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Ausgangsfragen: Was sind die grundlegenden methodisch-theoretischen Veränderungen des Faches in den vergangenen dreißig bis vierzig Jahren? Welchen Stellenwert haben Methoden und Theorien heute im Fach? In welchem Verhältnis steht die germanistische zur allgemeinen Methoden- und Theoriereflexion in den Geisteswissenschaften? Befinden wir uns am Ende des 'theoretischen Zeitalters'? Hat die Konzentration auf Methodik und Theorie das Fach der gebildeten Öffentlichkeit noch mehr als ohnehin entfremdet? Worin bestünden bzw. existieren überhaupt Alternativen zur Theorie? Etwa in Form einer Renaissance von Biographie oder Hermeneutik? Braucht das Fach überhaupt eine breite Debatte über seine theoretischen Horizonte und methodischen Standards? Oder sind andere Fragen vordringlicher, etwa eine stärkere Reflexion der gesellschaftlichen Aufgaben der Germanistik?
This work presents an effective model for strongly interacting matter and the QCD equation of state (EoS). The model includes both hadron and quark degrees of freedom and takes into account the transition of chiral symmetry restoration as well as the deconfinement phase transition. At low temperatures T and baryonic densities ρB a hadron resonance gas is described using a SU(3)-flavor sigma-omega model and a quark phase is introduced in analogy to PNJL models for higher T and ρB. In this way, the correct asymptotic degrees of freedom are used in a wide range of T and ρB. Here, results of this model concerning the chiral and deconfinement phase transitions and thermodynamic model properties are presented. Large hadron resonance multiplicities in the transition region emphasize the importance of heavy-mass resonance states in this region and their impact on the chiral transition behavior. The resulting phase diagram of QCD matter at small chemical potentials is in line with latest lattice QCD and thermal model results.
Cytoprotective functions of amyloid precursor protein family members in stress signaling and aging
(2013)
Poster presentation: Molecular Neurodegeneration: Basic biology and disease pathways Cannes, France. 10-12 September 2013.
Background: The amyloid precursor protein (APP) is processed via two different metabolic pathways: the amyloidogenic and the non-amyloidogenic pathway, the latter of which leading to generation of the secreted N-terminal APP fragment sAPPα [1]. Previous studies from our group suggest that sAPPα exerts potent neuroprotective effects and inhibits stress-triggered cell death via modulation of gene expression, as well as by antagonizing different types of neurotoxic stress [2]. It was also observed that the biochemical processing of APP is downregulated during aging which in turn reduced the secretion of sAPPα [3]. Based on these observations, we have studied the potential physiological function of sAPPα/APP and APLPs (APP like proteins) on the regulation of age-associated, stress induced signaling pathways, apoptosis and senescence.
Materials and methods: SH-SY5Y, PC12, IMR90 cells were used as cellular models. Depletion of APP, APLP1 (APP like protein 1) and APLP2 (APP like protein 2) in SH-SY5Y cells was achieved by stable lentiviral knockdown. To analyze the protective function of sAPPα, we have used conditioned supernatants of wild type APP overexpressing HEK cells and recombinant His-tagged sAPPα purified from yeast. The cells were treated with sAPPα prior to the addition of different stress stimuli (MG132, epoxomicin, UV, H2O2) after which cell death, gene expression and senescence were analyzed by MTT assays, caspase activity assays, Western blots and X-Gal staining respectively.
Results: Our data show that sAPPα can antagonize premature senescence induced by repetitive short term induction of proteasomal stress in IMR-90 cells and apoptosis triggered by prolonged proteasomal stress and other death stimuli in PC12, SH-SY5Y and IMR90 cells which was accompanied by a sAPPα-dependent inhibition of the JNK stress signaling pathway. In contrast, no significant changes in cell viability and apoptosis were observed when APP knockdown cells were pretreated with sAPPα.
Conclusions: Our observations suggest that sAPPα can antagonize both apoptosis and cellular senescence and requires expression of holo-APP to mediate its cytoprotective effects. They also support the notion that the physiological function of APP is linked to modulation of neuronal and brain aging.
poster presentation at the 31st International Symposium on Lattice Field Theory LATTICE 2013:
We explore and compare three mixed action setups with Wilson twisted mass sea quarks and different valence quark actions: (1) Wilson twisted mass, (2) Wilson twisted mass + clover and (3) Wilson + clover. Our main goal is to reduce lattice discretization errors in mesonic spectral quantities, in particular to reduce twisted mass parity and isospin breaking.
