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- Comicroman (17)
- Computer (17)
- ESG (17)
- Emanzipation (17)
- Escola de Frankfurt (17)
- Essay (17)
- Etymologie (17)
- Fagus sylvatica (17)
- Fehler (17)
- Filmographie (17)
- Florida (17)
- Französische Revolution (17)
- Freie Gewerkschaft (17)
- Frühe Neuzeit (17)
- Frühneuhochdeutsch (17)
- Grillparzer, Franz (17)
- Gutzkow, Karl (17)
- Horrorfilm (17)
- Industriearbeiterin (17)
- Islamismus (17)
- Judentum (17)
- Kajkavisch (17)
- Kapitalmarktrecht (17)
- Komödie (17)
- Marx, Karl (17)
- Methode (17)
- Mundart (17)
- Natur <Motiv> (17)
- Nearctic (17)
- Oesterle, Günter (17)
- Photographie (17)
- Portugal (17)
- Presse (17)
- Professionalisierung (17)
- Pronomen (17)
- Präposition (17)
- Rezensionen (17)
- Schriftstellerin (17)
- Schule (17)
- Shakespeare, William (17)
- Social System (17)
- Spieltheorie (17)
- Sprachkritik (17)
- Stilistik (17)
- Student (17)
- Surgery (17)
- Synergie (17)
- Tabu (17)
- Teoria crítica (17)
- Textverstehen (17)
- Turkey (17)
- Vielfalt (17)
- Wertpapieremission (17)
- Wettbewerb (17)
- climate (17)
- gene therapy (17)
- glioma (17)
- host plants (17)
- memory (17)
- mortality (17)
- parasitoid (17)
- schizophrenia (17)
- stroke (17)
- treatment (17)
- tumor microenvironment (17)
- vegetation classification (17)
- Adverb (16)
- Angiogenesis (16)
- Anthologie (16)
- Biomarkers (16)
- Caribbean (16)
- CiNyungwe (16)
- Distribution (16)
- EBA (16)
- Euro (16)
- Finanzwirtschaft (16)
- Fiscal Policy (16)
- Gene expression (16)
- Genossenschaftsbewegung (16)
- Gesprochene Sprache (16)
- Gewerkverein der Heimarbeiterinnen Deutschlands für Kleider- und Wäschekonfektion und verwandte Berufe (1900-) (16)
- Gleichberechtigung (16)
- Grammatikalisation (16)
- Grass, Günter (16)
- Hausarbeit (16)
- Hegel, Georg Wilhelm Friedrich (16)
- Herrschaft (16)
- Industriearbeit (16)
- Infektionsabwehr (16)
- Infrarot (16)
- Journalismus (16)
- Kollokation (16)
- Koti (16)
- Kreditwesen (16)
- Krim (16)
- Memory (16)
- Migration <Motiv> (16)
- Modellierung (16)
- Mähren (16)
- Müller, Heiner (16)
- Nibelungenlied (16)
- Nordrhein-Westfalen (16)
- Nyungwe (16)
- Open Access (16)
- Outcome (16)
- Preußen (16)
- Prostitution (16)
- Pädagogik (16)
- Relativistic heavy-ion collisions (16)
- Selbstdarstellung (16)
- Sicherheit (16)
- Sicherheitspolitik (16)
- Sprachpolitik (16)
- Sprachstatistik (16)
- Sprachverstehen (16)
- Stadt <Motiv> (16)
- Synthesis (16)
- Systematics (16)
- Terminologie (16)
- Transparenz (16)
- Transylvanian Saxons (16)
- Ungarisch (16)
- Unternehmen (16)
- Vergleich (16)
- Wahlkampf (16)
- Wirklichkeit (16)
- Zeitung (16)
- asset pricing (16)
- cryptic species (16)
- culture (16)
- financial stability (16)
- hippocampus (16)
- inflation (16)
- miRNA (16)
- multiple sclerosis (16)
- new genera (16)
- ordination (16)
- phenology (16)
- populism (16)
- proteomics (16)
- terrorism (16)
- uncertainty (16)
- word order (16)
- Ägypten (16)
- ALICE (15)
- Alphabetisierung (15)
- Altgermanistik (15)
- Arbeitslosigkeit (15)
- Asia (15)
- Australia (15)
- Außenpolitik (15)
- Bildnis (15)
- Börne, Ludwig (15)
- Carabidae (15)
- Chuwabu (15)
- Cirrhosis (15)
- Contagion (15)
- Culture (15)
- Das Ganze (15)
- Datenschutz (15)
- EKoti (15)
- Echuwabo (15)
- Erzählforschung (15)
- Finanzierung (15)
- France (15)
- Fußball (15)
- Gefühl <Motiv> (15)
- Geschichte 1800-1900 (15)
- Grammatiktheorie (15)
- Historismus (15)
- Hochschuldidaktik (15)
- Hochschule (15)
- Hymenoptera (15)
- ISIS (15)
- Ideologie (15)
- Immunology (15)
- Indogermanische Sprachen (15)
- Interkulturelles Lernen (15)
- Konsumgenossenschaft (15)
- Korruption (15)
- Kritische Theorie (15)
- Kulturanthropologie (15)
- Kulturwissenschaft (15)
- Kulturwissenschaftliche Bibliothek Warburg (15)
- Landarbeiterin (15)
- Lehrbuch (15)
- Lepidoptera (15)
- Literaturgeschichte (15)
- Machine Learning (15)
- Macht (15)
- Maschinelle Übersetzung (15)
- Mimesis (15)
- Mitgliederwerbung (15)
- Morphosyntax (15)
- Muttersprache (15)
- Nachhaltigkeit (15)
- Nationalbewusstsein (15)
- Nominalphrase (15)
- Obama (15)
- Palaearctic (15)
- Pension Insurance (15)
- Politische Verfolgung (15)
- Prophetie (15)
- Protest (15)
- QCD (15)
- QGP (15)
- Quantitative Easing (15)
- Sarawak (15)
- Simulation (15)
- Solvency II (15)
- Sprechakt (15)
- Topikalisierung (15)
- Twitter (15)
- Verlag (15)
- Wahlagitation (SPD) (15)
- Warburg, Aby Moritz (15)
- Westafrika (15)
- Wiederholung (15)
- Wikileaks (15)
- Wolf, Christa (15)
- X-ray crystallography (15)
- endothelial cells (15)
- gene expression (15)
- heavy-ion collisions (15)
- human rights (15)
- introduced species (15)
- key to species (15)
- mass spectrometry (15)
- obesity (15)
- oxidative stress (15)
- parasitoids (15)
- recognition (15)
- reduction of pain (15)
- structural biology (15)
- systemic risk (15)
- temperature (15)
- teoria crítica (15)
- tissue oxygen partial pressure (15)
- tissue temperature (15)
- Agamben, Giorgio (14)
- Anglizismus (14)
- Arabisch (14)
- Arbeitsgemeinschaft Sammlung Deutscher Drucke (14)
- Artikulatorische Phonetik (14)
- Asset Pricing (14)
- Aussprache (14)
- Barock (14)
- Biogeography (14)
- Bitcoin (14)
- Bürgertum (14)
- Chewa-Sprache (14)
- Children (14)
- Chwabo (14)
- DNA (14)
- Demography (14)
- Döblin, Alfred (14)
- ESR Spectra (14)
- Epistemologie (14)
- Epoche (14)
- Erzählperspektive (14)
- European Central Bank (14)
- Flüchtlinge (14)
- Form (14)
- Fortschritt (14)
- Frieden (14)
- Gattungstheorie (14)
- Gegenwart (14)
- Genossenschaft (14)
- Gentherapie (14)
- Geschichte 1801-1870 (14)
- Griechenland (14)
- Habermas (14)
- Hadron (14)
- Held (14)
- Homosexualität (14)
- Humanismus (14)
- Indien (14)
- Infrastruktur (14)
- Inszenierung (14)
- Interrogativsatz (14)
- Israel (14)
- Jean Paul (14)
- Joyce, James (14)
- Kapitalmarkt (14)
- Kindersprache (14)
- Klima (14)
- Kommentar (14)
- Krise (14)
- Lernen (14)
- Literarische Gestalt (14)
- Literarische Übersetzung (14)
- Ludwig (14)
- Magnetic resonance imaging (14)
- Mathematik (14)
- Molinio-Arrhenatheretea (14)
- Mortality (14)
- Mörike, Eduard (14)
- Mündlichkeit (14)
- Nachkriegszeit (14)
- Nachlass (14)
- Neoliberalismus (14)
- New Zealand (14)
- New species (14)
- Nungisch (14)
- Pandemie (14)
- Parkinson’s disease (14)
- Parodie (14)
- Pension (14)
- Philhellenismus (14)
- Private Investment (14)
- Radiotherapy (14)
- Reformation (14)
- Risikomanagement (14)
- Russia (14)
- Sauerstoffversorgung (14)
- Schwedisch (14)
- Schönheit (14)
- Screening (14)
- Slowakisch (14)
- South Africa (14)
- Spitteler, Carl (14)
- Sprachvariante (14)
- Sprichwort (14)
- Strategie (14)
- Subjektivität (14)
- Taxonomie (14)
- Terror (14)
- Topographie <Kulturwissenschaft> (14)
- Transformation (14)
- Trauma (14)
- Vokal (14)
- Wagner, Richard (14)
- Walther <von der Vogelweide> (14)
- Widerstand (14)
- Wissenschaftskommunikation (14)
- Wortschatz (14)
- banking (14)
- credit risk (14)
- epigenetics (14)
- eutrophication (14)
- extracellular matrix (14)
- financial crisis (14)
- flora (14)
- focus (14)
- insurance (14)
- interculturality (14)
- lectotype (14)
- lung cancer (14)
- macrophages (14)
- planthopper (14)
- radical prostatectomy (14)
- tissue blood flow (14)
- ubiquitination (14)
- wound healing (14)
- Analyse (13)
- Andes (13)
- Anti-Utopie (13)
- Apoidea (13)
- Ausländer (13)
- Bachtin, Michail M. (13)
- Barbar <Motiv> (13)
- Bayern (13)
- Biopolitik <Motiv> (13)
- Borges, Jorge Luis (13)
- Bourdieu, Pierre (13)
- Capsule endoscopy (13)
- Clearing (13)
- Cognition (13)
- Croatian language (13)
- Cryoelectron microscopy (13)
- Cryptocurrency (13)
- Das Andere (13)
- Deutschlehrer (13)
- Diagnostik (13)
- Ding <Motiv> (13)
- Ecocriticism (13)
- Ecuador (13)
- Energie (13)
- Epidemiology (13)
- Epigenetik (13)
- Faschismus (13)
- Filmtheorie (13)
- Finanzkrise (13)
- Fremdbild (13)
- Gesicht <Motiv> (13)
- Großstadt <Motiv> (13)
- HCV (13)
- Habitat (13)
- Handel (13)
- Heinrich von (13)
- Herder (13)
- Herwegh, Georg (13)
- Identity (13)
- Immunotherapy (13)
- Karikatur (13)
- Kasus (13)
- Kinder- und Hausmärchen (13)
- Kinderschutz (13)
- Klein- und Mittelbetrieb (13)
- Kompositum (13)
- Kreativität (13)
- Kulturpolitik (13)
- Lehrmittel (13)
- Literaturkanon (13)
- Mammakarzinom (13)
- Medientheorie (13)
- Middle East (13)
- Moral (13)
- Motivation (13)
- Multikulturelle Gesellschaft (13)
- Multistable figures (13)
- Museum (13)
- NADPH oxidase (13)
- Nation (13)
- Negation (13)
- Netzpolitik (13)
- Oncology (13)
- Oriental Region (13)
- Paul (13)
- Performativität <Kulturwissenschaften> (13)
- Phylogeny (13)
- Possessivität (13)
- Prag (13)
- Predigt (13)
- R2P (13)
- ROS (13)
- Rezeptionsästhetik (13)
- Rothacker, Erich (13)
- Römisches Reich (13)
- Saving (13)
- Schrift (13)
- Souveränität (13)
- Sozialer Wandel (13)
- Spanien (13)
- Sprachgebrauch (13)
- Sprachkompetenz (13)
- Sprachlehrbuch (13)
- Suttner, Bertha von (13)
- Tagalog (13)
- Transylvania (13)
- Ungarn (13)
- Vergangenheitsbewältigung (13)
- Vergesellschaftung (13)
- Verkehr (13)
- Vertrauen (13)
- Volkserzählung (13)
- Weiblichkeit (13)
- Zeitgenössische Kunst (13)
- artificial intelligence (13)
- bladder cancer (13)
- caves (13)
- child (13)
- cirrhosis (13)
- communication (13)
- cytokines (13)
- endemic (13)
- epidemiology (13)
- fiscal policy (13)
- fungi (13)
- genitalia (13)
- globalization (13)
- hrvatski jezik (13)
- ideology (13)
- islamic state (13)
- liquidity (13)
- meiofauna (13)
- metabolism (13)
- neurodegeneration (13)
- red riječi (13)
- review (13)
- signal transduction (13)
- species delimitation (13)
- spider (13)
- survival (13)
- synaptic plasticity (13)
- Öffentlichkeit (13)
- ABS (12)
- Aesthetics (12)
- Afghanistan (12)
- Aktivismus (12)
- Allegorie (12)
- Ambiguität (12)
- Arbeiterinnenfrage (12)
- Arbeiterinnenverein (12)
- Argentina (12)
- Asymmetrische Information (12)
- Bank Lending (12)
- Behavior (12)
- Berliner Kindheit um neunzehnhundert (12)
- Bloch, Ernst (12)
- Buch (12)
- Bulgarisch (12)
- Börsenrecht (12)
- Bürgerliche Frauenbewegung (12)
- Chronotopos (12)
- Comments disabled (12)
- Computerspiel (12)
- Consumption (12)
- Datenbank (12)
- Deutsches Sprachgebiet (12)
- Divina Commedia (12)
- Ecology (12)
- Einfühlung (12)
- Endothelial cells (12)
- England (12)
- Familienname (12)
- Faust (12)
- Florenz (12)
- Frauenliteratur (12)
- George, Stefan (12)
- Germanist (12)
- Geschichte 1450-1650 (12)
- Geschlechterverhältnis (12)
- Gewalt <Motiv> (12)
- Greece (12)
- Grundschule (12)
- Heros (12)
- Historische Sprachwissenschaft (12)
- History (12)
- Idealisierung (12)
- Intellektueller (12)
- Investmentfonds (12)
- Kamerun (12)
- Kapitalertrag (12)
- Katastrophe <Motiv> (12)
- Kleidung (12)
- Klimaänderung (12)
- Kommunismus (12)
- Konsonant (12)
- Kopula (12)
- Lexikografie (12)
- Luther, Martin (12)
- Massenmedien (12)
- Membranproteine (12)
- MiFID II (12)
- Militär (12)
- Modalverb (12)
- Myanmar (12)
- NMR-Spektroskopie (12)
- Namibia (12)
- Nationalsozialismus <Motiv> (12)
- Neuer Markt (12)
- Neugriechisch (12)
- Paratext (12)
- Personenname (12)
- Pinus sylvestris (12)
- Portfolio Selection (12)
- Portugiesisch / Brasilien (12)
- Proust, Marcel (12)
- Psychologie (12)
- Publizistik (12)
- Rechtsradikalismus (12)
- Referenzidentität (12)
- Reise (12)
- Repräsentation (12)
- Revolution (12)
- Rheinland-Pfalz (12)
- Romania (12)
- Rumänien (12)
- Sage (12)
