Dupieux, Pascal ; Durkac, M. ; Dzalaiova, N. ; Eder, Tabea Maria ; Ehlers, Raymond James ; Eikeland, Viljar Nilsen ; Eisenhut, Florian ; Elia, Domenico ; Erazmus, Barbara Ewa ; Ercolessi, Francesca ; Erhardt, Filip ; Ersdal, Magnus Rentsch ; Espagnon, Bruno ; Eulisse, Giulio ; Evans, David ; Evdokimov, Sergey ; Fabbietti, Laura ; Faggin, Mattia ; Faivre, Julien ; Fan, Feng ; Fan, W. ; Fantoni, Alessandra ; Fasel, Markus ; Fecchio, Pietro ; Feliciello, Alessandro ; Feofilov, Grigori A. ; Fernández Téllez, Arturo ; Ferrandi, L. ; Ferrer, M.B. ; Ferrero, Andrea ; Ferrero, C. ; Ferretti, Alessandro ; Feuillard, V.J. G. ; Filova, V. ; Finogeev, Dmitry ; Fionda, Fiorella Maria Celeste ; Flor, Fernando Antonio ; Flores, Amanda Nicole ; Foertsch, Siegfried Valentin ; Fokin, I. ; Fokin, Sergey ; Fragiacomo, Enrico ; Frajna, E. ; Fuchs, Ulrich ; Funicello, Nicola ; Furget, Christophe ; Furs, Artur ; Fusayasu, T. ; Gaardhøje, Jens Jørgen ; Gagliardi, Martino ; Gago Medina, Alberto Martín ; Duarte Galvan, Carlos ; Gangadharan, Dhevan Raja ; Ganoti, Paraskevi ; Garabatos, Chilo ; Garcia, J.R. A. ; Garcia-Solis, Edmundo Javier ; Gargiulo, Corrado ; Garner, Katharina ; Gasik, Piotr ; Gautam, Amrit ; Ducati, Maria Beatriz de Leone Gay ; Germain, Marie ; Ghimouz, A. ; Ghosh, C. ; Giacalone, Marco ; Giubellino, Paolo ; Giubilato, Piero ; Glaenzer, Aude Marie Camille ; Glässel, Peter ; Glimos, Ewa ; Goh, D.J. Q. ; Gonzalez, Victor ; Gorgon, Marek Boguslaw ; Gotovac, Sven ; Grabski, Varlen ; Graczykowski, Łukasz Kamil ; Grecka, Ekaterina ; Grelli, Alessandro ; Grigoraș, Costin ; Grigoriev, Vladislav A. ; Grigoryan, Smbat ; Grosa, Fabrizio ; Große-Oetringhaus, Jan Fiete ; Grosso, Raffaele ; Grund, David ; Guardiano, G.G. ; Guernane, Rachid ; Guilbaud, Maxime Rene Joseph ; Gulbrandsen, Kristjan Herlache ; Gündem, Tuba ; Gunji, Taku ; Guo, W. ; Gupta, Anik ; Gupta, Ramni ; Gupta, Ramni ; Guzman, S.P. ; Gwizdziel, K. ; Gyulai, L. ; Habib, Michael Karim ; Hadjidakis, Cynthia Marie ; Haider, F.U. ; Hamagaki, Hideki ; Hamdi, A. ; Hamid, Mohammed ; Han, Y. ; Hannigan, Ryan ; Haque, Md Rihan ; Harris, John W. ; Harton, Austin Vincent ; Hassan, Hadi ; Hatzifotiadou, Despina ; Hauer, Philip ; Havener, Laura Brittany ; Heckel, Stefan Thomas ; Hellbär, Ernst ; Helstrup, Håvard ; Hemmer, M. ; Herman, Tomáš ; Herrera Corral, Gerardo Antonio ; Herrmann, Florian ; Herrmann, S. ; Hetland, Kristin Fanebust ; Heybeck, Benedict ; Hillemanns, Hartmut ; Hippolyte, Boris ; Hoffmann, F.W. ; Hofman, Bas ; Hohlweger, Bernhard ; Hong, Geunhee ; Horst, M. ; Horzyk, A. ; Hou, Y. ; Hristov, Peter ; Hughes, Charles ; Huhn, Patrick ; Huhta, Laura Maria ; Hulse, C.V. ; Humanic, Thomas J. ; Hutson, Alek ; Hutter, Dirk ; Iddon, James Philip ; Ilkaev, Radiy ; Ilyas, Hira ; Inaba, Motoi ; Innocenti, Gian Michele ; Ippolitov, Mikhail ; Isakov, Artem ; Isidori, Tommaso ; Islam, Md Samsul ; Ivanov, Marian ; Ivanov, Marian ; Ivanov, V. ; Jablonski, Miroslaw ; Jacak, Barbara ; Jacazio, Nicolò ; Jacobs, Peter Martin ; Jadlovska, Slavka ; Jadlovsky, Jan ; Jaelani, Syaefudin ; Jaffe, L. ; Jahnke, Cristiane ; Jakubowska, Monika Joanna ; Janik, Malgorzata Anna ; Janson, Thomas ; Jercic, Marko ; Jia, S. ; Jimenez, A.A. P. ; Jonas, Florian ; Jowett, John M. ; Jung, Jerome ; Jung, Michael ; Junique, Antoine Jean-Simon ; Jusko, Anton ; Kabus, Maja Jadwiga ; Kaewjai, J. ; Kalinak, Peter ; Kalteyer, Annalena Sophie ; Kalweit, Alexander Philipp ; Kaplin, Vladimir ; Karasu Uysal, Ayben ; Karatović, David ; Karavichev, Oleg V. ; Karavicheva, Tatiana L. ; Karczmarczyk, Przemyslaw ; Karpechev, Evgeny ; Kebschull, Udo ; Keidel, Ralf ; Keijdener, D.L. D. ; Keil, Markus ; Ketzer, Bernhard ; Khade, S.S. ; Khan, Ahsan Mehmood ; Khan, Shaista ; Khanzadeev, Alexei ; Kharlov, Yury ; Khatun, Anisa ; Khuntia, Arvind ; Kidson, M.B. ; Kileng, Bjarte ; Kim, B. ; Kim, C. ; Kim, D.J. ; Kim, E.J. ; Kim, J. ; Kim, J.S. ; Kim, J. ; Kim, M. ; Kim, S. ; Kim, T. ; Kimura, K. ; Kirsch, Stefan ; Kisel, Ivan ; Kiselev, Sergej N. ; Kisiel, Adam Ryszard ; Kitowski, J.P. ; Klay, Jennifer Lynn ; Klein, Jochen ; Klein, Spencer Robert ; Klein-Bösing, Christian ; Kleiner, Matthias ; Klemenz, Thomas ; Kluge, Alexander ; Knospe, Anders Garritt ; Kobdaj, Chinorat ; Kollegger, Thorsten ; Kondratyev, Andrey ; Kondratyeva, Natalia ; Kondratyuk, Evgeny ; König, Joshua Leon ; Königstorfer, Stephan Alexander ; Konopka, Piotr Jan ; Kornakov, Georgy ; Koryciak, Sebastian Dominik ; Kotliarov, Artem ; Kovalenko, Vladimir ; Kowalski, Marek ; Kozhuharov, V. ; Králik, Ivan ; Kravčáková, Adela ; Krcal, L. ; Kreis, Lukas ; Krivda, Marian ; Krizek, Filip ; Krizkova Gajdosova, Katarina ; Kroesen, Martin ; Krüger, Mario ; Krupova, D.M. ; Kryshen, Evgeny ; Kučera, Vít ; Kuhn, Christian Claude ; Kuijer, Paulus Gerardus ; Kumaoka, Takuya ; Kumar, D. ; Kumar, Lokesh ; Kumar, N. ; Kumar, Shyam ; Kundu, Sourav ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kvapil, Jakub ; Kweon, Min Jung ; Kwon, J.Y. ; Kwon, Youngil ; La Pointe, Sarah Louise ; La Rocca, Paola ; Lakrathok, Anantachai ; Lamanna, Massimo ; Langoy, Rune ; Larionov, Pavel ; Laudi, Elisa ; Lautner, Lukas ; Lavicka, Roman ; Lazareva, Tatiana V. ; Lea, Ramona ; Lee, H. ; Legras, G. ; Lehrbach, Johannes ; Lelek, T.M. ; Lemmon, Roy Crawford ; León Monzón, Ildefonso ; Lesch, Marcel Markus ; Lesser, Ezra Douglas ; Lévai, Péter ; Li, X. ; Li, Xing Long ; Lien, Jørgen André ; Lietava, Roman ; Likmeta, I. ; Lim, Bong-Hwi ; Lim, S.H. ; Lindenstruth, Volker ; Lindner, Amelia ; Lippmann, Christian ; Liu, Alwina Ruixin ; Liu, D.H. ; Liu, J. ; Lofnes, Ingrid Mckibben ; Loizides, Constantinos ; Lokos, S. ; Lomker, J. ; Lončar, Petra ; López, Jorge Andres ; Lopez, Xavier Bernard ; López Torres, Ernesto ; Lu, P. ; Luhder, Jens Robert ; Lunardon, Marcello ; Luparello, Grazia ; Ma, Yu-Gang ; Maevskaya, Alla ; Mager, Magnus ; Maire, Antonin ; Makariev, Martin Vasilev ; Malaev, Mikhail ; Malfattore, Giovanni ; Malik, Nasir Mehdi ; Malik, Qasim Waheed ; Malik, Salman Khurshid ; Malinina, Liudmila ; Mal’Kevich, Dmitry ; Mallick, Dukhishyam ; Mallick, Neelkamal ; Mandaglio, Giuseppe ; Mandal, Sushobhan Kumar ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Mao, Yaxian ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Marín, Ana ; Markert, Christina ; Martinengo, Paolo ; Martinez, Jacobb Lee ; Martínez Hernández, Mario Iván ; Martínez Garcia, Ginés ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Massacrier, Laure Marie ; Mastroserio, Annalisa ; Matonoha, Oliver ; Matuoka, P.F. T. ; Matyja, Adam Tomasz ; Mayer, Christoph ; Lafuente Mazuecos, Antonio ; Mazzaschi, Francesco ; Mazzilli, Marianna ; Mdhluli, J.E. ; Mechler, Adrian Florin ; Melikyan, Yury ; Menchaca-Rocha, Arturo Alejandro ; Meninno, Elisa ; Sasikumar Menon, Anjaly ; Meres, Michal ; Mhlanga, Sibaliso ; Miake, Yasuo ; Micheletti, Luca ; Migliorin, Lucrezia Camilla ; Mihaylov, Dimitar Lubomirov ; Mikhaylov, Konstantin ; Mishra, Aditya Nath ; Miśkowiec, Dariusz Czesław ; Modak, Abhi ; Mohanty, Auro Prasad ; Mohanty, Bedangadas ; Mohisin Khan, Mohammed ; Molander, Mikael Andreas ; Moravcova, Zuzana ; Mordasini, Cindy ; Godoy, Denise Aparecida Moreira de ; Morozov, Igor ; Morsch, Andreas ; Mrnjavac, Teo ; Muccifora, Valeria ; Muhuri, Sanjib ; Mulligan, James Declan ; Mulliri, Alice ; Munhoz, Marcelo Gameiro ; Munzer, Robert Helmut ; Murakami, Hikari ; Murray, Sean ; Musa, Luciano ; Musinsky, Jan ; Myrcha, Julian Wojciech ; Naik, Bharati ; Nambrath, A.I. ; Nandi, Basanta Kumar ; Nania, Rosario ; Nappi, Eugenio ; Nassirpour, Adrian Fereydon ; Nath, Abhishek ; Nattrass, Christine ; Naydenov, M.N. ; Neagu, Alexandra ; Negru, A. ; Nellen, Lukas ; Nesbo, Simon Voigt ; Nešković, Gvozden ; Nesterov, Dmitrii ; Nielsen, Borge Svane ; Nielsen, E.G. ; Nikolaev, Sergey ; Nikulin, Sergey ; Nikulin, Vladimir ; Noferini, Francesco ; Noh, S. ; Nomokonov, Petr V. ; Norman, Jaime ; Novitzky, Norbert ; Nowakowski, Piotr ; Nyanin, Alexander ; Nystrand, Joakim Ingemar ; Ogino, Masanori ; Ohlson, Alice ; Okorokov, Vitaly A. ; Oleniacz, Janusz ; Silva, Antonio Carlos Oliveira da ; Oliver, Michael Henry ; Önnerstad, Anna ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Otwinowski, Jacek Tomasz ; Oya, M. ; Oyama, Ken ; Pachmayer, Yvonne C. ; Padhan, Sonali ; Pagano, Davide ; Paić, Guy ; Palasciano, Antonio ; Panebianco, Stefano Matthias ; Park, H. ; Park, H. ; Park, Jonghan ; Parkkila, Jasper