Refine
Year of publication
- 2009 (862) (remove)
Document Type
- Article (362)
- Book (118)
- Doctoral Thesis (116)
- Part of Periodical (89)
- Working Paper (80)
- Conference Proceeding (28)
- Report (21)
- Part of a Book (15)
- Preprint (12)
- Review (10)
Language
- English (862) (remove)
Keywords
- Deutschland (6)
- Haushalt (6)
- Lambda-Kalkül (6)
- Pragmatik (6)
- USA (6)
- new species (6)
- Bank (5)
- Optimalitätstheorie (5)
- China (4)
- Household Finance (4)
Institute
- Medizin (113)
- Biochemie und Chemie (112)
- Biowissenschaften (43)
- Physik (42)
- Geowissenschaften (41)
- Center for Financial Studies (CFS) (35)
- Frankfurt Institute for Advanced Studies (FIAS) (29)
- Informatik (21)
- Wirtschaftswissenschaften (21)
- E-Finance Lab e.V. (20)
We study the beam-energy and system-size dependence of \phi meson production (using the hadronic decay mode \phi -- K+K-) by comparing the new results from Cu+Cu collisions and previously reported Au+Au collisions at \sqrt{s_NN} = 62.4 and 200 GeV measured in the STAR experiment at RHIC. Data presented are from mid-rapidity (|y|<0.5) for 0.4 < pT < 5 GeV/c. At a given beam energy, the transverse momentum distributions for \phi mesons are observed to be similar in yield and shape for Cu+Cu and Au+Au colliding systems with similar average numbers of participating nucleons. The \phi meson yields in nucleus-nucleus collisions, normalised by the average number of participating nucleons, are found to be enhanced relative to those from p+p collisions with a different trend compared to strange baryons. The enhancement for \phi mesons is observed to be higher at \sqrt{s_NN} = 200 GeV compared to 62.4 GeV. These observations for the produced \phi(s\bar{s}) mesons clearly suggest that, at these collision energies, the source of enhancement of strange hadrons is related to the formation of a dense partonic medium in high energy nucleus-nucleus collisions and cannot be alone due to canonical suppression of their production in smaller systems.
The STAR Collaboration at the Relativistic Heavy Ion Collider presents measurements of 𝐽/𝜓→𝑒+𝑒− at midrapidity and high transverse momentum (𝑝𝑇>5 GeV/𝑐) in 𝑝+𝑝 and central Cu+Cu collisions at √𝑠𝑁𝑁=200 GeV. The inclusive 𝐽/𝜓 production cross section for Cu+Cu collisions is found to be consistent at high 𝑝𝑇 with the binary collision-scaled cross section for 𝑝+𝑝 collisions. At a confidence level of 97%, this is in contrast to a suppression of 𝐽/𝜓 production observed at lower 𝑝𝑇. Azimuthal correlations of 𝐽/𝜓 with charged hadrons in 𝑝+𝑝 collisions provide an estimate of the contribution of 𝐵-hadron decays to 𝐽/𝜓 production of 13%±5%.
The archaeal ATP synthase is a multisubunit complex that consists of a catalytic A(1) part and a transmembrane, ion translocation domain A(0). The A(1)A(0) complex from the hyperthermophile Pyrococcus furiosus was isolated. Mass analysis of the complex by laser-induced liquid bead ion desorption (LILBID) indicated a size of 730 +/- 10 kDa. A three-dimensional map was generated by electron microscopy from negatively stained images. The map at a resolution of 2.3 nm shows the A(1) and A(0) domain, connected by a central stalk and two peripheral stalks, one of which is connected to A(0), and both connected to A(1) via prominent knobs. X-ray structures of subunits from related proteins were fitted to the map. On the basis of the fitting and the LILBID analysis, a structural model is presented with the stoichiometry A(3)B(3)CDE(2)FH(2)ac(10).
Medical students are exposed to infectious diseases during the course of their clinical training. Unfortunately, vaccination rates among medical students remain insufficient. However, immunizations against vaccine-preventable diseases should be carried out before the students enter clinical courses. This is vital in order to prevent nosocomial infections. We screened 366 medical students in their first clinical year for hospital-related viral diseases. Serum samples were collected between April and May 2007. Antibody testing was carried out using commercial ELISA systems against measles, mumps, rubella, varicella, hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV). Overall, 63.9% (n=234) of the students were sufficiently vaccinated against HBV. In contrast, 31.7% (n=116) had not received any HBV vaccine dosage, and 4.4% (n=16) had not completed the full vaccine cycle (<3 dosage). Remarkably, two students showed serological markers of resolved HBV infection. In addition, one student was HCV-positive and one was HIV-positive, respectively. The following seronegative rates were found: measles (7.9%), mumps (17.5%), rubella (6.5%), and varicella (2.2%). Further work is needed to identify optimal strategies for improving vaccination rates among medical students. It is imperative to identify and limit possible disparities in immunity of vaccine-preventable diseases before initial patient contact. With regard to the primary diagnosis of serious virus diseases including HBV, HCV and HIV, medical students should be screened for these blood borne pathogens.
The single nucleotide polymorphism 118A>G of the human micro-opioid receptor gene OPRM1, which leads to an exchange of the amino acid asparagine (N) to aspartic acid (D) at position 40 of the extracellular receptor region, alters the in vivo effects of opioids to different degrees in pain-processing brain regions. The most pronounced N40D effects were found in brain regions involved in the sensory processing of pain intensity. Using the mu-opioid receptor-specific agonist DAMGO, we analyzed the micro-opioid receptor signaling, expression, and binding affinity in human brain tissue sampled postmortem from the secondary somatosensory area (SII) and from the ventral posterior part of the lateral thalamus, two regions involved in the sensory processing and transmission of nociceptive information. We show that the main effect of the N40D micro-opioid receptor variant is a reduction of the agonist-induced receptor signaling efficacy. In the SII region of homo- and heterozygous carriers of the variant 118G allele (n=18), DAMGO was only 62% as efficient (p=0.002) as in homozygous carriers of the wild-type 118A allele (n=15). In contrast, the number of [3H]DAMGO binding sites was unaffected. Hence, the micro-opioid receptor G-protein coupling efficacy in SII of carriers of the 118G variant was only 58% as efficient as in homozygous carriers of the 118A allele (p<0.001). The thalamus was unaffected by the OPRM1 118A>G SNP. In conclusion, we provide a molecular basis for the reduced clinical effects of opioid analgesics in carriers of mu-opioid receptor variant N40D.