- Sehen (12)
- Semantics (12)
- Sepsis (12)
- Sozialgeschichte (12)
- Spannung (12)
- Stadtentwicklung (12)
- Standardsprache (12)
- Struktur (12)
- Subjekt (12)
- Suffix (12)
- Suicide (12)
- Tanz (12)
- Tempus (12)
- Theodor Adorno (12)
- Topik (12)
- Training (12)
- Transfer (12)
- United States (12)
- Vendée (France) (12)
- Verbreitung (12)
- Vereinte Nationen (12)
- Walser, Robert (12)
- Wirtschaftssprache (12)
- Zeit <Motiv> (12)
- Zustandsgleichung (12)
- alien species (12)
- alphabetisation (12)
- barcoding (12)
- cell death (12)
- colorectal cancer (12)
- disturbance (12)
- dry grassland (12)
- financial literacy (12)
- first record (12)
- health (12)
- human (12)
- language (12)
- leukemia (12)
- mouse (12)
- orthography (12)
- prevalence (12)
- restoration (12)
- risk (12)
- semantics (12)
- simulation (12)
- spiders (12)
- stress (12)
- surgery (12)
- syntax (12)
- validity (12)
- Überwachung (12)
- Ableitung <Linguistik> (11)
- Adjunkt <Linguistik> (11)
- Alphabet (11)
- Alzheimer’s disease (11)
- Arbeitsmarkt (11)
- Arbeitsmarktpolitik (11)
- Arzneimittel (11)
- Aspekt (11)
- Auslandsgermanistik (11)
- Autophagy (11)
- Bioenergetics (11)
- Bolivia (11)
- Bryophytes (11)
- Bundesverfassungsgericht (11)
- Börsenordnung (11)
- Canguilhem, Georges (11)
- Cerambycidae (11)
- Chatten <Kommunikation> (11)
- Chemotherapy (11)
- Cisena (11)
- Computerphilologie (11)
- Czech Republic (11)
- Derivatives (11)
- Deutsch als Zweitsprache (11)
- Diabetes mellitus (11)
- Dienstmädchen (11)
- Diplomatie (11)
- Diskriminierung (11)
- Dissertation (11)
- Dokumentation (11)
- Droste-Hülshoff, Annette von (11)
- Dürrenmatt, Friedrich (11)
- EIOPA (11)
- Einkommensverteilung (11)
- Emotions (11)
- Endoscopy (11)
- Europäische Zentralbank (11)
- Evangelischer Arbeiterinnenverein (11)
- Federal Reserve (11)
- Freundschaft (11)
- Geburtenregelung (11)
- Geschichte <Motiv> (11)
- Globalization (11)
- Grimm, Wilhelm (11)
- Guatemala (11)
- Hadron-Hadron Scattering (11)
- Hadron-Hadron scattering (experiments) (11)
- Hegel (11)
- Heidegger, Martin (11)
- Hofmannsthal (11)
- Imagination (11)
- Immunologie (11)
- In vitro (11)
- Inversionsfigur (11)
- Italienbild (11)
- Jahrhundertwende (11)
- Jesus Christus (11)
- Joseph von (11)
- Jürgen Habermas (11)
- Konnotation (11)
- Kontrastive Phraseologie (11)
- Kredit (11)
- Kulturvermittlung (11)
- Kurzgeschichte (11)
- Lacan, Jacques (11)
- Legende (11)
- Leidenschaft (11)
- Life Insurance (11)
- Literaturgattung (11)
- Low Interest Rates (11)
- Makonde-Sprache (11)
- Mali (11)
- Mediterranean (11)
- Melancholie (11)
- Menschenrechte (11)
- Molecular biology (11)
- Mollusca (11)
- Mutterschaft (11)
- Mutterschaftsversicherung (11)
- Optionspreistheorie (11)
- Ovidius Naso, Publius (11)
- PCR (11)
- Peter (11)
- Peter Tauber (11)
- Politische Bildung (11)
- Pop-Kultur (11)
- Preis <Auszeichnung> (11)
- Primary care (11)
- Psychology (11)
- Quark Gluon Plasma (11)
- Quark-Gluon Plasma (11)
- RHIC (11)
- Rechtssprache (11)
- Rousseau, Jean-Jacques (11)
- Saccharomyces cerevisiae (11)
- Schizophrenia (11)
- Schutzverantwortung (11)
- Science-Fiction (11)
- Selbstbild (11)
- Sena (11)
- Silbe (11)
- TLAC (11)
- Textgeschichte (11)
- Theatertheorie (11)
- Tieck, Ludwig (11)
- Tiere <Motiv> (11)
- Transkulturalität (11)
- Uncertainty (11)
- VEGF (11)
- Verfassung (11)
- Verfilmung (11)
- Wahrnehmungswechsel (11)
- Waldgesellschaften (11)
- Weerth, Georg (11)
- Wohnverhältnisse (11)
- Wortfeld (11)
- Zeichen (11)
- Zweig, Stefan (11)
- al-Qaida (11)
- asymmetric information (11)
- bees (11)
- crisis (11)
- forest management (11)
- grammar (11)
- grazing (11)
- habitat (11)
- hydrogen bonding (11)
- infection (11)
- integrins (11)
- intercultural communication (11)
- justice (11)
- macrophage polarization (11)
- magnetic resonance imaging (11)
- male genitalia (11)
- metastasis (11)
- model uncertainty (11)
- new synonym (11)
- outcome (11)
- p53 (11)
- participation (11)
- physical activity (11)
- psoriasis (11)
- public debt (11)
- quark gluon plasma (11)
- radiotherapy (11)
- real-time data (11)
- responsibility (11)
- risk factors (11)
- sexual dimorphism (11)
- targeted therapy (11)
- transparency (11)
- trauma (11)
- vegetation (11)
- Ästhetische Wahrnehmung (11)
- Österreich-Ungarn (11)
- 19. Jahrhundert (10)
- 5-lipoxygenase (10)
- ACLF (10)
- Achtundsechziger (10)
- Aktienkurs (10)
- Anthrozoologie (10)
- Arbeit <Motiv> (10)
- Arbeitsrecht (10)
- Arbeitsverhältnisse (10)
- Archivierung (10)
- Asset Allocation (10)
- Autor (10)
- Bankenaufsicht (10)
- Barrierefreiheit (10)
- Barthes, Roland (10)
- Baudelaire, Charles (10)
- Big Data (10)
- Bildungsroman (10)
- Biopolitik (10)
- Boko Haram (10)
- Bratoljub Klaić (10)
- Brustkrebs (10)
- Bundestag (10)
- C. elegans (10)
- CDU (10)
- COPD (10)
- Chile (10)
- Conservation (10)
- Costa Rica (10)
- Cyberwar (10)
- Debatte (10)
- Deutsch-Ostafrika (10)
- Diagnostic markers (10)
- Dialektik (10)
- Ding (10)
- Disclosure (10)
- Disticha Catonis (10)
- Diversity (10)
- EGFR (10)
- Educação (10)
- Egypt (10)
- Eichendorff (10)
- Einkommen (10)
- Ellenberg indicator values (10)
- Energieumsatz <Medizin> (10)
- Entstehung (10)
- Erlebnisbericht (10)
- Evolutionspsychologie (10)
- Facebook (10)
- Fachinformationsdienst (10)
- Fauna (10)
- Fintech (10)
- Fragebogen (10)
- Frankfurt / Universität (10)
- Frankfurt <Main> / Universität / Poelzig-Bau (10)
- Frauenpolitik (SPD) (10)
- Frauenpresse (10)
- Freedom (10)
- GARCH-Prozess (10)
- Geld (10)
- Geld <Motiv> (10)
- Generative Grammatik (10)
- Gerechtigkeit (10)
- Germanistenverband (10)
- Geschichtsbild (10)
- Gesundheitswesen (10)
- Grenze (10)
- Hamburg (10)
- Heart failure (10)
- Heavy-ion collisions (10)
- Heimat (10)
- Hepatocellular carcinoma (10)
- Humor (10)
- IR Spectra (10)
- Inclusion (10)
- Integriertes Lernen (10)
- Investor Protection (10)
- Ionenstrahl (10)
- Jiddisch (10)
- Joachim Wittstock (10)
- Jugendsprache (10)
- Justice (10)
- Kapitalmarkteffizienz (10)
- Kinderarbeit (10)
- Klitisierung (10)
- Knowledge (10)
- Kolumbien (10)
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- Äquivalenz (8)
- 500-1500 (7)
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- Adaptation (7)
- Aktiengesellschaft (7)
- Aktionär (7)
- Alemão como língua estrangeira (7)
- Alien species (7)
- Allgemeinmedizin (7)
- Alzheimer's disease (7)
- Ambivalenz (7)
- Anpassung (7)
- Anreizsystem (7)
- Anthophila (7)
- Anthropology (7)
- Antifaschismus (7)
- Anura (7)
- Aphorismus (7)
- Arbeitsvermittlung (7)
- Argumentation (7)
- Ausnahmezustand (7)
- Auswanderung (7)
- Autism spectrum disorder (7)
- Azerbaijan (7)
- Baltoslawische Sprachen (7)
- Basidiomycota (7)
- Bayesian estimation (7)
- Behinderung (7)
- Belize (7)
- Beuys, Joseph (7)
- Biological invasions (7)
- Biophysical chemistry (7)
- Black holes (7)
- Bobrowski, Johannes (7)
- Borrelia (7)
- Brandenburg (7)
- Bremen (7)
- Brüder Grimm (7)
- CRISPR/Cas9 (7)
- Cancer treatment (7)
- Capital-Asset-Pricing-Modell (7)
- Charakterisierung (7)
- Chemiker (7)
- Chewa (7)
- Chichewa (7)
- Christliche Arbeiterbewegung (7)
- Colorectal cancer (7)
- Computational models (7)
- Corporate Social Responsibility (7)
- Culicidae (7)
- Curculionidae (7)
- Cyanobacteria (7)
- Das Böse (7)
- Das Heilige (7)
- Das Sakrale (7)
- Data processing (7)
- Data science (7)
- Deflation (7)
- Derivat, Wertpapier (7)
- Deutscher Einwanderer (7)
- Deutschland / Vereinigung (7)
- Deutschland <Bundesrepublik> (7)
- Deutschland <DDR> / Revolution <1989> (7)
- Deutschlandbild (7)
- Development (7)
- Dienstmädchenverein (7)
- Digital Rights (7)
- Digital Services Act (7)
- Dodd-Frank Act (7)
- Drogenkonsum (7)
- Drogenszene (7)
- Drung (7)
- EZB (7)
- Eastern Arc (7)
- Eco, Umberto (7)
- Electroencephalography (7)
- Elektronische Bibliothek (7)
- Empfindsamkeit (7)
- Empirische Ästhetik (7)
- Engel <Motiv> (7)
- Enzensberger, Hans Magnus (7)
- Epigenetics (7)
- Episches Theater (7)
- Epos (7)
- Erwerbslosigkeit (7)
- Erzähler (7)
- Essayismus (7)
- Ethica ordine geometrico demonstrata (7)
- Ethnizität (7)
- Euro Area (7)
- Europabild (7)
- Expedition Brochure (7)
- Expeditionsbericht (7)
- Exposure (7)
- Fachportal (7)
- Fantastische Literatur (7)
- Fassbinder, Rainer Werner (7)
- Fernunterricht (7)
- Fichte, Johann Gottlieb (7)
- Filmkritik (7)
- Finance (7)
- Financial Regulation (7)
- Finanzierungsstruktur (7)
- Flaubert, Gustave (7)
- Foreign language teaching (7)
- Forensic entomology (7)
- Forschungsbericht (7)
- Frauenemanzipation (7)
- Frauenpolitik (SDAP) (7)
- Freidenker (7)
- Freie Liebe (7)
- Freizeit (7)
- GARCH (7)
- GIS (7)
- GPCR (7)
- Gegenwartsliteratur (7)
- Genauigkeit (7)
- Gene regulation (7)
- Genossenschaftliche Frauenbewegung (7)
- Genregulation (7)
- Genus verbi (7)
- German literature (7)
- Gerontologie (7)
- Geschichte 1933-1945 (7)
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- Geschlechterbeziehung (7)
- Gesundheitspolitik (7)
- Gewerbeaufsicht (7)
- Goethe-Universität Frankfurt (7)
- Gottsched, Johann Christoph (7)
- Griechenland (Altertum) (7)
- Guattari, Félix (7)
- HCC (7)
- Harz (7)
- Hemiptera (7)
- Herb induced liver injury (7)
- Herta Müller (7)
- Hilfsverb (7)
- Hitchcock (7)
- Hungary (7)
- Ich (7)
- Identification key (7)
- Identifikation (7)
- Identitätspolitik (7)
- Ikone (7)
- Immunohistochemistry (7)
- Immunological methods (7)
- Immunologische Methoden (7)
- Immunsuppression (7)
- Indústria cultural (7)
- International Financial Reporting Standards (7)
- Internationale Politik (7)
- Internationaler Vergleich (7)
- Jena (7)
- John (7)
- Johnson, Uwe (7)
- Kannibalismus <Motiv> (7)
- Kapitalgewinn (7)
- Kardiovaskuläre Krankheit (7)
- Karl Philipp (7)
- Karriere (7)
- Kasperl (7)
- Katholische Arbeiterinnenbewegung (7)
- Kausalität (7)
- Kenya (7)
- Klopstock, Friedrich Gottlieb (7)
- Komposition <Wortbildung> (7)
- Konfliktlösung (7)
- Kreditwürdigkeit (7)
- Kriegsfürsorge (7)
- Kritische Ausgabe (7)
- Kulturerbe (7)
- Kunstpädagogik (7)
- Kybernetik (7)
- Latein (7)
- Lattice QCD (7)
- Laudatio (7)
- Lebensstil (7)
- Leibniz, Gottfried Wilhelm (7)
- Lesekompetenz (7)
- Liberdade (7)
- Linguistische Datenverarbeitung (7)
- Linkshegelianer (7)
- Lycosidae (7)
- MLL (7)
- Macaronesia (7)
- Macht <Motiv> (7)
- Machtstruktur (7)
- Makonde (7)
- Malaise trap (7)
- Manipulation (7)
- Mann (7)
- Marcuse (7)
- Martin (7)
- Martyrium (7)
- Marxismus (7)
- Mechanisms of disease (7)
- Medialität (7)
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- Metonymie (7)
- Michel Foucault (7)
- Mitgliedsstaaten (7)
- Modalpartikel (7)
- Molecular neuroscience (7)
- Molekulardynamik (7)
- Monte-Carlo-Simulation (7)
- Moose (7)
- Moral Hazard (7)
- Morphonologie (7)
- Mygalomorphae (7)
- Märtyrer <Motiv> (7)
- Müller (7)
- Mündliche Kommunikation (7)
- NK cells (7)
- Nationenbildung (7)
- Naturphilosophie (7)
- Nebenläufigkeit (7)
- Neoliberalism (7)
- Nestroy, Johann (7)
- Neurology (7)
- Neuronales Netz (7)
- Neurons (7)
- Nietzsche (7)
- Normative Ordnungen (7)
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- Numerale (7)
- Nyanja (7)
- Nyanja-Sprache (7)
- Obesity (7)
- Odonata checklist (7)
- Orchidaceae (7)
- Organische Synthese (7)
- Osteoporosis (7)
- Othering (7)
- PD-L1 (7)
- PI3K (7)
- Palästina (7)
- Pathogenesis (7)
- Performance (7)
- Pharmazie (7)
- Phase Diagrams (7)
- Philosoph (7)
- Pholcidae (7)
- Plato (7)
