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In the first part of the thesis we investigate Lyapunov exponents for general flat vector bundles over Riemann surfaces and we describe properties of Lyapunov exponents on special loci of the moduli space of flat vector bundles. In the second part of the thesis we show how the knowledge of Lyapunov exponent over a sporadic Teichmüller curve can be used to compute the algebraic equation of the associated universal family of curves.
This study was designed to characterize morphologic stages during neuroma development post amputation with an eye toward developing better treatment strategies that intervene before neuromas are fully formed. Right forelimbs of 30 Sprague Dawley rats were amputated and limb stumps were collected at 3, 7, 28, 60 and 90 Days Post Amputation (DPA). Morphology of newly formed nerves and neuromas were assessed via general histology and neurofilament protein antibody staining. Analysis revealed six morphological characteristics during nerve and neuroma development; 1) normal nerve, 2) degenerating axons, 3) axonal sprouts, 4) unorganized bundles of axons, 5) unorganized axon growth into muscles, and 6) unorganized axon growth into fibrotic tissue (neuroma). At early stages (3 & 7 DPA) after amputation, normal nerves could be identified throughout the limb stump and small areas of axonal sprouts were present near the site of injury. Signs of degenerating axons were evident from 7 to 90 DPA. From day 28 on, variability of nerve characteristics with signs of unorganized axon growth into muscle and fibrotic tissue and neuroma formation became visible in multiple areas of stump tissue. These pathological features became more evident on days 60 and 90. At 90 DPA frank neuroma formation was present in all stump tissue. By following nerve regrowth and neuroma formation after amputation we were able to identify 6 separate histological stages of nerve regrowth and neuroma development. Axonal regrowth was observed as early as 3 DPA and signs of unorganized axonal growth and neuroma formation were evident by 28 DPA. Based on these observations we speculate that neuroma treatment and or prevention strategies might be more successful if targeted at the initial stages of development and not after 28 DPA.
Este artigo procurou refletir sobre alguns aspectos teóricos acerca da Teoria do Reconhecimento desenvolvida por Axel Honneth. Herdeiro da tradição teórica do pensamento crítico frankfurtiano – do qual se destacam pensadores como Adorno, Horkheimer, Marcuse e Habermas –, Honneth propõe uma inovadora teoria normativa dos conflitos sociais. Como fio condutor de sua análise, emerge o argumento de que a evolução social está estruturada pelos conflitos morais dos sujeitos sociais, em busca do reconhecimento recíproco de suas identidades. Assim, ao desenvolver sua teoria, Honneth articula elementos da Teoria Crítica, da filosofia do jovem Hegel e da psicologia social de Mead. Este artigo tem justamente o ensejo de refletir sobre a teia conceitual sobre a qual Honneth fundamenta sua proposta teórica.
Nosso objetivo neste trabalho é tentar esclarecer o mal-estar causado por algumas leituras que muitas vezes despacham a influência e a presença constante de Hegel na obra de Adorno de forma muito breve e fácil, seja a partir da perspectiva antissistêmica da filosofia adorniana, ou então, desde a perspectiva negativa que a dialética assume em seu pensamento. Nesse sentido, pretendemos expor alguns pontos fundamentais da filosofia hegeliana, em relação aos quais Adorno se coloca claramente como herdeiro. Pretendemos mostrar que o filósofo de Frankfurt pensa não somente sobre estes pontos, mas também a partir deles, i.e., superando-os.
Object recognition is such an everyday task it seems almost mundane. We look at the spaces around us and name things seemingly effortlessly. Yet understanding how the process of object recognition unfolds is a great challenge to vision science. Models derived from abstract stimuli have little predictive power for the way people explore "naturalistic" scenes and the objects in them. Naturalistic here refers to unaltered photographs of real scenes. This thesis therefore focusses on the process of recognition of the objects in such naturalistic scenes. People can, for instance, find objects in scenes much more efficiently than models derived from abstract stimuli would predict. To explain this kind of behavior, we describe scenes not solely in terms of physical characteristics (colors, contrasts, lines, orientations, etc.) but by the meaning of the whole scene (kitchen, street, bathroom, etc.) and of the objects within the scene (oven, fire hydrant, soap, etc.). Object recognition now refers to the process of the visual system assigning meaning to the object.
The relationship between objects in a naturalistic scene is far from random. Objects do not typically float in mid-air and cannot take up the same physical space. Moreover, certain scenes typically contain certain objects. A fire hydrant in the kitchen would seem like an anomaly to the average observer. These "rules" can be described as the "grammar" of the scene. Scene grammar is involved in multiple aspects of scene- and object perception. There is, for instance, evidence that overall scene category influences identification of individual objects. Typically, experiments that directly target object recognition do not involve eye movements and studies that involve eye movements are not directly aimed at object recognition, but at gaze allocation. But eye movements are abundant in everyday life, they happen roughly 4 times per second. Here we therefore present two studies that use eye movements to investigate when object recognition takes place while people move their eyes from object to object in a scene. The third study is aimed at the application of novel methods for analyzing data from combined eye movement and neurophysiology (EEG) measurements.
One way to study object perception is to violate the grammar of a scene by placing an object in a scene it does not typically occur in and measuring how long people look at the so-called semantic inconsistency, compared to an object that one would expect in the given scene. Typically, people look at semantic inconsistencies longer and more often, signaling that it requires extra processing. In Study 1 we make use of this behavior to ask whether object recognition still happens when it is not necessary for the task. We designed a search task that made it unnecessary to register object identities. Still, participants looked at the inconsistent objects longer than consistent objects, signaling they did indeed process object and scene identities. Interestingly, the inconsistent objects were not remembered better than the consistent ones. We conclude that object and scene identities (their semantics) are processed in an obligatory fashion; when people are involved in a task that does not require it. In Study 2, we investigate more closely when the first signs of object semantic processing are visible while people make eye movements.
Although the finding that semantic inconsistencies are looked at longer and more often has been replicated often, many of these replications look at gaze duration over a whole trial. The question when during a trial differences between consistencies occur, has yielded mixed results. Some studies only report effects of semantic consistency that accumulate over whole trials, whereas others report influences already on the duration of the very first fixations on inconsistent objects. In study 2 we argue that prior studies reporting first fixation duration may have suffered from methodological shortcomings, such as low trial- and sample sizes, in addition to the use of non-robust statistics and data descriptions. We show that a subset of fixations may be influenced more than others (as is indicated by more skewed fixation duration distributions). Further analyses show that the relationship between the effect of object semantics on fixation durations and its effect on oft replicated cumulative measures is not straightforward (fixation duration distributions do not predict dwell effects) but the effect on both measures may be related in a different way. Possibly, the processing of object meaning unfolds over multiple fixations, only when one fixation does not suffice. However, it would be very valuable to be able to study how processing continues, after a fixation ends.
Study 3 aims to make such a measure possible by combining EEG recordings with eye tracking measurements. Difficulties in analyzing eye tracking–EEG data exist because neural responses vary with different eye movements characteristics. Moreover, fixations follow one another in short succession, causing neural responses to each fixation to overlap in time. These issues make the well-established approach of averaging single trial EEG data into ERPs problematic. As an alternative, we propose the use of multiple regression, explicitly modelling both temporal overlap and eye movement parameters. In Study 3 we show that such a method successfully estimates the influence of covariates it is meant to control for. Moreover, we discuss and explore what additional covariates may be modeled and in what way, in order to obtain confound-free estimates of EEG differences between conditions. One important finding is that stimulus properties of physically variable stimuli such as complex scenes, can influence EEG signals and deserve close consideration during experimental design or modelling efforts. Overall, the method compares favorably to averaging methods.
From the studies in this thesis, we directly learn that object recognition is a process that happens in an obligatory fashion, when the task does not require it. We also learn that only a subset of first fixations to objects are affected by the processing of object meaning and its fit to its surroundings. Comparison between first fixation and first dwell effects suggest that, in active vision, object semantics processing sometimes unfolds over multiple fixations. And finally, we learn that regression-based methods for combined eye tracking-EEG analysis provide a plausible way forward for investigating how object recognition unfolds in active vision.
Vorwort
(2018)
Die zwölfte Ausgabe der Aussiger Beiträge fokussiert auf regionale und historische Identitäten und die Frage, ob und wie die historische Diskontinuität in der Selbstdarstellung und Konstruktion von dieser/n Identität(en) in den Grenzregionen Tschechiens reflektiert wird. Städte, Gemeinden, Vereine, aber auch Firmen samt ihrer berühmten Marken werden als relativ beständige Subjekte inszeniert, deren Image oft auf ihrer Tradition beruht. Der an manchen Orten in den Grenzregionen Tschechiens fast vollständige Bevölkerungsaustausch bedeutete für die davon betroffenen Städte, Institutionen oder Firmen einen beträchtlichen Einschnitt in die Kontinuität ihrer Entwicklung. In diesem Zusammenhang sind insbesondere folgende Fragen von Bedeutung: Wie gehen die Städte, Gemeinden, Vereine und Firmen mit dem Thema Vertreibung und der Diskontinuität ihrer Geschichte um? Wie wird ihre Selbstdarstellung in den repräsentativen historischen Publikationen, Informations- und Propagationsmaterialien und öffentlichen Feierlichkeiten durch die Diskontinuität des Bevölkerungstransfers geprägt? Und wie werden dabei auch ihre Darstellungen in Stadtromanen, Regionalliteratur usw. genutzt und (um)gedeutet?
Aglaja Veteranyis Roman "Warum das Kind in der Polenta kocht" (1999) thematisiert die misslungene Integration der Ich-Erzählerin, einer Zirkusnomadin, die in der materiell gesicherten Umgebung der neuen Heimat Schweiz als Künstlerin Fuß zu fassen versucht. Der Beitrag untersucht, welche Rolle die Emotionen bei der Gestaltung von Identität und Heimaträumen spielen und inwiefern sich die neue, vielversprechende Heimat für die Hauptfigur nach und nach als 'unheimlich' herausstellt. Parallel dazu wird im Text den Spuren von innerer Verunsicherung und Angst sowie der Gewalttätigkeit in der Familie nachgegangen, die allmählich durch die Freilegung der verdrängten Kindheitserinnerungen der Ich-Erzählerin 'zur Sprache gebracht' werden und dazu führen, dass sich das auf den ersten Blick positiv konnotierte Gegenbild zur Schweiz - das Bild der rumänischen 'Zirkus-Heimat' - schließlich ebenfalls als 'unheimliche Heimat' entpuppt.
Die Tuberkulose ist eine der bedeutendsten Infektionskrankheiten weltweit. In Deutschland spielt sie eine untergeordnete Rolle und betrifft hauptsächlich Risikogruppen. Bisher wurde noch keine mehrere Jahre umfassende Arbeit zur Epidemiologie der Tuberkulose anhand molekularbiologischer Faktoren in einer deutschen Stadt veröffentlicht. In dieser Arbeit wurden mittels 24-loci MIRU-VNTR und Spoligotypisierung die Mykobakterienstämme von Patienten in Frankfurt am Main aus dem Zeitraum von 2008 bis 2016 genetisch typisiert und aus Fällen mit übereinstimmendem DNA-Fingerabdruck bestehende molekulare Cluster identifiziert, um in Zusammenschau mit epidemiologischen Patientendaten die Übertragungswege in Frankfurt am Main besser zu verstehen. Dabei wurden mittels logistischer Regression Risikofaktoren für Clusterzugehörigkeit identifiziert, einzelne Cluster auf epidemiologische Plausibilität hin untersucht und die Bedeutung der Tuberkulose vor dem Hintergrund zunehmender Migration beschrieben.
