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Background Fermentation of lignocellulosic biomass is an attractive alternative for the production of bioethanol. Traditionally, the yeast Saccharomyces cerevisiae is used in industrial ethanol fermentations. However, S. cerevisiae is naturally not able to ferment the pentose sugars D-xylose and L-arabinose, which are present in high amounts in lignocellulosic raw materials. Results We describe the engineering of laboratory and industrial S. cerevisiae strains to co-ferment the pentose sugars D-xylose and L-arabinose. Introduction of a fungal xylose and a bacterial arabinose pathway resulted in strains able to grow on both pentose sugars. Introduction of a xylose pathway into an arabinose-fermenting laboratory strain resulted in nearly complete conversion of arabinose into arabitol due to the L-arabinose reductase activity of the xylose reductase. The industrial strain displayed lower arabitol yield and increased ethanol yield from xylose and arabinose. Conclusion Our work demonstrates simultaneous co-utilization of xylose and arabinose in recombinant strains of S. cerevisiae. In addition, the co-utilization of arabinose together with xylose significantly reduced formation of the by-product xylitol, which contributed to improved ethanol production.
We study effects of the mean field in hot compressed nuclear matter in the context of the Vlasov Uehling-Uhlenbeck theory. The expansion of a spherical distribution at different temperatures is studied along with collisions of Nb+Nb and Au+Au at lab energies from 50 to 1050 MeV/nucleon. In both the expansion and the actual heavy ion collision simulation, a transition behavior is seen only at the lowest temperature (T<10 MeV) or bombarding energy (E=50 MeV/nucleon), where the attractive part of the mean field is able to bind the expanding matter. At the lowest energy one thus sees the formation of a central residue, whereas at higher bombarding energies there is complete disintegration of the centrally colliding nuclei. The spectrum of emitted nucleons is found to be much hotter than the kinetic energy spectrum of the central emitting region. The extracted temperature slope parameters are in agreement with recent data.
Background: Particle Swarm Optimization (PSO) is an established method for parameter optimization. It represents a population-based adaptive optimization technique that is influenced by several "strategy parameters". Choosing reasonable parameter values for the PSO is crucial for its convergence behavior, and depends on the optimization task. We present a method for parameter meta-optimization based on PSO and its application to neural network training. The concept of the Optimized Particle Swarm Optimization (OPSO) is to optimize the free parameters of the PSO by having swarms within a swarm. We assessed the performance of the OPSO method on a set of five artificial fitness functions and compared it to the performance of two popular PSO implementations. Results: Our results indicate that PSO performance can be improved if meta-optimized parameter sets are applied. In addition, we could improve optimization speed and quality on the other PSO methods in the majority of our experiments. We applied the OPSO method to neural network training with the aim to build a quantitative model for predicting blood-brain barrier permeation of small organic molecules. On average, training time decreased by a factor of four and two in comparison to the other PSO methods, respectively. By applying the OPSO method, a prediction model showing good correlation with training-, test- and validation data was obtained. Conclusion: Optimizing the free parameters of the PSO method can result in performance gain. The OPSO approach yields parameter combinations improving overall optimization performance. Its conceptual simplicity makes implementing the method a straightforward task.
The existence of a mean-square continuous strong solution is established for vector-valued Itö stochastic differential equations with a discontinuous drift coefficient, which is an increasing function, and with a Lipschitz continuous diffusion coefficient. A scalar stochastic differential equation with the Heaviside function as its drift coefficient is considered as an example. Upper and lower solutions are used in the proof.
Streamer chamber data for collisions of Ar + KCl and Ar + BaI2 at 1.2 GeV/nucleon are compared with microscopic model predictions based on the Vlasov-Uehling-Uhlenbeck equation, for various density-dependent nuclear equations of state. Multiplicity distributions and inclusive rapidity and transverse momentum spectra are in good agreement. Rapidity spectra show evidence of being useful in determining whether the model uses the correct cross sections for binary collisions in the nuclear medium, and whether momentum-dependent interactions are correctly incorporated. Sideward flow results do not favor the same nuclear stiffness parameter at all multiplicities.
We demonstrate that strangeness separates in the Gibbs-phase coexistence between a baryon-rich quark-gluon plasma and hadron matter, even at T=0. For finite temperatures this is due to the associated production of kaons (containing s¯ quarks) in the hadron phase while s quarks remain in the deconfined phase. The s-s¯ separation results in a strong enhancement of the s-quark abundance in the quark phase. This mechanism is further supported by cooling and net strangeness enrichment due to the prefreezeout evaporation of pions and K+, K0, which carry away entropy and anti- strangeness from the system. Metastable droplets (i.e., stable as far as weak interactions are not regarded) of strange-quark matter (‘‘strangelets’’) can thus be formed during the phase transition. Such cool, compact, long-lived clusters could be experimentally observed by their unusually small Z/A ratio (≤0.1–0.3). Even if the strange-quark-matter phase is not stable under strong interactions, it should be observable by the delayed correlated emission of several hyperons. This would serve as a unique signature for the transient formation of a quark-gluon plasma.