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- Politikberatung (7)
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- Polytrauma (7)
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- Privacy (7)
- Privatisierung des Krieges (7)
- Programmiersprache (7)
- Proteins (7)
- Proteomanalyse (7)
- Präsenzlehre (7)
- Psycholinguistik (7)
- QCD phase diagram (7)
- Qualität (7)
- Quanten-Chromodynamik (7)
- Quantenchromodynamik (7)
- Quantum chromodynamics (7)
- Quark (7)
- Quercus (7)
- Quercus robur (7)
- RFQ (7)
- Reaction time (7)
- Reduktion (7)
- Referenz <Linguistik> (7)
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- Rekonstruktion (7)
- Religionskritik (7)
- Responsibility to protect (7)
- Retirement (7)
- Rhinotragini (7)
- Risk assessment (7)
- Rolle (7)
- Romanistik (7)
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- Rubus (7)
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- Schwangerschaftsabbruch (7)
- Sensory processing (7)
- Short story (7)
- Sichtbarkeit (7)
- Simmel, Georg (7)
- Slovakia (7)
- Snowden (7)
- Software (7)
- Sozialdemokratische Partei Deutschlands (SPD, 1890-) (7)
- Sparkasse (7)
- Species distribution modelling (7)
- Speech (7)
- Sprachgeschichte (7)
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- Tschechien (7)
- Ungeheuer (7)
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- Vergütung (7)
- Verhalten (7)
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- Vision (7)
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- War (7)
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- Willensfreiheit (7)
- Wissensproduktion (7)
- Wolfram <von Eschenbach> (7)
- Wöchnerinnenschutz (7)
- X-Ray (7)
- X-Ray Structure Analysis (7)
- acute lymphoblastic leukemia (7)
- antiviral therapy (7)
- anxiety (7)
- art (7)
- asthma (7)
- atrial fibrillation (7)
- beetles (7)
- biophysics (7)
- bipolar disorder (7)
- breeding (7)
- cGMP (7)
- capital structure (7)
- cell cycle (7)
- childhood (7)
- citizen science (7)
- cloud forest (7)
- cluster analysis (7)
- cochlear implant (7)
- colon cancer (7)
- concurrency (7)
- conduct disorder (7)
- cooperation (7)
- cytotoxicity (7)
- decision making (7)
- deep learning (7)
- deliberative democracy (7)
- density functional theory (7)
- descriptions (7)
- diet (7)
- diffusion tensor imaging (7)
- dung beetles (7)
- emancipation (7)
- episodic memory (7)
- expectations (7)
- fibrosis (7)
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- forensic entomology (7)
- forward guidance (7)
- freshwater (7)
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- functional traits (7)
- genetics (7)
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- hematopoietic stem cell transplantation (7)
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- homeostasis (7)
- human capital (7)
- immunology (7)
- indicator values (7)
- innovation (7)
- intertextuality (7)
- islamism (7)
- karst (7)
- leafhoppers (7)
- legal pluralism (7)
- leverage (7)
- liver cirrhosis (7)
- liverworts (7)
- longhorned beetles (7)
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- mathematical modeling (7)
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- mice (7)
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- natural history (7)
- natural killer cells (7)
- neophytes (7)
- network analysis (7)
- new subspecies (7)
- nitric oxide (7)
- oligomerization (7)
- parasitoid wasps (7)
- particulate matter (7)
- perception (7)
- phytodiversity (7)
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- predictive coding (7)
- pregnancy (7)
- prognosis (7)
- prophylaxis (7)
- prudential supervision (7)
- qualitative research (7)
- quality control (7)
- racism (7)
- representation (7)
- resilience (7)
- rna (7)
- seizure (7)
- shadow banking (7)
- signaling (7)
- sleep (7)
- social security (7)
- solitary bees (7)
- spectroscopy (7)
- stability (7)
- subjectivity (7)
- terminology (7)
- text book (7)
- thermal and non-thermal effects (7)
- thermische und nicht-thermische Effekte (7)
- thrombosis (7)
- trade (7)
- training (7)
- transcription (7)
- transcriptome (7)
- tumor-associated macrophages (7)
- vector (7)
- venture capital (7)
- whiteflies (7)
- wound exudation (7)
- zoogeography (7)
- Ökosystem (7)
- 3D printing (6)
- 401(k) plan (6)
- ATM (6)
- Abduktion <Logik> (6)
- Abnehmer (6)
- Achim von (6)
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- Addition Compounds (6)
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- Affect (6)
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- Altern (6)
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- Alzheimer (6)
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- Analogie (6)
- Andreas (6)
- Anna Amalia <Sachsen-Weimar-Eisenach (6)
- Antike <Motiv> (6)
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- Apoptose (6)
- Arbeitsgedächtnis (6)
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- BRD4 (6)
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- Balzac, Honoré de (6)
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- Böll, Heinrich (6)
- C-reactive protein (6)
- CDK4/6 (6)
- COSMO-CLM (6)
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- Canetti, Elias (6)
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- Cassirer, Ernst (6)
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- Fragmentation (6)
- Frankfurt <Main, 2003> (6)
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- Funktionale Kategorie (6)
- Fusion (6)
- Fühmann, Franz (6)
- Garten <Motiv> (6)
- Gedenken (6)
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- Goethe, Johann Wolfgang von / Die Leiden des jungen Werthers (6)
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- Grimmelshausen, Hans Jakob Christoffel von (6)
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- Internationale Arbeiterhilfe (IAH, 1921-) (6)
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- Kommunistische Partei Deutschlands (KPD, 1918-) (6)
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- Normative reconstruction (6)
- Novemberrevolution (6)
- Numerical accuracy (6)
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- Oral anticoagulation (6)
- Ost-West-Konflikt (6)
- Outcomes (6)
- PD1/PDL1 (6)
- PELDOR (6)
- PTSD (6)
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- Palatalisierung (6)
- Parabel <Literatur> (6)
- Paracelsus (6)
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- DVPW (4)
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- Das Monströse (4)
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- Denkmalpflege (4)
- Denosumab (4)
- Density equalizing mapping (4)
- Der Nachsommer (4)
- Der Prozess (4)
- Der Schwierige (4)
- Der Unbestechliche (4)
- Der Vorleser (4)
- Deradikalisierung (4)
- Descartes, René (4)
- Desmiphorini (4)
- Deutsche Bundesbank (4)
- Deutsche Zentrumspartei (Z, 1870-) (4)
- Deutscher Bund für Mutterschutz (DBM, 1905-) (4)
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- Dialogue (4)
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- Die Judenbuche (4)
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- Digitale Daten (4)
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- Dispositiv (4)
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- Docking (4)
- Doderer, Heimito von (4)
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- Dyserinck, Hugo (4)
- Dyson–Schwinger equations (4)
- Döblin, Alfred / Berlin Alexanderplatz (4)
- Düffel, John von (4)
- E. coli (4)
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- Eich, Günter (4)
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- Einbahnstraße (4)
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- Flow (4)
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- Gewerkschaftsbund der Angestellten (GdA, 1920-) (4)
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- Goethe, Johann Wolfgang von / Die Wahlverwandtschaften (4)
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- Graphic Novel (4)
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- Grillparzer, Franz / König Ottokars Glück und Ende (4)
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- Paul, Jean (4)
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- Schami, Rafik (4)
- Schelling, Friedrich Wilhelm Joseph von (4)
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Almost ten years after the European Commission action plan on building a capital markets union (CMU) and despite incremental progress, e.g. in the form of the EU Listing Act, the picture looks dire. Stock exchanges, securities markets, and supervisory authorities remain largely national, and, in many cases, European companies have decided to exclusively list overseas. Notwithstanding the economic and financial benefits of market integration, CMU has become a geopolitical necessity. A unified capital market can bolster resilience, strategic autonomy, and economic sovereignty, reduce dependence on external funding, and may foster economic cooperation between member states.
The reason for the persistent stand-still in Europe’s CMU development is not so much the conflict between market- and state-based integration, but rather the hesitancy of national regulatory and supervisory bodies to relinquish powers. If EU member states wanted to get real about CMU (as they say, and as they should), they need to openly accept the loss of sovereignty that follows from a true unified capital market. Building on economic as well as historical evidence, the paper offers viable proposals on how to design competent institutions within the current European framework.
This note outlines the case for speedy capital market integration and for the adoption of a common regulatory framework and single supervisory authority from a political economy perspective. We also show the alternative case for harmonization and centralization via regulatory competition, elaborating how competition between EU jurisdictions by way of full mutual recognition may lead to a (cost-)efficient and standardized legal framework for capital markets. Lastly, the note addresses the political economy conflict that underpins the implementation of both models for integrating capital markets. We point out that, in both cases, national authorities experience a loss of legislative and jurisdictional competence at the national level. We predict that any plan to foster a stronger capital market union, following an institution based or a market-based strategy, will face opposition from powerful national stakeholders.
In der Bibliographie sind alle bisher ermittelten Publikationen von und über Curt SigmarGutkind verzeichnet. Belegexemplare der von ihm verfassten Aufsätze und Zeitungsbeiträge(Rezensionen, Theaterkritiken usw.) befinden sich in seinem im Mannheimer Stadtarchivaufbewahrten Nachlass. Alle Einträge wurden autoptisch geprüft.
Hugh Blairs umfangreiche "Lectures on Rhetoric and Belles Lettres" sind eines der erfolgreichsten Werke der englischsprachigen Rhetoriktradition. Der Stilbegriff bildet das Zentrum von Blairs Ästhetikkonzept. Blair greift einerseits auf die rhetorische Tradition zurück, bezieht sich andererseits aber auch auf wahrnehmungstheoretische Überlegungen aus der zeitgenössischen empiristischen Psychologie. Neben den ästhetischen Qualitäten des Stils rücken dabei Fragen der Verständnissicherung durch stilistische Klarheit in den Fokus. Blairs "Lectures" greifen damit über das Feld der Ästhetik entscheidend hinaus.