Background: After induction of DNA double strand breaks (DSBs), the DNA damage response (DDR) is activated. One of the earliest events in DDR is the phosphorylation of serine 139 on the histone variant H2AX (gH2AX) catalyzed by phosphatidylinositol 3-kinases-related kinases. Despite being extensively studied, H2AX distribution[1] across the genome and gH2AX spreading around DSBs sites[2] in the context of different chromatin compaction states or transcription are yet to be fully elucidated.
Materials and methods: gH2AX was induced in human hepatocellular carcinoma cells (HepG2) by exposure to 10 Gy X-rays (250 kV, 16 mA). Samples were incubated 0.5, 3 or 24 hours post irradiation to investigate early, intermediate and late stages of DDR, respectively. Chromatin immunoprecipitation was performed to select H2AX, H3 and gH2AX-enriched chromatin fractions. Chromatin-associated DNA was then sequenced by Illumina ChIP-Seq platform. HepG2 gene expression and histone modification (H3K36me3, H3K9me3) ChIP-Seq profiles were retrieved from Gene Expression Omnibus (accession numbers GSE30240 and GSE26386, respectively).
Results: First, we combined G/C usage, gene content, gene expression or histone modification profiles (H3K36me3, H3K9me3) to define genomic compartments characterized by different chromatin compaction states or transcriptional activity. Next, we investigated H3, H2AX and gH2AX distributions in such defined compartments before and after exposure to ionizing radiation (IR) to study DNA repair kinetics during DDR. Our sequencing results indicate that H2AX distribution followed H3 occupancy and, thus, the nucleosome pattern. The highest H2AX and H3 enrichment was observed in transcriptionally active compartments (euchromatin) while the lowest was found in low G/C and gene-poor compartments (heterochromatin). Under physiological conditions, the body of highly and moderately transcribed genes was devoid of gH2AX, despite presenting high H2AX levels. gH2AX accumulation was observed in 5’ or 3’ flanking regions, instead. The same genes showed a prompt gH2AX accumulation during the early stage of DDR which then decreased over time as DDR proceeded.
Finally, during the late stage of DDR the residual gH2AX signal was entirely retained in heterochromatic compartments. At this stage, euchromatic compartments were completely devoid of gH2AX despite presenting high levels of non-phosphorylated H2AX.
Conclusions: We show that gH2AX distribution ultimately depends on H2AX occupancy, the latter following H3 occupancy and, thus, nucleosome pattern. Both H2AX and H3 levels were higher in actively transcribed compartments. However, gH2AX levels were remarkably low over the body of actively transcribed genes suggesting that transcription levels antagonize gH2AX spreading. Moreover, repair processes did not take place uniformly across the genome; rather, DNA repair was affected by genomic location and transcriptional activity. We propose that higher H2AX density in euchromaticcompartments results in high relative gH2AXconcentration soon after the activation of DDR, thus favoring the recruitment of the DNA repair machinery to those compartments. When the damage is repaired and gH2AX is removed, its residual fraction is retained in the heterochromatic compartments which are then targeted and repaired at later times.
Oral presentation: 23rd World Congress of the World Society of Cardio-Thoracic Surgeons. Split, Croatia. 12-15 September 2013.
Background: Partial upper sternotomy (PUS) is established less invasive approach for single and double valve surgery. Reports of aortic surgery performed through PUS are rare.
Methods: The records of 52 patients undergoing primary elective surgery on the proximal aorta through PUS between 2005 and 2011 were reviewed. Patients mean age was 57 years, 35% were in NYHA Class III or IV, 59% had recent cardiac decompensation, and 17% had pulmonary hypertension. The PUS was taken down to the 4th left intercostal space in 44 patients (85%).
Results: No conversion to full sternotomy was necessary. The aortic cross-clamp, cardiopulmonary bypass and operative times averaged 136 ± 20 min., 186 ± 36 min. and 327 ± 83 min., respectively. In eight patients, the right axillary artery was cannulated for establishing cardiopulmonary bypass; the others were cannulated centrally. All patients except one received a procedure on the ascending aorta, either replacement in 30 (58%) or reduction aortoplasty in 21 (40%). Aortic root replacement was additionally performed in 31 patients (60%), including David in 20 (38%) and Ross procedure in 6 (11.5%). The aortic arch was replaced either partially in 5 (10%) or totally in 3 (6%) patients, in moderate hypothermia employing antegrade cerebral perfusion. Additional procedures, included mitral valve repair in 15 (29%) patients and coronary grafting. Ventilation time, intensive care unit and hospital stay averaged 17 ± 12 hours, 2 ± 1, and 11 ± 9 days. Chest drainage was 470 ± 380 ml/24 hours. Permanent neurologic deficit did not occur. Wound dehiscence was observed in a single patient (2%). Thirty-day and hospital mortality were not observed.