Insgesamt wurden im Studienzeitraum 61 molekulare Cluster identifiziert. Der Clusteranteil (28,6%) und der Anteil rezenter Übertragung (18,7%) lagen in der Größenordnung anderer Niedriginzidenzländer. Es dominierten kleine Cluster, nur vereinzelt kam es zu Infektionsketten mit mehr als 3 Fällen. Obwohl 81% der Patienten aus dem Ausland stammten und nur 19% aus Deutschland, hatten Migranten ein signifikant niedrigeres Risiko, einem Cluster anzugehören als Deutsche. Unter den Clustern bestanden 42,6% sowohl aus Patienten deutscher als auch Patienten nichtdeutscher Herkunft. Im Ausland geborene Patienten in gemischten Clustern lebten zum Diagnosezeitpunkt durchschnittlich bereits 10 Jahre in Deutschland und stammten mehrheitlich aus europäischen Ländern. Eine TB-Übertragung von kürzlich eingewanderten Patienten auf einheimische Bürger fand in begrenztem Umfang statt, begründet aber keine Ängste vor einer erhöhten Gefährdung der in Deutschland geborenen Bevölkerung im Hinblick auf die Tuberkulose in Frankfurt am Main.
Nur 9,8% der molekularen Cluster konnten epidemiologisch bestätigt werden. Infektionswege, die über das familiäre Umfeld oder bestimmte Risikomilieus (Drogen, Obdachlosigkeit) hinausgehen, ließen sich anamnestisch nur schwer erfassen. Männer, in Deutschland geborene Personen und iv-drogenabhängige Personen wiesen ein erhöhtes Risiko auf, sich vor Ort mit Tuberkulose zu infizieren oder die Erkrankung auf andere zu übertragen. Dies trifft vermutlich auch auf andere deutsche Großstädte zu und betont die Notwendigkeit einer Integration von iv-Drogenabhängigen in die medizinische Regelversorgung und die Bedeutung einer Zusammenarbeit von öffentlichem Gesundheitsdienst und entsprechenden Hilfseinrichtungen.
Es ist von einer Überschätzung des Clusteranteils mittels 24-loci MIRU-VNTR auszugehen, weshalb für zukünftige Arbeiten die feinere Typisierung und somit eine zuverlässigere Identifikation von Clustern mittels Whole Genome Sequencing wünschenswert ist. Für die bundesweite Verbesserung der TB-Kontrolle ist weiterhin eine enge Zusammenarbeit zwischen den Gesundheitsämtern erforderlich. Um zu untersuchen, wie sich die TB-Epidemiologie von Frankfurt am Main im bundesweiten Vergleich darstellt, sind ähnlich angelegte Arbeiten aus anderen deutschen Großstädten notwendig.
Perception, particularly in the visual domain, is drastically influenced by rhythmic changes in ambient lighting conditions. Anticipation of daylight changes by the circadian system is critical for survival. However, the neural bases of time-of-day-dependent modulation in human perception are not yet understood. We used fMRI to study brain dynamics during resting-state and close-to-threshold visual perception repeatedly at six times of the day. Here we report that resting-state signal variance drops endogenously at times coinciding with dawn and dusk, notably in sensory cortices only. In parallel, perception-related signal variance in visual cortices decreases and correlates negatively with detection performance, identifying an anticipatory mechanism that compensates for the deteriorated visual signal quality at dawn and dusk. Generally, our findings imply that decreases in spontaneous neural activity improve close-to-threshold perception.
A remarkable new species of Poecilocloeus (Orthoptera: Acrididae: Proctolabinae) found damaging coffee plantations in the Western Andes of Colombia is described and named P. coffeaphilus n. sp. This new species is part of a distinct and colorful group of Proctolabinae grasshoppers, with most species found at low altitudes in the rainforest of the Amazon basin. In contrast, the new species is found at elevations of 1600 to 1800 m in the canopy of dense cloud forests, in the southwestern part of the department of Antioquia (Western Cordillera, Colombian Andes). Information about the natural history, behavior, natural enemies and control strategies in coffee plantations is given for this new species of masked grasshopper. A key to the Neotropical species of the fruticolus species group is presented.
The Australian genus of Eurybrachidae Stål, 1862 (Hemiptera, Fulgoromorpha) Olonia Stål, 1862 is redescribed and reviewed. Seven new species are described: O. bourgoini sp. nov. (N Queensland, Chillagoe), O. danielsi sp. nov. (N Queensland, Cape York Peninsula), O. guillaumei sp. nov. (N Queensland), O. hochae sp. nov. (N Queensland, Undara), O. monteithi sp. nov. (Queensland), O. rylandae sp. nov. (N Queensland, Chillagoe) and O. soulierae sp. nov. (Queensland). Platybrachys nobilis (Stål, 1863) is transferred to Olonia and the new combination Olonia nobilis (Stål, 1863) comb. nov., is proposed. Olonia ornata Lallemand, 1928 and O. apicalis (Walker, 1851) are removed from Olonia and transferred to Platybrachys Stål, 1859 and Maeniana Metcalf, 1952, respectively. Hence, the new combinations Platybrachys ornata (Lallemand, 1928) comb. nov. and Maeniana apicalis (Walker, 1851) comb. nov. are proposed. The new genus Stalobrachys gen. nov. is described to accommodate Olonia alboapicata Jacobi, 1928 and the new combination S. alboapicata (Jacobi, 1928) gen. et comb. nov. is proposed. The male genitalia are illustrated and photographs of habitus, a distribution map, biological data and an identification key are provided. The genus Olonia currently contains twelve species and the genus Stalobrachys gen. nov. has one species.
A new species of the genus Birdantis Stål, 1863 (Hemiptera: Fulgoridae), B. bhaskarai sp. nov. from Larat Island (Tanimbar), is described. Birdantis collaris (Walker, 1870) stat. rev. and B. trilineata (Schmidt, 1926) stat. rev. are reinstated as valid species, respectively from status of subspecies and as junior synonym of B. delibuta Stål, 1863. These four species, as well as the other one previously described from the Maluku Islands, B. decens Stål, 1863, are illustrated from their type specimens. An identification key, a distribution map, illustrations of habitus and details of male genitalia are provided. The synonymy between Myrilla Distant, 1888 and Birdantis is formally reinstated and all species formerly placed in the subgenus Birdantis (Myrilla) are transferred to Birdantis sensu stricto. Birdantis is transferred to the subfamily Aphaeninae Blanchard, 1847 and now contains eighteen species distributed in Maluku (five species), New Guinea and neighbouring islands (ten species) and Australia
(three species).
We develop a model that reproduces the average return and volatility spread between sin and non-sin stocks. Our investors do not necessarily boycott sin companies. Rather, they are open to invest in any company while trading off dividends against ethicalness. We show that when dividends and ethicalness are complementary goods and investors are sufficiently risk averse, the model predicts that the dividend share of sin companies exhibits a positive relation with the future return and volatility spreads. Our empirical analysis supports the model's predictions.
Extrakt
(2018)
The mechanisms of transfer of crustal material from the subducting slab to the overlying mantle wedge are still debated. Mélange rocks, formed by mixing of sediments, oceanic crust, and ultramafics along the slab-mantle interface, are predicted to ascend as diapirs from the slab-top and transfer their compositional signatures to the source region of arc magmas. However, the compositions of melts that result from the interaction of mélanges with a peridotite wedge remain unknown. Here we present experimental evidence that melting of peridotite hybridized by mélanges produces melts that carry the major and trace element abundances observed in natural arc magmas. We propose that differences in nature and relative contributions of mélanges hybridizing the mantle produce a range of primary arc magmas, from tholeiitic to calc-alkaline. Thus, assimilation of mélanges into the wedge may play a key role in transferring subduction signatures from the slab to the source of arc magmas.
Damage control resuscitation may lead to postoperative intra-abdominal hypertension or abdominal compartment syndrome. These conditions may result in a vicious, self-perpetuating cycle leading to severe physiologic derangements and multiorgan failure unless interrupted by abdominal (surgical or other) decompression. Further, in some clinical situations, the abdomen cannot be closed due to the visceral edema, the inability to control the compelling source of infection or the necessity to re-explore (as a “planned second-look” laparotomy) or complete previously initiated damage control procedures or in cases of abdominal wall disruption. The open abdomen in trauma and non-trauma patients has been proposed to be effective in preventing or treating deranged physiology in patients with severe injuries or critical illness when no other perceived options exist. Its use, however, remains controversial as it is resource consuming and represents a non-anatomic situation with the potential for severe adverse effects. Its use, therefore, should only be considered in patients who would most benefit from it. Abdominal fascia-to-fascia closure should be done as soon as the patient can physiologically tolerate it. All precautions to minimize complications should be implemented.
Willi Schütz
(2018)
From the early 2000s, a new discourse emerged, in Africa and the international donor community, that higher education was important for development in Africa. Within this zeitgeist of converging interests, a range of agencies agreed that a different, collaborative approach to linking higher education to development was necessary. This led to the establishment of the Higher Education Research and Advocacy Network in Africa (Herana) to concentrate on research and advocacy about the possible role and contribution of universities to development in Africa. This book is the final publication to emerge from the Herana project. The project has also published more than 100 articles, chapters, reports, manuals and datasets, and many presentations have been delivered to share insights gained from the work done by Herana. Given its prolific dissemination, it seems reasonable to ask whether this fourth and final publication will offer the reader anything new. This book is certainly different from previous publications in several respects. First, it is the only book to include an analysis of eight African universities based on the full 15 years of empirical data collected by the project. Second, previous books and reports were published mid-project. This book has benefited from an extended gestation period allowing the authors and contributors to reflect on the project without the distractions associated with managing and participating in a large-scale project. For the first time, some of those who have been involved in Herana since its inception have had the opportunity to at least make an attempt to see part of the wood for the trees. Different does not necessarily mean new. An emphasis on the newness of the data and perspectives presented in this book is important because it shows that it is more than a historical record of a donor-funded project. Rather, each chapter in this book brings, to a lesser or greater extent, something new to our understanding of universities, research and development in Africa.
A full session was organized in memory of Helmut Oeschler during the 2017 edition of the Strangeness in Quark Matter Conference. It was heart-warming to discuss with the audience his main achievements and share anecdotes about this exceptionally praised and appreciated colleague, who was also a great friend for many at the conference. A brief summary of the session is provided with these proceedings.
Host flower records for 111 species of Cerambycinae, collected from 40 plant species (21 families) in three Bolivian Departments during the period 2002–2011 are presented for the following tribes: Basipterini, Callichromatini, Clytini, Compsocerini, Eburiini, Ectenessini, Heteropsini, Hexoplonini, Molorchini, Oxycoleini, Pteroplatini, Rhopalophorini, Tillomorphini, and Trachyderini. The importance of anthophilous cerambycids as pollinators, their behavior, and methods used for collecting them are presented, and some preliminary comparisons between the tropical fauna in the north and the temperate fauna in the Chaco forests of the south are outlined.