Dorothea Gotfurt, 1907–1995
(2024)
Dorothea Gotfurt kam 1935 als Exilantin nach England. Dort wurde sie zur Übersetzerin. Zwischen 1955 und 1970 veröffentlichte sie vor allem im Scherz-Verlag (Bern), aber auch bei Fischer (Frankfurt/M.), Rowohlt (Reinbek) oder Szolnay (Wien) über dreißig von ihr ins Deutsche gebrachte Romane aus der zeitgenössischen englischsprachigen Literatur.
Im November durfte er seinen 77. Geburtstag feiern, von Ruhestand ist aber noch keine Spur. Gerade bereitet er sich in seinem Büro über der Neuen Mensa am alten Campus in Bockenheim mit großem Elan auf die nächste Seminarsitzung vor. »Die Lehre an der Universität wie an Fachhochschulen war mir nie eine Last. Ich habe versucht, die Studierenden zu motivieren oder bei Bedarf gar zu provozieren, um zu kommunizieren, weil wir alle viel mehr von gegenseitigem Austausch haben«, sagt Ludwig Salgo. Zahlreiche Studierende der Sozialen Arbeit, aus der Rechtswissenschaft, aber auch aus der Erziehungswissenschaft haben seine Veranstaltungen besucht; etliche Juristinnen und Juristen haben bei ihm promoviert, sich für die pädagogische oder juristische Laufbahn qualifiziert. Sein zentrales Thema in Forschung und Lehre: das Verhältnis Eltern-Kind-Staat. Anfang 2012 ging er in den Ruhestand, doch die Lehre blieb vorerst seine große Passion. Jetzt beendet er seine Seniorprofessur an der Goethe-Universität zum Semesterende nach zehn Jahren: »Nun ist es genug«, sagt er. In der Fortbildung für Jugendämter, Verfahrensbeistände und Juristen, auch in Stiftungen und Verbänden, hier vor allem im Kinderschutzbund in Frankfurt, möchte er weiterhin aktiv bleiben, auch um für das Thema Kindeswohl zu sensibilisieren. Dass er dann mehr Zeit für seine große Leidenschaft haben wird, freut ihn: »Ich leide an der Melomanie«, sagt der passionierte Freund klassischer Musik. »Wie Nietzsche treffenderweise einmal bemerkt hat, wäre das Leben ohne Musik ein Irrtum.«
Unter Experten in Sachen Übersetzungsgeschichte ist Johann Diederich Gries kein Unbekannter. Er zählt z. B. zu den zehn "bedeutende[n] Übersetzerpersönlichkeiten von der frühen Neuzeit bis heute", deren Leben und Werk in der Europäischen Übersetzungsgeschichte von Jörn Albrecht und Iris Plack dargestellt wird. Friedmar Apels von Gottsched und Bode bis Dedecius und Enzensberger reichende "Leseliste zur Geschichte des Übersetzens in Deutschland" umfasst 60 Übersetzer, von Gries werden dessen Calderón- und Tasso-Übersetzungen zur Lektüre empfohlen.
Im vorliegenden Beitrag geht es um die Frage, wie sich Natürlichkeit als ein zentrales Stilkonzept im 18. Jahrhundert auf die syntaktische Gestaltung von Texten ausgewirkt hat. Grundlage der empirischen Untersuchung sind neunzig Musterbriefe, die aus drei Ausgaben des Schröter'schen Briefstellers (1,1743, 7,1767, 8,1785) stammen und die im Sinne der 'neuen' Stilauffassungen überarbeitet wurden. Die Briefe zeigen unter anderem einen Rückgang in der Satzkomplexität, eine Aufwertung der Selbstreferenz und eine verstärkte Einbindung mündlichkeitsnaher Strukturen.
We describe a new species of karst-dwelling pitviper from Chumphon Province of Peninsular Thailand, in the Isthmus of Kra, based on morphological and molecular data (2427 bp from cyt b, ND4 and 16S rRNA mitochondrial DNA genes). Morphologically, Trimeresurus kraensis sp. nov. is distinguished from other congeners by the following combination of morphological characters: a dark/bottle-green dorsum with reddish-brown or purple crossbands; pale green venter lacking dark dots; stripes present on the lateral sides of the ventrals; internasals generally in contact; one large supraocular scale on each side of the head; iris pale copper; tail brown with dark purplish-brown crossbars; dorsal scales in 21–21–15 rows; ventral scales 167 in a single male, 169–171 in females; subcaudal scales 62 in a single male, 52–54 in females, all paired. White vertebral spots present in males, located on approximately every two or four dorsal scales; dark brown spots forming discontinuous pattern present on 1–3 lateral dorsal scale rows; males with reddish-brown postocular stripe with jagged edges. The new species differs from the morphologically similar species Trimeresurus venustus s. str. by a notable divergence in cytochrome b mitochondrial DNA gene sequences (p = 5.9%).
In the vast abyssal plains northwest of Iceland, white glass sponges of the genus Caulophacus Schulze, 1886 were inhabited by reddish Bythocaris G.O. Sars, 1870 shrimps and pinkish amphipods. After in situ observations at 3700 m depth, in -1°C waters by a remotely operated vehicle, members of this assemblage were collected and preserved for molecular studies. Based on integrative taxonomic analyses, the amphipods were identified as a new species of the genus Halirages Boeck, 1871 – Halirages spongiae sp. nov. Lörz, Nack & Tandberg –, as described in detail below. Part of our integrative approach was to establish reference DNA barcodes for known species of Halirages. However, our investigation of material of Calliopiidae G.O. Sars, 1895 collected around Iceland and Norway revealed slight morphological discrepancies in all the described species of Halirages. Except for Halirages fulvocinctus (M. Sars, 1858), none of the encountered specimens of Calliopiidae fully matched a current species description. We illuminate the morphological characteristics of nine operational taxonomic units, which also represented clades in COI and 28S. We set the Icelandic samples in the context of Halirages from Canada and Norway. A key to the world species of Halirages is provided.
Highlights
• Seed size mediates seedling recruitment in tropical forests and pastures.
• Large-seeded species recruited better than small-seeded species in the forest.
• Recruitment of large-seeded species in pastures was limited by surface temperature.
• Large-seeded species should be protected against drought in regenerating pastures.
Abstract
Seedling recruitment is a key process of plant regeneration that often depends on plant functional traits, such as seed size. To optimize forest restoration efforts, we need to better understand how seedling recruitment of different seed sizes varies along environmental gradients with strong variation in abiotic and biotic factors. To understand these interacting effects, we conducted a sowing experiment with different-sized seeds in forests and pastures in the tropical mountains of southern Ecuador. We quantified seedling recruitment in relation to temperature, soil moisture and biotic pressures. We sowed seeds of five tree species of varying seed size at three elevations (1000, 2000 and 3000 m a.s.l.) in primary forest and pastures. We tested (1) how habitat type influences the recruitment of seedlings belonging to three small- and two large-seeded species, and (2) how abiotic and biotic factors limit seedling recruitment of species with different seed sizes. We found that seedlings of the two large-seeded species recruited better than seedlings of the three small-seeded species, but only in the forest habitat. Seedling recruitment of large seeds was primarily limited by high surface temperature, which explains lower recruitment of large seeds in pastures compared to forests. Our study shows that seed size can be a key trait mediating variability in seedling recruitment in tropical ecosystems. We conclude that restoration measures should aim to mitigate extreme temperatures in tropical pastures to aid the natural regeneration of large-seeded tree species.
The epitranscriptome embodies many new and largely unexplored functions of RNA. A major roadblock in the epitranscriptomics field is the lack of transcriptome-wide methods to detect more than a single RNA modification type at a time, identify RNA modifications in individual molecules, and estimate modification stoichiometry accurately. We address these issues with CHEUI (CH3 (methylation) Estimation Using Ionic current), a new method that concurrently detects N6-methyladenosine (m6A) and 5-methylcytidine (m5C) in individual RNA molecules from the same sample, as well as differential methylation between any two conditions. CHEUI processes observed and expected nanopore direct RNA sequencing signals with convolutional neural networks to achieve high single-molecule accuracy and outperforms other methods in detecting m6A and m5C sites and quantifying their stoichiometry. CHEUI’s unique capability to identify two modification types in the same sample reveals a non-random co-occurrence of m6A and m5C in mRNA transcripts in cell lines and tissues. CHEUI unlocks an unprecedented potential to study RNA modification configurations and discover new epitranscriptome functions.
The epitranscriptome embodies many new and largely unexplored functions of RNA. A major roadblock in the epitranscriptomics field is the lack of transcriptome-wide methods to detect more than a single RNA modification type at a time, identify RNA modifications in individual molecules, and estimate modification stoichiometry accurately. We address these issues with CHEUI (CH3 (methylation) Estimation Using Ionic current), a new method that concurrently detects N6-methyladenosine (m6A) and 5-methylcytidine (m5C) in individual RNA molecules from the same sample, as well as differential methylation between any two conditions. CHEUI processes observed and expected nanopore direct RNA sequencing signals with convolutional neural networks to achieve high single-molecule accuracy and outperforms other methods in detecting m6A and m5C sites and quantifying their stoichiometry. CHEUI’s unique capability to identify two modification types in the same sample reveals a non-random co-occurrence of m6A and m5C in mRNA transcripts in cell lines and tissues. CHEUI unlocks an unprecedented potential to study RNA modification configurations and discover new epitranscriptome functions.
The epitranscriptome embodies many new and largely unexplored functions of RNA. A major roadblock in the epitranscriptomics field is the lack of transcriptome-wide methods to detect more than a single RNA modification type at a time, identify RNA modifications in individual molecules, and estimate modification stoichiometry accurately. We address these issues with CHEUI (CH3 (methylation) Estimation Using Ionic current), a new method that concurrently detects N6-methyladenosine (m6A) and 5-methylcytidine (m5C) in individual RNA molecules from the same sample, as well as differential methylation between any two conditions. CHEUI processes observed and expected nanopore direct RNA sequencing signals with convolutional neural networks to achieve high single-molecule accuracy and outperforms other methods in detecting m6A and m5C sites and quantifying their stoichiometry. CHEUI’s unique capability to identify two modification types in the same sample reveals a non-random co-occurrence of m6A and m5C in mRNA transcripts in cell lines and tissues. CHEUI unlocks an unprecedented potential to study RNA modification configurations and discover new epitranscriptome functions.
Sentence repetition tasks (SRTs) have been extensively used as measures of bilinguals’ language abilities. Most studies relied on SRTs in which the target sentences were not connected to each other. However, participants’ performance may differ if these sentences are embedded in discourse, since discourse provides participants with additional cues for sentence comprehension and interpretation. For the present study, we designed a discourse-based SRT, whereby the target sentences were connected to each other in a story. We examined the effect of discourse on bilinguals’ performance in the SRT and investigated whether this effect varied based on the language of administration, bilinguals’ dominance score and type of target structure. We tested 32 Italian-German bilingual children (7–12 years) living in Germany with two SRTs in each language, one with discourse and one without discourse. Participants showed a better performance in the SRTs with discourse, especially in the heritage language (Italian). The effect of discourse was visible across the board with all target structures. On the whole, SRTs with discourse seem to reduce the processing costs associated with lexical retrieval and shifts in scenarios, thus tapping more directly into children's processing abilities, compared to more traditional SRTs. The results are discussed in terms of ecological validity of different assessment instruments.
Highlights
• Six Newton methods for solving matrix quadratic equations in linear DSGE models.
• Compared to QZ using 99 different DSGE models including Smets and Wouters (2007).
• Newton methods more accurate than QZ with comparable computation burden.
• Apt for refining solutions from alternative methods or nearby parameterizations.
Abstract
This paper presents and compares Newton-based methods from the applied mathematics literature for solving the matrix quadratic that underlies the recursive solution of linear DSGE models. The methods are compared using nearly 100 different models from the Macroeconomic Model Data Base (MMB) and different parameterizations of the monetary policy rule in the medium-scale New Keynesian model of Smets and Wouters (2007) iteratively. We find that Newton-based methods compare favorably in solving DSGE models, providing higher accuracy as measured by the forward error of the solution at a comparable computation burden. The methods, however, suffer from their inability to guarantee convergence to a particular, e.g. unique stable, solution, but their iterative procedures lend themselves to refining solutions either from different methods or parameterizations.
The hierarchical feature regression (HFR) is a novel graph-based regularized regression estimator, which mobilizes insights from the domains of machine learning and graph theory to estimate robust parameters for a linear regression. The estimator constructs a supervised feature graph that decomposes parameters along its edges, adjusting first for common variation and successively incorporating idiosyncratic patterns into the fitting process. The graph structure has the effect of shrinking parameters towards group targets, where the extent of shrinkage is governed by a hyperparameter, and group compositions as well as shrinkage targets are determined endogenously. The method offers rich resources for the visual exploration of the latent effect structure in the data, and demonstrates good predictive accuracy and versatility when compared to a panel of commonly used regularization techniques across a range of empirical and simulated regression tasks.