Conclusions: Less invasive surgery on the aortic root, ascending aorta and aortic arch can be performed safely and reproducibly. Potential benefits include a minimized risk of wound dehiscence and reduced postoperative bleeding. The PUS does not compromise the quality of the operation.
The present article discusses several aspects of the so-called correlate-es construction in German. This complex clausal construction can be identified by a correlative nominal element es ('it') occuring in the matrix clause and a right-peripheral full clausal argument linked to es. The article supports the hypothesis that correlative es has a janus-faced nature between an expletive and a referential meaning. This is the reason why existing approaches are not sufficient to capture the properties of the discussed construction in its entirety. The first part of the article sums up the common view on correlative es including the empirical properties of the construction as well as a brief survey of the relevant previous approaches trying to account for correlative es. Based on new empirical data, the second part of the article shows that none of these accounts is able to capture all relevant facts of the correlate-es construction because existing approaches usually ignore that the realization of correlative es is verb-class dependent. Hence, a new constraint-based analysis is developed that takes both empirical observations into account, the verb-class dependence and the janus-faced nature.
We show how the variation in the passive in Danish, English, and German can be accounted for. The dimensions in which the three languages differ are
- the existence of a morphological passive in Danish
- a subject requirement in Danish and English resulting in expletive insertion in impersonal
- constructions in Danish and absence of impersonal passives in English the possibility to promote the secondary object to subject in Danish
The differences are accounted for by differences in the structural/lexical case distinction and by mapping processes that insert expletives in Danish. The passive in general is accounted for by a lexical rule that is uniform across languages and hence captures the generalization regarding passive.
This paper presents an analysis of the complex NP island effects in Chinese. I follow Ginzburg & Sag (2000)'s analysis of in situ wh-interrogative construction and propose that feature percolation from the non-head clause daughter to the head daughter is required for a proper treatment of in situ wh-relative. A semantic analysis of the idiosyncrasy of weishenme 'why' reveals that a definite reading is forced for a wh-relative when weishenme stays in situ. This requirement causes feature percolation into relative head to fail. In this way I show that island effects in Chinese can be independently ruled out in the grammar as a case of contradiction.
Khoekhoe, a Central Khoisan language, has been claimed to have a clause-second position and topological fields similar to German and Dutch. The position in front of the clause-second position can be occupied by either the matrix verb or a dependent. We argue that monomoraic words are exempt from the general head-final order of Khoekhoe and suggest that this can give rise to discontinuous constituents, where second-position clitics intervene within the VP. We show that this idea provides a simple account of Khoekhoe word order variation and formalize it within a linearization-based HPSG analysis that has a wider scope than the previous Minimalist analyses of Khoekhoe and that is compatible with evidence from tonology.
In this paper I introduce the notion of Usage Preferences (UPs), which are statistically significant preferences in usage which can concern any aspect of linguistics. I suggest that multiple violations of UPs can have additive effects, causing grammatical sentences to be judged as unacceptable. A new judgment on sentences is proposed, the downarrow (↓) to mark sentences that are taken to be grammatical but unacceptable due to UP violations. I illustrate the idea of UPs on the basis of a discussion of the English verbal anaphor do so, involving both a corpus analysis and two acceptability experiments. This leads to a discussion of the relationship between grammaticality and acceptability and to remarks on the methodological importance of taking UPs into account both in linguistic theorizing and in the construction of acceptability experiments.
In most recent work, Crysmann and Bonami (2012) suggest to reconcile the insights of inferential-realisational morphology (Anderson, 1992; Stump, 2001; Brown and Hippisley, 2012) with the full typology of variable morphotactics: situations where the expression of analogous feature sets can appear in various positions in the string. The authors proposed to account for these facts by importing, into HPSG, a variant of Paradigm Function Morphology (Stump, 2001) where realisation rules are doubly indexed for linear position and paradigmatic opposition. In this paper we first introduce more empirical challenges for theories of morphotactics that neither PFM nor the reformist approach of Crysmann and Bonami (2012) can accommodate. We then argue for a reappraisal of methods for morph introduction, and propose a new approach that replaces stipulation of classes of paradigmatic opposition with a general distinction between expression and conditioning (Carstairs, 1987; Noyer, 1992) which greatly expands the scope of Pāṇini’s Principle.
Unbounded dependencies in Modern Standard Arabic often involve not a gap but a null resumptive pronoun. The facts are quite complex, but it is not too difficult to extend the SLASH mechanism of HPSG to handle dependencies with a null resumptive pronoun. It is also not too difficult to restrict the distribution of gaps appropriately.