Ten South American species are removed from the genus Odontocera Audinet-Serville (Coleoptera: Cerambycidae) and placed in Odontocroton Clarke new genus. The new genus is further organized into two informal groups. Group A includes Odontocroton flavicauda (Bates, 1873) new combination, Odontocroton flavirostris (Melzer, 1930) new combination, Odontocroton melzeri (Fisher, 1952) new combination and Odontocroton soror (Gounelle, 1911) new combination. Group B includes Odontocroton apicalis (Klug, 1825) new combination, Odontocroton quinquecallosus (Zajciw, 1963) new combination, Odontocroton sanguinolentus (Bates, 1873) new combination, Odontocroton septemtuberculatus (Zajciw, 1963) new combination, Odontocroton rufifrons (Fisher, 1937) new rank and new combination, and provisionally Odontocroton monnei (Zajciw, 1968), new combination. A monotypic new genus, Rhinobatesia Clarke, is described for the Central American species Rhinobatesia rugicollis (Bates, 1880) new combination, which was formerly in Odontocera. The Central American Odontocera nevermanni Fisher, 1930 is placed as a junior synonym of R. rugicollis, and Odontocera typhoeus Fisher, 1947 is placed as a junior synonym of Odontogracilis gracilis (Klug, 1825). A key to separate Odontocroton and Rhinobatesia as well as the species of the former is provided. All species are illustrated, including the tegmen of the aedeagus when available. Host flower records for the Bolivian species are also provided.
Coordination of circuit breakers? Volume migration and volatility spillover in fragmented markets
(2018)
We study circuit breakers in a fragmented, multi-market environment and investigate whether a coordination of circuit breakers is necessary to ensure their effectiveness. In doing so, we analyze 2,337 volatility interruptions on Deutsche Boerse and research whether a volume migration and an accompanying volatility spillover to alternative venues that continue trading can be observed. Different to prevailing theoretical rationale, trading volume on alternative venues significantly decreases during circuit breakers on the main market and we do not find any evidence for volatility spillover. Moreover, we show that the market share of the main market increases sharply during a circuit breaker. Surprisingly, this is amplified with increasing levels of fragmentation. We identify high-frequency trading as a major reason for the vanishing trading activity on the alternative venues and give empirical evidence that a coordination of circuit breakers is not essential for their effectiveness as long as market participants shift to the dominant venue during market stress.
We study the introduction of single-market liquidity provider incentives in fragmented securities markets. Specifically, we investigate whether fee rebates for liquidity providers enhance liquidity on the introducing market and thereby increase its competitiveness and market share. Further, we analyze whether single-market liquidity provider incentives increase overall market liquidity available for market participants. Therefore, we measure the specific liquidity contribution of individual markets to the aggregate liquidity in the fragmented market environment. While liquidity and market share of the venue introducing incentives increase, we find no significant effect for turnover and liquidity of the whole market.
AGAINST THE BACKGROUND OF FRAGMENTED EUROPEAN EQUITIES TRADING, MARKET OPERATORS HAVE EMPLOYED DIFFERENT STRATEGIES TO INCREASE LIQUIDITY ON THEIR MARKET RELATIVE TO OTHER TRADING VENUES. ONE OF THESE STRATEGIES IS TO INCENTIVIZE LIQUIDITY PROVIDERS VIA FEE REBATES. THIS ARTICLE PRESENTS AN EMPIRICAL INVESTIGATION OF THE INTRODUCTION OF THE XETRA LIQUIDITY PROVIDER PROGRAM AT DEUTSCHE BÖRSE AND ITS IMPACT ON LIQUIDITY AND TRADING VOLUME ON THE INTRODUCING MARKET ITSELF AND ON THE CONSOLIDATED EUROPEAN MARKET.
We investigate different designs of circuit breakers implemented on European trading venues and examine their effectiveness to manage excess volatility and to preserve liquidity. Specifically, we empirically analyze volatility and liquidity around volatility interruptions implemented on the German and Spanish stock market which differ regarding specific design parameters. We find that volatility interruptions in general significantly decrease volatility in the post interruption phase. Unfortunately, this decrease in volatility comes at the cost of decreased liquidity. Regarding design parameters, we find tighter price ranges and shorter durations to support volatility interruptions in achieving their goals.
In der erziehungswissenschaftlichen Übergangsforschung wird Angeboten zur Begleitung von und Beratung zu Übergängen in Erwerbsarbeit aus einer ethnografischen Perspektive kaum Aufmerksamkeit gewidmet. Im Kontext beruflicher Veränderungsprozesse von Erwachsenen finden sich ethnografische Betrachtungen bislang lediglich in ethnografisch orientierter Organisationsforschung mit Fokus auf Organisationsberatung im Weiterbildungsbereich und im Rahmen aktivierender arbeitsmarktpolitischer Maßnahmen aus machtanalytischer Perspektive (vgl. beispielsweise Ott 2011; Dollhausen 2010). Mit Blick auf die personenbezogenen Dienstleistungen der Begleitung und Beratung liegt jedoch ein analytischer Zugang nahe, der eine prozessuale Perspektive auf die organisationale Rahmung von Übergängen in Erwerbsarbeit einnimmt und dabei die Innenperspektive von Beratungsprozessen und deren Praktiken in den Fokus rückt.
Vor diesem Hintergrund beschäftigt sich der Beitrag aus ethnografischer Perspektive mit der Herstellung und Gestaltung von Beratungssettings im Kontext der Beratungsangebote Coaching und Transfergesellschaft. Im Rahmen des DFG-Forschungsprojekts "Transition Processing" werden hierfür mittels teilnehmender Beobachtung angebotstypische Situationen und reale Handlungsvollzüge der Beteiligten empirisch erfasst. In diesem Zusammenhang liegt der Fokus der Analyse auf dem Umgang mit Artefakten, die – wie sich im empirischen Datenmaterial zeigt – sowohl im Coaching als auch in der Transfergesellschaft für die Inszenierung einer Beratung eine zentrale gestalterische Rolle spielen.
Im Folgenden wird zunächst das Projekt "Transition Processing", dem der thematische Zuschnitt dieses Beitrags entlehnt ist, vorgestellt (2.). Daran anschließend werden die theoretischen und methodischen Grundlegungen dieses Beitrags eingegrenzt (3.). Im 4. Abschnitt wird beispielhaft skizziert, wie sich Materialität als Steuerungselement in der Beratung des Coachings und der Transfergesellschaft zeigt. Abschließend werden die beiden Handlungsfelder Coaching und Transfergesellschaft im Fazit vergleichend betrachtet (5.).
This paper argues that extant approaches to presupposition projection that either rely on strict linear order (Schlenker, 2009) or hierarchy (Romoli and Mandelkern, 2017) cannot provide a uniform account of data drawn from head-final languages. While building on Schlenker’s theory, this paper resolves the issues by restricting the calculation of local contexts to specific points in the parsing process. The consequence is that the theory makes a prediction robust to the head directionality parameter
Ausgangspunkt meiner Interpretation ist die der "Vertreibung" vorangehende Romantrilogie Robert Menasses; der Autor scheint nämlich eine ausgesprochene Vorliebe für Inversionen zu besitzen. Die sogenannte "Trilogie der Entgeisterung" umfasst neben "Sinnliche Gewißheit" (1988) die Romane "Selige Zeiten, brüchige Welt" (1991) und "Schubumkehr" (1995) sowie das in "Selige Zeiten, brüchige Welt" thematisierte und von Menasse anschließend selbst verfasste philosophische Werk der Romanfigur Leo Singer, die "Phänomenologie der Entgeisterung. Geschichte des verschwindenden Wissens" (1995). In der Trilogie wird mit der "Rückentwicklung […] vom 'Absoluten Wissen' […] zur 'Sinnlichen Gewißheit'" nicht nur die Inversion von Hegels "Phänomenologie des Geistes" (1807) vollzogen, sondern auch der "klassische Entwicklungsroman" wird in der Weise umgekehrt, dass das Individuum "eine Anlage nach der anderen, ein Talent nach dem anderen, eine Fähigkeit nach der anderen" verliert, bis es schließlich "eine verkümmerte Existenz" geworden ist. Meine Hypothese ist, dass auch im Falle der Vertreibung der Struktur des Romans zwei Inversionen zu Grunde liegen und dass hier ebenfalls eine prominente philosophische Vorlage von Relevanz ist, nämlich Walter Benjamins Essay "Über den Begriff der Geschichte" (1942).
Recent research indicates that attentional stimulus selection could be a rhythmic process. In monkey, neurons in V4 and IT exhibit rhythmic spiking activity in the theta range in response to a stimulus. When two stimuli are presented together, the rhythmic neuronal responses to each occur in anti-phase, a result indicative of competitive interactions. In addition, it was recently demonstrated that these alternating oscillations in monkey V4 modulate the speed of saccadic responses to a target flashed on one of the two competing stimuli. Here, we replicate a similar behavioral task in humans (7 participants, each performed 4000 trials) and report a pattern of results consistent with the monkey findings: saccadic response times fluctuate in the theta range (6 Hz), with opposite phase for targets flashed on distinct competing stimuli.
Karl Dedecius, 1921–2016
(2018)
Karl Dedecius gilt als einer der produktivsten deutschen Übersetzer polnischer Literatur und als herausragende Persönlichkeit des deutsch-polnischen Dialogs in der zweiten Hälfte des 20. Jahrhunderts. Er starb am 26. Februar 2016 hochbetagt in Frankfurt am Main und hinterließ ein umfangreiches Œuvre, das ca. 200 übersetzte Bücher polnischer und russischer Literatur (darunter zahlreiche Anthologien) sowie mehrere essayistische Werke umfasst. Das Kernstück bilden die 50 Titel der von ihm initiierten und herausgegebenen "Polnischen Bibliothek" (1982–2000) sowie die sieben jeweils ca. 900 Seiten starken Bände des "Panoramas der polnischen Literatur des 20. Jahrhunderts" (1996–2000). Die Liste der von ihm übersetzten Autoren umfasst gut 300 Namen.
Harvest of Thorns
(2018)
The 1990 Commonwealth Writers Regional Prize voted Harvest of Thorns the winner in the Best Book category. Harvest of Thorns tells the story of Benjamin Tichafa who grows up in Rhodesia in the 1960s. From a conservative, religious family, but exposed to the heady ideas of the black nationalist movements, the young student is pulled in different directions. Isolated and troubled at boarding school, he is provoked into leaving, making his way to Mozambique, and joining the freedom fighters. There, in the crucible of a bitter civil war of liberation, the young man develops into manhood. Returning, hardened, at independence, he feels that little has changed, not least within his own family circumstances, and asks himself what it means to be free in the new Zimbabwe.
Poetic Blazons From Africa
(2018)
Poetic Blazons from Africa is an effort by the poet to bring into life the feelings and thoughts of a voice in agony. This effort takes the reader through pain that seems to come with every step that individual takes. The poet seems in tears as he traverses the rigours that characterize his terrain. Joy and happiness appear just remote though there are a fleeting moments of hope. The poet seems so drowned in choking pain that he appears to have failed to eliminate from childhood to the extent that at times he talks about his last lap as though he has already resigned on the purpose of living. His heart seems to have been jilted and he will not love again. Or would he?
This paper describes work on the morphological and syntactic annotation of Sumerian cuneiform as a model for low resource languages in general. Cuneiform texts are invaluable sources for the study of history, languages, economy, and cultures of Ancient Mesopotamia and its surrounding regions. Assyriology, the discipline dedicated to their study, has vast research potential, but lacks the modern means for computational processing and analysis. Our project, Machine Translation and Automated Analysis of Cuneiform Languages, aims to fill this gap by bringing together corpus data, lexical data, linguistic annotations and object metadata. The project’s main goal is to build a pipeline for machine translation and annotation of Sumerian Ur III administrative texts. The rich and structured data is then to be made accessible in the form of (Linguistic) Linked Open Data (LLOD), which should open them to a larger research community. Our contribution is two-fold: in terms of language technology, our work represents the first attempt to develop an integrative infrastructure for the annotation of morphology and syntax on the basis of RDF technologies and LLOD resources. With respect to Assyriology, we work towards producing the first syntactically annotated corpus of Sumerian.