In plants, a family of more than 20 heat stress transcription factors (Hsf) controls the expression of heat stress (hs) genes. There is increasing evidence for the functional diversification between individual members of the Hsf family fulfilling distinct roles in response to various environmental stress conditions and developmental signals. In response to hs, accumulation of both heat stress proteins (Hsp) and Hsfs is induced. In tomato, the physical interaction between the constitutively expressed HsfA1 and the hs-inducible HsfA2 results in synergistic transcriptional activation (superactivation) of hs gene expression. Here, we show that the interaction is strikingly specific and not observed with other class A Hsfs. Hetero-oligomerization of the two-component Hsfs is preferred to homo-oligomerization, and each Hsf in the HsfA1/HsfA2 hetero-oligomeric complex has its characteristic contribution to its function as superactivator. Distinct regions of the oligomerization domain are responsible for specific homo- and hetero-oligomeric interactions leading to the formation of hexameric complexes. The results are summarized in a model of assembly and function of HsfA1/A2 superactivator complexes in hs gene regulation.
The cell division cycle protein 37 (Cdc37) and the 90-kDa heat shock protein (Hsp90) are molecular chaperones, which are crucial elements in the protein signaling pathway. The largest class of client proteins for Cdc37 and Hsp90 are protein kinases. The catalytic domains of these kinases are stabilized by Cdc37, and their proper folding and functioning is dependent on Hsp90. Here, we present the x-ray crystal structure of the 16-kDa middle domain of human Cdc37 at 1.88 angstroms resolution and the structure of this domain in complex with the 23-kDa N-terminal domain of human Hsp90 based on heteronuclear solution state NMR data and docking. Our results demonstrate that the middle domain of Cdc37 exists as a monomer. NMR and mutagenesis experiments reveal Leu-205 in Cdc37 as a key residue enabling complex formation. These findings can be very useful in the development of small molecule inhibitors against cancer.
An efficient route for delivering specific proteins and peptides into neurons could greatly accelerate the development of therapies for various diseases, especially those involving intracellular defects such as Parkinson disease. Here we report the novel use of polybutylcyanoacrylate nanoparticles for delivery of intact, functional proteins into neurons and neuronal cell lines. Uptake of these particles is primarily dependent on endocytosis via the low density lipoprotein receptor. The nanoparticles are rapidly turned over and display minimal toxicity to cultured neurons. Delivery of three different functional cargo proteins is demonstrated. When primary neuronal cultures are treated with recombinant Escherichia coli beta-galactosidase as nanoparticle cargo, persistent enzyme activity is measured beyond the period of nanoparticle degradation. Delivery of the small GTPase rhoG induces neurite outgrowth and differentiation in PC12 cells. Finally, a monoclonal antibody directed against synuclein is capable of interacting with endogenous alpha-synuclein in cultured neurons following delivery via nanoparticles. Polybutylcyanoacrylate nanoparticles are thus useful for intracellular protein delivery in vitro and have potential as carriers of therapeutic proteins for treatment of neuronal disorders in vivo.
Inhibition of the soluble epoxide hydrolase (sEH) has beneficial effects on vascular inflammation and hypertension indicating that the enzyme may be a promising target for drug development. As the enzymatic core of the hydrolase domain of the human sEH contains two tyrosine residues (Tyr383 and Tyr466) that are theoretically crucial for enzymatic activity, we addressed the hypothesis that the activity of the sEH may be affected by nitrosative stress. Epoxide hydrolase activity was detected in human and murine endothelial cells as well in HEK293 cells and could be inhibited by either authentic peroxynitrite (ONOO−) or the ONOO− generator 3-morpholino-sydnonimine (SIN-1). Protection of the enzymatic core with 1-adamantyl-3-cyclohexylurea in vitro decreased sensitivity to SIN-1. Both ONOO− and SIN-1 elicited the tyrosine nitration of the sEH protein and mass spectrometry analysis of tryptic fragments revealed nitration on several tyrosine residues including Tyr383 and Tyr466. Mutation of the latter residues to phenylalanine was sufficient to abrogate epoxide hydrolase activity. In vivo, streptozotocin-induced diabetes resulted in the tyrosine nitration of the sEH in murine lungs and a significant decrease in its activity. Taken together, these data indicate that the activity of the sEH can be regulated by the tyrosine nitration of the protein. Moreover, nitrosative stress would be expected to potentiate the physiological actions of arachidonic acid epoxides by preventing their metabolism to the corresponding diols.
The transporter associated with antigen processing (TAP) is an essential machine of the adaptive immune system that translocates antigenic peptides from the cytosol into the endoplasmic reticulum lumen for loading of major histocompatibility class I molecules. To examine this ABC transport complex in mechanistic detail, we have established, after extensive screening and optimization, the solubilization, purification, and reconstitution for TAP to preserve its function in each step. This allowed us to determine the substrate-binding stoichiometry of the TAP complex by fluorescence cross-correlation spectroscopy. In addition, the TAP complex shows strict coupling between peptide binding and ATP hydrolysis, revealing no basal ATPase activity in the absence of peptides. These results represent an optimal starting point for detailed mechanistic studies of the transport cycle of TAP by single molecule experiments to analyze single steps of peptide translocation and the stoichiometry between peptide transport and ATP hydrolysis.
Cyclic AMP analogs containing hydrophobic modification of C(8) at the adenine ring such as 8-(4-chlorophenylthio)-cAMP (8-pCPT-cAMP) and 8-(4-chlorophenylthio)-2'-O-methyl-cAMP (8-pCPT-2'-O-methyl-cAMP) can penetrate membranes due to their high lipophilicity and directly activate intracellular cAMP effectors. Therefore, these cAMP analogs have been used in numerous studies, assuming that their effects reflect the consequences of direct activation of cAMP effectors. The present study provides evidence that 8-pCPT-modified cAMP analogs and their corresponding putative hydrolysis products (8-(4-chlorophenylthio)-adenosine (8-pCPT-ado) and 8-(4-chlorophenylthio)-2'-O-methyl-adenosine (8-pCPT-2'-O-methyl-ado)) inhibit the equilibrative nucleoside transporter 1 (ENT1). In PC12 cells, in which nucleoside transport strongly depended on ENT1, 8-pCPT-ado, 8-pCPT-2'-O-methyl-ado, and, to a smaller extent, 8-pCPT-2'-O-methyl-cAMP caused an increase of protein kinase A substrate motif phosphorylation and anti-apoptotic effect by an A(2A) adenosine receptor (A(2A)R)-dependent mechanism. In contrast, the effects of 8-pCPT-cAMP were mainly A(2A)R-independent. In HEK 293 showing little endogenous ENT1-dependent nucleoside transport, transfection of ENT1 conferred A(2A)R-dependent increase in protein kinase A substrate motif phosphorylation. Together, the data of the present study indicate that inhibition of ENT1 and activation of adenosine receptors have to be considered when interpreting the effects of 8-pCPT-substituted cAMP/adenosine analogs.