Simpler Syntax is an approach to grammar that calls for very restrictive limits on the notion of 'grammatical competence'. Specifically, it does not account for unacceptability judgments for sentences that are well-formed if they are fully licensed by the constructions of the language. SS leads us to seek accounts for such judgments in terms other than grammar per se, e.g., processing complexity, semantic or pragmatic well-formedness, discourse coherence, etc. I review several examples that suggest that the line that SS draws between competence on the one hand and performance and other mechanisms on the other is on the right track. Specifically, it does not account for unacceptability judgments for sentences that are well-formed if they are fully licensed by the constructions of the language. SS leads us to seek accounts for such judgments in terms other than grammar per se, e.g., processing complexity, semantic or pragmatic well-formedness, discourse coherence, etc. I review several examples that suggest that the line that SS draws between competence on the one hand and performance and other mechanisms on the other is on the right track.
This paper presents a unified approach to multiple nominative and accusative constructions in Korean. We identify 16 semantic relations holding between two consecutive NPs in multiple case marking constructions, and propose each semantic relation as a licensing condition on double case marking. We argue that the multiple case marking constructions are merely the sequences of double case marking, which are formed by dextrosinistrally sequencing the pairs of the same-case marked NPs of same or different type. Some appealing consequences of this proposal include a new comprehensive classification of the sequences of same-case NPs and a straightforward account of some long standing problems such as how the additional same-case NPs are licensed, and in what respects the multiple nominative marking and the multiple accusative marking are alike and different from each other.
Nonverbal predicates in Modern Hebrew have been the subject of investigation in a number of studies. However, to our knowledge, none of them was corpus-based. Corpus searches reveal that the nonverbal constructions which are most commonly addressed in the literature are not the most commonly used ones. Once a broader range of data is considered additional issues are raised. Our analysis addresses these issues, unifying the treatment of three types of copular constructions that we identify in MH. The analysis is implemented as part of a larger-scale grammar, and is extensively tested.
Hungarian infinitival constructions have both mono-clausal and bi-clausal properties at the same time. The arguments of the infinitive behave the same way as the arguments of the finite verb do, but the non-finite verb has its own left periphery. After discussing the general description of Hungarian sentence structure and presenting an HPSG analysis for it – including a description of the connection between word order and scope order in the Hungarian left periphery – this paper presents an analysis for Hungarian infinitival constructions. The analysis lexically distinguishes the left peripheral arguments of the infinitive from its complements, and allows the infinitive and its left peripheral arguments to form constituents, while the complements of the infinitive are inherited to the finite verb.
This paper presents a syntactic HPSG analysis of distance distributivity in Polish, where the challenge is to uniformly analyse a number of function lexemes PO 'each' which share their form and semantic contribution, but differ in their syntactic behaviour. To this end, the HPSG notion of weak head is employed in a novel way.
In Dutch V-final clauses the verbs tend to form a cluster in which the main verb is separated from its syntactic arguments by one or more other verbs. In HPSG the link between the main verb and its arguments is canonically modeled in terms of argument inheritance, also known as argument composition or generalized raising. When applied to Dutch, this treatment yields a number of problems, making incorrect predictions about the interaction with the binding principles and the passive lexical rule. To repair them this paper proposes an alternative, in which subject raising and complement raising are modeled in terms of different devices. More specifically, while subject raising is modeled in terms of lexical constraints, as for English, complement raising is modeled in terms of a more general constraint on headed phrases. This new constraint not only accounts for complement raising out of verbal complements, it also deals with complement raising out of adjectival and adpositional complements, as well as with complement raising out of PP adjuncts and subject NPs. It is, hence, a rather powerful device. To prevent overgeneration we add a number of constraints. For Dutch, the relevant constraints block complement raising out of CPs, V-initial VPs and P-initial PPs. For English, the Empty COMPS Constraint is sufficient to block complement raising entirely.