Agent
(2018)
Seit einiger Zeit tümmeln sich Agenten in der deutschen Sprache, die dort eigentlich nichts zu suchen haben. Äußerst beunruhigend ist, dass sich dort sowohl 'virtuelle' als auch 'reale Agenten' finden, die in 'agentenbasierten Modellierungen' für die Simulierung der Interaktion in sozialen Netzwerken und als 'Bio-Agenten' in Form von Ameisen, deren Staaten 'Multiagentensysteme' repräsentieren, oder Schlauchpilzen (der Art 'Fusarium oxysporum') tätig sind, die Kokapflanzen noch bis tief in den Amazonas hinein verfolgen - und ganz unvermutet als 'Agenten des Wandels' im Ruhrgebiet wieder auftauchen, diesmal allerdings als Bezeichnung für eher harmlose Ökoprojekte. [...] Nach dem Beginn der Aufklärung hat sich der 'agent' bis ins einundzwanzigste Jahrhundert hinein auch noch in seinen verschiedenen Erscheinungsformen fast viral vermehrt.
Zur Behandlung von chronisch entzündlichen Erkrankungen besteht nach wie vor ein dringendes medizinisches Bedürfnis, da die bisher eingesetzten Medikamente gerade in der Langzeittherapie zu schwerwiegenden Nebenwirkungen führen können. Um chronisch entzündliche Erkrankungen in Zukunft adäquat therapieren zu können, sind bereits verschiedene neuartige Ansätze in klinischer bzw. präklinischer Entwicklung. Ein möglicher Ansatz besteht in einer dualen Hemmung der mikrosomalen Prostaglandin E2 Synthase-1 (mPGES-1) und der 5-Lipoxygenase (5-LO). Im Rahmen dieser Arbeit wurden die Struktur-Wirkungs-Beziehungen (SAR) von zwei verschiedenen Leitstrukturen an der 5 LO und der mPGES 1 untersucht. Die erste Leitstruktur entstammt aus den Arbeiten von Waltenberger et al. und besitzt im Grundgerüst eine Sulfonamidstruktur. In dieser Arbeit ist es gelungen, durch eine gezielte Untersuchung der Struktur-Wirkungsbeziehungen, die Leitstruktur I an der 5 LO und der mPGES-1 in ihrer Potenz zu optimieren. Die Leitstruktur (IC50: 5-LO (zellfrei) = 5.7 µM, IC50: 5 LO (PMNL) = 3.7 µM, IC50: mPGES-1 = 4.5 µM) konnte durch Variation in allen drei Positionen modifiziert werden, so dass die optimierte Struktur 170 (IC50: 5-LO (zellfrei) = 2.3 µM, IC50: 5-LO (PMNL) = 0.4 µM, IC50: mPGES-1 = 0.7 µM) entstanden ist. Für die Verbindung 170 wurden die pharmakokinetischen Eigenschaften, wie Löslichkeit und metabolische Stabilität, sowie der Wirkmechanismus auf molekularer Ebene bestimmt. Ebenso konnte für Verbindung 170 auch in vivo anti-entzündliche Eigenschaften festgestellt werden.
Die zweite Leitstruktur stammt ebenfalls aus den Arbeiten von Waltenberger et al. und besitzt im Grundgerüst eine Mercaptobenzothiazol-Grundstruktur. Aufgrund der Ähnlichkeit zu den bekannten Pirinixinsäurederivaten wurde auch hier für die Untersuchung der Struktur-Wirkungs-Beziehungen zunächst eine Kettenverlängerung an der Alkylkette vorgenommen. Es ließ sich auch hier durch eine gezielte SAR, die Leitstruktur bis hin zum submikromolaren Bereich in Verbindung 219 optimieren. Gleichzeitig ist es gelungen in Verbindung 219 einer der am potentesten dual ausgeglichensten dualen 5 LO/mPGES-1 Inhibitoren zu identifizieren.
Zusammenfassend lässt sich sagen, dass in dieser Arbeit es gelungen ist durch gezielte Untersuchungen der Struktur-Wirkungs-Beziehungen zwei verschiedene Substanzklassen zu dualen 5-LO/mPGES-1 Inhibitoren zu optimieren. Ebenso konnte für Substanz 170 auch in vivo anti-entzündliche Eigenschaften festgestellt werden. Diese Arbeit soll dazu beitragen, das therapeutische Potential von dualen 5-LO/mPGES-1 Inhibitoren als anti-entzündliche Wirkstoffe in Zukunft besser einschätzen zu können.
Aims. To investigate the correlation between the apparent diffusion coefficient (ADC) value and cervical intervertebral disc degeneration in adult symptomatic patients.
Methods. A total of 52 symptomatic and 40 healthy volunteers were included. DWI and routine MRI examinations were performed to their cervical spines. The cervical discs (from C2-C3 to C6-C7) were graded according to the Pfirrmann grading system, and ADC values of the nucleus pulposus (NP) were measured. Differences of the ADC values between different genders and anatomic levels were analyzed; the correlation between the ADC value and the Pfirrmann grade was investigated. The cut-off ADC values of each Pfirrmann grade were calculated.
Results. The mean ADC value of the NP decreased with increasing Pfirrmann grade (I–V) upon both patients and asymptotic volunteers. The ADC value decreased descendingly from C2-C3 to C5-C6 (P<0.05) and then increased at C6-C7 (P<0.05). Additionally, the comparison of the ADC values between different genders achieved statistical significance at each anatomical level (P<0.05), except at C6-C7 (P<0.05). Significant negative correlations between the ADC value and either age or Pfirrmann grade were observed.
Conclusions. Our preliminary findings suggest that the ADC value obtained by DWI can provide a reliable indicator to evaluate the cervical disc degeneration.
Consistent individual differences in behavioral tendencies (animal personality) can affect individual mate choice decisions. We asked whether personality traits affect male and female mate choice decisions similarly and whether potential personality effects are consistent across different mate choice situations. Using western mosquitofish (Gambusia affinis) as our study organism, we characterized focal individuals (males and females) twice for boldness, activity, and sociability/shoaling and found high and significant behavioral repeatability. Additionally, each focal individual was tested in two different dichotomous mate choice tests in which it could choose between computer-animated stimulus fish of the opposite sex that differed in body size and activity levels, respectively. Personality had different effects on female and male mate choice: females that were larger than average showed stronger preferences for large-bodied males with increasing levels of boldness/activity (i.e., towards more proactive personality types). Males that were larger than average and had higher shoaling tendencies showed stronger preferences for actively swimming females. Size-dependent effects of personality on the strength of preferences for distinct phenotypes of potential mating partners may reflect effects of age/experience (especially in females) and social dominance (especially in males). Previous studies found evidence for assortative mate choice based on personality types or hypothesized the existence of behavioral syndromes of individuals’ choosiness across mate choice criteria, possibly including other personality traits. Our present study exemplifies that far more complex patterns of personality-dependent mate choice can emerge in natural systems.
Three new species of Willowsia collected from Guizhou Province, China are described here: W. sexachaeta sp. nov., W. christianseni sp. nov., and W. tanae sp. nov. They have spinulate scales on the body. Colour pattern and dorsal chaetotaxy are the main diagnostic characters for these species. A table summarizing the main differences between all Chinese Willowsia species is given.
Purpose: Anastomotic leakage is a major surgical complication following esophagectomy and gastric pull-up. Specific risk factors such as celiac trunk (TC) stenosis and high calcification score of the aorta have been identified, but no data are available on their relative prognostic values. This retrospective study aimed to compare and evaluate calcification score versus stenosis quantification with regards to prognostic impact on anastomotic leakage.
Patients and methods: Preoperative contrast-enhanced computed tomography scans of 164 consecutive patients with primary esophageal cancer were evaluated by two radiologists to apply a calcification score (0–3 scale) assessing the aorta, the celiac axis and the right and left postceliac arteries. Concurrently, the presence and degree of stenosis of TC and superior mesenteric artery were recorded for stenosis quantification.
Results: Anastomotic leakage was noted in 14/164 patients and 12/14 showed stenosis of TC (n=11). The presence of TC stenosis was found to have a significant impact on anastomotic healing (p=0.004). The odds ratio for the prediction of anastomotic leakage by the degree of stenosis was 1.04 (95% CI, 1.02–1.07). Ten of 14 patients had aortic calcification scores of 1 or 2, but calcification scores of the aorta, the celiac axis and the right and left postceliac arteries did not correlate with the corresponding TC stenosis values and showed no influence on patient outcome as defined by the occurrence of anastomotic insufficiency (p=0.565, 0.855, 0.518 and 1.000, respectively). Inter-reader reliability of computed tomography analysis and absolute agreement on calcium scoring was mostly over 90%. No significant differences in preoperative comorbidities and patient characteristics were found between those with and without anastomotic leakage.
Conclusion: Measurement of TC stenosis in preoperative contrast-enhanced computed tomography scans proved to be more reliable than calcification scores in predicting anastomotic leakage and should, therefore, be used in the risk assessment of patients undergoing esophagectomy and gastric pull-up.
Reference of pronouns may be constrained via lexical presuppositions, including marked F-features, implicated presuppositions, and deictic center shifting in certain languages.
This paper explores the acquisition of personal reference terms in Thai, a language that has a highly complex personal reference system. The participants of the study were 67 typicallydeveloping children (TD) and 29 children with autism spectrum disorders (ASD), a population which has long been observed to have difficulties with pronouns. The children were asked to complete simple production and comprehension tasks on personal reference terms. Overall, ASD children performed on par in production but significantly poorer in comprehension than TD children. Given the freedom of choice in the production task, ASD children preferred using fixed referential terms for self-reference, whereas TD children opted for personal pronouns. In terms of comprehension, ASD children were shown to generally be able to detect the person features but they seemed to struggle the most with the pragmatic aspects of personal reference terms. Our results support previous literature that lexical presuppositions are acquired earlier than implicated presuppositions. We add to the literature that the types or the amount of implicated presuppositions matter in acquisition
Aims: The ILUVIEN Registry Safety Study is an ongoing, multicentre, open-label, observational study collecting real-world data on the safety and effectiveness of the 0.2 µg/day fluocinolone acetonide (FAc) implant in patients treated according to the European label requirements.
Methods: Patients included in this analysis were treated for the licensed indication of chronic diabetic macular oedema (cDMO; that is, DMO that persists or recurs despite treatment). Data presented in the current analysis were collected from patient records up to 6 March 2017. Visual acuity (VA) data, including mean change in VA over time and at last observation, intraocular pressure (IOP) over the course of the study, IOP events, use of IOP-lowering therapy and cup:disc ratio were analysed. Information on additional DMO treatments post-FAc implant was also captured.
Results: Five hundred and sixty-three patients (593 eyes) were enrolled on the study. Mean IOP for the overall population remained within the normal range throughout follow-up and 76.7% of patients did not require IOP-lowering therapy following treatment with the FAc implant. Sixty-nine per cent of eyes did not require additional DMO treatments. Mean VA in the overall population increased from 51.9 letters at baseline to 55.6 letters at month 12, with a significant increase of 2.9 letters at last observation. Patients with short-term cDMO experienced greater VA gains than those with long-term cDMO.
Conclusions: The results of this analysis are comparable with those of other studies, including the Fluocinolone Acetate for Macular Edema study. The study reinforces the good safety and effectiveness profile of FAc, and demonstrates the benefit of early FAc treatment.
