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Video and image data are regularly used in the field of benthic ecology to document biodiversity. However, their use is subject to a number of challenges, principally the identification of taxa within the images without associated physical specimens. The challenge of applying traditional taxonomic keys to the identification of fauna from images has led to the development of personal, group, or institution level reference image catalogues of operational taxonomic units (OTUs) or morphospecies. Lack of standardisation among these reference catalogues has led to problems with observer bias and the inability to combine datasets across studies. In addition, lack of a common reference standard is stifling efforts in the application of artificial intelligence to taxon identification. Using the North Atlantic deep sea as a case study, we propose a database structure to facilitate standardisation of morphospecies image catalogues between research groups and support future use in multiple front-end applications. We also propose a framework for coordination of international efforts to develop reference guides for the identification of marine species from images. The proposed structure maps to the Darwin Core standard to allow integration with existing databases. We suggest a management framework where high-level taxonomic groups are curated by a regional team, consisting of both end users and taxonomic experts. We identify a mechanism by which overall quality of data within a common reference guide could be raised over the next decade. Finally, we discuss the role of a common reference standard in advancing marine ecology and supporting sustainable use of this ecosystem.
A estrutura silábica do alemão como língua estrangeira na interlíngua de aprendizes brasileiros
(2019)
A presente pesquisa explora as estratégias de reformulação de constituintes silábicos complexos na Interlíngua de 18 brasileiros aprendizes do Alemão como Língua Estrangeira. Nossa hipótese prevê que estes aprendizes possuem dificuldades na produção de ataques iniciais e codas finais do ALE e, ao tentar acomodá-las ao molde silábico da LM, aplicam diferentes estratégias de reparação. A partir do conceito de Interlíngua (SELINKER 1972) como língua natural, sistemática e emergente de um processo complexo e dinâmico, desenvolvida autonomamente por falantes não-nativos de uma LE em seu processo de aquisição/aprendizagem com o objetivo de comunicar-se estrategicamente, e que sofre adaptações a partir da testagem de hipóteses acerca da LE e eventos de interação, realizamos análise transversal das ocorrências de ataque e coda complexas em correlação com o nível de proficiência do aprendiz, o estilo (LIN 2001, 2003) e a marcação do constituinte (GRENNBERG 1966b). Os dados revelaram que a frequência de modificação de clusters apresenta correlação com estes fatores: quanto mais formal a tarefa e avançado o aprendiz, menos modificações ocorrem. A influência da marcação silábica e dos universais linguísticos foi constatada para a coda, tipologicamente marcada, sendo mais frequentemente modificada que o ataque.
A encenação autoral de Christian Kracht: o caso d' "Os Mortos" de Kracht, de Joyce e de Huston
(2019)
Partimos do pressuposto que os escritores, ao longo da história, sempre se utilizaram de estratégias encenatórias tanto em relação às suas obras como às suas figuras públicas, e de que o fazem não só para se estabelecer no campo literário, mas para o fazê-lo de um modo específico (JÜRGENSEN; KAYSER, 2011; BOURDIEU, 2000). Tendo em vista o último romance de Christian Kracht, "Die Toten" (2016), cujo título pode ser livremente traduzido como "Os Mortos", e as relações intertextuais que podem ser estabelecidas com o conto homônimo de James Joyce (1914) e sua adaptação para o cinema dirigida por John Huston (1987), temos por objetivo investigar de que modo essas relações contribuem para a encenação de Christian Kracht e para seu posicionamento no campo literário.