Zum Themenfeld "Diversität und Vielfalt" diskutierten im Rahmen des 8. Treffens des Nachwuchsnetzwerkes "Stadt, Raum, Architektur" Wissenschaftler_innen aus den Sozial-, Geistes- und Raumwissenschaften an den Instituten für Humangeographie, Kulturanthropologie und Europäische Ethnologie der Goethe-Universität Frankfurt am Main am 9. und 10. November 2012. Vor dem Hintergrund aktueller Debatten um die Konzeptualisierung von sowie den praktischen Umgang mit soziokultureller Vielfalt fand ein produktiver Austausch aus den Perspektiven der Stadtplanung, der Architekturwissenschaft sowie der sozial- und kulturwissenschaftlichen Stadt- und Raumforschung statt. Die Ergebnisse dieser interdisziplinären Auseinandersetzung hinsichtlich einer globalen Diskursverschiebung von "Multikulturalismus" zu "Diversität" und der Adaption entsprechender Strategien in Politik, Wirtschaft und Gesellschaft werden in diesem Tagungsbericht anhand theoretischer Ansätze zu "Super-Diversity", Kosmopolitismus und Transnationalismus diskutiert. Empirisch werden insbesondere Fragen zu Standortmarketing, Integrationspolitiken und der Verräumlichung von Diversität sowie konkreter Praktiken der Segregation, Marginalisierung und Aushandlung von Differenz aufgegriffen. Abschließend wird die Frage nach Konflikten und Potenzialen einer "neuen Diversität" aus stadtplanerischer, dekolonialer und poststrukturalistischer Perspektive diskutiert.
Modeling the effects of neuronal morphology on dendritic chloride diffusion and GABAergic inhibition
(2014)
Poster presentation at the Twenty Third Annual Computational Neuroscience Meeting: CNS*2014 Québec City, Canada. 26-31 July 2014.
Gamma-aminobutyric acid receptors (GABAARs) are ligand-gated chloride (Cl−) channels which mediate the majority of inhibitory neurotransmission in the CNS. Spatiotemporal changes of intracellular Cl− concentration alter the concentration gradient for Cl− across the neuronal membrane and thus affect the current flow through GABAARs and the efficacy of GABAergic inhibition. However, the impact of complex neuronal morphology on Cl− diffusion and the redistribution of intracellular Cl− is not well understood. Recently, computational models for Cl− diffusion and GABAAR-mediated inhibition in realistic neuronal morphologies became available [1-3]. Here we have used computational models of morphologically complex dendrites to test the effects of spines on Cl− diffusion. In all dendritic morphologies tested, spines slowed down longitudinal Cl− diffusion along dendrites and decreased the amount and spatial spread of synaptically evoked Cl− changes. Spine densities of 2-10 spines/µm decreased the longitudinal diffusion coefficient of Cl− to 80-30% of its value in smooth dendrites, respectively. These results suggest that spines are able to limit short-term ionic plasticity [4] at dendritic GABAergic synapses.
Poster presentation at 1st International Workshop on Odor Spaces.
Mice are exceptional in their ability to capture their chemical environment, mapping the olfactory world into a basic sensory representation with over one thousand different types of chemical sensors, that is, olfactory sensory neurons (OSNs). OSNs of each type converge in the olfactory bulb onto exclusive distinct physiological areas called glomeruli. The glomeruli constitute the first relay station of olfactory stimulus representation in the mouse brain. Thus, the stimulus induced glomerular input pattern spatially embodies an important part of the sensory representation in the olfactory bulb. Still, topographic organization principles (chemotopy, tunotopy) are under debate. One reason might be that investigation are, due to experimental limitations, only performed on stimuli sets in the size of one hundred odors. But this represents only a tiny snapshot of the vast amount of molecules in the olfactory world and topographic relationships might be disguised in the incomplete representation of molecular receptive ranges (MRR). Therefore we investigated the problem with the MOR18-2 glomerulus as point of reference: First we determined it's MRR. Then, based on a measurement set covering this MRR, we elucidated the topographic embedding. It shows that MOR18-2 is embedded in a hierarchy of patchy tunotopic domains.
Der Frankfurter Tag der Rechtspolitik inszeniert sich mittlerweile als traditionsreich. Seit dreiundzwanzig Jahren, weiß Rudolf Steinberg, ehemaliger Präsident der Universität Frankfurt und Redner an diesem Tage, ist die Veranstaltung in der Welt und nennt als maßgeblichen Geburtshelfer: sich selbst. Vanité oblige. Dabei vergisst er zu erwähnen, dass die Frankfurter Tage der Rechtspolitik nach und nach auf einen halben Arbeitstag zusammengeschrumpft sind und in der Vergangenheit nicht selten einen so trüben Eindruck machten, dass man dazu überging, über Prüfungsandrohung Druck auf Studierende auszuüben, die mittlerweile die Reihen füllen, was heißt: Komparsenrollen einnehmen. Es reden und diskutieren andere. ...