ISOE-Newsletter Nr. 2/2024
(2024)
Wissenschaftskommunikation zu Risiken von Ewigkeitschemikalien +++ Gemeinsam statt gegeneinander: Waldkonflikte konstruktiv lösen +++ Künstlerische Forschung: Projektstipendium „Insectopolis“ vergeben +++ Sommersemester 2024: Soziale Ökologie und Transdisziplinarität in der Lehre +++ Ökologische Kipppunkte in der mongolischen Steppe erkennen und vermeiden +++ Aktuelle Beiträge im ISOE Blog +++ Aus dem ISOE +++ Das ISOE in den Medien +++ Termine +++ Publikationen
A powerful technique to distinguish the enantiomers of a chiral molecule is the Coulomb Explosion Imaging (CEI). This technique allows us to determine the handedness of a single molecule. In CEI, the molecule becomes charged by losing many electrons in a very short period of time by interacting with the light. The repulsion forces between the positive charged particles of the molecule leads the molecule to break into parts-fragments. By measuring the three vector momentum of (at least) four fragments, the handedness observable can be determined. In this thesis, CEI is induced by absorption of a single high energy photon, which creates an inner-shell hole (K shell) of the molecule. The subsequent cascade of Auger decays lead to fragmentation. We decided to work with the formic acid molecule in this thesis. Two different experiments were conducted. The first experiment focused on exciting electrons to different energy states, while the second experiment focused on extracting directly a photoelectron to the continuum and measure the angular distribution of the photoelectron in the molecular frame. The primary goal was to search for chiral signal in a pure achiral planar molecule under the previous electron processes. The results of these findings were further implemented to two more molecules.
We carry out an in-depth analysis of the prompt-collapse behaviour of binary neutron star (BNS) mergers. To this end, we perform more than 80 general relativistic BNS merger simulations using a family of realistic Equations of State (EOS) with different stiffness, which feature a first order deconfinement phase transition between hadronic and quark matter. From these simulations we infer the critical binary mass Mcrit that separates the prompt from the non-prompt collapse regime. We show that the critical mass increases with the stiffness of the EOS and obeys a tight quasi-universal relation, Mcrit/MTOV ≈ 1.41 ± 0.06, which links it to the maximum mass MTOV of static neutron stars, and therefore provides a straightforward estimate for the total binary mass beyond which prompt collapse becomes inevitable. In addition, we introduce a novel gauge independent definition for a one-parameter family of threshold masses in terms of curvature invariants of the Riemann tensor which characterizes the development toward a more rapid collapse with increasing binary mass. Using these diagnostics, we find that the amount of matter remaining outside the black hole sharply drops in supercritical mass mergers compared to subcritical ones and is further reduced in mergers where the black hole collapse is induced by the formation of a quark matter core. This implies that Mcrit, particularly for merger remnants featuring quark matter cores, imposes a strict upper limit on the emission of any detectable electromagnetic counterpart in BNS mergers.
A considerable effort has been dedicated recently to the construction of generic equations of state (EOSs) for matter in neutron stars. The advantage of these approaches is that they can provide model-independent information on the interior structure and global properties of neutron stars. Making use of more than 106 generic EOSs, we assess the validity of quasi-universal relations of neutron-star properties for a broad range of rotation rates, from slow rotation up to the mass-shedding limit. In this way, we are able to determine with unprecedented accuracy the quasi-universal maximum-mass ratio between rotating and nonrotating stars and reveal the existence of a new relation for the surface oblateness, i.e., the ratio between the polar and equatorial proper radii. We discuss the impact that our findings have on the imminent detection of new binary neutron-star mergers and how they can be used to set new and more stringent limits on the maximum mass of nonrotating neutron stars, as well as to improve the modeling of the X-ray emission from the surface of rotating stars.
"Mir ist so digk vor gesait" : Studien zur erzählerischen Gestaltung des "Meleranz" von dem Pleier
(2024)
In der germanistischen Mediävistik richtet sich das Forschungsinteresse vornehmlich auf die höfische Literatur und dabei insbesondere auf die frühen und späten Artusromane. Vor allem die Werke von Hartmann von Aue und Wolfram von Eschenbach sind zentrale Forschungsobjekte, während Texte wie Pleiers ‚Meleranz‘ bisher nur begrenzt Beachtung fanden.
Die Forschungslücke, die die vorliegende Arbeit adressiert, liegt in der detaillierten Analyse der spezifischen Erzähltechniken des pleierschen Textes, die sich sowohl durch die Verwendung traditioneller arthurischer Motive als auch durch innovative narrative Ansätze auszeichnen. Ausgehend von dem Befund eines stark zurückgenommenen Erzählers wird untersucht, welche narrativen Strategien und Verfahren der Pleier im ‚Meleranz‘ anwendet, um trotz dieser Abkehr von der implizierten poetischen Regelhaftigkeit einer dominanten Erzählerfigur das Erzählen vom Ritter ‚Meleranz‘ gelingen und zugleich an einigen Stellen ausgesprochen konventionell wirken zu lassen.
Um aufzudecken, wie der Text ohne die Stimme eines deutlich hervortretenden Erzählers vermittelt wird, nutze ich im Verlauf der Arbeit eine Typologie der Stoffvermittlung durch (arthurische) Erzähler. In den Einzelstudien zum ‚Meleranz‘ werden seine Motive, Erzählmuster und Figurenkonstellationen in einem close reading erarbeitet und mit der Typologie abgeglichen, um bestimmen zu können, welche Vermittlungsformen im pleierschen Text genutzt werden. Mit Hilfe dieses Vergleichs kann das Erzählverfahren im ‚Meleranz‘ extrapoliert und gleichzeitig offengelegt werden. Mittels dieses Vorgehens wird verdeutlicht werden, dass es sich beim ‚Meleranz‘ um einen Text handelt, der arthurische Konventionen lediglich anders inszeniert, um die vermittelnde Funktion der Stimme des Erzählers zu substituieren oder ihr Fehler auszugleichen.
Background: Urachal cancer (UrC) is a rare disease with limited availability of representative incidence and clinical data. Although, the prevalence is accounting for less than 1% of bladder tumors, the 5-year survival rate is around only 50% for patients with resectable tumors, and even worse for patients with metastatic disease. Due to the lack of comprehensive prospective studies, our current knowledge of UrC is still limited.
Objective: The present study aimed to summarize the available registry-based studies with unselected UrC patients to evaluate its incidence and clinicopathological characteristics.
Material and methods: We conducted a systematic literature search of registry-based UrC publications on the 15th of May 2023 in 5 databases, which identified 4,748 publications. After duplicate removal and selection by 2 independent investigators, 6 publications proved to be appropriate for the final meta-analysis. Estimated incidence and clinicopathological parameters were extracted.
Results: Estimated incidence ranged between 0.022 and 0.060/ 100.000 person-years, with the highest occurrence in Japan and the lowest in Canada, while the random effect model calculated an overall incidence rate of 0.04 (95%CI: 0.03–0.05) 100.000 person-years. The median age at first diagnosis was 60 years (range: 58–64). The female to male ratio was 2:3. Lymph node or distant metastases were present in 9% and 14% of patients. The predominant tumour type was adenocarcinoma (86%) followed by urothelial carcinoma (12%) and squamous cell carcinoma (2%). The 5-year survival rate was 51.0% with 95%CI: 45.2–57.4.
Conclusions: Our study provides an up-to-date comparison of estimated incidence rates between 6 countries of 3 continents based on rigorously selected registry-based studies. The results suggest low incidence rates for UrC with considerable geographic differences. The present meta-analysis provides unbiased registry-based data on the incidence, clinicopathological parameters and survival of UrC.
Über einen Schriftsteller und seinen Körper : Aris Fioretos wird neuer Frankfurter Poetikdozent
(2024)
The Russian invasion of Ukraine illustrates the increasingly judicialized nature of international relations and geopolitics. By viewing aspects of the invasion as illegal – in particular through the identification of war crimes and crimes against humanity – the international response draws attention to the political geographies of international criminal investigation. Human rights groups, academics, journalists, and open-source forensic investigations have joined forces to collect, evaluate and analyze the violent nature of war crimes. While similar shifts in evidence gathering have been observed in the case of the Bosnia-Herzegovina war and the Assad regime's violence against Syrian citizens, the use of evidence-gathering technologies and evidence-securing institutions in the case of Ukraine is distinctive. In this scholarly intervention we seek to illustrate the intimate geopolitics of evidence gathering by zooming in on two different elements that shape evidential procedures in Ukraine: i) the blurring of civilian/military boundaries; and ii) the challenges of access. By evaluating what is new and what is similar to previous war sites, we suggest that these two areas reflect a geopolitics of evidence gathering, highlighting its global-local intimacies. Both these areas are well positioned to foster new research on the (geo)legal nature of war crimes in political geography and beyond.
Diversität und Diskurs – Wie (un-)politisch ist die Universität? : Ringvorlesung im Sommersemester
(2024)
Highlights
• Deletion of SPPL3 promotes resistance of malignant B cells to NK cell cytotoxicity
• Loss of SPPL3 blocks ligand binding to NK receptors via increased N-glycosylation
• B3GNT2 deletion reduces LacNAc addition and restores SPPL3-KO cell sensitivity to NK cells
• SPPL3-deficient cells are enriched in tetra-antennary N-glycans with LacNAc elongations
Summary
Natural killer (NK) cells are primary defenders against cancer precursors, but cancer cells can persist by evading immune surveillance. To investigate the genetic mechanisms underlying this evasion, we perform a genome-wide CRISPR screen using B lymphoblastoid cells. SPPL3, a peptidase that cleaves glycosyltransferases in the Golgi, emerges as a top hit facilitating evasion from NK cytotoxicity. SPPL3-deleted cells accumulate glycosyltransferases and complex N-glycans, disrupting not only binding of ligands to NK receptors but also binding of rituximab, a CD20 antibody approved for treating B cell cancers. Notably, inhibiting N-glycan maturation restores receptor binding and sensitivity to NK cells. A secondary CRISPR screen in SPPL3-deficient cells identifies B3GNT2, a transferase-mediating poly-LacNAc extension, as crucial for resistance. Mass spectrometry confirms enrichment of N-glycans bearing poly-LacNAc upon SPPL3 loss. Collectively, our study shows the essential role of SPPL3 and poly-LacNAc in cancer immune evasion, suggesting a promising target for cancer treatment.
Highlights
• Gender cues are defined differently across languages.
• We propose a new refined and standardized definition of gender transparency.
• Gender transparency is quantifiable with values that match theoretical expectations.
• We present the first quantitative method to measure the gender transparency of languages.
Abstract
Languages can express grammatical gender through different ortho-phonological regularities present in nouns (e.g., the cues “-o” and “-a” for the masculine and the feminine respectively in Italian, Portuguese, or Spanish). The term “gender transparency” was coined to describe these regularities (Bates et al., 1995). In gendered languages, we can hence distinguish between transparent nouns, i.e., those displaying form regularities; opaque nouns, i.e., those with ambiguous endings; and irregular nouns, i.e., those that display the typical form regularities but are associated with the opposite gender. Following a descriptive analysis of such regularities, languages have been recently classified according to their degree of gender transparency, which seems relevant in regard to gender acquisition and processing. Yet, there are certain inconsistencies in determining which languages are overall transparent and which are opaque. In particular, it is not clear whether some other complex regularities such as derivational suffixes are also “transparent” cues for gender, what really constitutes an “opaque” noun, or which role orthography and morphology have in transparency. Given the existing inconsistencies in classifying languages as transparent or opaque, this work introduces a proposal to assess gender transparency systematically. Our methodology adapts the standardized factors proposed by Audring (2019) to analyse the relative complexity of gender systems. Such factors are adapted to gender transparency on the basis of the literature on gender acquisition and processing. To support the feasibility of such a proposal, the concepts have been instantiated in a quantitative model to obtain for the first time an objective measure of gender transparency using European Portuguese and Dutch as instances of target languages. Our results coincide with the theoretically expected outcome: European Portuguese obtains a high value of gender transparency while Dutch obtains a moderately low one. Future adaptations of this model to the gender systems of other languages could allow the continuum of gender transparency to sustain robust predictions in studies on gender processing and acquisition.
Microbial rhodopsins are omnipresent on Earth, however the vast majority of them remain uncharacterized. Here we describe a new rhodopsin group from cold-adapted organisms and cold environments, such as glaciers, denoted as CryoRhodopsins (CryoRs). Our data suggest that CryoRs have dual functionality switching between inward transmembrane proton translocation and photosensory activity, both of which can be modulated with UV light. CryoR1 exhibits two subpopulations in the ground state, which upon light activation lead to transient photocurrents of opposing polarities. A distinguishing feature of the group is the presence of a buried arginine residue close to the cytoplasmic face of its members. Combining single-particle cryo-electron microscopy and X-ray crystallography with the rhodopsin activation by lit, we demonstrate that the arginine stabilizes a UV-absorbing intermediate of an extremely slow CryoRhodopsin photocycle. Together with extensive spectroscopic characterization, our investigations on CryoR1 and CryoR2 proteins reveal mechanisms of photoswitching in the newly identified group and demonstrate principles of the adaptation of these rhodopsins to low temperatures.Microbial rhodopsins are omnipresent on Earth, however the vast majority of them remain uncharacterized. Here we describe a new rhodopsin group from cold-adapted organisms and cold environments, such as glaciers, denoted as CryoRhodopsins (CryoRs). Our data suggest that CryoRs have dual functionality switching between inward transmembrane proton translocation and photosensory activity, both of which can be modulated with UV light. CryoR1 exhibits two subpopulations in the ground state, which upon light activation lead to transient photocurrents of opposing polarities. A distinguishing feature of the group is the presence of a buried arginine residue close to the cytoplasmic face of its members. Combining single-particle cryo-electron microscopy and X-ray crystallography with the rhodopsin activation by light, we demonstrate that the arginine stabilizes a UV-absorbing intermediate of an extremely slow CryoRhodopsin photocycle. Together with extensive spectroscopic characterization, our investigations on CryoR1 and CryoR2 proteins reveal mechanisms of photoswitching in the newly identified group and demonstrate principles of the adaptation of these rhodopsins to low temperatures.