The membrane-bound heterotrimeric nitrate reductase A (NarGHI) catalyzes the oxidation of quinols in the cytoplasmic membrane of Escherichia coli and reduces nitrate to nitrite in the cytoplasm. The enzyme strongly stabilizes a menasemiquinone intermediate at a quinol oxidation site (Q(D)) located in the vicinity of the distal heme b(D). Here molecular details of the interaction between the semiquinone radical and the protein environment have been provided using advanced multifrequency pulsed EPR methods. (14)N and (15)N ESEEM and HYSCORE measurements carried out at X-band ( approximately 9.7 GHz) on the wild-type enzyme or the enzyme uniformly labeled with (15)N nuclei reveal an interaction between the semiquinone and a single nitrogen nucleus. The isotropic hyperfine coupling constant A(iso)((14)N) approximately 0.8 MHz shows that it occurs via an H-bond to one of the quinone carbonyl group. Using (14)N ESEEM and HYSCORE spectroscopies at a lower frequency (S-band, approximately 3.4 GHz), the (14)N nuclear quadrupolar parameters of the interacting nitrogen nucleus (kappa = 0.49, eta = 0.50) were determined and correspond to those of a histidine N(delta), assigned to the heme b(D) ligand His-66 residue. Moreover S-band (15)N ESEEM spectra enabled us to directly measure the anisotropic part of the nitrogen hyperfine interaction (T((15)N) = 0.16 MHz). A distance of approximately 2.2 Abetween the carbonyl oxygen and the nitrogen could then be calculated. Mechanistic implications of these results are discussed in the context of the peculiar properties of the menasemiquinone intermediate stabilized at the Q(D) site of NarGHI.
We previously proposed that the dimeric cytochrome bc(1) complex exhibits half-of-the-sites reactivity for ubiquinol oxidation and rapid electron transfer between bc(1) monomers (Covian, R., Kleinschroth, T., Ludwig, B., and Trumpower, B. L. (2007) J. Biol. Chem. 282, 22289-22297). Here, we demonstrate the previously proposed half-of-the-sites reactivity and intermonomeric electron transfer by characterizing the kinetics of ubiquinol oxidation in the dimeric bc(1) complex from Paracoccus denitrificans that contains an inactivating Y147S mutation in one or both cytochrome b subunits. The enzyme with a Y147S mutation in one cytochrome b subunit was catalytically fully active, whereas the activity of the enzyme with a Y147S mutation in both cytochrome b subunits was only 10-16% of that of the enzyme with fully wild-type or heterodimeric cytochrome b subunits. Enzyme with one inactive cytochrome b subunit was also indistinguishable from the dimer with two wild-type cytochrome b subunits in rate and extent of reduction of cytochromes b and c(1) by ubiquinol under pre-steady-state conditions in the presence of antimycin. However, the enzyme with only one mutated cytochrome b subunit did not show the stimulation in the steady-state rate that was observed in the wild-type dimeric enzyme at low concentrations of antimycin, confirming that the half-of-the-sites reactivity for ubiquinol oxidation can be regulated in the wild-type dimer by binding of inhibitor to one ubiquinone reduction site.
We have investigated the role of reactive oxygen species and thiol-oxidizing agents in the induction of cell death and have shown that adenocarcinoma gastric (AGS) cells respond differently to the oxidative challenge according to the signaling pathways activated. In particular, apoptosis in AGS cells is induced via the mitochondrial pathway upon treatment with thiol-oxidizing agents, such as diamide. Apoptosis is associated with persistent oxidative damage, as evidenced by the increase in carbonylated proteins and the expression/activation of DNA damage-sensitive proteins histone H2A.X and DNA-dependent protein kinase. Resistance to hydrogen peroxide is instead associated with Keap1 oxidation and rapid translocation of Nrf2 into the nucleus. Sensitivity to diamide and resistance to hydrogen peroxide are correlated with GSH redox changes, with diamide severely increasing GSSG, and hydrogen peroxide transiently inducing protein-GSH mixed disulfides. We show that p53 is activated in response to diamide treatment by the oxidative induction of the Trx1/p38(MAPK) signaling pathway. Similar results were obtained with another carcinoma cell line, CaCo2, indicating that these findings are not limited to AGS cells. Our data suggest that thiol-oxidizing agents could be exploited as inducers of apoptosis in tumor histotypes resistant to ROS-producing chemotherapeutics.
The β-subunits of Na,K-ATPase and H,K-ATPase have important functions in maturation and plasma membrane targeting of the catalytic α-subunit but also modulate the transport activity of the holoenzymes. In this study, we show that tryptophan replacement of two highly conserved tyrosines in the transmembrane domain of both Na,K- and gastric H,K-ATPase β-subunits resulted in considerable shifts of the voltage-dependent E1P/E2P distributions toward the E1P state as inferred from presteady-state current and voltage clamp fluorometric measurements of tetramethylrhodamine-6-maleimide-labeled ATPases. The shifts in conformational equilibria were accompanied by significant decreases in the apparent affinities for extracellular K+ that were moderate for the Na,K-ATPase β-(Y39W,Y43W) mutation but much more pronounced for the corresponding H,K-ATPase β-(Y44W,Y48W) variant. Moreover in the Na,K-ATPase β-(Y39W,Y43W) mutant, the apparent rate constant for reverse binding of extracellular Na+ and the subsequent E2P-E1P conversion, as determined from transient current kinetics, was significantly accelerated, resulting in enhanced Na+ competition for extracellular K+ binding especially at extremely negative potentials. Analogously the reverse binding of extracellular protons and subsequent E2P-E1P conversion was accelerated by the H,K-ATPase β-(Y44W,Y48W) mutation, and H+ secretion was strongly impaired. Remarkably tryptophan replacements of residues in the M7 segment of Na,K- and H,K-ATPase α-subunits, which are at interacting distance to the β-tyrosines, resulted in similar E1 shifts, indicating their participation in stabilization of E2. Thus, interactions between selected residues within the transmembrane regions of α- and β-subunits of P2C-type ATPases exert an E2-stabilizing effect, which is of particular importance for efficient H+ pumping by H,K-ATPase under in vivo conditions.