Based on a non-rigorous formalism called the “cavity method”, physicists have made intriguing predictions on phase transitions in discrete structures. One of the most remarkable ones is that in problems such as random k-SAT or random graph k-coloring, very shortly before the threshold for the existence of solutions there occurs another phase transition called condensation [Krzakala et al., PNAS 2007]. The existence of this phase transition seems to be intimately related to the difficulty of proving precise results on, e. g., the k-colorability threshold as well as to the performance of message passing algorithms. In random graph k-coloring, there is a precise conjecture as to the location of the condensation phase transition in terms of a distributional fixed point problem. In this paper we prove this conjecture, provided that k exceeds a certain constant k0.
Vom 27. Juli bis 05. August 2014 veranstaltete die Akademie BURG FÜRSTENECK die 4. Hessische Schülerakademie für die Mittelstufe (Jgs. 7-9). Es gibt nichts Schöneres als Ferien! Das dachten sicher auch die 60 zwölf- bis fünfzehnjährigen Schülerinnen und Schüler, die sich in den alten Burgmauern trafen. Allerdings entschieden sie sich nach einer aufwändigen Bewerbung dafür, einen Teil ihrer Sommerferien „ganz anders“ zu verbringen. Neugierig und voller Wissensdurst beschäftigten sich die vielfältig begabten jungen Menschen in den Hauptkursen mit folgenden Themen: Zaubern in der Chemie, geheimnisvollen Botschaften in der Mathematik, der Entdeckung des Lebensraums Baum in Biologie, überraschenden Experimenten in der Physik und den Facetten des Teenageralltags, dargestellt im Kurs Kunst und Kultur.
Europeana provides a common access point to digital cultural heritage objects across different cultural domains among which the libraries. The recent development of the Europeana Data Model (EDM) provide new ways for libraries to experiment with Linked Data. Indeed the model is designed as a framework reusing various wellknown standards developed in the Semantic Web Community, such as the Resource Description Framework (RDF), the OAI Object Reuse and Exchange (ORE), and Dublin Core namespaces. It provides new opportunities for libraries to provide rich and interlinked metadata to the Europeana aggregation.
However to be able to provide data to Europeana, libraries need to create mappings from the librarystandard to EDM. This step involves decisions based on domainspecific requirements and on the possibilities offered by EDM. The crossdomain nature of EDM limiting in some cases the completeness of the mappings, extension of the model have been proposed to accommodate the library needs.
The "Digitised Manuscripts to Europeana" project (DM2E) has created an extension of EDM to optimise the mappings of librarydata for manuscripts. This extension is in the form of subclasses and subproperties that further specialise EDM concepts and properties. It includes spatial creation and publishing information, specific contributor and publication type properties and more.
Furthermore the granularity of the mapping has been extended to allow references and annotations on page level as required for scholarly work. As part of this project the metadata of the Hebrew Manuscripts as well as of the Medieval Manuscripts presented in the Digital Collections of the Frankfurt University Library have been mapped to this extension. This includes links to the Integrated Authority File (GND) of the German National Library with further links to the Virtual International Authority File (VIAF).
Based on this development a new comprehensive mapping from the digitalisation metadata format METS/MODS to EDM has been established for all materials of the Frankfurt Judaica in "Judaica Europeana ". It demonstrates today’s capabilities of the creation of linked Data structures in Europeana based on library catalogue data and structural data from the digitalisation process.
Vom 12.-14. September 2013 fand die 10. Arbeitstagung der AG Frühe Neuzeit in München statt. ARNDT BRENDECKE (München) hieß alle Teilnehmer der Tagung in München willkommen. Die Frühneuzeitforschung behandele seit langer Zeit mit bemerkenswert innovativen Ansätzen Latenzen. Diese werden traditioneller Weise mit einem "Plot der Moderne" in Verbindung gebracht, der unterstellt, dass der Wandel zur Moderne im Modus einer Inkubation vorbereitet, ja "ausgebrütet" werde, wie z.B. beim Geist des Kapitalismus, der Sozialdisziplinierung oder der Konfessionalisierung. Praxeologische Ansätze würden auch auf das Latente verweisen, nämlich auf Praktiken, die dem Diskurs und dem zeitgenössischen Nachdenken weitgehend entzogen waren. Damit bestehe die Chance, an innovative, vielschichtige und stark reflexive Traditionen der Frühneuzeitforschung anzuknüpfen, zugleich aber Distanz zu hegelianischen Unterstellungen über das unsichtbare Wesentliche der Geschichte zu gewinnen. ...