Der Beitrag untersucht den Gebrauch des Tonbegriffs im ästhetischen und poetologischen Diskurs des mittleren und späten 18. Jahrhunderts. Ausgangspunkt dafür ist eine Verhältnisbestimmung der Termini Schreibart, Stil und Ton, aus der die gattungspoetologische Bedeutung des Tons hervorgeht. Entgegen dem seit der romantischen Ästhetik dominanten Verständnis verbindet die Dichtungstheorie des 18. Jahrhunderts (Friedrich Gottlieb Klopstock, Johann Joachim Eschenburg, Johann Jakob Engel, Johann Christoph Adelung) mit dem Begriff nicht nur die klangliche Dimension von Literatur, sondern auch eine affektive Grundierung von Gattungsformen und ein Konzept für die Beschreibung von gattungshybriden Texten.
Der Beitrag sucht Georg Christoph Lichtenbergs Position im Sprachdenken der zweiten Hälfte des 18. Jahrhunderts zu bestimmen. Diese ist durch eine Kombination von anthropologischen und technisch-pragmatischen, sprachhandwerklichen Überlegungen zur "Wörterfertigung" geprägt, bei der Fragen von Lexik und Nomenklatur im Vordergrund stehen. Zu den Leitkriterien des guten Stils gehören Lichtenberg zufolge Wahrheit und Genauigkeit sowie Natürlichkeit und Individualisierung.
Focusing on the specific case of knowledge production in and about Iran, in this chapter, we discuss the risk of reproducing a Northern perspective in the attempts to produce knowledge on and through the Global South(s). We argue that such reproduction leads to cognitive suppression, further peripheralization, or even recolonization of the South(s). We also stress the lasting effects of methodological nationalism among attempts at decolonization and its political consequences, such as in the adoption of nativist discourses historically connected to the 'Islamic' Revolution by scholars focusing on the Global South(s) and in area studies concerning Iran. To avoid these effects, we suggest considering the politics of scale in our recognition and problematization of the hierarchization of Northern and Southern sites of knowledge production and their particularities.
During fieldwork, anthropologists are given many names that point to their intersectional placement regarding race, class, gender, nationality, and religion. Yet, careful consideration of vernacular forms of designation reveals that such generalizing categories do not always reflect the ways in which people are named and positioned in a given context. While acknowledging the relevance of intersectionality, this paper discusses the relationship between naming and social positionality through a comparative consideration of names employed to designate Dulley in Angola and Santos in Senegal. It explores how these designators, ascribed to the researchers by their interlocutors, contextually identify their positionality. Through concrete examples, it shows how this process of emplacement can both enable and restrict one's possibilities of action and experience.
With reference to the Marx Seminars at the University of São Paulo, this chapter discusses the creation of a specific tradition in the social sciences that marks a crucial moment in the history of postcolonial and decolonial studies. By means of the concept of periphery, I reconstruct how this tradition refuted temporal and stadial dualisms. Moreover, I argue that the development of this new perspective in the social sciences must be understood in terms of its efforts to rethink Marx but also, and more importantly, by the need to rethink Brazil's place in the world. Following this thread, I analyse Roberto Schwarz's work as paradigmatic for a proper understanding of the centrality of the concept of periphery in these discussions.
This chapter is a journey of thought exploring decolonial critique as a situated practice while thinking through exilic consciousness and its constitutive conditions. I begin by reflecting on decolonialities to gesture toward varied forms of decolonial projects that need to be situated, given that each location generates different sets of questions/problems that demand different answers. In this way, I reconfigure the exilic condition, and the space of displacement in general, as a plurilingual space that unsettles various colonial forms of epistemic monolingualism predicated on the selfsufficiency of thought. To this end, I reflect on the potentiality of exilic consciousness to generate decolonial critique when thinking from/about the Global South. Finally, this chapter demonstrates the significance of acknowledging the diverse locations and trajectories of decolonial critique and the plurality of thought embedded within the exilic intellectual formation that can potentially undo colonial forms of knowledge-making and being in the world.
Invitation, to exi(s)t
(2024)
This joint piece aspires to be a dialogue. In a dialogue, people speak and, most importantly, listen, from their respective positions. Drawing from Trinh T. Minh-ha's notion of speaking nearby, Dulley and Streva reflect on the relationship between authorship, authority, and authoritarianism; the parallel between listening and reading, on the one hand, and speaking and writing, on the other hand; the entanglement between disciplinary systems of knowledge and colonial structures of power; the opacity of others and the imperialistic drive to reduce them to transparency; the supposed subject of knowledge and the void. As they converse on these matters, they speak nearby authors from both the so-called Global South and the so-called Global North who are thus juxtaposed, further developed, and displaced towards a politics and ethics of fugitivity. What follows is an invitation to exi(s)t.
In this brief discussion, I reflect on the significance of using the category of the global south for reconfiguring the scope of the history of knowledge. While I see this as a productive paradigm shift that has already given rise to mould-breaking works, I focus here on the cross-hemispheric histories of extractive capitalism and how both colonial violence and anticolonial resistance have shaped knowledge-making. I argue that thinking through 'entangled ecologies' can be a tool for countering the existing conceptual order, which has led to the north-south division in the first place. Attending to epistemic and ontological entanglements would enable us to ask better and deeper questions about the increasingly complex interconnections across human and nonhuman worlds, especially given the planetary crises we face today.
In this reflection piece, I look at the feminist artistic landscape emerging in Berlin with its growing, diverse migrant community. I examine the ways in which women* artists challenge the imposed notions of their migrant status in the city and their states of belonging within it. I demonstrate this through two feminist initiatives I have been involved in that aim to amplify the voices of women* artists whose creative practices disrupt carefully constructed frameworks relating to borders of inclusion and exclusion. I argue that the artistic practices of women* in these networks are killjoy because they unapologetically get in the way, dismantling carefully constructed frameworks that delineate borders of inclusion and exclusion. By reflecting on homemaking practices in exile, I exemplify how feminisms from the global south decentralize claims to truth by taking the means of production into their own hands. By framing the chapter around the recent protests in Berlin unfolding in solidarity with the feminist revolution in Iran, I reveal the possible limits of such actions when they do not embrace intersectionality. Ultimately, I propose to invest in feminist artistic practices that destabilize exclusionary politics by creating visibility and bridging theory and practice.
Coarse-grained modeling has become an important tool to supplement experimental measurements, allowing access to spatio-temporal scales beyond all-atom based approaches. The GōMartini model combines structure- and physics-based coarse-grained approaches, balancing computational efficiency and accurate representation of protein dynamics with the capabilities of studying proteins in different biological environments. This paper introduces an enhanced GōMartini model, which combines a virtual-site implementation of Gō models with Martini 3. The implementation has been extensively tested by the community since the release of the new version of Martini. This work demonstrates the capabilities of the model in diverse case studies, ranging from protein-membrane binding to protein-ligand interactions and AFM force profile calculations. The model is also versatile, as it can address recent inaccuracies reported in the Martini protein model. Lastly, the paper discusses the advantages, limitations, and future perspectives of the Martini 3 protein model and its combination with Gō models.
Das erziehungswissenschaftliche Projekt »InterCare« will erforschen, wie junge Menschen die Doppelbelastung von Ausbildung/Studium und Pflege bewältigen. Offizieller Start des Projekts, das über vier Jahre hinweg mit 1,2 Millionen Euro von der VolkswagenStiftung gefördert wird, ist im Oktober 2024. Die Soziologin und Altersforscherin Dr. Anna Wanka koordiniert InterCare und erläutert das Design des Projekts.
Rationale: Potassium (K) is a major component of several silicate minerals and seawater, and, therefore, constraining past changes in the potassium cycle is a promising way of tracing large-scale geological processes on Earth. However, [K] measurement using inductively coupled plasma mass spectrometry (ICP-MS) is challenging due to an ArH+ interference, which may be of a similar magnitude to the K+ ion beam in samples with <0.1% m/m [K].
Methods: In this work, we investigated the effect of the ArH+ interference on K/Ca data quality by comparing results from laser-ablation (LA)-ICP-MS measured in medium and high mass resolution modes and validating our LA results via solution ICP-optical emission spectroscopy (OES) and solution ICP-MS measurements. To do so, we used a wide range of geological reference materials, with a particular focus on marine carbonates, which are potential archives of past changes in the K cycle but are typically characterised by [K] < 200 μg/g. In addition, we examine the degree to which trace-element data quality is driven by downhole fractionation during LA-ICP-MS measurements.
Results: Our results show that medium mass resolution (MR) mode is sufficiently capable of minimising the effect of the ArH+ interference on K+. However, the rate of downhole fractionation for Na and K varies between different samples as a result of their differing bulk composition, resulting in matrix-specific inaccuracy. We show how this can be accounted for via downhole fractionation corrections, resulting in an accuracy of better than 1% and a long-term reproducibility (intermediate precision) of <6% (relative standard deviation) in JCp-1NP using LA-ICP-MS in MR mode.
Conclusion: Our [K] measurement protocol is demonstrably precise and accurate and applicable to a wide range of materials. The measurement of K/Ca in relatively low-[K] marine carbonates is presented here as a key example of a new application opened up by these advances.
Der Begriff des 'körnigen Stils' steht in der Sprach- und Literaturkritik des 18. Jahrhunderts für eine kurze und gehaltvolle, oft auch als 'nachdrücklich' beschriebene Schreibart. Im Literaturstreit zwischen Johann Christoph Gottsched und den 'Schweizern' erlangte er zugleich programmatische und polemische Bedeutung. Im Zentrum des Aufsatzes steht die für das 'Körnige' konstitutive Konstellation von Kürze, Kraft und Konkretion. Ausgehend von Theodor W. Adornos stilsoziologischer Beobachtung, dass der lakonische Stil in Briefen des 18. Jahrhunderts Ausdruck bürgerlicher Notdurft sei, zeige ich an Texten von Johann Christoph Adelung, Johann Jacob Breitinger, Gottfried Wilhelm Leibniz und Johann Gottfried Herder, dass das Stilideal des Körnigen im 18. Jahrhundert mit dem Streben nach einer Erneuerung und Bereicherung der deutschen Schriftsprache einherging. Zum Kapital, aus dem diese neue Sprache sich speisen sollte, gehörte das ausdifferenzierte Vokabular des Handwerks und des Handels. Der zeitgenössischen Theorie zufolge stellte der körnige Stil also weniger die Notdurft als den Reichtum und die Sprachmächtigkeit des Bürgertums zur Schau.
In seiner "Poétique française" (1763) und seinen "Eléments de littérature" (1787) entwickelt der französische Dichter und Theoretiker Jean-François Marmontel Ansichten zum Stil, die von der traditionellen Regelpoetik geprägt sind, allmählich aber einen Übergang zur Individualstilpoetik andeuten. Während er diese verschiedenen Paradigmen durch den Geschmacksbegriff noch zu vereinen sucht, zeigt die deutsche Rezeption seiner Theorie, insbesondere Gottlob Benedikt von Schirachs Übertragung, wie sich der Kompromiss aufzulösen beginnt und wie sich neben der Durchsetzung der Individualstilpoetik auch eine Trennung zwischen Wissenschaft und Kunst anbahnt.
Am Nachdruck, wie er bei Johann Christoph Gottsched, Johann Jacob Bodmer, Johann Jacob Breitinger, Johann Georg Sulzer und Johann Gottfried Herder diskutiert wird, lässt sich exemplarisch beobachten, wie eine Gruppe von rhetorischen Verfahren zur Kennzeichnung von nationalen Kollektivstilen ausgebaut wird. Eine wichtige Voraussetzung für die Ausweitung des Nachdrucks von einer Stilfigur zu einem 'nachdrücklichen Stil', so die hier verfolgte These, ist der über physikalische Leitvorstellungen von Druck, Stoß und Wurf geleistete metaphorische Anschluss an ästhetische Kraftvorstellungen.
Beispiel und Regel im 18. Jahrhundert. Ein Blick in Christian Ludwigs zweisprachige Wörterbücher
(2024)
Zweisprachige Wörterbücher des 18. Jahrhunderts sind eine wichtige Quelle für die Analyse impliziter stilistischer Urteile. Sie wurden einerseits, insbesondere in der zweiten Jahrhunderthälfte, von den präskriptiven Regeln der großen monolingualen Wörterbücher und Grammatiken beeinflusst, andererseits hatten sie die Aufgabe, Fremdsprachenlernern deskriptiv Gebrauchsmuster an Beispielen vorzuführen. Der Beitrag zeichnet nach, wie sich die Autoren dieser doppelten Herausforderung stellten und wie das entstehende präskriptive Regelsystem vor dem Hintergrund der Stilpluralisierung im 18. Jahrhundert zu interpretieren ist.
In seinem Frühwerk "Über die neuere deutsche Literatur" arbeitet der junge Johann Gottfried Herder an der Herausbildung einer neuen Prosa. Durch kommentiertes Zitieren aus den "Briefen, die neueste Literatur betreffend" entwirft er das Ideal einer 'biegsamen' und 'behaglichen' ungebundenen Schreibweise, die sich ganz wesentlich in Stilversuchen manifestiert - in beschriebenen, kritisierten und zitierten sowie denjenigen des Verfassers selbst.