Elias ; Patra, Rajendra Nath ; Paul, Biswarup ; Pei, Hua ; Peitzmann, Thomas ; Peng, Xinye ; Pennisi, Michele ; Pereira, Luis Gustavo ; Peresunko, Dmitry Yurevich ; Mesa Perez, Guillermo ; Perrin, Sébastien ; Pestov, Yury N. ; Petráček, Vojtech ; Petrov, Vitalii ; Petrovici, Mihai A. ; Pezzi, Rafael Peretti ; Piano, Stefano ; Pikna, Miroslav ; Pillot, Philippe ; Pinazza, Ombretta ; Pinsky, Lawrence ; Pinto, Chiara ; Pisano, Silvia ; Płoskoń, Mateusz ; Planinic, Mirko ; Pliquett, Fabian ; Poghosyan, Martin G. ; Polichtchouk, Boris ; Politano, Stefano ; Poljak, Nikola ; Pop, Amalia ; Porteboeuf-Houssais, Sarah Julie ; Pozdniakov, Valeriy ; Yoval Pozos, Irandheny ; Pradhan, K.K. ; Prasad, Sidharth Kumar ; Prasad, S. ; Preghenella, Roberto ; Prino, Francesco ; Pruneau, Claude A. ; Pshenichnov, Igor A. ; Puccio, Maximiliano ; Pucillo, S. ; Pugelova, Z. ; Qiu, S. ; Quaglia, Luca ; Quishpe, Raquel Estefania ; Ragoni, Simone ; Rakotozafindrabe, Andry Malala ; Ramello, Luciano ; Rami, Fouad ; Ramirez, S.A. R. ; Rancien, Thibaut Albert ; Rasa, M. ; Räsänen, Sami Sakari ; Rath, Rutuparna ; Rauch, Max Philip ; Ravasenga, Ivan ; Read, Kenneth Francis ; Reckziegel, Christian ; Redelbach, Andreas Ralph ; Redlich, Krzysztof ; Reetz, C.A. ; Rehman, Attiq ur ; Reidt, Felix ; Reme-Ness, Haakon André ; Rescakova, Zuzana ; Reygers, Klaus ; Riabov, Andrei ; Riabov, Viktor G. ; Ricci, R. ; Richter, Matthias ; Riedel, Anton Albert ; Riegler, Werner ; Ristea, Cătălin-Lucian ; Rodrı́guez Cahuantzi, Mario ; Røed, Ketil ; Rogalev, Roman ; Rogochaya, Elena ; Rogoschinski, Tim Sebastian ; Rohr, David ; Röhrich, Dieter ; Fierro Rojas, Pablo ; Rojas Torres, Solangel ; Rokita, Przemyslaw Stefan ; Romanenko, Gleb ; Ronchetti, Federico ; Rosano, Antonina ; Dominguez Rosas, Edgar ; Rosłon, Krystian ; Rossi, Andrea ; Roy, Ankhi ; Roy, S. ; Rubini, Nicola ; Vazquez Rueda, Omar ; Ruggiano, Daniela ; Rui, Rinaldo ; Rumyantsev, Boris ; Russek, P.G. ; Russo, R. ; Rustamov, Anar ; Ryabinkin, Evgeny ; Ryabov, Yury ; Rybicki, Andrzej ; Rytkönen, Heidi Maria ; Rzęsa, Wioleta ; Saarimaki, O.A. M. ; Sadek, Rita ; Sadhu, Samrangy ; Sadovskiy, Sergey ; Sætre, Jon-are ; Šafařík, Karel ; Saha, Sumit Kumar ; Saha, Swati ; Sahoo, Baidyanath ; Sahoo, Baidyanath ; Sahoo, Raghunath ; Sahoo, Sarita ; Sahu, Dushmanta ; Sahu, Pradip Kumar ; Saini, Jogender ; Sajdakova, K. ; Sakai, Shingo ; Panikkassery Salvan, Malavika ; Sambyal, Sanjeev Singh ; Sanna, Isabella ; Saramela, Thiago Badaró ; Sarkar, Debojit ; Sarkar, Nachiketa ; Sarma, Pranjal ; Sarritzu, Valerio ; Mantovani Sarti, Valentina ; Sas, Mike Henry Petrus ; Schambach, Joachim ; Scheid, Horst Sebastian ; Schiaua, Claudiu Cornel ; Schicker, Rainer ; Schmah, Alexander ; Schmidt, Christian Joachim ; Schmidt, Hans Rudolf ; Schmidt, Marten Ole ; Schmidt, M. ; Schmidt, Nicolas ; Schmier, Austin Robert ; Schotter, Romain ; Schröter, A. ; Schukraft, Jürgen ; Schwarz, Kilian ; Schweda, Kai ; Scioli, Gilda ; Scomparin, Enrico ; Seger, Janet Elizabeth ; Sekiguchi, Yuko ; Sekihata, Daiki ; Selyuzhenkov, Ilya ; Senyukov, Serhiy ; Seo, Jin Joo ; Serebryakov, Dmitry ; Šerkšnytė, Laura ; Sevcenco, Adrian ; Shaba, Tebogo Joyce ; Shabetai, Alexandre ; Shahoyan, Ruben ; Shangaraev, Artem ; Sharma, A. ; Sharma, B. ; Sharma, D. ; Sharma, H. ; Sharma, M. ; Sharma, S. ; Sharma, S. ; Sharma, U. ; Shatat, Afnan ; Sheibani, Oveis ; Shigaki, Kenta ; Shimomura, Maya ; Shin, J. ; Shirinkin, Sergey ; Shou, Qiye ; Sibiriak, Yury ; Siddhanta, Sabyasachi ; Siemiarczuk, Teodor ; Silva, Tiago Fiorini da ; Silvermyr, David Olle Rickard ; Simantathammakul, T. ; Simeonov, R. ; Singh, B. ; Singh, B. ; Singh, R. ; Singh, R. ; Singh, R. ; Singh, S. ; Singh, V.K. ; Singhal, Vikas ; Sarkar-Sinha, Tinku ; Sitar, Branislav ; Sitta, Mario ; Skaali, Toralf Bernhard ; Skorodumovs, Georgijs ; Slupecki, Maciej ; Smirnov, N. ; Snellings, Raimond ; Solheim, Emilie ; Song, J. ; Songmoolnak, Arnon ; Soramel, Francesca ; Soto-Hernandez, Analyce Bella ; Spijkers, Rik ; Sputowska, Iwona Anna ; Staa, Joey ; Stachel, Johanna ; Stan, Ionel ; Steffanic, Patrick John ; Stiefelmaier, Stephan ; Stocco, Diego ; Storehaug, Ida ; Stratmann, Peter ; Strazzi, Sofia ; Pliatskas Stylianidis, Christos ; Suaide, Alexandre Alarcon do Passo ; Suire, Christophe Pierre ; Sukhanov, Mikhail ; Šuljić, Miljenko ; Sultanov, Rishat ; Sumberia, Vikash ; Sumowidagdo, Suharyo ; Swain, Sagarika ; Szarka, Imrich ; Szymkowski, M. ; Taghavi, Seyed Farid ; Taillepied, Guillaume ; Takahashi, Jun ; Tambave, Ganesh ; Tang, S. ; Tang, Z. ; Tapia Takaki, Jesus Daniel ; Țăpuş, Nicolae ; Tarasovicova, Lucia Anna ; Tarzila, Madalina-Gabriela ; Tassielli, Giovanni Francesco ; Tauro, Arturo ; Tejeda Muñoz, Guillermo ; Telesca, Adriana ; Terlizzi, Livia ; Terrevoli, Cristina ; Thakur, Sanchari ; Thomas, Deepa ; Tikhonov, Anatoly ; Timmins, Anthony Robert ; Tkacik, Milan ; Tkacik, Tomas ; Toia, Alberica ; Tokumoto, R. ; Topilskaya, Nataliya ; Toppi, Marco ; Torales Acosta, Fernando ; Tork, T. ; Torres Ramos, Arianna Grisel ; Trifiró, Antonio ; Triolo, A.S. ; Tripathy, Sushanta ; Tripathy, Tulika ; Trogolo, Stefano ; Trubnikov, Victor ; Trzaska, Wladyslaw Henryk ; Trzcinski, Tomasz Piotr ; Tumkin, Alexandr ; Turrisi, Rosario ; Tveter, Trine Spedstad ; Ullaland, Kjetil ; Ulukutlu, B. ; Uras, Antonio ; Urioni, Marta ; Usai, Gianluca ; Vala, Martin ; Valle, Nicolò ; Doremalen, Lennart Vincent Rogier van ; Leeuwen, Marco van ; van Veen, C.A. ; van Weelden, R.J. G. ; Vyvre, Pierre vande ; Varga, Dezsö ; Varga, Zoltán ; Vasileiou, Maria ; Vasiliev, Andrey ; Vázquez Doce, Oton ; Vechernin, Vladimir ; Vercellin, Ermanno ; Vergara Limón, Sergio ; Vermunt, Lucas Anne ; Vértesi, Róbert ; Verweij, Marta ; Vicković, Linda ; Vilakazi, Zabulon ; Villalobos Baillie, Orlando ; Villani, A. ; Vino, Gioacchino ; Vinogradov, Alexander A. ; Virgili, Tiziano ; Virta, M.M. O. ; Vislavicius, Vytautas ; Vodopyanov, Alexander ; Volkel, Benedikt ; Völkl, Martin Andreas ; Voloshin, Kirill ; Voloshin, Sergei ; Volpe, Giacomo ; Haller, Barthélémy von ; Vorobyev, Ivan ; Vozniuk, Nikita ; Vrláková, Janka ; Wang, C. ; Wang, D. ; Wang, Y. ; Wegrzynek, Adami Tadeusz ; Weiglhofer, Felix Thomas ; Wenzel, Sandro Christian ; Wessels, Johannes P. ; Weyhmiller, S.L. ; Wiechula, Jens ; Wikne, Jon ; Wilk, Grzegorz Andrzej ; Wilkinson, Jeremy ; Willems, Guido Alexander ; Windelband, Bernd ; Winn, Michael ; Wright, Josephina Rae ; Wu, W. ; Wu, Y. ; Xu, Ran ; Yadav, A. ; Yadav, A.K. ; Yalcin, Serpil ; Yamaguchi, Yorito ; Yang, S. ; Yano, Satoshi ; Yin, Zhongbao ; Yoo, In-Kwon ; Yoon, Jin-Hee ; Yuan, S. ; Yüncü, Alperen ; Zaccolo, Valentina ; Zampolli, Chiara ; Zanone, Federica ; Zardoshti, Nima ; Zarochentsev, Andrey ; Závada, Petr ; Zaviyalov, Nikolaj ; Zhalov, Mikhail ; Zhang, B. ; Zhang, L. ; Zhang, S. ; Zhang, X. ; Zhang, Y. ; Zhang, Z. ; Zhao, M. ; Zherebchevskii, Vladimir ; Zhi, Y. ; Zhou, D. ; Zhou, Y. ; Zhu, J. ; Zhu, Y. ; Zugravel, Stefan Cristi ; Zurlo, Nicola
A newly developed observable for correlations between symmetry planes, which characterize the direction of the anisotropic emission of produced particles, is measured in Pb-Pb collisions at sNN−−−√=2.76 TeV with ALICE. This so-called Gaussian Estimator allows for the first time the study of these quantities without the influence of correlations between different flow amplitudes. The centrality dependence of various correlations between two, three and four symmetry planes is presented. The ordering of magnitude between these symmetry plane correlations is discussed and the results of the Gaussian Estimator are compared with measurements of previously used estimators. The results utilizing the new estimator lead to significantly smaller correlations than reported by studies using the Scalar Product method. Furthermore, the obtained symmetry plane correlations are compared to state-of-the-art hydrodynamic model calculations for the evolution of heavy-ion collisions. While the model predictions provide a qualitative description of the data, quantitative agreement is not always observed, particularly for correlators with significant non-linear response of the medium to initial state anisotropies of the collision system. As these results provide unique and independent information, their usage in future Bayesian analysis can further constrain our knowledge on the properties of the QCD matter produced in ultrarelativistic heavy-ion collisions.