Die Gründerinnen des Arbeitskreises für spätmittelalterliche Wirtschaftsgeschichte Julia Bruch (Köln), Ulla Kypta (Frankfurt am Main) und Tanja Skambraks (Mannheim) luden vom 15. bis zum 16. November zu einer ersten Konferenz mit dem Titel "Neue Methoden der spätmittelalterlichen Wirtschaftsgeschichte" ein. In ihrer Begrüßungs- und Einführungsrede verwies ULLA KYPTA (Frankfurt am Main) auf die Methodenvielfalt in den Wirtschaftswissenschaften und die Schwierigkeiten bei der adäquaten Auswahl und dem sinnvollen Gebrauch derselben innerhalb der Wirtschaftsgeschichte. So bedinge die Anwendung von wirtschaftswissenschaftlichen Modellen immer wieder die Konfrontation mit den empirischen Quellenbefunden. Neben den wirtschaftswissenschaftlichen seien die sozial- und kulturwissenschaftlichen Ansätze ebenfalls in das Methodenspektrum der Wirtschaftshistoriker aufzunehmen. ...
Impairment in past tense production as well as interaction between tense and aspect have been found in both fluent and non-fluent aphasia (e.g. Dragoy & Bastiaanse, 2013). Inflection has been found to be relatively preserved in semantic dementia (SD) (Thompson et al., 2012). The aims of the present study are a) to compare the morphosyntactic abilities of patients with aphasia and SD in tense and aspect marking and b) to explore the interaction of lexical (+/- telic) and grammatical (perfective/imperfective) aspect in aphasia and SD. A sentence completion task was administered to 30 native speakers of Greek: 10 patients with aphasia (6 anomic, 2 Wernicke and 2 agrammatic), 10 age and education-matched controls, 5 patients with SD and 5 controls. The material consisted of unergative, unaccusative and transitive verbs (12 of each verb class) and the participants had to apply present (imperfective) and past (perfective) tense. Unergative and unaccusative verbs differ in terms of their aspectual properties with the unergative being [-telic], and unaccusative [+telic]. Transitive verbs vary. A principal distinction between the tested conditions was the standard ummarked combination ([+telic] verbs in past perfective and [–telic] verbs in present imperfective) vs. the marked one ([+telic] verbs in present imperfective and [–telic] in past perfective). Both control groups performed at ceiling in all conditions. Aphasic participants were significantly more impaired than the control group in all conditions. SD participants were significantly more impaired than the controls only in the production of present tense (M-W U= 1.5, p= 0.024). There was no difference between past perfective and present imperfective for neither group, but there was an interaction between verb class and tense for the aphasic participants, as performance in unaccusative verbs in past perfective (unmarked condition) was significantly better than in unergatives in past perfective (marked condition) (Z=2.512, p=0.012) but performance in unaccusatives in present imperfective (marked condition) was significantly worse than performance in unergatives in present imperfective (unmarked condition) (Z=2.680, p=0.004). In sum, aphasic participants performed significantly better in the unmarked than in the marked conditions. Such an interaction was not found for the SD group. Aphasic participants performed significantly worse than the SD subjects in past perfective tense (M-W U= 7.5, p=0.029) in total, and the difference was significant only for unaccusative verbs (M-W U= 6.5, p=0.021), although both groups performed very well in this condition. There was no difference in present, neither for each verb class separately nor for the total score. A general past tense deficit cannot be upheld for either group. Rather, SD participants appear relatively impaired in producing present tense. We argue for slight morphosyntactic impairment in SD, although with a different underlying cause than in aphasia. Moreover, our data suggest an effect of aspectual markedness in aphasia but not in SD. We discuss this finding in the light of the different neuropathology of the two populations.
XIII Nuclei in the Cosmos, 7-11 July, 2014 Debrecen, Hungary.
As an alternative production scenario to the so-called g process, the most abundant p nucleus 92Mo may be produced by a chain of proton-capture reactions in supernovae type Ia. The reactions 90Zr(p,g) and 91Nb(p,g) are the most important reactions in this chain. We have measured the first reaction using high-resolution in-beam g-spectroscopy at HORUS, Cologne, Germany, to contribute to the existing experimental data base. So far, we only investigated the high-energy part of the Gamow window and the analysis is still in progress. We plan to study the second reaction in standard kinematics at the FRANZ facility, Frankfurt, Germany. Current developments at FRANZ will be explained in detail.
Die Hessische Schülerakademie 2014 stand ganz im Zeichen ihres 10jährigen Bestehens. Seit Gründung der Oberstufenakademie im Jahre 2004 durch Cynthia Hog-Angeloni und Wolfgang Metzler hat sich die "HSAKA" selbstverständlich verändert; das ist bei einem so ambitionierten Projekt auch gar nicht anders denkbar. Die Hessische Schülerakademie hat sich behauptet, indem sie immer wieder neue Impulse aufgenommen und sich beständig um Verbesserung bemüht hat – und sie ist gewachsen.