Concebido para suprir as lacunas de uma existência que se tornara pública e notória com a publicação do "Werther", o relato autobiográfico de "Dichtung und Wahrheit" dedicará boa parte das quase 300 páginas de seus sete últimos livros à narração das circunstâncias que teriam possibilitado a Goethe encontrar um campo de atuação e influência compatíveis com a estrondosa repercussão do "Werther", mas ao mesmo tempo condizentes com uma vocação poética a que Goethe recusa qualquer interferência direta e 'didática' nos assuntos humanos, visto como passa a concebê-la 'inteiramente como natureza'. O artigo se propõe passar em revista esse momento decisivo de elaboração da 'Bildung' goethiana compreendido sobretudo nos livros 13 a 16, o qual coincide com a definição dos fundamentos da vocação poética que marcará a fisionomia espiritual da produção de Goethe vida afora. Para tanto, investigará a pertinência do conceito de teleologia como princípio explicativo oportuno à elucidação do referido momento, à luz da discussão proposta por Fotis Jannidis (1996); e analisará o papel das referências e influências que maior importância tiveram para Goethe nesse processo: Lavater, Basedow e Zimmermann, entre os convivas, Spinoza e Prometeu entre os luminares.
Based on accumulating evidence of a role of lipid signaling in many physiological and pathophysiological processes including psychiatric diseases, the present data driven analysis was designed to gather information needed to develop a prospective biomarker, using a targeted lipidomics approach covering different lipid mediators. Using unsupervised methods of data structure detection, implemented as hierarchal clustering, emergent self-organizing maps of neuronal networks, and principal component analysis, a cluster structure was found in the input data space comprising plasma concentrations of d = 35 different lipid-markers of various classes acquired in n = 94 subjects with the clinical diagnoses depression, bipolar disorder, ADHD, dementia, or in healthy controls. The structure separated patients with dementia from the other clinical groups, indicating that dementia is associated with a distinct lipid mediator plasma concentrations pattern possibly providing a basis for a future biomarker. This hypothesis was subsequently assessed using supervised machine-learning methods, implemented as random forests or principal component analysis followed by computed ABC analysis used for feature selection, and as random forests, k-nearest neighbors, support vector machines, multilayer perceptron, and naïve Bayesian classifiers to estimate whether the selected lipid mediators provide sufficient information that the diagnosis of dementia can be established at a higher accuracy than by guessing. This succeeded using a set of d = 7 markers comprising GluCerC16:0, Cer24:0, Cer20:0, Cer16:0, Cer24:1, C16 sphinganine, and LacCerC16:0, at an accuracy of 77%. By contrast, using random lipid markers reduced the diagnostic accuracy to values of 65% or less, whereas training the algorithms with randomly permuted data was followed by complete failure to diagnose dementia, emphasizing that the selected lipid mediators were display a particular pattern in this disease possibly qualifying as biomarkers.
Persistent and, in particular, neuropathic pain is a major healthcare problem with still insufficient pharmacological treatment options. This triggered research activities aimed at finding analgesics with a novel mechanism of action. Results of these efforts will need to pass through the phases of drug development, in which experimental human pain models are established components e.g. implemented as chemical hyperalgesia induced by capsaicin. We aimed at ranking the various readouts of a human capsaicin–based pain model with respect to the most relevant information about the effects of a potential reference analgesic. In a placebo‐controlled, randomized cross‐over study, seven different pain‐related readouts were acquired in 16 healthy individuals before and after oral administration of 300 mg pregabalin. The sizes of the effect on pain induced by intradermal injection of capsaicin were quantified by calculating Cohen's d. While in four of the seven pain‐related parameters, pregabalin provided a small effect judged by values of Cohen's d exceeding 0.2, an item categorization technique implemented as computed ABC analysis identified the pain intensities in the area of secondary hyperalgesia and of allodynia as the most suitable parameters to quantify the analgesic effects of pregabalin. Results of this study provide further support for the ability of the intradermal capsaicin pain model to show analgesic effects of pregabalin. Results can serve as a basis for the designs of studies where the inclusion of this particular pain model and pregabalin is planned.