Der unter der Ägide der Freunde und Förderer der Goethe-Universität von der Paul Ehrlich-Stiftung ausgelobte Paul Ehrlich-und-Ludwig Darmstaedter-Preis ist die renommierteste Auszeichnung, die in Deutschland für medizinische Forschung verliehen wird. Den mit 120.000 Euro dotierten Preis nahm in der Frankfurter Paulskirche in diesem Jahr der Arzt und Immunologe Prof. Dennis L. Kasper (81) von der Harvard Medical School entgegen. Er hat die ersten Wörter der biochemischen Sprache entdeckt, mit der Darmbakterien unserem Immunsystem zu einer gesunden Entwicklung verhelfen. Den mit 60.000 Euro dotierten Nachwuchspreis erhielt der Chemiker Dr. Johannes Karges (31) von der Ruhr-Universität Bochum für die Entwicklung eines Verfahrens zur ferngesteuerten Tumortherapie.
SAFE Update April 2024
(2024)
Highligthts
• Marburg virus infects and replicates in primary human proximal tubular cells (PTC).
• Transcriptome analyses at multiple time points revealed a profound inflammatory response by IFNα, -y and TNFα signaling.
• Among the strongly downregulated gene sets were targets of the transcription factors MYC and E2F, the G2M checkpoint, as well as oxidative phosphorylation.
• Importantly, the downregulated factors comprise PGC-1α, a key factor in mitochondrial biogenesis and renal energy homeostasis, to be substantially downregulated in MARV-infected PTC.
• Our results suggest inflammation-induced changes in tubular energy metabolism as a possible factor in MARV-associated tubular dysfunction.
Abstract
Marburg virus, a member of the Filoviridae, is the causative agent of Marburg virus disease (MVD), a hemorrhagic fever with a case fatality rate of up to 90 %. Acute kidney injury is common in MVD and is associated with increased mortality, but its pathogenesis in MVD remains poorly understood. Interestingly, autopsies show the presence of viral proteins in different parts of the nephron, particularly in proximal tubular cells (PTC). These findings suggest a potential role for the virus in the development of MVD-related kidney injury. To shed light on this effect, we infected primary human PTC with Lake Victoria Marburg virus and conducted transcriptomic analysis at multiple time points. Unexpectedly, infection did not induce marked cytopathic effects in primary tubular cells at 20 and 40 h post infection. However, gene expression analysis revealed robust renal viral replication and dysregulation of genes essential for different cellular functions. The gene sets mainly downregulated in PTC were associated with the targets of the transcription factors MYC and E2F, DNA repair, the G2M checkpoint, as well as oxidative phosphorylation. Importantly, the downregulated factors comprise PGC-1α, a well-known factor in acute and chronic kidney injury. By contrast, the most highly upregulated gene sets were those related to the inflammatory response and cholesterol homeostasis. In conclusion, Marburg virus infects and replicates in human primary PTC and induces downregulation of processes known to be relevant for acute kidney injury as well as a strong inflammatory response.
The ALICE Collaboration reports a differential measurement of inclusive jet suppression using pp and Pb−Pb collision data at a center-of-mass energy per nucleon-nucleon collision sNN−−−√=5.02 TeV. Charged-particle jets are reconstructed using the anti-kT algorithm with resolution parameters R= 0.2, 0.3, 0.4, 0.5, and 0.6 in pp collisions and R= 0.2, 0.4, 0.6 in central (0−10%), semi-central (30−50%), and peripheral (60−80%) Pb−Pb collisions. A novel approach based on machine learning is employed to mitigate the influence of jet background. This enables measurements of inclusive jet suppression in new regions of phase space, including down to the lowest jet pT≥40 GeV/c at R=0.6 in central Pb−Pb collisions. This is an important step for discriminating different models of jet quenching in the quark-gluon plasma. The transverse momentum spectra, nuclear modification factors, derived cross section, and nuclear modification factor ratios for different jet resolution parameters of charged-particle jets are presented and compared to model predictions. A mild dependence of the nuclear modification factor ratios on collision centrality and resolution parameter is observed. The results are compared to a variety of jet-quenching models with varying levels of agreement.
Die Lincoln-Siedlung in der Wissenschaftsstadt Darmstadt ist sowohl bundesweites Modellprojekt in Sachen nachhaltiger Mobilität als auch Gegenstand verschiedener Forschungsprojekte. Im Projekt NaMoLi II wird die Zufriedenheit der Bewohnenden in der Lincoln-Siedlung mit dem Mobilitätskonzept und seiner Umsetzung analysiert. Des Weiteren wird geprüft, ob und in welcher Form die vorhandenen Rahmenbedingungen eine nachhaltige Mobilität fördern und wie sich die im Quartier bzw. im Umfeld vorhandenen Angebote der Versorgung und sozialen Infrastruktur auf das Mobilitätsverhalten insbesondere neu Zugezogener auswirken. Hierzu hat eine ausgewählte Bevölkerungsgruppe aus der Lincoln-Siedlung über einen Zeitraum von einer Woche Tagebuchprotokolle ihrer täglichen Mobilität geführt. Teilgenommen haben 14 Haushalte mit insgesamt 28 Personen, die zum Zeitpunkt der Erhebung maximal 15 Monate im Quartier gelebt haben. Die Protokolle wurden von allen Haushaltsangehörigen ab dem Grundschulalter geführt, jüngere Kinder sind in den Tagebüchern der Eltern erfasst. Notiert wurden Wegezwecke und Wegeziele, das genutzte Verkehrsmittel, Start- und Ankunftszeit sowie die (geschätzte) Entfernung. Des Weiteren wurden Kennwerte zur Haushaltsstruktur erhoben, zu geänderten Gewohnheiten nach dem Umzug in die Lincoln-Siedlung sowie nach Problemen in der Alltagsmobilität gefragt. Die Ergebnisse der Mobilitätstagebücher bieten einen interessanten Einblick in den Mobilitätsalltag einer spezifischen Teilnahmegruppe, die ein besonderes Interesse an Mobilitätsthemen gezeigt hat und die sich weitgehend nachhaltig in ihrem Alltag bewegt. Das Fahrrad ist das wichtigste Verkehrsmittel, gefolgt von den eigenen Füßen. Die Mehrzahl der Wegeziele liegt innerhalb eines Radius von bis zu zwei Kilometer. Die multimodalen Angebote im Quartier werden gut genutzt. Es hat sich gezeigt, dass die Methode der Tagebuchprotokolle über einen längeren Zeitraum zielführend ist, um Hinweise für die Alltagstauglichkeit des Mobilitätskonzeptes sowie zu dessen Weiterentwicklung bzw. Nachsteuerung zu erlangen.
Targeted protein degradation (TPD) has recently emerged as an exciting new drug modality. However, the strategy of developing small molecule-based protein degraders has evolved over the past two decades and has now established molecular tags that are already in clinical use, as well as chimeric molecules, PROteolysis TArgeting Chimeras (PROTACs), based mainly on ligand systems developed for the two E3 ligases CRBN and VHL. The large size of the human E3 ligase family suggests that PROTACs can be developed by targeting a large diversity of E3 ligases, some of which have restricted expression patterns with the potential to design disease- or tissue-specific degraders. Indeed, many new E3 ligands have been published recently, confirming the druggability of E3 ligases. This review summarises recent data on E3 ligases and highlights the challenges in developing these molecules into efficient PROTACs rivalling the established degrader systems.
Evidence-based and comprehensible health information is a key element of evidence-based medicine and public health. The goal is informed decision-making based on realistic estimations of health risks and accurate expectations about benefits and harms of interventions. In Germany, standards of evidence-based risk information were poorly followed during the COVID-19 pandemic. Frequently, public information was biased, fragmentary and misleading. Pandemic-related threat scenarios induced emotional distress and unnecessary anxiety. A systematic and comprehensive evaluation of the pandemic measures is crucial, but still pending in Germany. A critical analysis of risk communication by experts, politicians and the media during the pandemic should be a key element of the evaluation process. Evaluation of decision making and media reporting during the pandemic should improve preparedness for future crises.
Background: Despite known clinical benefits, guideline-recommended heart rate (HR) control is not achieved for a significant proportion of patients with HF with reduced ejection fraction. The wearable cardioverter-defibrillator (WCD) provides continuous HR monitoring and alerts that could aid medication titration.
Objective: This study sought to evaluate sex differences in achieving guideline-recommended HR control during a period of WCD use.
Methods: Data from patients fitted with a WCD from 2015 to 2018 were obtained from the manufacturer’s database (ZOLL). The proportion of patients with adequate nighttime resting HR control at the beginning of use (BOU) and at the end of use (EOU) were compared by sex. Adequate HR control was defined as having a nighttime median HR <70 beats/min.
Results: A total of 21,440 women and a comparative sample of 17,328 men (median 90 [IQR 59–116] days of WCD wear) were included in the final dataset. Among patients who did not receive a shock, over half had insufficient HR control at BOU (59% of women, 53% of men). Although the proportion of patients with resting HR ≥70 beats/min improved by EOU, 43% of women and 36% of men did not achieve guideline-recommended HR control.
Conclusion: A significant proportion of women and men did not achieve adequate HR control during a period of medical therapy optimization. Compared with men, a greater proportion of women receiving WCD shocks had insufficiently controlled HR in the week preceding ventricular tachyarrhythmia/ventricular fibrillation and 43% of nonshocked women, compared with 36% of men, did not reach adequate HR control during the study period. The WCD can be utilized as a remote monitoring tool to record HR and inform adequate uptitration of beta-blockers, with particular focus on reducing the treatment gap in women.
EF-P and its paralog EfpL (YeiP) differentially control translation of proline containing sequences
(2024)
Polyproline sequences (XPPX) stall ribosomes, thus being deleterious for all living organisms. In bacteria, translation elongation factor P (EF-P) plays a crucial role in overcoming such arrests. 12% of eubacteria possess an EF-P paralog – YeiP (EfpL) of unknown function. Here, we functionally and structurally characterize EfpL from Escherichia coli and demonstrate its yet unrecognized role in the translational stress response. Through ribosome profiling, we analyzed the EfpL arrest motif spectrum and discovered additional stalls beyond the canonical XPPX motifs at single-proline sequences (XPX), that both EF-P and EfpL can resolve. Notably, the two factors can also induce pauses. We further report that, contrary to the housekeeping EF-P, EfpL can sense the metabolic state of the cell, via lysine acylation. Together, our work uncovers a new player in ribosome rescue at proline-containing sequences, and provides evidence that co-occurrence of EF-P and EfpL is an evolutionary driver for higher bacterial growth rates.
Interferon-stimulated gene-15 (ISG15) is an interferon-induced protein with two ubiquitin-like (Ubl) domains linked by a short peptide chain, and the conjugated protein of the ISGylation system. Similar to ubiquitin and other Ubls, ISG15 is ligated to its target proteins with a series of E1, E2, and E3 enzymes known as Uba7, Ube2L6/UbcH8, and HERC5, respectively. Ube2L6/UbcH8 plays a literal central role in ISGylation, underscoring it as an important drug target for boosting innate antiviral immunity. Depending on the type of conjugated protein and the ultimate target protein, E2 enzymes have been shown to function as monomers, dimers, or both. UbcH8 has been crystalized in both monomeric and dimeric forms, but the functional state is unclear. Here, we used a combined approach of small-angle X-ray scattering (SAXS) and nuclear magnetic resonance (NMR) spectroscopy to characterize UbcH8′s oligomeric state in solution. SAXS revealed a dimeric UbcH8 structure that could be dissociated when fused with an N-terminal glutathione S-transferase molecule. NMR spectroscopy validated the presence of a concentration-dependent monomer-dimer equilibrium and suggested a backside dimerization interface. Chemical shift perturbation and peak intensity analysis further suggest dimer-induced conformational dynamics at ISG15 and E3 interfaces - providing hypotheses for the protein′s functional mechanisms. Our study highlights the power of combining NMR and SAXS techniques in providing structural information about proteins in solution.
Highlights
• Students have limited concerns about privacy in learning analytics (LA).
• Students' privacy concerns in LA vary across countries.
• Culture shapes students' privacy concerns in LA.
• Power distance, uncertainty avoidance and masculinity affect privacy concerns in LA.
• Cultural values should be considered in LA privacy management.
Abstract
Applications of learning analytics (LA) can raise concerns from students about their privacy in higher education contexts. Developing effective privacy-enhancing practices requires a systematic understanding of students’ privacy concerns and how they vary across national and cultural dimensions. We conducted a survey study with established instruments to measure privacy concerns and cultural values for university students in five countries (Germany, South Korea, Spain, Sweden, and the United States; N = 762). The results show that students generally trusted institutions with their data and disclosed information as they perceived the risks to be manageable even though they felt somewhat limited in their ability to control their privacy. Across the five countries, German and Swedish students stood out as the most trusting and least concerned, especially compared to US students who reported greater perceived risk and less control. Students in South Korea and Spain responded similarly on all five privacy dimensions (perceived privacy risk, perceived privacy control, privacy concerns, trusting beliefs, and non-self-disclosure behavior), despite their significant cultural differences. Culture measured at the individual level affected the antecedents and outcomes of privacy concerns. Perceived privacy risk and privacy control increase with power distance. Trusting beliefs increase with a desire for uncertainty avoidance and lower masculinity. Non-self-disclosure behaviors rise with power distance and masculinity and decrease with more uncertainty avoidance. Thus, cultural values related to trust in institutions, social equality and risk-taking should be considered when developing privacy-enhancing practices and policies in higher education.