We investigate the properties of the QCD matter across the deconfinement phase transition. In the scope of the parton-hadron string dynamics (PHSD) transport approach, we study the strongly interacting matter in equilibrium as well as the out-of equilibrium dynamics of relativistic heavy-ion collisions. We present here in particular the results on the electromagnetic radiation, i.e. photon and dilepton production, in relativistic heavy-ion collisions and the relevant correlator in equilibrium, i.e. the electric conductivity. By comparing our calculations for the heavy-ion collisions to the available data, we determine the relative importance of the various production sources and address the possible origin of the observed strong elliptic flow ν2 of direct photons.
We discuss recent applications of the partonic perturbative QCD based cascade model BAMPS with focus on heavy-ion phenomenology in the hard and soft momentum range. First, the elliptic flow and suppression of charm and bottom quarks are studied at LHC energies. Thereafter, we compare in a detailed study the standard Gunion-Bertsch approximation of the matrix elements for inelastic processes to the exact results in leading order perturbative QCD. Since a disagreement is found, we propose an improved Gunion-Bertsch matrix element, which agrees with the exact result in all phase space regions.
We have measured the radiative neutron-capture cross section and the total neutron-induced cross section of one of the most important isotopes for the s process, the 25Mg. The measurements have been carried out at the neutron time-of-flight facilities n_TOF at CERN (Switzerland) and GELINA installed at the EC-JRC-IRMM (Belgium). The cross sections as a function of neutron energy have been measured up to approximately 300 keV, covering the energy region of interest to the s process. The data analysis is ongoing and preliminary results show the potential relevance for the s process.
We present results for calculating fusion cross-sections using a new microscopic approach based on a time-dependent density-constrained DFT calculations. The theory is implemented by using densities and other information obtained from TDDFT time-evolution of the nuclear system as a constraint on the density for DFT calculations.
Poster presentation at The Twenty Third Annual Computational Neuroscience Meeting: CNS*2014 Québec City, Canada. 26-31 July 2014: We study random strongly heterogeneous recurrent networks of firing rate neurons, introducing the notion of cohorts: groups of co-active neurons, who compete for firing with one another and whose presence depends sensitively on the structure of the input. The identities of neurons recruited to and dropped from an active cohort changes smoothly with varying input features. We search for network parameter regimes in which the activation of cohorts is robust yet easily switchable by the external input and which exhibit large repertoires of different cohorts. We apply these networks to model the emergence of orientation and direction selectivity in visual cortex. We feed these random networks with a set of harmonic inputs that vary across neurons only in their temporal phase, mimicking the feedforward drive due to a moving grating stimulus. The relationship between the phases that carries the information about the orientation of the stimulus determines which cohort of neurons is activated. As a result the individual neurons acquire non-monotonic orientation tuning curves which are characterized by high orientation and direction selectivity. This mechanism of emergence for direction selectivity differs from the classical motion detector scheme, which is based on the nonlinear summation of the time-shifted inputs. In our model these two mechanisms coexist in the same network, but can be distinguished by their different frequency and contrast dependences. In general, the mechanism we are studying here converts temporal phase sequence into population activity and could therefore be used to extract and represent also various other relevant stimulus features.
D2.1. provides further elaboration of the original research design and informs about ideas for the final Volume II of bEUcitizen. It is closely connected to task 1 of work package 2: specifying various concrete tasks for the different work packages and formulating overarching questions suitable to provide substantive cohesion and integration of the overall project. The elaboration of 10 crosscutting topics (to become chapters in the “horizontal” book, D2.3.) is a first step towards this goal. Discussing these cross-cutting topics is supposed to feed, infuse and inspire the work done in the different work packages and to build cross-cutting connections between them. Themes 1-10 merge into a valuable overview of the multi-faceted research on (EU) citizenship. They access the main issues of EU-citizenship and citizenship in general from different angles and different disciplines. Taken together these contributions help to identify barriers towards EU citizenship and ways to overcome them. Each Theme formulates questions how it might feed and be fed by further information and findings in the other work packages.
D2.1. is mainly meant for internal use. Its functions are firstly to inform about preliminary ideas, eventual contributions to planned final results and secondly to make out some more of less specific guiding questions that connect the work done by the single researchers in every different work package to the project as a whole. This task implies a normative yardstick, a clear picture of what would be a "good" EU citizenship practice. Elaborating on such a normative yardstick is a meta-topic that cuts across the range of cross-cutting topics presented in this working paper.