Biogenesis of mitochondrial cytochrome c oxidase (COX) relies on a large number of assembly factors, among them the transmembrane protein Surf1. The loss of human Surf1 function is associated with Leigh syndrome, a fatal neurodegenerative disorder caused by severe COX deficiency. In the bacterium Paracoccus denitrificans, two homologous proteins, Surf1c and Surf1q, were identified, which we characterize in the present study. When coexpressed in Escherichia coli together with enzymes for heme a synthesis, the bacterial Surf1 proteins bind heme a in vivo. Using redox difference spectroscopy and isothermal titration calorimetry, the binding of the heme cofactor to purified apo-Surf1c and apo-Surf1q is quantified: Each of the Paracoccus proteins binds heme a in a 1:1 stoichiometry and with Kd values in the submicromolar range. In addition, we identify a conserved histidine as a residue crucial for heme binding. Contrary to most earlier concepts, these data support a direct role of Surf1 in heme a cofactor insertion into COX subunit I by providing a protein-bound heme a pool.
Changes in the balance of cholesterol absorption and synthesis and moderately elevated plasma plant sterols have been suggested to be atherogenic. Measuring cholestanol, lathosterol, campesterol, and sitosterol, we investigated the relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease (CAD) in 2,440 participants of the Ludwigshafen Risk and Cardiovascular health (LURIC) study. The coronary status was determined by angiography, and the severity of CAD was assessed by the Friesinger Score (FS). An increase in the ratio of cholestanol to cholesterol was associated with high FS (P = 0.006). In contrast, a high ratio of lathosterol to cholesterol went in parallel with low FS (P < 0.001). Whereas the campesterol to cholesterol ratio significantly correlated with the FS (P = 0.026), the relationship of the sitosterol to cholesterol ratio with the FS did not reach statistical significance in the whole group. Increased campesterol, sitosterol, and cholestanol to lathosterol ratios were associated high FS (P < 0.001). To conclude, there is a modest association of high cholesterol absorption and low cholesterol synthesis with an increased severity of CAD. An atherogenic role of plasma plant sterols themselves, however, seems unlikely in subjects without sitosterolaemia.
Macrophages ingesting apoptotic cells attenuate inflammatory responses, such as reactive oxygen species (ROS) generation. In atherosclerosis, ongoing inflammation and accumulation of apoptotic/necrotic material are observed, suggesting defects of phagocytes in recognizing or responding to dying cells. Modified lipoproteins such as oxidized LDL (oxLDL) are known to promote inflammation and to interfere with apoptotic cell clearance. Here, we studied the impact of cells exposed to oxLDL on their ability to interfere with the oxidative burst in phagocytes. In contrast to apoptotic cells, cells dying in response to or in the presence of oxLDL failed to suppress ROS generation despite efficiently being taken up by phagocytes. In addition, apoptotic cells, but not oxLDL-treated cells, inhibited phosphorylation of extracellular signal-regulated kinase, which is important for NADPH oxidase activation. oxLDL treatment did not interfere with activation of the antiinflammatory transcriptional regulator peroxisome proliferator-activated receptor gamma by apoptotic cells. Moreover, cells exposed to oxLDL failed to suppress lipopolysaccharide- induced proinflammatory cytokine expression, whereas apoptotic cells attenuated these phagocyte responses. Thus, the presence of oxLDL during cell death impaired the ability of apoptotic cells to act antiinflammatory with regard to oxidative burst inhibition and cytokine expression in phagocytes.
[MesnacnacZn(μ-H)]2 (1) was synthesized by reaction of MesnacnacZnI with either an equimolar amount of KNH(iPr)BH3 or an excess of NaH and characterized by multinuclear NMR and IR spectroscopy as well as X-ray diffraction. Two polymorphs of 1 were found and their structures determined on single crystals.
Flavins are employed to transform physical input into biological output signals. In this function, flavins catalyze a variety of light-induced reactions and redox processes. However, nature also provides flavoproteins with the ability to uncouple the mediation of signals. Such proteins are the riboflavin-binding proteins (RfBPs) with their function to store riboflavin for fast delivery of FMN and FAD. Here we present in vitro and in vivo data showing that the recently discovered archaeal dodecin is an RfBP, and we reveal that riboflavin storage is not restricted to eukaryotes. However, the function of the prokaryotic RfBP dodecin seems to be adapted to the requirement of a monocellular organism. While in eukaryotes RfBPs are involved in trafficking riboflavin, and dodecin is responsible for the flavin homeostasis of the cell. Although only 68 amino acids in length, dodecin is of high functional versatility in neutralizing riboflavin to protect the cellular environment from uncontrolled flavin reactivity. Besides the predominant ultrafast quenching of excited states, dodecin prevents light-induced riboflavin reactivity by the selective degradation of riboflavin to lumichrome. Coordinated with the high affinity for lumichrome, the directed degradation reaction is neutral to the cellular environment and provides an alternative pathway for suppressing uncontrolled riboflavin reactivity. Intriguingly, the different structural and functional properties of a homologous bacterial dodecin suggest that dodecin has different roles in different kingdoms of life.
The YidC/Oxa1/Alb3 family of membrane proteins controls the insertion and assembly of membrane proteins in bacteria, mitochondria, and chloroplasts. Here we describe the molecular mechanisms underlying the interaction of Alb3 with the chloroplast signal recognition particle (cpSRP). The Alb3 C-terminal domain (A3CT) is intrinsically disordered and recruits cpSRP to the thylakoid membrane by a coupled binding and folding mechanism. Two conserved, positively charged motifs reminiscent of chromodomain interaction motifs in histone tails are identified in A3CT that are essential for the Alb3-cpSRP43 interaction. They are absent in the C-terminal domain of Alb4, which therefore does not interact with cpSRP43. Chromodomain 2 in cpSRP43 appears as a central binding platform that can interact simultaneously with A3CT and cpSRP54. The observed negative cooperativity of the two binding events provides the first insights into cargo release at the thylakoid membrane. Taken together, our data show how Alb3 participates in cpSRP-dependent membrane targeting, and our data provide a molecular explanation why Alb4 cannot compensate for the loss of Alb3. Oxa1 and YidC utilize their positively charged, C-terminal domains for ribosome interaction in co-translational targeting. Alb3 is adapted for the chloroplast-specific Alb3-cpSRP43 interaction in post-translational targeting by extending the spectrum of chromodomain interactions.