Ever since the modern state of Malawi came into existence more than a hundred years ago, religion has played its role in the history of the country, and has interacted with politics and society in many ways, such as with the early Blantyre Mission, the Chilembwe Rising, and the struggle against the Federation of Rhodesia and Nyassaland. This book presents two preachers, Elliot Kamwana and Wilfred Gudu, who, in their different ways and at different times, challenged British colonial power which ruled over Malawi at that time.
Due to immigration influxes, Germany’s ethnic diversity is on steady rise. Although citizens of immigrant origin make up a high percentage of the population in all Western European countries, they are descriptively underrepresented in most legislative bodies. As widely acknowledged, political parties form the key channels through which societal developments are fed into parliament. By selecting parliamentary candidates, they constitute the most crucial nexus of the population to be represented and legislative bodies. Despite the pivotal role of the intra-party candidate selection in shaping who runs for election, the question of how candidates of immigrant background fare in the candidate selection and whether the criteria political parties use for selecting candidates of immigrant background are the same as for native-born candidates remained a blind spot of the research on minority representation. Therefore, the dissertation scrutinizes the thresholds candidates of immigrant background need to overcome to run for legislative office. It thus tackles the questions of how political parties go about selecting candidates of immigrant background in comparison to native-born candidates and which contextual factors drive their choice of selection behavior. For this purpose, the dissertation develops three ideal-typical selection strategies political parties can adopt towards candidates of immigrant background, which are referred to as neutrality, opening or closure, and empirically tests which selection strategy is in use. To explore parties’ selection behavior towards candidates of immigrant background, the dissertation combines the advantages of quantitative analysis by employing candidate surveys at the state and national level, with advantages of qualitative analysis by conducting interviews with candidates of immigrant background. As the analysis reveals, neutrality is the predominant selection strategy that political parties use towards candidates of immigrant background, the reason being that neutral selection practices involve the fewest intra-party conflicts.
Developments in managing CF continue to drive dramatic improvements in survival. As newborn screening rolls-out across Europe, CF centres are increasingly caring for cohorts of patients who have minimal lung disease on diagnosis. With the introduction of mutation-specific therapies and the prospect of truly personalised medicine, patients have the potential to enjoy good quality of life in adulthood with ever-increasing life expectancy. The landmark Standards of Care published in 2005 set out what high quality CF care is and how it can be delivered throughout Europe. This underwent a fundamental re-write in 2014, resulting in three documents; center framework, quality management and best practice guidelines. This document is a revision of the latter, updating standards for best practice in key aspects of CF care, in the context of a fast-moving and dynamic field.
In continuing to give a broad overview of the standards expected for newborn screening, diagnosis, preventative treatment of lung disease, nutrition, complications, transplant/end of life care and psychological support, this consensus on best practice is expected to prove useful to clinical teams both in countries where CF care is developing and those with established CF centres. The document is an ECFS product and endorsed by the CF Network in ERN LUNG and CF Europe.
Der Beitrag besteht aus Cassins Zitatsammlung, die ihrem Versuch zugrunde liegt, die Psychoanalyse, ausgehend von der antiken, von Aristoteles und Platon gleichermaßen bekämpften Sophistik, zu denken. Dabei werden vor allem die Spuren herausgearbeitet, die die Sophistik im Werk Jacques Lacans hinterlassen hat. In spielerischer Weise wird die Sophistik aus dem Schatten der aristotelischen Metaphysik hervorgeholt und die Psychoanalyse, insbesondere diejenige Lacan'scher Prägung, als radikale Setzung auf die Wirkung des Buchstabens in neuem Licht dargestellt.
Around the world, more young people than ever before are attending university. Student numbers in South Africa have doubled since democracy and for many families, higher education is a route to a better future for their children. But alongside the overwhelming demand for higher education, questions about its purposes have intensified. Deliberations about the curriculum, culture and costing of public higher education abound from student activists, academics, parents, civil society and policy-makers. We know, from macro research, that South African graduates generally have good employment prospects. But little is known at a detailed level about how young people actually make use of their university experiences to craft their life courses. And even less is known about what happens to those who drop out. This accessible book brings together the rich life stories of 73 young people, six years after they began their university studies. It traces how going to university influences not only their employment options, but also nurtures the agency needed to chart their own way and to engage critically with the world around them. The book offers deep insights into the ways in which public higher education is both a private and public good, and it provides significant conclusions pertinent to anyone who works in and cares about universities.
The paper analyses the contagion channels of the European financial system through the stochastic block model (SBM). The model groups homogeneous connectivity patterns among the financial institutions and describes the shock transmission mechanisms of the financial networks in a compact way. We analyse the global financial crisis and European sovereign debt crisis and show that the network exhibits a strong community structure with two main blocks acting as shock spreader and receiver, respectively. Moreover, we provide evidence of the prominent role played by insurances in the spread of systemic risk in both crises. Finally, we demonstrate that policy interventions focused on institutions with inter-community linkages (community bridges) are more effective than the ones based on the classical connectedness measures and represents consequently, a better early warning indicator in predicting future financial losses.
The neutron capture cross section of some unstable nuclei is especially relevant for s-process nucleosynthesis studies. This magnitude is crucial to determine the local abundance pattern, which can yield valuable information of the s-process stellar environment. In this work we describe the neutron capture (n,γ) measurement on two of these nuclei of interest, 204Tl and 171Tm, from target production to the final measurement, performed successfully at the n_TOF facility at CERN in 2014 and 2015. Preliminary results on the ongoing experimental data analysis will also be shown. These results include the first ever experimental observation of capture resonances for these two nuclei.
On February 20 at the Max Planck Institut für europäische Rechtsgeschichte, the Legal Historian and member of the Constitutional Court of Peru, Dr. Carlos Ramos Núñez, presented a crucial intervention on the problems that face the current constitutionalism in Latin America. Faced with a heterogeneous group of historians, philosophers and theoreticians of law, interested in the vicissitudes of Latin American juridical evolution, the political-juridical tensions of the Peruvian present served him as a framework to raise various constitutional problems and controversies. ...
A group of Amazonian harvestmen is recognized and described as Amazochroma gen. nov. This taxon includes Discocyrtus carvalhoi Mello-Leitão, 1941 (type species), the only species of Discocyrtus previously thought to occur in Amazonia, and Amazochroma pedroi gen. et sp. nov., described here from the Brazilian states of Acre and Rondônia. New records are added for Amazochroma carvalhoi gen. et comb. nov, expanding its distribution from the Brazilian state of Mato Grosso northwards also to Pará and Amazonas in Brazil and additionally French Guiana and Suriname. Diagnostic features of Amazochroma gen. nov. include: trichromatic pattern of legs, dry marks on the dorsal scutum and base of legs and diastema in the row of macrosetae C of the penis ventral plate. A morphological maximum parsimony analysis (1022 scorings; 16 taxa; 64 characters) is performed to test whether Amazochroma gen. nov. is a member of Discocyrtus and if the traditional allocation of Discocyrtus in Pachylinae is defendable. A clade is retrieved containing three groups: Amazochroma carvalhoi gen. et comb. nov, here described as a new subfamily of Gonyleptidae - Roeweriinae subfam. nov. Discocyrtanus Roewer, 1929 and Roeweria Mello-Leitão, 1923 are accordingly here transferred from Pachylinae to Roeweriinae subfam. nov.
Religious Conversion: An African Perspective includes a selection of key texts which are not easily accessible elsewhere. Most of the chapters discuss the long-standing thesis of Robin Horton who argues that religious change results from social transformation. The contributors provide different perspectives on what remains an ongoing provocative, though inconclusive debate. The book has chapters on conversion in Africa from such authorities as Robin Horton, Humphrey Fisher, and Richard Gray. It also contains chapters on Zambia by Elizaebeth Colson, Brendan Carmody, Austin Cheyeka, Felix Phiri and W Van Binsbergen. This collection of chapters provides an introduction to the discussion surrounding the query: Did the Christian and Muslim messages bring something fundamentally new to the African religious horizon? What has indigenisation meant? What is the role of traditional religion?
Taxonomic revision of Brasiloniscus (Oniscidea, Pudeoniscidae) with description of a new species
(2018)
The Neotropical genus Brasiloniscus, erected by Lemos de Castro (1973), is revised and validated herein. The genus was originally described including two species, B. maculatus and B. verrucosus, but no type species was designated. According to § 13 of ICZN (1999) the name of the genus is therefore unavailable. Both species are redescribed, and B. maculatus is designated as the type species of the genus. The genus name will thus be available for the systematics of Oniscidea. In addition, a new species, B. littoralis gen. et sp. nov., is described based on material from the Brazilian Atlantic Forest from the state of Rio de Janeiro.
Ambrosia artemisiifolia (common ragweed) is an invasive species native to North America and was accidentally introduced to Europe in the 19th century. Widespread in disturbed habitats, it is a major weed in spring-sown crops and it causes serious allergic rhinitis and asthma due to its allergenic pollen. The aim of this research was to analyse the effects of both competitive vegetation and herbivory by Ophraella communa to control A. artemisiifolia in an agricultural area of north-western Italy. Hayseed mixtures, both over-seeded over the resident plant community or after ploughing, when seeded before the winter season, were able to suppress the establishment of A. artemisiifolia as well as to reduce its growth in terms of plant height and inflorescence size. Defoliation of A. artemisiifolia by O. communa at the end of the growing season was conspicuous but most of the plants still produced flowers and seeds. However, significant O. communa attack was recorded for reproductive structures. As for non-target species, O. communa was mainly recorded on Asteraceae, with low density and low degree of damage. Reduction of inflorescence size due to competitive vegetation and damage to male flowers by O. communa may diminish the amount of available pollen. The results of this study may be useful for the implementation of management measures to control A. artemisiifolia in agricultural areas using mixtures of native species.
En este estudio se describen dos nuevas especies de hemípteros del género Aleuropleurocelus (Hemiptera: Aleyrodidae): Aleuropleurocelus mexicanus Carapia y Sánchez sp. nov., encontrada en los estados de Coahuila, México, Puebla, Sonora, y Tlaxcala en hojas de Quercus agrifolia Née y Quercus sp., y Aleuropleurocelus anahuac Carapia y Sánchez sp. nov. encontrada en los estados de México, Morelos y Puebla en el envés de hojas de Quercus. Se proporcionan microfotografías de estructuras morfológicas de puparios y se discute la separación con otras especies ovales de Aleuropleurocelus.
n this contribution we lay down a lattice setup that allows for the nonperturbative study of a field theoretical model where a SU(2) fermion doublet, subjected to non-Abelian gauge interactions, is also coupled to a complex scalar field doublet via a Yukawa and an “irrelevant” Wilson-like term. Using naive fermions in quenched approximation and based on the renormalizedWard identities induced by purely fermionic chiral transformations, lattice observables are discussed that enable: a) in theWigner phase, the determinations of the critical Yukawa coupling value where the purely fermionic chiral transformation become a symmetry up to lattice artifacts; b) in the Nambu-Goldstone phase of the resulting critical theory, a stringent test of the actual generation of a fermion mass term of non-perturbative origin. A soft twisted fermion mass term is introduced to circumvent the problem of exceptional configurations, and observables are then calculated in the limit of vanishing twisted mass.
Testing a non-perturbative mechanism for elementary fermion mass generation: numerical results
(2018)
Based on a recent proposal according to which elementary particle masses could be generated by a non-perturbative dynamical phenomenon, alternative to the Higgs mechanism, we carry out lattice simulations of a model where a non-abelian strongly interacting fermion doublet is also coupled to a doublet of complex scalar fields via a Yukawa and an “irrelevant" Wilson-like term. In this pioneering study we use naive fermions and work in the quenched approximation. We present preliminary numerical results both in the Wigner and in the Nambu-Goldstone phase, focusing on the observables relevant to check the occurrence of the conjectured dynamical fermion mass generation effect in the continuum limit of the critical theory in its spontaneously broken phase.