A newly developed observable for correlations between symmetry planes, which characterize the direction of the anisotropic emission of produced particles, is measured in Pb-Pb collisions at sNN−−−√=2.76 TeV with ALICE. This so-called Gaussian Estimator allows for the first time the study of these quantities without the influence of correlations between different flow amplitudes. The centrality dependence of various correlations between two, three and four symmetry planes is presented. The ordering of magnitude between these symmetry plane correlations is discussed and the results of the Gaussian Estimator are compared with measurements of previously used estimators. The results utilizing the new estimator lead to significantly smaller correlations than reported by studies using the Scalar Product method. Furthermore, the obtained symmetry plane correlations are compared to state-of-the-art hydrodynamic model calculations for the evolution of heavy-ion collisions. While the model predictions provide a qualitative description of the data, quantitative agreement is not always observed, particularly for correlators with significant non-linear response of the medium to initial state anisotropies of the collision system. As these results provide unique and independent information, their usage in future Bayesian analysis can further constrain our knowledge on the properties of the QCD matter produced in ultrarelativistic heavy-ion collisions.
Release of neuropeptides from dense core vesicles (DCVs) is essential for neuromodulation. Compared to the release of small neurotransmitters, much less is known about the mechanisms and proteins contributing to neuropeptide release. By optogenetics, behavioral analysis, electrophysiology, electron microscopy, and live imaging, we show that synapsin SNN-1 is required for cAMP-dependent neuropeptide release in Caenorhabditis elegans hermaphrodite cholinergic motor neurons. In synapsin mutants, behaviors induced by the photoactivated adenylyl cyclase bPAC, which we previously showed to depend on acetylcholine and neuropeptides (Steuer Costa et al., 2017), are altered like in animals with reduced cAMP. Synapsin mutants have slight alterations in synaptic vesicle (SV) distribution, however, a defect in SV mobilization was apparent after channelrhodopsin-based photostimulation. DCVs were largely affected in snn-1 mutants: DCVs were ∼30% reduced in synaptic terminals, and not released following bPAC stimulation. Imaging axonal DCV trafficking, also in genome-engineered mutants in the serine-9 protein kinase A phosphorylation site, showed that synapsin captures DCVs at synapses, making them available for release. SNN-1 co-localized with immobile, captured DCVs. In synapsin deletion mutants, DCVs were more mobile and less likely to be caught at release sites, and in non-phosphorylatable SNN-1B(S9A) mutants, DCVs traffic less and accumulate, likely by enhanced SNN-1 dependent tethering. Our work establishes synapsin as a key mediator of neuropeptide release.
Bojkova, Denisa ; Stack, Richard ; Rothenburger, Tamara ; Kandler, Joshua D. ; Ciesek, Sandra ; Wass, Mark N. ; Michaelis, Martin ; Cinatl, Jindrich
Omicron BA.1 variant isolates were previously shown to replicate less effectively in interferon-competent cells and to be more sensitive to interferon treatment than a Delta isolate. Here, an Omicron BA.2 isolate displayed intermediate replication patterns in interferon-competent Caco-2-F03 cells when compared to BA.1 and Delta isolates. Moreover, BA.2 was less sensitive than BA.1 and similarly sensitive as Delta to betaferon treatment. Delta and BA.1 displayed similar sensitivity to the approved anti-SARS-CoV-2 drugs remdesivir, nirmatrelvir, EIDD-1931 (the active metabolite of molnupiravir) and the protease inhibitor aprotinin, whereas BA.2 was less sensitive than Delta and BA.1 to EIDD-1931, nirmatrelvir and aprotinin. Nirmatrelvir, EIDD-1931, and aprotinin (but not remdesivir) exerted synergistic antiviral activity in combination with betaferon, with some differences in the extent of synergism detected between the different SARS-CoV-2 variants. In conclusion, even closely related SARS-CoV-2 (sub)variants can differ in their biology and in their response to antiviral treatments. Betaferon combinations with nirmatrelvir and, in particular, with EIDD-1931 and aprotinin displayed high levels of synergism, which makes them strong candidates for clinical testing. Notably, effective antiviral combination therapies are desirable, as a higher efficacy is expected to reduce resistance formation.