The mode of the antitumoral activity of multimutated oncolytic herpes simplex virus type 1 G207 has not been fully elucidated yet. Because the antitumoral activity of many drugs involves the inhibition of tumor blood vessel formation, we determined if G207 had an influence on angiogenesis. Monolayers of human umbilical vein endothelial cells and human dermal microvascular endothelial cells, but not human dermal fibroblasts, bronchial epithelial cells, and retinal glial cells, were highly sensitive to the replicative and cytotoxic effects of G207. Moreover, G207 infection caused the destruction of endothelial cell tubes in vitro. In the in vivo Matrigel plug assay in mice, G207 suppressed the formation of perfused vessels. Intratumoral treatment of established human rhabdomyosarcoma xenografts with G207 led to the destruction of tumor vessels and tumor regression. Ultrastructural investigations revealed the presence of viral particles in both tumor and endothelial cells of G207-treated xenografts, but not in adjacent normal tissues. These findings show that G207 may suppress tumor growth, in part, due to inhibition of angiogenesis.
We developed a Monte Carlo event generator for production of nucleon configurations in complex nuclei consistently including effects of nucleon–nucleon (NN) correlations. Our approach is based on the Metropolis search for configurations satisfying essential constraints imposed by short- and long-range NN correlations, guided by the findings of realistic calculations of one- and two-body densities for medium-heavy nuclei. The produced event generator can be used for Monte Carlo (MC) studies of pA and AA collisions. We perform several tests of consistency of the code and comparison with previous models, in the case of high energy proton–nucleus scattering on an event-by-event basis, using nucleus configurations produced by our code and Glauber multiple scattering theory both for the uncorrelated and the correlated configurations; fluctuations of the average number of collisions are shown to be affected considerably by the introduction of NN correlations in the target nucleus. We also use the generator to estimate maximal possible gluon nuclear shadowing in a simple geometric model.
Forewarned is forearmed
(2009)
The upcoming high energy experiments at the LHC are one of the most outstanding efforts for a better understanding of nature. It is associated with great hopes in the physics community. But there is also some fear in the public, that the conjectured production of mini black holes might lead to a dangerous chain reaction. In this Letter we summarize the most straightforward arguments that are necessary to rule out such doomsday scenarios.
We apply a coupled transport-hydrodynamics model to discuss the production of multi-strange meta-stable objects in Pb + Pb reactions at the FAIR facility. In addition to making predictions for yields of these particles we are able to calculate particle dependent rapidity and momentum distributions. We argue that the FAIR energy regime is the optimal place to search for multi-strange baryonic object (due to the high baryon density, favoring a distillation of strangeness). Additionally, we show results for strangeness and baryon density fluctuations. Using the UrQMD model we calculate the strangeness separation in phase space which might lead to an enhanced production of MEMOs compared to models that assume global thermalization.
Aim of antiviral therapy of patients with chronic hepatitis C is the sustained elimination of the hepatitis C virus (HCV). The standard of care (SOC) is peginterferon alfa-2a/-2b with ribavirin for 48 weeks or 24 weeks in patients infected with HCV genotype 1 or 2/3, respectively. Overall, approximately half of the patients can be cured by SOC. Based on baseline viral load and the speed of virologic response during treatment, individualization of treatment duration is possible. However, this approach is not sufficient to substantially improve the sustained virologic response (SVR) rates. This goal can be achieved with new HCV specific inhibitors against the NS3/4A polymerase and the NS5B polymerase. Recent trials reported SVR rates in the order of 67-69% and 67-75% for the combination of SOC with the protease inhibitors telaprevir and boceprevir, respectively, in patients with HCV genotype 1 infection. Several new HCV specific inhibitors such as protease inhibitors, nucleoside and non-nucleoside polymerase inhibitors as well as non HCV specific compounds with anti-HCV activity such as cyclophilin inhibitors, silibinin, and nitazoxanide are currently in clinical evaluation. The review describes recent developments and discusses limitations posed by resistance development and drug toxicity.
Effects of a phase transition on HBT correlations in an integrated Boltzmann+hydrodynamics approach
(2009)
A systematic study of HBT radii of pions, produced in heavy ion collisions in the intermediate energy regime (SPS), from an integrated (3+1)d Boltzmann+hydrodynamics approach is presented. The calculations in this hybrid approach, incorporating an hydrodynamic stage into the Ultra-relativistic Quantum Molecular Dynamics transport model, allow for a comparison of different equations of state retaining the same initial conditions and final freeze-out. The results are also compared to the pure cascade transport model calculations in the context of the available data. Furthermore, the effect of different treatments of the hydrodynamic freeze-out procedure on the HBT radii are investigated. It is found that the HBT radii are essentially insensitive to the details of the freeze-out prescription as long as the final hadronic interactions in the cascade are taken into account. The HBT radii RL and RO and the RO/RS ratio are sensitive to the EoS that is employed during the hydrodynamic evolution. We conclude that the increased lifetime in case of a phase transition to a QGP (via a Bag Model equation of state) is not supported by the available data.
The case of a 64 year old female patient is presented who has treated herself for 9 months with various Indian Ayurvedic herbal products for her vitiligo and experienced a causally related severe hepatotoxicity (ALT, 601 U/L; AST, 663 U/L; Bilirubin, 5.0 mg/dL). After discontinuation, a rapid improvement was observed. Causality assessment with the updated CIOMS (Council for International Organizations of Medical Sciences) scale showed a probable causality (+8 points) for Bakuchi tablets containing extracts from Psoralea corylifolia leaves with psoralens as ingredients, as the primary candidate causing the hepatotoxic reaction. The degree of probability was lower with +6 points for other used herbs: Khadin tablets containing extracts from Acacia catechu leaves; Brahmi tablets containing Eclipta alba or Bacopa monnieri; and Usheer tea prepared from Vetivexia zizaniodis. The case is the first report of Indian Ayurvedic herbal products being potentially hepatotoxic in analogy to some other herbs.
Hepatotoxicity by drugs and dietary supplements (DDS) is a rare and unpredictable event but with the risk of a life-threatening clinical course when it occurs. It may emerge despite intensive chemical, toxicological and observational studies that indicate no hepatotoxic signals. This suggests major clinical and regulatory issues that must be addressed in the area of accurate testing, reporting, and accessibility of reliable data. Consequently, in a clinical setting, safety concerns are key elements in the treatment of patients, and require that the diagnosis of DDS hepatotoxicity clearly be established. Causality of DDS hepatotoxicity may be pursued using a diagnostic algorithm consisting of a pre-test, a main-test as the scale of the updated CIOMS (Council for International Organizations of Medical Sciences), and a post-test. The results of these tests are then sent item by item to the National Health Agency, where the case will undergo further evaluation for pharmacovigilance, strategic aspects and safety issues. After this analysis, all items of the tests are included in the regulatory database freely accessible to the health and scientific community. With this diagnostic and regulatory algorithm the risk of misdiagnoses and inappropriate regulatory measures may be minimized and the safety improved. In conclusion, DDS hepatotoxicity is a rare but is a potentially life-threatening entity requiring a reliable diagnosis with the aid of a diagnostic algorithm, and a thorough pharmacovigilance evaluation by national and international health agencies. Safety aspects in DDS hepatotoxicity represent a major clinical and regulatory issue and should consequently be addressed.