Rezension zu: Psychology of Retention:Theory, Research and Practice / Melinde Coetzee, Ingrid L. Potgieter and Nadia Ferreira (Eds.), ISBN:978-3-319-98919-8 Publisher:Springer Nature, 2018, R1600 (Preis SA)
The following five species of Dermestidae (Coleoptera) are recorded for the first time from Guatemala: Attagenus fasciatus (Thunberg), Dermestes (Dermestinus) caninus caninus Germar, Orphinus fulvipes (Guérin-Méneville), Trogoderma simplex Jayne and Thorictodes heydeni Reitter. The species are recorded from the Guatemalan departments of Petén, Izabal and Zacapa.
Background: The differentiation between Gaucher disease type 3 (GD3) and type 1 is challenging because pathognomonic neurologic symptoms may be subtle and develop at late stages. The ophthalmologist plays a crucial role in identifying the typical impairment of horizontal saccadic eye movements, followed by vertical ones. Little is known about further ocular involvement. The aim of this monocentric cohort study is to comprehensively describe the ophthalmological features of Gaucher disease type 3. We suggest recommendations for a set of useful ophthalmologic investigations for diagnosis and follow up and for saccadometry parameters enabling a correlation to disease severity.
Methods: Sixteen patients with biochemically and genetically diagnosed GD3 completed ophthalmologic examination including optical coherence tomography (OCT), clinical oculomotor assessment and saccadometry by infrared based video-oculography. Saccadic peak velocity, gain and latency were compared to 100 healthy controls, using parametric tests. Correlations between saccadic assessment and clinical parameters were calculated.
Results: Peripapillary subretinal drusen-like deposits with retinal atrophy (2/16), preretinal opacities of the vitreous (4/16) and increased retinal vessel tortuosity (3/16) were found. Oculomotor pathology with clinically slowed saccades was more frequent horizontally (15/16) than vertically (12/16). Saccadometry revealed slowed peak velocity compared to 100 controls (most evident horizontally and downwards). Saccades were delayed and hypometric. Best correlating with SARA (scale for the assessment and rating of ataxia), disease duration, mSST (modified Severity Scoring Tool) and reduced IQ was peak velocity (both up- and downwards). Motility restriction occurred in 8/16 patients affecting horizontal eye movements, while vertical motility restriction was seen less frequently. Impaired abduction presented with esophoria or esotropia, the latter in combination with reduced stereopsis.
Conclusions: Vitreoretinal lesions may occur in 25% of Gaucher type 3 patients, while we additionally observed subretinal lesions with retinal atrophy in advanced disease stages. Vertical saccadic peak velocity seems the most promising "biomarker" for neuropathic manifestation for future longitudinal studies, as it correlates best with other neurologic symptoms. Apart from the well documented abduction deficit in Gaucher type 3 we were able to demonstrate motility impairment in all directions of gaze.
Apigenin (4′,5,7-trihydroxyflavone) (Api) is an important component of the human diet, being distributed in a wide number of fruits, vegetables and herbs with the most important sources being represented by chamomile, celery, celeriac and parsley. This study was designed for a comprehensive evaluation of Api as an antiproliferative, proapoptotic, antiangiogenic and immunomodulatory phytocompound. In the set experimental conditions, Api presents antiproliferative activity against the A375 human melanoma cell line, a G2/M arrest of the cell cycle and cytotoxic events as revealed by the lactate dehydrogenase release. Caspase 3 activity was inversely proportional to the Api tested doses, namely 30 μM and 60 μM. Phenomena of early apoptosis, late apoptosis and necrosis following incubation with Api were detected by Annexin V-PI double staining. The flavone interfered with the mitochondrial respiration by modulating both glycolytic and mitochondrial pathways for ATP production. The metabolic activity of human dendritic cells (DCs) under LPS-activation was clearly attenuated by stimulation with high concentrations of Api. Il-6 and IL-10 secretion was almost completely blocked while TNF alpha secretion was reduced by about 60%. Api elicited antiangiogenic properties in a dose-dependent manner. Both concentrations of Api influenced tumour cell growth and migration, inducing a limited tumour area inside the application ring, associated with a low number of capillaries.