Non-ribosomal peptide synthetases (NRPSs) are the origin of a wide range of natural products, including many clinically used drugs. Engineering of these often giant biosynthetic machineries to produce novel non-ribosomal peptides (NRPs) at high titre is an ongoing challenge. Here we describe a strategy to functionally combine NRPS fragments of Gram-negative and -positive origin, synthesising novel peptides at titres up to 290 mg l-1. Extending from the recently introduced definition of eXchange Units (XUs), we inserted synthetic zippers (SZs) to split single protein NRPSs into up to three independently expressed and translated polypeptide chains. These synthetic type of NRPS (type S) enables easier access to engineering, overcomes cloning limitations, and provides a simple and rapid approach to building peptide libraries via the combination of different NRPS subunits.
System size and centrality dependence of the balance function in A + A collisions at √sNN = 17.2 GeV
(2004)
Alt, Christopher ; Antičić, Tome ; Baatar, B. ; Barna, Daniel ; Bartke, Jerzy ; Betev, Latchezar ; Białkowska, Helena ; Billmeier, Anja ; Blume, Christoph ; Boimska, Bożena ; Botje, Michiel ; Bracinik, Juraj ; Bramm, Roland ; Brun, René ; Bunčić, Predrag ; Cerny, Vladimír ; Christakoglou, Panagiotis ; Chvala, Ondrej ; Cramer, John G. ; Csató, Péter ; Darmenov, Nikolay ; Dimitrov, Anton ; Dinkelaker, Peter ; Eckardt, Volker ; Farantatos, Gerassimos ; Flierl, Dominik Bernhard ; Fodor, Zoltán ; Foka, Panagiota ; Freund, Peter ; Friese, Volker ; Gál, József ; Gaździcki, Marek ; Georgopoulos, George ; Gładysz-Dziaduś, Ewa ; Grebieszkow, Katarzyna ; Hegyi, Sándor ; Höhne, Claudia ; Kadija, Krešo ; Karev, Alexandre ; Kliemant, Michael ; Kniege, Stefan ; Kolesnikov, Vadim I. ; Kollegger, Thorsten ; Kornas, Ewelina ; Korus, Robert ; Kowalski, Marek ; Kraus, Ingrid ; Kreps, Michal ; Leeuwen, Marco van ; Lévai, Péter ; Litov, Leandr ; Lungwitz, Benjamin ; Makariev, Martin ; Malakhov, Aleksandr I. ; Markert, Christina ; Mateev, Matej D. ; Mayes, Bill W. ; Melkumov, Georgy L. ; Meurer, Christine ; Mischke, André ; Mitrovski, Michael Kosta ; Molnár, József ; Mrówczyński, Stanislaw ; Pálla, Gabriella ; Panagiotou, Apostolos D. ; Panayotov, Dobromir ; Petridis, Athanasios ; Pikna, Miroslav ; Pinsky, Lawrence ; Pühlhofer, Falk ; Reid, Jeffrey G. ; Renfordt, Rainer Arno Ernst ; Richard, Agnes Carol Joanna ; Roland, Christof ; Roland, Gunther ; Rybczyński, Maciej ; Rybicki, Andrzej ; Sandoval, Andres ; Sann, Hans ; Schmitz, Norbert ; Seyboth, Peter ; Siklér, Ferenc ; Sitar, Branislav ; Skrzypczak, Ewa ; Stefanek, Grzegorz ; Stock, Reinhard ; Ströbele, Herbert ; Šuša, Tatjana ; Szentpétery, Imre ; Sziklai, János ; Trubnikov, Victor ; Varga, Dezsö ; Vassiliou, Maria ; Veres, Gábor I. ; Vesztergombi, György ; Vranić, Danilo ; Wetzler, Alexander Albert ; Włodarczyk, Zbigniew ; Yoo, In-Kwon ; Zaranek, Jacek ; Zimányi, József
Electric charge correlations were studied for p+p, C+C, Si+Si and centrality selected Pb+Pb collisions at sqrt s_NN = 17.2$ GeV with the NA49 large acceptance detector at the CERN-SPS. In particular, long range pseudo-rapidity correlations of oppositely charged particles were measured using the Balance Function method. The width of the Balance Function decreases with increasing system size and centrality of the reactions. This decrease could be related to an increasing delay of hadronization in central Pb+Pb collisions.