Although human cytomegalovirus (HCMV) is generally not regarded to be an oncogenic virus, HCMV infection has been implicated in malignant diseases from different cancer entities. On the basis of our experimental findings, we developed the concept of “oncomodulation” to better explain the role of HCMV in cancer. Oncomodulation means that HCMV infects tumor cells and increases their malignancy. By this concept, HCMV was proposed to be a therapeutic target in a fraction of cancer patients. However, the clinical relevance of HCMV-induced oncomodulation remains to be clarified. One central question that has to be definitively answered is if HCMV establishes persistent virus replication in tumor cells or not. In our eyes, recent clinical findings from different groups in glioblastoma patients and especially the detection of a correlation between the numbers of HCMV-infected glioblastoma cells and tumor stage (malignancy) strongly increase the evidence that HCMV may exert oncomodulatory effects. Here, we summarize the currently available knowledge about the molecular mechanisms that may contribute to oncomodulation by HCMV as well as the clinical findings that suggest that a fraction of tumors from different entities is indeed infected with HCMV.
Recently, pertussis has become a problem also in the adult population, with incidences even higher than in children. Pediatric health care workers (HCWs) are an important source of transmission, exposing very young and immunocompromised patients to an increased risk of potentially severe pertussis infections. Encouraging HCWs to get vaccinated can play a vital role in stopping the transmission of pertussis, thereby reducing institutional outbreaks.
In Germany, HCWs come up with all sorts of reasons for not getting pertussis vaccination. This study was meant to provide information in order to better understand the backgrounds of these attitudes.
A survey was conducted at the children's university hospital in Frankfurt, using an anonymous questionnaire. Survey results were used to design an intervention to increase the immunization rate of staff. Disappointingly, our efforts to increase the acceptance of the immunization program by providing information in advance were not yet satisfying.
Misconception about pertussis vaccination was prevalent especially among nursing staff. The main reasons for non-compliance included: unawareness of an own risk of infection, the belief that pertussis is not a serious illness, fear of side effects, the belief that the pertussis vaccine might trigger the pertussis disease itself, and skepticism about the efficacy of the pertussis vaccination.
Superconducting, energy variable heavy ion linac with constant
β, multicell cavities of CH-type
(2009)
An energy variable ion linac consisting of multigap, constant-β cavities was developed. The effect of phase sliding, unavoidable in any constant-β section, is leading to a coherent rf phase motion, which fits well to the H-type structures with their long π-mode sections and separated lenses. The exact periodicity of the cell lengths within each cavity results in technical advantages, such as higher calculation accuracy when only one single period can be simulated, simpler manufacturing, and tuning. This is most important in the case of superconducting cavities. By using this concept, an improved design for a 217 MHz cw superconducting heavy ion linac with energy variation has been worked out. The small output energy spread of ± 3 AkeV is provided over the whole range of energy variation from 3.5 to 7.3 AMeV. These capabilities would allow for a competitive research in the field of radiochemistry and for a production of super heavy elements (SHE), especially. A first 19-cell cavity of that type was designed, built, and rf tested successfully at the Institute for Applied Physics (IAP) Frankfurt. A 325.224 MHz, seven-cell cavity with constant β = 0.16 is under development and will be operated in a frequency controlled mode. It will be equipped with a power coupler and beam tests with Unilac beams at GSI are foreseen.
A decorated pair of trousers excavated from a well-preserved tomb in the Tarim Basin proved to have a highly informative life history, teased out by the authors – with archaeological, historical and art historical dexterity. Probably created under Greek influence in a Bactrian palace, the textile started life in the third/second century BC as an ornamental wall hanging, showing a centaur blowing a war-trumpet and a nearly life-size warrior of the steppe with his spear. The palace was raided by nomads, one of whom worked a piece of the tapestry into a pair of trousers. They brought no great luck to the wearer who ended his days in a massacre by the Xiongnu, probably in the first century BC. The biography of this garment gives a vivid glimpse of the dynamic life of Central Asia at the end of the first millennium.
Selena Axelrod Winsnes has been engaged, since 1982, in the translation into English, and editing of Danish language sources to West African history, sources published from 1697 to 1822, the period during which Denmark-Norway was an actor in the Transatlantic Slave Trade. Five major books have been published. They describe all aspects of life on the Gold Coast [Ghana], the Middle Passage and the Danish Caribbean islands [US Virgin Islands], as seen by five different men. Each had his own agenda and mind-set, and the books, both singly and combined, hold a wealth of information - of interest both to scholars and lay readers. They provide important insights into the cultural baggage the enslaved Africans carried with them to the America's. One of the books, L.F. Rømer's 'A Reliable Account of the Coast of Guinea' was runner-up for the prestigious International Texts Prize awarded by the U.S. African Studies Association.
Selena Axelrod Winsnes has been engaged, since 1982, in the translation into English, and editing of Danish language sources to West African history, sources published from 1697 to 1822, the period during which Denmark-Norway was an actor in the Transatlantic Slave Trade. Five major books have been published. They describe all aspects of life on the Gold Coast [Ghana], the Middle Passage and the Danish Caribbean islands [US Virgin Islands], as seen by five different men. Each had his own agenda and mind-set, and the books, both singly and combined, hold a wealth of information - of interest both to scholars and lay readers. They provide important insights into the cultural baggage the enslaved Africans carried with them to the America's. One of the books, L.F. Rømer's 'A Reliable Account of the Coast of Guinea' was runner-up for the prestigious International Texts Prize awarded by the U.S. African Studies Association.
Theatre and drama are very much part of our every day lives. These four plays: Belonging by Mirirai Moyo, When I Meet my Mother by Kathleen McCreery, In the Continuum by Danai Gurira and Nikkole Salter, and Power Failure by Jide Afoylan reveal the dynamism and variety of theatre. They also reveal that from Zimbabwe to Brazil, Nigeria to the USA, societies despite their diversity share many common problems and challenges. Annotated for schools with questions and notes by Rory Kilalea, teachers and students will find this a richly accessible text.