Robust predictions of alien species richness are useful to assess global biodiversity change. Nevertheless, the capacity to predict spatial patterns of alien species richness remains largely unassessed. Using 22 data sets of alien species richness from diverse taxonomic groups and covering various parts of the world, we evaluated whether different statistical models were able to provide useful predictions of absolute and relative alien species richness, as a function of explanatory variables representing geographical, environmental and socio-economic factors. Five state-of-the-art count data modelling techniques were used and compared: Poisson and negative binomial generalised linear models (GLMs), multivariate adaptive regression splines (MARS), random forests (RF) and boosted regression trees (BRT). We found that predictions of absolute alien species richness had a low to moderate accuracy in the region where the models were developed and a consistently poor accuracy in new regions. Predictions of relative richness performed in a superior manner in both geographical settings, but still were not good. Flexible tree ensembles-type techniques (RF and BRT) were shown to be significantly better in modelling alien species richness than parametric linear models (such as GLM), despite the latter being more commonly applied for this purpose. Importantly, the poor spatial transferability of models also warrants caution in assuming the generality of the relationships they identify, e.g. by applying projections under future scenario conditions. Ultimately, our results strongly suggest that predictability of spatial variation in richness of alien species richness is limited. The somewhat more robust ability to rank regions according to the number of aliens they have (i.e. relative richness), suggests that models of aliens species richness may be useful for prioritising and comparing regions, but not for predicting exact species numbers.
Anomiopus cirulito Cano n. sp., from the tropical forest of the Mayan Biosphere Reserve, Petén, Guatemala is described. This is the northernmost known species of the genus Anomiopus Westwood (Coleoptera: Scarabaeidae: Scarabaeinae) and is related to the Costa Rican and Panamanian Anomiopus panamensis (Paulian).
Autosomal recessive Ataxia Telangiectasia (A-T) is characterized by radiosensitivity, immunodeficiency and cerebellar neurodegeneration. A-T is caused by inactivating mutations in the Ataxia-Telangiectasia-Mutated (ATM) gene, a serine-threonine protein kinase involved in DNA-damage response and excitatory neurotransmission. The selective vulnerability of cerebellar Purkinje neurons (PN) to A-T is not well understood.
Im Folgenden werden die Freiheit der Person, vornehmlich das Recht auf Habeas Corpus, mithin der Schutz gegen willkürliche Inhaftierungen und die Freiheit des Eigentums, so wie sie in der Paulskirche konzipiert wurden, in Betracht gezogen. Die Vorgehensweise wird vor allem rechtsphilosophisch bzw. analytisch sein: Zunächst werden die jeweiligen Artikel und Paragraphen der Erklärung der Paulskirchenverfassung erörtert, in welchen die respektiven Grundrechte aufgebaut werden. Anschließend werden sie mit den entsprechenden Vorschriften anderer Grund- und Menschenrechtskatalogen verglichen, insbesondere mit den Verfassungen der süddeutschen Staaten, mit der Französischen Erklärung von 1789, mit der Allgemeinen Erklärung der Menschenrechte von 1948 und mit dem heutigen deutschen Grundgesetz. Hie und da wird gelegentlich auch auf relevante historische Ereignisse und prägende Literatur Bezug genommen, wobei dies den eigentlichen Gegenstand der derzeitigen Untersuchung nicht ausmacht.
Acute myeloid leukemia (AML) is characterized by uncontrolled proliferation and accumulation of immature myeloblasts, which impair normal hematopoiesis. While this definition categorizes the disease into a distinctive group, the large number of different genetic and epigenetic alterations actually suggests that AML is not a single disease, but a plethora of malignancies. Still, most AML patients are not treated with targeted medication but rather by uniform approaches such as chemotherapy. The identification of novel treatment options likely requires the identification of cancer cell vulnerabilities that take into account the different genetic and epigenetic make-up of the individual tumors. Here we show that STK3 depletion by knock-down, knock-out or chemical inhibition results in apoptotic cells death in some but not all AML cell lines and primary cells tested. This effect is mediated by a premature activation of cyclin dependent kinase 1 (CDK1) in presence of elevated cyclin B1 levels. The anti-leukemic effects seen in both bulk and progenitor AML cells suggests that STK3 might be a promising target in a subset of AML patients.
Following a taxonomic revision of Begonia L. (Begoniaceae, Cucurbitales) from Northeast India based on 332 herbarium specimens, 38 species are confirmed to occur in the region, of which ten are endemic. One new species is described, Begonia koelzii R.Camfield sp. nov., in B. sect. Platycentrum (Klotzsch) A.DC. One species is reduced into synonymy; B. barbata Wall. is now a synonym of B. thomsonii A.DC. Three species, B. difformis (Irmsch.) W.C.Leong, C.I Peng & K.F.Chung, B. labordei H.Lév. and B. handelii Irmsch., are reported new for India, and B. lushaiensis C.E.C.Fisch. is reinstated as an accepted species, having previously been synonymised under B. modestiflora Kurz. A key to the species in the region and preliminary conservation assessments are presented.
A taxonomic revision of Panamanian species of the genus Dasymutilla Ashmead (Hymenoptera, Mutillidae) is presented and a key for the six species is given, all recognized from both sexes. Dasymutilla colorado Cambra, Williams and Quintero sp. nov., from central and eastern Panama, is described and illustrated. Sex associations permitted us to make the following five synonymies: D. sleipniri Manley and Pitts, 2007 (male) under D. phya (Cameron, 1895) (female); D. deyrollesi Mickel, 1937 (male) and Sphaerophthama [sic.] temaxensis Cameron, 1895 under Dasymutilla araneoides (Smith, 1862) (female); D. ionothorax Manley and Pitts, 2007 (male) under Dasymutilla spilota Manley and Pitts, 2007 (female); and D. guanacaste Manley and Pitts, 2007 (male) under D. paradoxa (Gerstaecker, 1874) (female). Seasonal flight activity for Dasymutilla from six years of continuous malaise trappings in Barro Colorado Island is presented.
Eu busco neste artigo mostrar alguns aspectos relativos a diferentes pesquisas e reflexões que empreendi em anos recentes sobre o conceito de indústria cultural. A questão central é o pensamento de Theodor W. Adorno com especial atenção para a atualidade de sua dialética negativa. Minha intervenção acerca da atualidade do conceito de indústria cultural possui três passos argumentativos: o entrelaçamento entre racionalidade e dominação como a base de uma teoria da sociedade em Adorno; algumas mudanças no capitalismo contemporâneo e suas implicações para um conceito de indústria cultural no século XXI e; a posição da indústria cultural no contexto da Sociologia brasileira. O objetivo central do artigo, produzido na forma de ensaio, é enfatizar a atualidade da teoria crítica da sociedade de Theodor Adorno mediante argumentos específicos ao campo da Sociologia.
The present study aims at analyzing the role of nativeness, the amount of input in L1 acquisition and the multilingual competence in the performance of Italian–German bilingual speakers. We compare novel data from the performance of adult L2 learners (L1: Italian; late L2: German) and that of heritage speakers (heritage language: Italian; majority language: German) to previous data from monolingual speakers of Italian. The comparison deals with the produced word order at the syntax-discourse interface in sentences containing New Information Subjects in answers to questions that prompt the identification of the clausal subject. Overall, adult L2 speakers and heritage speakers perform alike but crucially differently from Italian monolinguals. These data reveal that multilingual proficiency determines an increased variety in the adopted answering strategies; in particular, the German-like strategy is active in Italian. Nativeness alone is thus no guarantee for a homogeneous performance across groups, nor do we find similar patterns of performance in speakers who grew up as monolinguals. Data also show heritage speakers’ sensitivity to verb classes, with answering strategies varying in accordance with the verb argument structure. Participants’ productions reveal an interesting relation in sentences with transitive verbs between subject position (pre-/postverbal) and object form (lexical DP/clitic pronoun).
Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. In this study, we aimed to further characterize the role of macrophage-derived EVs in immune responses against hepatitis C virus (HCV) and the potential of polyunsaturated fatty acids (PUFAs) to modulate this modality of innate immunity. To this end, EVs were isolated from interferon-stimulated macrophage cultures or from serum of patients with acute or chronic hepatitis C. EVs were characterized by electron microscopy, flow cytometry, RNA-sequencing, and Western blot analysis. The effect of EVs on replication of HCV was assessed in coculture models. Functional analyses were performed to assess the impact of PUFAs on EV-mediated antiviral immunity. We found that macrophages secreted various cytokines shortly after stimulation with type I and II IFN, which orchestrated a fast but short-lasting antiviral state. This rapid innate immune answer was followed by the production of macrophage-derived EVs, which induced a late, but long-lasting inhibitory effect on HCV replication. Of note, exposure of macrophages to PUFAs, which are important regulators of immune responses, dampened EV-mediated antiviral immune responses. Finally, EVs from patients with hepatitis C exhibited long-lasting antiviral activities during IFN therapy as well. The antiviral effect of EVs from Caucasian and Japanese patients differed, which may be explained by different nutritional uptake of PUFAs. In conclusion, our data indicate that macrophage-derived EVs mediate long-lasting inhibitory effects on HCV replication, which may bridge the time until efficient adaptive immune responses are established, and which can be blunted by PUFAs.
Lizards of Paraguay: an integrative approach to solve taxonomic problems in central South America
(2018)
Paraguay is located in the center of South America with drier and warmer climatic conditions in the western part of the country, and more temperate and humid in the eastern region. Biogeographically, Paraguay is a key spot in South America, where several ecoregions converge. In my study, I sampled most of the ecoregions of Paraguay. The main objective of my work is to solve taxonomic problems, identified through genetic barcoding analyses, in the central region of South America. To achieve this objective, I used selected taxa of the Paraguayan Squamata as models taking into consideration the crucial geographic position of the country, plus the scarce available genetic data of Paraguayan reptiles.
The collecting activities were performed in the framework of a barcoding inventory project of the Paraguayan herpetofauna and carried out mostly in rural areas searching for animals in different types of habitats using active search as the sampling technique.
For genetics, the extraction of DNA was performed with DNeasy® Blood & Tissue Kit of Qiagen® for sets of few samples, and the fiber glass plate protocol for sets of 96 samples. I assessed the quality of sequences after amplification in agarose gel electrophoresis. The first marker sequenced was 16S mtDNA, used for barcoding analysis. A DNA barcode is a genetic identifier for a species. Once a taxonomic problem was detected, I generate more gene sequences to target the issue.
All the analyses to test phylogenetic hypotheses (based on single genes or concatenated datasets) were performed under Maximum Likelihood and Bayesian approaches. To root the phylogenetic trees, I chose the available taxon (or taxa) most closely related to the respective studied group as outgroups. For the general tree of Paraguayan Squamata, based on barcodes of 16S, I chose Sphenodon punctatus.
I generated a total of 142 sequences of 64 species of Squamata from Paraguay (Appendix I). The final alignment of 615 bp comprised 249 samples. The best substitution model for the Barcoding dataset based on the gene 16S was GTR+G, according to the BIC.
To complement molecular evidence generated with the ML grouping of 16S barcodes, I took a morphological approach based on voucher specimens collected during fieldwork (usually the same specimens that I used for genetic analysis), supplemented by the revision of museum collections.