We investigate the onset of multifragmentation employing an improved version of the N-body ‘‘quantum’’ molecular-dynamics approach. We study in detail the reaction 18O+197Au at 84 MeV/nucleon and find good agreement between the calculated results and the data for the double-differential proton cross section, the mass yield, the multiplicity, the kinetic energy of the fragments, and even for the kinematic correlations between intermediate mass fragments (IMF’s), which have been measured in this experiment for the first time. We observe a strong correlation between the impact parameter and both the size of the target remnant as well as the average proton multiplicity. Hence both observables can be used to determine the impact parameter experimentally. The IMF’s come from the most central collisions. The calculations confirm the experimental result that they are not emitted from an equilibrated system. Although the inclusive energy spectra look thermal, we cannot identify an impact parameter-independent isotropically emitting source. Even in central collisions global equilibrium is not observed. We find that multifragment emission at this bombarding energy is caused by a process very similar to that proposed in the macroscopic cold multifragmentation model. Thus it has a different origin than at beam energies around 1 GeV/nucleon, although the mass yield has an almost identical slope.
We investigate the hydrodynamical flow of nuclear matter in a conical-shock-wave scenario of a central, asymmetric heavy-ion collision. This work is motivated by a suggestion of Chapline and Granik that the creation of a deconfined phase of quarks and gluons behind the shock will appreciably increase the deflection angle of the matter flow. We employ several hadron matter equations of state recently suggested to solve the conical-shock-wave problem and compare the results with a calculation using the bag equation of state. We find that large differences in the deflection angle obtained in the rest frame of the shock vanish in the laboratory system. However, a signature for the deconfinement transition may be the transverse momentum of the matter flow, which is up to a factor of 2 larger for the quark-gluon plasma. Thus, an excitation function of the mean transverse momentum would show an increase at a certain bombarding energy, signaling the onset of the deconfinement transition.
We study the transition from fusion-fission phenomena at about 20 MeV/nucleon multifragmentation at 100–200 MeV/nucleon in the reaction 16O+80Br employing the quantum molecular dynamics model. The time evolution of the density and mass distribution, the charged-particle multiplicity, and spectra as well as angular distributions of light particles are investigated. The results exhibit the transition of the disassembly mechanism, but no sharp change is found. The results are in good agreement with recently measured 4-Pi data.
Inclusive neutron spectra were measured at 0°, 4°, 8°, 15°, 30°, and 42° from Nb-Nb and Au-Au collisions at 800 MeV/nucleon. A peak that originates from neutron evaporation from the projectile appears in the spectra at angles out to 8°. The shapes and magnitudes of the spectra are compared with those calculated from models of nucleus-nucleus collisions. The differential cross sections for Au-Au collisions are about four times those for Nb-Nb collisions. The predictions of the Vlasov-Uehling-Uhlenbeck (VUU) and QMD theories agree with the angular distributions of the differential cross sections except at small angles; the VUU prediction overestimates the angular distributions from a few degrees to about 20°, whereas the QMD prediction underestimates the angular distributions below 8°. The Firestreak model overestimates the angular distribution for Nb-Nb collisions and underestimates it for Au-Au collisions. Also, the VUU and QMD models agree with the measured double-differential cross sections in more angular and energy regions than the Firestreak and intranuclear cascade models; however, none of the models can account for the peaks at small angles (θ≤15°).
Within a relativistic mean-field theory (RMFT) experimental data on the single-particle spectra of lambda hypernuclei are well reproduced. It is shown that the coupling constants cannot be fixed unambiguously from the single-particle spectra. The stability and structure of multi-lambda hypernuclei is explored on the basis of the RMFT using the coupling constants as determined from the observed single lambda hypernuclear levels. It is predicted that multistrange nuclei exhibit an enhanced interaction radius, which further increases in the case of finite temperatures. We suggest that multi-lambda hypernuclei could be produced in high-energy heavy ions and observed in secondary noncharge-changing reactions. The equation of state of lambda matter and the possibility of pure lambda droplets are also discussed.
Shock discontinuities around the confinement-deconfinement transition in baryon-rich dense matter
(1989)
Nuclear transport models are important tools for interpretation of many heavy-ion experiments and are essential in efforts to probe the nuclear equation of state. In order to fulfill these roles, the model predictions should at least agree with observed single-particle-inclusive momentum spectra; however, this agreement has recently been questioned. The present work compares the Vlasov-Uehling-Uhlenbeck model to data for mass-symmetric systems ranging from 12C+12C to 139La+139La, and we find good agreement within experimental uncertainties at 0.4A and 0.8A GeV. For currently available data, these uncertainties are too large to permit effective nucleon-nucleon scattering cross sections in the nuclear medium to be extracted at a useful level of precision.
Nuclear transport models including density- and momentum-dependent mean-field effects are compared to intranuclear-cascade models and tested on recent data on inclusive p-like cross sections for 800A-MeV La+La. We find a remarkable agreement between most model calculations but a systematic disagreement with the measured yield at 20°, possibly indicating a need for modification of nuclear transport properties at high densities.