Administrative law may best be defined by describing what it encompasses: it is that branch of law which deals with the individual versus governmental or administrative power. It covers court restraint of actions or inactions of public institutions, administrative processes of central and local government, parliamentary and subordinate legislat on and the means and procedures by which the rights of individuals are protected against abuse of power by public or local authorities, public corporations, tribunals and other bodies which discharge functions of public nature entrusted to them by law for the benefit of the citizen. It is hoped that this book will act as a wake-up call to all those who have been entrusted with the duty of making decisions affecting the rights of citizens to update themselves so as to discharge their duties correctly and in spirit of good governance. Administrative Law in Tanzania: A Digest of Cases covers high profile and landmark cases in topical areas of constitutional and administrative law from colonial days to present time, names, procedures in applying for prerogative remedies, constitutional principles and human rights, separation of powers between the Executive, the Legislature and the Judicature, natural justice and the rule of law, statutory ouster of jurisdiction of courts, and the right to legal representation.
The 'Washington consensus' which ushered in neo-liberal policies in Africa is over. It was buried at the G20 meeting in London in early April, 2009. The world capitalist system is in shambles. The champions of capitalism in the global North are rewriting the rules of the game to save it. The crisis creates an opening for the global South, in particular Africa, to refuse to play the capitalist-imperialist game, whatever the rules. It is time to rethink and revisit the development direction and strategies on the continent. This is the central message of this intensely argued book. Issa Shivji demonstrates the need to go back to the basics of radical political economy and ask fundamental questions: who produces the society's surplus product, who appropriates and accumulates it and how is this done. What is the character of accumulation and what is the social agency of change? The book provides an alternative theoretical framework to help African researchers and intellectuals to understand their societies better and contribute towards changing them in the interest of the working people.
This book presents a study of the life history of Mtoro bin Mwinyi Bakari (c. 1869 - 1927). Mtoro bin Mwinyi Bakari grew up and studied Islamic Sciences in Bagamoyo, Tanzania. He became a Swahili lecturer and author in Germany and is known to have written Desturi za Wasuaheli, an important work in Swahili culture. The book introduces the wider historical context of his writings, and, in particular, reconstructs the racism and discrimination in both the colonial and metropolitan contexts, features which negatively influenced his career and his life as a whole. The study also offers insights into contributions of the colonized to the study of African languages and cultures during this same historical context.
The 2007 general elections in Kenya led to major unrest. The aim of this book is to examine and analyse the events that set the country on fire for several weeks. The situation has largely stabilised since April 2008, when the articles collected in this book were first individually published. Some political information has been updated post April 2008. The coalition government took shape with Mwai Kibaki remaining President while Raila Odinga became the Prime Minister. The country however remains in suspense, as do the donors who had made it possible for Kenya to restore a semblance of peace. But to what point will they be interested in investing in the country and to protect their place in it? The collection comprises a translation of a special issue of Les Cahiers d'Afrique de l'Est, n?37, the journal of the Institut Fran?ais de Recherche en Afrique (IFRA) and a collection of articles from Politique Africaine, n?109. On site researchers - Bernard Calas, Anne Cussac, Dominique Connan, Musambayi Katumanga, J?r?me Lafargue, and Patrick Mutahi; fieldwork carried out between December 2007 and February 2008 by Florence Brisset-Foucault, Ronan Porhel, Brice Rambaud; and in-depth country knowledge by Claire M?dard and Herv? Maupeu, combined to produce a mass of data within a short time. Whilst the tone of the book is not highly optimistic, the thrust is not intended to dampen the unanimous sense of hope in the country that the political and social situation will once more be more than just tolerable.
War and Peace in Contemporary Eritrean Poetry focuses on Eritrean written poetry from roughly the last three decades of the twentieth century. The poems appear in the anthology Who Needs a Story? Contemporary Eritrean Poetry in Tigrinya, Tigre and Arabic from which a selection is offered here in their original scripts of Ge'ez or Arabic, and in English translation. Who Needs a Story? is the first anthology of contemporary poetry from Eritrea ever published, and War and Peace in Contemporary Eritrean Poetry is the first book on the subject. Therefore, the groundbreaking effort of the former warrants a discussion of its means of cultural production. All of the poets in Who Needs a Story? participated in the Eritrean struggle for independence (1961-91) as freedom fighters and/or as supporters in the Eritrean diaspora. Thus, contemporary Eritrean poetry divides itself between experiences of war and peace, although one can contain the other as well. War and Peace in Contemporary Eritrean Poetry also includes an extended analysis of one of Eritrea's most famous contemporary poets Reesom Haile, as an example of the kind of extended analysis that many of the poets of Who Needs a Story? should stimulate and, last but not least, a meditation on how the author, a non-native speaker, personally becomes involved in Eritrean poetry translation.
This third volume of Tell Me, Friends collects stories and plays written by students and staff at the University of Dar es Salaam between 2006 and 2008. The stories in the collection are: 'Our Man' by Saida Yahya-Othman; 'The Window Seat' by Benjamin Branoff; 'The Concealed Project' by Zuhura Badru; 'The Total Crisis' by Simon Mlundi; and 'Testimony' by Emmanuel Lema. The plays are: 'The Monster' by Anna Chikoti; 'Love is...' by Kimberly McLeod; 'A Tanzanian Rooftop' by Benjamin Branoff; 'Judges on Trial' by Frowin Paul Nyoni; 'The Route to Success' by Yunus Ng'umbi; and 'The Mop' by Vincensia Shule. Read and share these stories and plays, and enjoy how they depict some of the social-economic and political factors that condition and shape our societies today.
Language is a tool used to express thoughts, to hide thoughts or to hide lack of thoughts. It is often a means of domination. The question is who has the power to define the world around us. This book demonstrates how language is being manipulated to form the minds of listeners or readers. Innocent words may be used to conceal a reality which people would have reacted to had the phenomena been described in a straightforward manner. The nice and innocent concept 'cost sharing', which leads our thoughts to communal sharing and solidarity, may actually imply privatization. The false belief that the best way to learn a foreign language is to have it as a language of instruction actually becomes a strategy for stupidification of African pupils. In this book 33 independent experts from 16 countries in the North and the South show how language may be used to legitimize war-making, promote Northern interests in the field of development and retain colonial speech as languages of instruction, languages of the courts and in politics. The book has been edited by two Norwegians: Birgit Brock-Utne is a professor at the University of Oslo and a consultant in education and development. From 1987 until 1992 she was a professor at the University of Dar es Salaam. Gunnar Garbo, author and journalist and former member of the Norwegian Parliament, was the Norwegian Ambassador to Tanzania from 1987 to 1992.