Summarizing my results, samples of Colobosaura exhibit large genetic distances, and accordingly I revalidated Colobosaura kraepelini (Appendix II). Tropidurus of the spinulosus group show two clades and among them there is little genetic and morphological variation, I synonymized T. tarara and T. teyumirim with T. lagunablanca, and T. guarani with T. spinulosus (Appendix III). I detected the presence of candidate species of Homonota, and I restricted the name H. horrida for Argentina, and described two new species of Homonota (Appendices IV and V), and a new species of Phyllopezus also in the Family Phyllodactylidae (Appendix VI).
In this work I present the most comprehensive analysis of genetic samples of Squamata from Paraguay. The results obtained here will be useful to help to clarify further taxonomic issues regarding the squamate fauna from the central region of South America. Moreover, the data generated for this study will have a positive impact in a larger geographic context, beyond Paraguayan borders.
Regarding the conservation of the Paraguayan reptiles, and considering the taxonomic changes accomplished here, it is important to note that many species lack legal protection. In Paraguay, the major problem for conservation is habitat loss due to extensive crop farming. Thus, currently, the protected areas are the best strategy for conservation of biodiversity in the country. However, many such areas face legal problems (e.g., lack of official measurements, management plans, forest guards, infrastructure, etc.) so that the maintenance of their biodiversity over time is not guaranteed.
In conclusion, in this study I present contributions on the taxonomy of mostly lizards from Paraguay. Due to lack of samples, I was not able to deal with a deep taxonomic revision of the country's snakes. Based on my results, I can argue that analyses of Xenodontini and Pseudoboini are currently a pressing research issue. This barcoding project may continue since some colleagues in Paraguay are interested in collaboration. Given that the sequenced specimens are yet a small portion of the actual diversity of Paraguay, it will be of utmost importance to continue and expand these studies that will further improve our taxonomic knowledge. Furthermore, it is desirable to have Paraguayan scientists not only involved, but to see them taking the lead of high quality taxonomic research.
The gecko genus Phyllopezus is distributed mainly along South America’s "Dry Diagonal" (Caatinga, Cerrado, and Chaco). The genus has been the subject of recent taxonomic analyses and includes four described species and seven candidate species referred to here as Phyllopezus pollicaris sensu lato. In Paraguay, Phyllopezus is known from the Chaco and Cerrado where it is abundant, and also from a small isolated population from a rocky hill formation named "Cordillera de Los Altos" (Los Altos mountain range). Here we analyzed genetic samples from across its range, including new samples from Paraguay, using DNA barcoding analysis of the mitochondrial 16S gene and phylogenetic analyses using both Bayesian and Maximum Likelihood methods. We found genetic and morphological differences among geckos from the Los Altos mountain range and the remaining Phyllopezus populations. Using both molecular and morphological evidence we describe a new Phyllopezus species, sister to P. przewalskii. Genetic differentiation among described and putative Phyllopezus species is greater than their morphological differences, which likely accounts for these cryptic taxa remaining undescribed for so long.
Complex I (proton-pumping NADH:ubiquinone oxidoreductase) is the largest enzyme of the mitochondrial respiratory chain and a significant source of reactive oxygen species (ROS). We hypothesized that during energy conversion by complex I, electron transfer onto ubiquinone triggers the concerted rearrangement of three protein loops of subunits ND1, ND3, and 49-kDa thereby generating the power-stoke driving proton pumping. Here we show that fixing loop TMH1-2ND3 to the nearby subunit PSST via a disulfide bridge introduced by site-directed mutagenesis reversibly disengages proton pumping without impairing ubiquinone reduction, inhibitor binding or the Active/Deactive transition. The X-ray structure of mutant complex I indicates that the disulfide bridge immobilizes but does not displace the tip of loop TMH1-2ND3. We conclude that movement of loop TMH1-2ND3 located at the ubiquinone-binding pocket is required to drive proton pumping corroborating one of the central predictions of our model for the mechanism of energy conversion by complex I proposed earlier.
Purpose: Acute kidney injury (AKI) is a severe complication in medical and surgical intensive care units accounting for a high morbidity and mortality. Incidence, risk factors, and prognostic impact of this deleterious condition are well established in this setting. Data concerning the neurocritically ill patients is scarce. Therefore, aim of this study was to determine the incidence of AKI and elucidate risk factors in this special population.
Methods: Patients admitted to a specialized neurocritical care unit between 2005 and 2011 with a length of stay above 48 hours were analyzed retrospectively for incidence, cause, and outcome of AKI (AKI Network-stage ≥2).
Results: The study population comprised 681 neurocritically ill patients from a mixed neurosurgical and neurological intensive care unit. The prevalence of chronic kidney disease (CKD) was 8.4% (57/681). Overall incidence of AKI was 11.6% with 36 (45.6%) patients developing dialysis-requiring AKI. Sepsis was the main cause of AKI in nearly 50% of patients. Acute kidney injury and renal replacement therapy are independent predictors of worse outcome (hazard ratio [HR]: 3.704; 95% confidence interval [CI]: 1.867-7.350; P < .001; and HR: 2.848; CI: 1.301-6.325; P = .009). Chronic kidney disease was the strongest independent risk factor (odds ratio: 12.473; CI: 5.944-26.172; P < .001), whereas surgical intervention or contrast agents were not associated with AKI.
Conclusions: Acute kidney injury in neurocritical care has a high incidence and is a crucial risk factor for mortality independently of the underlying neurocritical condition. Sepsis is the main cause of AKI in this setting. Therefore, careful prevention of infectious complications and considering CKD in treatment decisions may lower the incidence of AKI and hereby improve outcome in neurocritical care.
A typical characteristic of Central German dialects, especially of the Ripuarian dialect, is that it has collective nouns with ge- + -ze (cf. gesteinze) besides those with ge- + -e (cf. gesteine) corresponding to Dutch gesteente and gestene. A relationship between ge- + -ze and ge- + -te has been assumed for a long time. A corpus-based comparison is given in order to explain the genesis of these different formation types (ge- + -e, ge- + -ze, ge- + -te) and their relations. It seems likely that earlier Dutch formations influenced their Ripuarian counterparts. Rarely, the circumfix ge- + -te also occurs in Ripuarian texts and may be autochthone. One main result is that the suffic -ze in Ripuarian restores the collective formation in the circumfix ge- + -e when it was destroyed by the e-apokope. This is a rare instance where an element of word formation is replaced by another one in order to neutralize the isolation effect of sound change.
Wie sich Konzessivkonnektoren im 18. und 19. Jh. entwickelt haben, untersuchen Lisa Bürgerhoff, Jana Giesenschlag, Linda Kunow und Alexandra Kern für ihren Beitrag "Von ob ich schon wanderte zu obschon ich wanderte?! - Eine Korpusuntersuchung zur Konzessivität von 1700-1900". Ihre Untersuchungen im Deutschen Textarchiv zeigen unter anderem einen Zusammenhang zwischen der Zusammenschreibung der Konnektoren und einer eindeutig konzessiven Lesart, der für obschon, obgleich, obwohl und obzwar allerdings unterschiedlich stark ist. Auch die Faktizität der Teilsätze und das Auftreten verstärkender Partikeln sind für die Entwicklung der ob-Gruppe von Bedeutung. Als eindeutigste und frequenteste Konzessivkonnektoren stellen sich insgesamt obwohl und vor allem obzwar heraus.
Although modern biologics targeting different inflammatory mediators show promising therapeutic success, comprehensive knowledge about the molecular events in psoriatic keratinocytes that contribute to the pathogenesis and could serve as therapeutic targets is still scarce. However, recent efforts to understand the deregulated signal transduction pathways have led to the development of small molecule inhibitors e.g., tofacitinib targeting the Jak/Stat cascade that opens additional therapeutic options. Recently, the PI3-K/Akt/mTOR signaling pathway has emerged as an important player in the control of epidermal homeostasis. This review summarizes the current knowledge on the role of this pathway in the pathogenesis of psoriasis, especially the epidermal manifestation of the disease and discusses current approaches to target the pathway therapeutically.
Depiction verbs such as paint license i(mage)- and p(ortrait)-readings; for instance, Ben painted a cow can convey that Ben produced an image of an unspecific cow or a portrait of a specific cow. This paper takes issue with a property-based intensional analysis of depiction verbs (Zimmermann, 2006b, 2016) and instead argues for an extensional account. Accordingly, the i-reading is rooted in the introduction of worldly representations by the explicit noun cow as such, whereas the p-reading is rooted in the interpolation of an implicit representation via coercion. This take on the ambiguity captures the following key traits. On i-readings, only representations are accessible to quantifiers and anaphors; moreover, intensional effects such as substitution failure disappear once ordinary objects and representations are adequately distinguished. P-readings, by contrast, involve representations that depend on the portrayed ordinary objects as particulars; correspondingly, only ordinary objects are accessible to quantifiers and anaphors. The proposal is spelled out in Asher’s (2011) Type Composition Logic.
We propose a unified framework to measure the effects of different reforms of the pension system on retirement ages and macroeconomic indicators in the face of demographic change. A rich overlapping generations (OLG) model is built and endogenous retirement decisions are explicitly modeled within a public pension system. Heterogeneity with respect to consumption preferences, wage profiles, and survival rates is embedded in the model. Besides the expected direct effects of these reforms on the behavior of households, we observe that feedback effects do occur. Results suggest that individual retirement decisions are strongly influenced by numerous incentives produced by the pension system and macroeconomic variables, such as the statutory eligibility age, adjustment rates, the presence of a replacement rate, and interest rates. Those decisions, in turn, have several impacts on the macro-economy which can create feedback cycles working through equilibrium effects on interest rates and wages. Taken together, these reform scenarios have strong implications for the sustainability of pension systems. Because of the rich nature of our unified model framework, we are able to rank the reform proposals according to several individual and macroeconomic measures, thereby providing important support for policy recommendations on pension systems.
Im Rahmen eines Monitorings wurden alle im Artenhilfskonzept der BVNH von 1999 ermittelten sowie einzelne später bekannt gewordene hessische Vorkommen der Aufrechten Weißmiere im Frühjahr 2016 erneut aufgesucht und dokumentiert. Von diesen 27 Vorkommen konnten wir lediglich 15 bestätigen. Für einen großen Teil der untersuchten Populationen sind erhebliche Rückgänge der Individuenzahlen zu verzeichnen, lediglich vier Vorkommen sind stabil geblieben oder sogar leicht angestiegen. Bei der Interpretation der Individuenzahlen ist jedoch zu berücksichtigen, dass die Art mit großen witterungsbedingten Schwankungen der Populationsgröße auftritt und jahrweise auch völlig ausbleiben kann. Die Beobachtungen bestätigen eine akute Bedrohung durch das Brachfallen oder die Unterbeweidung der Wuchsorte und die damit verbundenen Folgeerscheinungen wie das Ausbleiben der durch den Viehtritt verursachten Offenböden oder die zunehmende Gehölzausbreitung. Der auf den Flächen entstehende Altgras- und Moosfilz verhindert mutmaßlich ein Auskeimen der Art. Als wesentliche Voraussetzung für die Erhaltung und langfristige Sicherung der Vorkommen der Aufrechten Weißmiere wird die Beibehaltung oder Wiedereinführung einer extensiven Nutzung angesehen. Neben einer Beweidung mit Schafen scheint sich auch eine extensive Rinderbeweidung günstig auf die Populationen auszuwirken. Um den Fortbestand der Art in Hessen zu sichern, sind auch Wiederansiedlungen von Moenchia erecta an erloschenen Wuchsorten in Betracht zu ziehen, sofern eine geregelte Folgenutzung in Form einer Beweidung gewährleistet ist.