The quantum molecular dynamic method is used to study multifragmentation and fragment flow and their dependence on in-medium cross sections, momentum dependent interactions, and the nuclear equation of state, for collisions of 197Au+197Au and 93Nb+93Nb in the bombarding energy regime from 100 to 800A MeV. Time and impact parameter dependence of the fragment formation and their implications for the conjectured liquid-vapor phase transition are investigated. We find that the inclusive fragment mass distribution is independent of the equation of state and exhibits a power-law behavior Y(A)∼A-τ with an exponent τ≊-2.3. True multifragmentation events are found in central collisions for energies Elab∼30–200 MeV/nucleon. The associated light fragment (d,t,α) to proton ratios increase with the multiplicity of charged particles and decrease with energy, in agreement with recent experiments. The calculated absolute charged particle multiplicities, the multiplicities of intermediate mass (A>4) fragments, and their respective rapidity distributions do compare well with recent 4π data, but are quite insensitive to the equation of state. On the other hand, these quantities depend sensitively on the nucleon-nucleon scattering cross section, and can be used to determine σ experimentally. The transverse momentum flow of the complex fragments increases with the stiffness of the equation of state. Reduced (in-medium) n-n scattering cross sections reduce the fragment flow. Momentum dependent interactions increase the fragment flow. It is shown that the measured fragment flow at 200A MeV can be reproduced in the model. We find that also the increase of the px/A values with the fragment mass is in agreement with experiments. The calculated fragment flow is too small as compared to the plastic ball data, if a soft equation of state with in-medium corrections (momentum dependent interactions plus reduced cross sections) is employed. An alternative, most intriguing resolution of the puzzle about the stiffness of the equation of state could be an increase of the scattering cross sections due to precritical scattering in the vicinity of a phase transition.
The statistical model is used to illustrate the consequences of a successive binary decay mechanism as the initial nuclear excitation is pushed towards the limits of stability. The partition of the excitation energy between light and heavy fragments is explicitly calculated, as are the consequences of the decay of the primary light fragments to particle-bound residual nuclei which would be observed experimentally. The test nucleus 100 44 Ru is considered at initial excitations of 100, 200, 400, and 800 MeV. Exit channels of n, p, and α; and 100 clusters of 3 ≤ Z ≤ 20 ≤ 4, 6 ≤ A ≤ 48 are considered from all nuclides in the deexcitation cascade. The total primary and final cluster yields are shown versus Z and initial excitation. The primary versus final yields are also shown individually for 12C, 26Mg, and 48Ca. We show how multifragmentation yields will change with the excitation energy due to a successive binary decay mechanism. Measurements that may be prone to misinterpretation are discussed, as are those that should be representative of initial nucleus excitation.
Distillation and survival of strange quark matter droplets in ultrarelativistic heavy ion collisions
(1991)
Recently it has been suggested that rather cold droplets of absolutely stable or metastable strange-quark matter may be distilled in heavy-ion collisions during the phase transition from a baryon-rich quark-gluon plasma (QGP) to hadron matter. Here we present a model describing the hadronization of the QGP through particle emission, which is based solely on thermodynamical arguments. Pions and K+’s and K0’s carry away entropy and antistrangeness from the system, thus facilitating the cooling process and the strangelet formation. Our results are supported by revised more sophisticated rate calculations. Two rather unexpected results are obtained when this model is applied to the investigation of strangelet production. The strangeness separation mechanism and the formation process works well even for higher initial entropies per baryon, tantamount to higher bombarding energies. The surviving strangelets have a rather high strangeness content, fs∼1.2–2 [i.e., Z/A∼(-0.1)–(-0.5)]. Hence droplets of strange-quark matter with a baryon number of ∼10–30 and with a negative charge may be produced. They may serve as a unique signature for the transient formation of a quark-gluon plasma in heavy-ion collisions.
Relativistic heavy ion collisions constitute a prolific source of hyperons: tens of hyperons per event are predicted at energies E≥10 GeV/nucleon, providing a scenario for the formation of metastable exotic multihypernuclear objects. They may exhibit exceptional properties: bound neutral (e.g., 4M2Λ2n, 10M2Λ8n, pure Λ droplets, 8Λ) and even negatively charged composites objects with positive baryon number (e.g., 4M2Σ-2n, 6M2Λ2Ξ-2n) could be formed in rare events. Such negative nuclei can easily be identified in a magnetic spectrometer. They could be considerably more abundant than antinuclei of the same A. We use the relativistic meson-baryon field theory—which gives an excellent description of normal nuclear and single-Λ hypernuclear properties—to calculate the rich spectrum of such exotic objects, their stability, and their structure. We also find solutions for a large variety of bound short-lived nuclei (e.g., 8M2Λ,2Σ-2p2n), which may decay strongly via formation of cascade (Ξ) particles. Multi-Ξ hypernuclei are also evaluated. A variety of potential candidates for such metastable exotic nuclei is presented. It turns out that the properties of such exotic multihypernuclear objects reveal quite similar features as the strangelet proposed as a unique signature for quark-gluon plasma formation in heavy ion collisions.