In the first half of the 20th century, when architecture and literature dreamed of transparency, glass was the material these dreams were made of. However, the historiography of both fields usually focuses on a few canonical works by male authors to tell the story of this shared fascination. Departing from this imbalance, this essay takes the opportunity to explore the glass culture of modernity through the lens of female projects whose stories often take place simultaneously on different continents. While the former silent film actor Evelyn Word Leigh builds a glass house for herself in Nyack, New York, artists and writers based in Europe – like Claude Cahun, Anaïs Nin, and Hilda 'H.D.' Doolittle – flesh out imaginary glass domes as construction sites of artistic subjectivities. Whether homes or domes, these creative women used glass environments to question and renegotiate their assigned places in Western societies, challenging the boundaries of female agency.
Für die Mitte des 18. Jahrhunderts wurde ein umfassender Wandel im Bereich des Stilverständnisses konstatiert, das ab 1750 von zwei gegensätzlichen Stilbegriffen geprägt ist: einem traditionell rhetorischen einerseits und einem sich neu etablierenden Individualstil andererseits. Der Beitrag versucht, mit einem Schlaglicht auf das Frühwerk Johann Georg Hamanns ("Sokratische Denkwürdigkeiten" und "Wolken") diesen für das Verständnis der stilgeschichtlichen Umbrüche zentralen Autor im skizzierten Diskursfeld zu verorten. Ein näherer Blick auf Hamanns sokratische Schreibart erlaubt es, die geläufige Rollenzuschreibung, die in Hamann vor allem einen Wegbereiter des Individualstils erkennt, zu problematisieren und ein Paradox herauszuarbeiten: Die Entwicklung zum Individualstil beginnt im Falle von Hamanns ironisch verstellter Maskenrede mit einer radikalen Depotenzierung der Autorinstanz.
While high-quality climate reconstructions of some past warm periods in the Cenozoic era now exist, the geological processes responsible for driving the observed longterm changes in atmospheric CO2 are not sufficiently well understood. The long-term change in atmospheric CO2 across the Cenozoic has been proposed to be driven by processes such as terrestrial weathering, organic carbon production and burial, reverse weathering, and volcanic degassing. One way of constraining the relative importance of the various driving forces proposed so far is to better understand the degree to which ocean chemistry has changed because the chemistry of seawater responds to geologic processes that drive atmospheric CO2. In addition, knowledge of the concentration of the major elements in seawater is crucial for accurately applying proxies such as those based on the boron isotopic composition and Mg/Ca of marine carbonates (a proxy for palaeo pH/CO2 and palaeotemperature, respectively). Previously reported records of seawater composition are primarily derived from fluid inclusions in marine evaporites; however, the results are sparse due to the limited availability of such deposits. In this thesis, changes in the Eocene seawater chemistry were reconstructed using trace element (elements/Ca) and isotopic (δ26Mg) proxies in a Larger Benthic Foraminifera (LBFs), i.e., Nummulites sp., to constrain the driving processes of long-term changes in seawater chemistry.
To achieve the objective of this thesis, first, a measurement protocol was established using LA-ICPMS to measure the K/Ca ratio simultaneously with other element/calcium ratios, which is challenging due to the interference of ArH+ on K+. Utilising this newly established measurement protocol, laboratory-cultured Operculina ammonoides grown at different seawater calcium concentrations ([Ca2+]), repeated at different temperatures, as well as modern O. ammonoides collected from different regions exhibiting a range of seawater parameters, were investigated. A significant correlation was observed between K/Casw and K/CaLBF, allowing K/CaLBF to potentially be used as a proxy for seawater major ion reconstructions. In addition, modern O. ammonoides demonstrated no significant influence of most seawater parameters (temperature, salinity, pH, or [CO32-]) on K/CaLBF. Modern O.
ammonoides were also assessed for their Mg isotopic composition (δ26Mg), revealing no significant effect of temperature or salinity on δ26MgLBF. Furthermore, the Mg isotopic fractionation in O. ammonoides was found to be close to that of inorganic calcite, indicating minimal vital effects in these large benthic foraminifera.
Operculina ammonoides is the nearest living relative of the abundant Eocene genus Nummulites, enabling the reconstruction of seawater chemistry using the calibration based on O. ammonoides. The trace elemental/calcium proxies, including Na/Ca, K/Ca, and Mg/Ca, as well as the δ26Mg proxy, were investigated in Eocene Nummulites. The result showed that during the Eocene, [Ca2+]sw was 1.6-2 times higher, while [K+]sw was ~2 times lower than the modern seawater composition. Furthermore, [Mg2+]sw decreased from the early Eocene (54.3− +9 7..69 mmol kg-1 at ~55 Ma) to Late Eocene (37.8− +4 4..3 4 mmol kg-1 at ~31 Ma), followed by
an increase toward modern seawater [Mg]. In contrast, the variability in δ26Mgsw values remained within a narrow range of ~0.3 ‰ throughout the Cenozoic. The reconstructed [Ca2+]sw agrees with the suggestion that Cenozoic seawater chemistry changes can be explained via a change in the seafloor spreading rate. When combined with existing records, the observed minimal change in δ26Mgsw with an increase in [Mg2+]sw suggests an additional possible role of a decrease in the formation of authigenic clay minerals coincident with the Cenozoic decline in deep ocean temperature, which is also supported by the increase in the [K+]sw reconstructed here for the first time. This finding highlights that the reduction in seafloor-spreading rate and decline in reverse weathering during the Cenozoic era has played a significant role in the evolution of seawater chemistry, emphasizing the importance of these processes in driving long-term changes in the carbon cycle.
Beyond well-established difficulties with working memory in individuals with attention deficit hyperactivity disorder (ADHD), evidence is emerging that other memory processes may also be affected. We investigated, first, which memory processes show differences in adults and adolescents with ADHD in comparison to control participants, focusing on working and short-term memory, initial learning, interference, delayed and recognition memory. Second, we investigated whether ADHD severity, co-occurring depressive symptoms, IQ and physical fitness are associated with the memory performance in the individuals with ADHD.
We assessed 205 participants with ADHD (mean age 25.8 years, SD 7.99) and 50 control participants (mean age 21.1 years, SD 5.07) on cognitive tasks including the digit span forward (DSF) and backward (DSB), the Rey Auditory Verbal Learning Test (RAVLT), and the vocabulary and matrix reasoning subtests of the Wechsler Abbreviated Scale of Intelligence. Participants with ADHD were additionally assessed on ADHD severity, depression symptoms and cardiorespiratory fitness. A series of regressions were run, with sensitivity analyses performed when variables were skewed.
ADHD-control comparisons were significant for DSF, DSB, delayed and recognition memory, with people with ADHD performing less well than the control participants. The result for recognition memory was no longer significant in sensitivity analysis. Memory performance was not associated with greater ADHD or depression symptoms severity. IQ was positively associated with all memory variables except DSF. Cardiorespiratory fitness was negatively associated with the majority of RAVLT variables.
Individuals with ADHD showed difficulties with working memory, short-term memory and delayed memory, as well as a potential difficulty with recognition memory, despite preserved initial learning.
We document the individual willingness to act against climate change and study the role of social norms in a large sample of US adults. Individual beliefs about social norms positively predict pro-climate donations, comparable in strength to universal moral values and economic preferences such as patience and reciprocity. However, we document systematic misperceptions of social norms. Respondents vastly underestimate the prevalence of climate-friendly behaviors and norms. Correcting these misperceptions in an experiment causally raises individual willingness to act against climate change as well as individual support for climate policies. The effects are strongest for individuals who are skeptical about the existence and threat of global warming.
The beetle genus Pharaxonotha Reitter (Coleoptera: Erotylidae: Pharaxonothinae) is found in the cones of cycad genera in the New World, including species of Ceratozamia Brongn., Dioon Lindl., Microcycas (Miq.) A.DC and Zamia L. Its presence and diversity are analyzed for the 17 species of Zamia known to occur in Panama. Nine species are recognized, and five new species are described: Pharaxonotha clarkorum Pakaluk, P. confusa Pakaluk, P. fortunensis Tang, Skelley and Taylor new species, P. holzmani Tang, Skelley and Taylor new species, P. kirschii Reitter, P. manicatae Tang, Skelley and Taylor new species, P. panamensis Tang, Skelley and Taylor new species, P. pseudoparasitica Tang, Skelley and Taylor new species, and P. taylori Skelley and Tang. A key to species of Pharaxonotha in Panama is presented.
ZooBank registration. urn:lsid:zoobank.org:pub:C054B0D4-FD00-4AE7-BBA7-C75A12368561
An overview of the genus Psephenops Grouvelle (Coleoptera: Psephenidae: Psepheninae) is provided with geographic distributions of the species. The taxonomic history of Psephenops smithi Grouvelle, the type species from Grenada and St. Vincent, and junior synonym Xexanchorinus latus Grouvelle from Grenada, is discussed, and lectotypes and paralectotypes are designated for both. Photographs of the type series and a non-type specimen with illustrated male genitalia, along with new distributional information for the species, are provided. The male, female, and associated larva of Psephenops trini Barr and Shepard, new species, are described and illustrated, as is the habitat of this species in Trinidad and Tobago. The Peruvian species Psephenus robacki Spangler is transferred from Psephenus Haldeman to Psephenops as Psephenops robacki (Spangler) new combination. Photographs of the female holotype are included, and possible new distributional records from Peru are reported.
ZooBank registration. urn:lsid:zoobank.org:pub:5C9ECB63-6A77-4FF6-8391-BF0F77BE5674
Pseudococcus longispinus (Targioni-Tozzetti) (Hemiptera: Pseudococcidae) is a widely-distributed pest that feeds on many economically important hosts, particularly tropical fruits and ornamentals. The potential distribution of this mealybug pest in South Korea remains a primary concern because of its high incidence of interceptions screened during inspection. Hence, this species prompted a modelling effort to assess its potential risk of introduction. Potential risk maps were developed for this pest with a CLIMEX model based on occurrence records under environmental data. The potential distribution of these pests in South Korea in the 2020s, 2050s and 2090s was projected based on the RCP 8.5 climate change scenario. Results showed that P. longispinus has little potential for invasion in the outdoor environment of South Korea due to high cold stress in the 2020s. However, some locations in Jejudo were predicted to be marginally suitable under future climate factors. In that respect, the results of this model prediction could be used to prepare a risk-based surveying program that improves the probability of detecting early P. longispinus populations.
ZooBank registration. urn:lsid:zoobank.org:pub:9E0CBFE6-E1AA-4B55-9E58-70B170E0FBD8
A new species, Chlorocoris charluzae Thomas (Hemiptera: Heteroptera: Pentatomidae), is described from Panama. Eludocoris grandis Thomas is reported from Panama for the first time. The distribution of Chlorocoris rufispinus Dallas to include Panama is confirmed. Arawacoris Thomas, described as a subgenus of Chlorocoris Spinola, is elevated to full genus.
ZooBank registration. urn:lsid:zoobank.org:pub:F4E45B6C-5BD8-4B3E-B599-3BB61855B392
Pears, Pyrus pyrifolia (Burm.f.) Nak. (Rosaceae) are one of the most widely grown fruit trees in South Korea. Approximately 11% of the total pear production in 2022 was exported to countries such as the US and Vietnam. Exported pears must be free of pest species that are considered of quarantine importance by the importing countries. Herein, a list of scale insects (Hemiptera: Coccomorpha) associated with pear trees is updated. Additionally, Spilococcus pacificus (Borchsenius) is added to the list of mealybugs affecting pears in South Korea and is briefly diagnosed based on non-type specimens and illustrated using photographs. Information on its distribution and plant hosts are also provided.
ZooBank registration. urn:lsid:zoobank.org:pub:48A93063-EB78-402F-82CE-168540C90FE2
Highlights
• High resolution profile of C. pipiens' sugar diet has been obtained using UHPLC-MS.
• Artificial feeding using ornamental plants provides similar sugar profiles as observed in field collected mosquitoes.
• Metabolomic profiling found secondary metabolites and pollutants of anthropogenic use.
Abstract: Culex pipiens (Linnaeus, 1758) mosquitoes search plant sources of sugars to cope with the energetic demand of various physiological processes. The crop as part of the digestive system is devoted to the storage of sugar-based meal obtained from various nectars sources. The profiling of sugars and metabolites in the Culex pipiens’ crop is scarce, and only few studies used Liquid Chromatography – Mass Spectrometry (LC-MS), which provides broad detection for biomonitoring environmental substances and even contaminants in the sugar diet of mosquitoes populations.
Therefore, sugar and metabolite profiling were performed on crops obtained from mosquitoes exposed to plant nectar under laboratory or natural conditions by Ultra High-Performance LC-MS (UHPLC-MS). This method allowed us a precise quantitative and qualitative identification of sugar diet and associated environmental compounds in the crop of the mosquito C. pipiens. Under laboratory condition, mosquitoes were allowed to feed on either glucose solution, commercially-available flowers or field collected flowers. In addition, we collected mosquitoes from the field to compare those crop metabolomes with metabolome patterns occurring after nectar feeding in the lab.
The sugar quantities and quality obtained from the crops of mosquitoes collected in the field were similar to those crops obtained from mosquitoes that fed on commercially-available flowers and from field collected flowers with a limit of detection of 10 μg/L for sucrose, glucose and sucrose. Next to sugar compounds, we identified 2 types of amino acids, 12 natural products, and 9 pesticides.
Next to the diversity of sugar compounds, we could confirm that secondary metabolites and environmental pollutants are typically up taken from floral nectar sources by C. pipiens. The in-depth knowledge on mosquito–plant interactions may inspire the development and further optimization of mosquito trap systems and arboviral surveillance systems.