Vorhofflimmern entsteht unter anderem durch ein Ungleichgewicht zwischen sympathischem und parasympathischem autonomen Nervensystem. Sowohl invasive Ansätze via Ablation oder Denervierung als auch minimalinvasive Ansätze via Elektrostimulation liefern erfolgsversprechende Ergebnisse in Bezug auf Beeinflussung eines bestehenden Vorhofflimmerns.
Interessanterweise konnte durch Akupunktur des Tragus eine Reduktion von Vorhofflimmer-Rezidiven nach Kardioversion erreicht werden. Ziel dieser Studie war die Evaluation von Akupunktur-induzierten kardialen (vegetativen) Effekten bei gesunden Probanden.
Herzgesunde männliche Probanden (n=24) wurden im Bereich des Vagus-Innervationsgebietes an der Concha inferior des Ohres (Herzpunkt 100, OHR) sowie an einem klassischen Akupunktur-Punkt des Herzens (ventralen Unterarm, P6/Neiguan, ARM) akupunktiert. Eine „Placebo“-Akupunktur eines Punktes, der gegen Gonarthrose-Schmerzen helfen soll (Magenpunkt 35), diente als Kontrolle. Die Hälfte der Probanden erhielt eine zusätzliche Messung ohne Akupunktur, um Effekte durch das alleinige Platzieren einer Nadel zu untersuchen.
Um eine Aktivierung des ANS zu bewirken und Veränderungen quantifizieren zu können, wurden 12-Kanal Langzeit-EKG Messungen wie folgt durchgeführt: 30 Minuten (min) in liegender Position unter Akupunktur, Entfernung der Akupunkturnadel, 5 min liegend, 5 min sitzend, 5 min stehend, 5 min sitzend.
Es erfolgten Analysen folgender Parameter der Herzfrequenzvariabilität: Herzfrequenz, SDNN, RMSSD, HF, LF, LF/HF. Des Weiteren wurden Periodic Dynamics Repolarization und Deceleration Capacity untersucht.
Verglichen mit Placebo-Akupunktur wurde sowohl durch Akupunktur am OHR als auch am ARM die Herzfrequenz in liegender und sitzender Körperpositionen signifikant gesenkt (Phasen 30L, 5S1, 5S2, ∆5L-5S1, ∆5S1-5ST).
Während die Akupunktur am OHR vor allem die SDNN signifikant erhöhte, führte die Akupunktur am ARM zu einer signifikanten Steigerung von RMSSD und dem parasympathischen Leistungsdichtespektrum-Parameter HF. Der Quotient LF/HF wurde ebenfalls signifikant gesenkt.
Kein Unterschied bestand zwischen Placebo-Akupunktur und Messung ohne Akupunktur, sodass postuliert werden kann, dass das alleinige Platzieren einer Nadel keinen nennenswerten Effekt auf das autonome Nervensystem besitzt.
Die Ergebnisse der Studie zeigen, dass eine Akupunktur an Orten, die mit dem autonomen Nervensystem verschaltet sind, zu einer Modulation des parasympathischen kardialen autonomen Nervensystems führen kann.
Eine Modulation der parasympathisch-sympathischen Balance durch minimalinvasive Zusatzbehandlung, wie in unserer Studie, könnte möglicherweise bei Patienten mit Vorhofflimmern zusätzlich zu medikamentöser oder nach invasiver Behandlung wie der Pulmonalvenenisolation das Therapieresultat verbessern und die Rezidivrate verringern.
The regulation of temporo-spatial compartmentalization of protein synthesis is of crucial importance for a variety of physiologic cellular functions. Here, we demonstrate that the cell membrane-anchored disintegrin metalloproteinase ADAM15, upregulated in a variety of aggressively growing tumor cells, in the hyperproliferative synovial membrane of inflamed joints as well as in osteoarthritic chondrocytes, transiently binds to poly(A) binding protein 1 (PABP) in cells undergoing adhesion. The cytoplasmic domain of ADAM15 was shown to selectively interact with the proline-rich linker of PABP. Immunostainings of adhesion-triggered cells demonstrate an ADAM15-dependent recruitment of PABP to cell membrane foci coinciding with ongoing mRNA translation as visualized by the detection of puromycin-terminated polypeptides. Moreover, the increase in cell membrane-associated neosynthesis of puromycylated proteins upon induction of cell adhesion was proven linked to ADAM15 expression in HeLa and ADAM15-transfected chondrocytic cells. Thus, down regulation of ADAM15 by siRNA and/or the use of a cell line transfected with a mutant ADAM15-construct lacking the cytoplasmic tail resulted in a considerable reduction in the amount of cell membrane-associated puromycylated proteins formed during induced cell adhesion.
These results provide first direct evidence for a regulatory role of ADAM15 on mRNA translation at the cell membrane that transiently emerges in response to triggering cell adhesion and might have potential implications under pathologic conditions of matrix remodeling associated with ADAM15 upregulation.
In order to consider the effects of online publishing on the career of researchers, as well as to encourage both its recognition and its improved positioning within the field and beyond, the CETAF Membership organized two workshops during which specific questions about scientific publishing in taxonomy were addressed: authorship citation and Open Access. The present opinion paper is the result of those workshops held on 19 October 2016 in Madrid and on 4 October 2017 in Heraklion. The discussions were aimed at reconciling the requirements of the relevant nomenclatural codes with recommendations for best practices that are adapted to the evolving landscape of e-publishing. By evaluating the different policies of a range of journals regarding authorship citation, we were able to recognise the conflicting and incoherent practices related to the citation of taxon authorships; an issue that is important to clarify for scientific (explicit source), practical (findability of source) and reputational (citation index) reasons. A collective policy on authorship citation also fits into the wider challenge faced by researchers and institutions, whereby interoperability and traceability become key priorities, both for facilitating access to scientific resources and for generating metrics that accurately represent the activities and output of the community. Publications resulting from publicly-funded research should be considered as an essential part of the research process and there has been a strong move towards Open Access, which increases visibility, citability, innovation and impact. Diverse models of Open Access have appeared in scientific publishing but while they each promote free access to the end user, they are not always equitable for the authors and funders of the original research. Herein we formulate recommendations for the relevant research communities and outline the advantages behind adopting a collective strategy towards the issues of authorship citation and Open Access.
The increase in alternative working arrangements has sparked a debate over the positive impact of increased flexibility against the negative impact of decreased financial security. We study the prevalence and determinants of intermediated work in order to document the relative importance of the arguments for and against this recent labor market trend. We link data on individual participation and losses from a Federal Trade Commission settlement with a Multi-Level Marketing firm with detailed county-level information. Participation is greater in middle-income areas and in areas where female labor market non-participation is higher, suggesting that flexibility offers real benefits. However, losses from MLM participation are higher in areas with lower education levels and higher income inequality, suggesting that the downsides of alternative work are particularly high in certain demographics. Our results illustrate that the advantages and disadvantages of alternative work arrangements accrue to different groups.
The influenza vaccination is recommended for all German pregnant women and health care personnel (HCP). We are the first to publish vaccination rates of mothers of hospitalized newborns and HCP in neonatal units. Between September 2016 and March 2017, data were collected in our level-III neonatology department in this descriptive multidisciplinary study, using an anonymous questionnaire. As a result, 513 persons were asked to participate, including 330 parents and 183 HCP. We received an 80.3% (412/513) response rate, 87.3% (288/330), and 67.8% (124/183) from parents and HCP, respectively. Ten percent (16/160) of mothers and 4.7% (6/127) of fathers had been vaccinated in 2016–2017 and 54.4% (87/160) mothers and 52.2% (66/127) fathers ever in their lifetime. In 2016–2017, 51.2% (21/41) of physicians had been vaccinated, 25.5% (14/55) of nurses, and 50.0% (14/28) of other staff members. When comparing those who had more than five influenza vaccinations in their life time, physicians were at 43.9% (18/41) versus nurses at 10.9% (6/55) (p < 0.01), and other HCP at 7.4% (2/27) (p < 0.01). The influenza vaccine uptake rate of 10% in mothers of hospitalized neonates is disappointingly low, resulting in 90% of hospitalized neonates being potentially vulnerable to influenza infection at a time where the risk for influenza-related complication can be severe.
Die Florenliste von Deutschland enthält die akzeptierten Namen der in Deutschland gefundenen Gefäßpflanzen-Sippen, einschließlich Hybriden, Synonyme in der floristischen Literatur (im Aufbau), Verbreitung in den Bundesländern (im Aufbau), Status der Vorkommen, Angabe zur Betonung der wissenschaftlichen Namen, deutsche Namen (im Aufbau) und Zitate der Erstbeschreibungen (im Aufbau). Nicht enthalten sind die nur kultiviert auftretenden Sippen. Die hier dokumentierte Version 10 wurde am 18. August 2018 unter https://www.kp-buttler.de/ veröffentlicht. Sie enthält 62.620 Namen, die sich auf 11.530 akzeptierte Sippen und 51.090 Synonyme verteilen.
The debate on effects of globalization on welfare states is extensive. Often couched in terms of a battle between the compensation and the efficiency thesis, the scholarly literature has provided contradictory arguments and findings. This article contributes to the scholarly debate by exploring in greater detail the micro-level foundations of compensation theory. More specifically, we distinguish between individual policy preferences for compensatory social policies (unemployment insurance) and human capital-focused social investment policies (education) and expect globalization to mainly affect demand for educational investment. A multi-level analysis of ISSP survey data provides empirical support for this hypothesis. This finding provides an important revision and extension of the classical analytical perspective of compensation theory, because it shows that citizens value the social investment function of the welfare state above and beyond simple compensation via social transfers. This might be particularly relevant in today's skill-centered knowledge economies.
Trotz der sorgsam gepflegten Begriffsgeschichte (kaum ein geistes- oder sozialwissenschaftliches Fachwörterbuch ohne entsprechendes Lemma) scheint 'Religion' ein auffällig unkonkreter, im Grunde ungeklärter Begriff, der in Anbetracht dessen in seinem Alltagsverständnis erstaunlich wenig erklärungsbedürftig scheint. Das Problem der Religionswissenschaft, ihren Gegenstand zu bestimmen, - dies soll hier als Indiz für das Problem mit dem Begriff 'Religion' dienen - liegt vielsagenderweise u. a. darin, dass keine Definition in der Lage ist, alles, was man als Religion zu bezeichnen gewohnt ist, gleichzeitig abzudecken und jeder Definitionsversuch als einseitig und letztlich als voreingenommen abgelehnt wurde. Es gab nie und gibt bis heute keine konsensfähige Definition und einige Fachvertreter*innen geben gar zu bedenken, so etwas wie Religion gebe es im Grunde eigentlich gar nicht.
In einem Brief vom 8. Juli 1891 schreibt der junge Hugo von Hofmannsthal an den acht Jahre älteren Richard Beer-Hofmann von seinen Lektüren in Bad Fusch. Darunter findet sich eine ganze Bandbreite internationaler literarischer und philosophischer Werke: von "Gogol" über "Andersen, Immermann, Maupassant" bis hin zu "Schopenhauer". Während die rezeptionsästhetische Aufnahme und Verarbeitung der erstgenannten Autoren bei den Schriftstellern der Wiener Moderne generell eine eher marginale Rolle spielt, ist die frühe Beschäftigung Hofmannsthals mit Schopenhauer freilich keine Einzelerscheinung. Ganz im Gegenteil gehört der Philosoph in der intellektuellen und literarischen Welt des Fin de Siècle zur Allgemeinbildung und ist bereits seit dem literarischen Realismus von vielen Schriftstellern (z.B. Hebbel, Raabe und Fontane) breit rezipiert, zentrale Aspekte seiner Philosophie sind auf vielfältige Weise poetisch produktiv verarbeitet worden.