From Goatherd to Governor is Edwin Mtei's autobiography. It is a story of the journey a few Africans of his generation made, from humble beginnings to heights of success and power. Mr. Mtei was the first Governor of the Bank of Tanzania and the architect of Central Banking in Tanzania, Secretary General of the East African Community and Minister of Finance in Nyerere's Government. Born in 1932 in Marangu, Moshi, he was brought up in a grass-thatched conical hut by his mother, a single parent; he attended 'bush' school at Ngaruma Lutheran Parish Church, and herded goats after lessons finished; he attended Old Moshi Middle and Tabora Secondary schools and went on to Makerere University College in 1953. He graduated from there with a Bachelor of Arts degree in Political Science, History and Geography in 1957. In his own words he states: 'I have felt it worthwhile starting right at the beginning of my life. In this way, I aim to give some idea as to what it was like growing up in my birthplace, Marangu, in the tribal and colonial environment of Tanganyika in the 1930s, 1940s and 1950s. I touch on some of the traditions and beliefs of those days and on some colonial laws that impacted on our lives and surroundings.' But as he himself states: 'The most interesting part of my story is that relating to the events when I held senior positions in Nyerere's Government, and in the public service generally.' That includes his falling out with Mwalimu Nyerere over IMF and its policies, and his resignation from his post as Minister of Finance. For the first time he tells his side of that story. In 1992 Mr. Mtei threw himself deep into the waters of multiparty politics. He founded Chama cha Demokrasia na Maendeleo (CHADEMA) - the Party for Democracy and Development - and worked tirelessly to see it grow and emerge as an important party in the opposition, despite his own failure to win the parliamentary seat for Arusha Urban in the 1995 election. Even at 77 Mr. Mtei does not mince his words. He says what he believes and says it with courage and conviction. This is history, spanning well over half a century, written by someone who was involved in and who observed closely the key events of his time. He is retired and works on his farm, Ogaden Estate, but still manages to ruffle feathers whenever he is asked to comment on the economy and politics of Tanzania and East Africa.
Talking Tales
(2009)
In Talking Tales a variety of women tell their stories in prose and poetry. They cast their nets wide, hauling in themes that celebrate as much as they castigate and mourn. There is the delight of discovering oneself on the cusp of womanhood, and of hearing about success in the fight for women's emancipation. There is also the wonder at the restorative power of love. However, the murkier side of human life is explored too: the failed search for love, unwanted advances, misunderstood affinities, incest, betrayal, disillusionment, unfruitful enterprise, domestic violence, corruption, brutality, injustice, the capriciousness of fortune...The realistic, the near-fantastic and the bizarre all find their place here. The themes are handled with forthrightness and humour as the writers take full advantage of the possibilities inherent in the different ways of telling tales: poetic, epistolary, expository, and straightforward narrative.
Female genital mutilation is the excruciating and damaging experience that Beyond the Dance a lot of women in many cultures across Africa and in many other parts of the world suffer. Even when the women find themselves, for one reason or another, relocate in what should be safe havens, this practice frequently follows them like a vengeance ghost. Beyond the dance is a compilation of testimonies and poems about the humiliation of female genital mutilation, and about the resulting deprivation and loss. It encompasses accounts, factual in some cases and lyrical in others, of the experience of this practice lived or witnessed, and the visceral responses to the practice. The anger is palpable, the bafflement tangible. Beside the pain, though, is the hope borne of the voices raised by governments, organisations, institutions and individuals, urging a stop to the practice and coaxing oft-unwilling communities into abandoning it or transforming it into a meaningful ritual that builds up rather than ruins. Through the pages of this volume we share the pain, thoughts, views and feelings of the victims of female genital cutting and of people concerned about the debilitating practice. We share the hope that they hold out for a firm and final end to the practice.
The traumatised woman who dies of grief, the girl whose dream to become a doctor is thwarted, the little girl who raises a vulnerable family of little children because her parents and all her relatives have been killed by LRA rebels, and many other harrowing tales comprise this collection of Farming Ashes These are real life experiences told by women of Northern Uganda about the atrocities that they have endured for over two decades at the hands of the notorious rebel leader, Joseph Kony and his vicious lieutenants. Farming Ashes offers cogent and explosive tales of the LRA exploits that are disturbing and baffling in the extreme and leave the reader asking the question: 'Why?' and longing for 'the world of no war', as one of the storytellers puts it.
The names of those who penned the writings in this impressive collection alone tell half the story. They tell their stories in different modes. They run the whole gamut - they tell of defiance, and spin hilarious tales of elopement and wry tales of despair, loss and lovelessness. Some of the poems lift up the heart, and others peel back the blinkers that blind our eyes. There is the romantic, the macabre and the surreal. The writings never leave you indifferent - you are likely to take sides, to get angry, to laugh, to cry, and to think of a lot that goes on inside the human heart.
Creative Writing In Prose
(2009)
Creative Writing In Prose is centered on novel writing but touches on other prose forms. It covers the process from the germination of the story to the submission of the manuscript for publication. Plot, narrative methods, the recording of dialogue and the subtle relationship between story and theme are all examined.
This book is an appraisal of law and practice in light of International Human Rights Law and Best Practices book is essential reading for anyone who wants to grasp the scope of the freedom of speech for Members of Parliament and even the general populace in a democratic setting. The book provides valuable insights into why the freedom of speech for Members of Parliament is so important. One of the most important pivotal statements alluded in this book is that, freedom of speech is crucial in any democracy, because open discussions of members are essential for voters to make informed decisions during elections.
Strathmore University organised the Fifth Annual Ethics Conference on Governance, Institutions and the Human Condition. Research papers were presented in four sessions, corresponding to four key milestones in the crisis that almost tore Kenya apart in January - February 2008: Constitutional law, Institutions, Education and the Land Issue. This book compiles the papers presented at the Conference by outstanding scholars and renowned personalities.
The narratives collected by Twaweza Communications in this volume tell yet another side of the story about the violence that engulfed Kenya towards the end of 2007 and the beginning of 2008. The narratives are part of a Daraja Initiative involving media monitoring, reflections and documentation of the traumatic post-election violence period often associated with the contested presidential results of 2007. The goal of the project is to contribute to the protection of constitutional rights of all Kenyans and to the development of a just and democratic country. Because violent conflicts constitute ruptures and continuities and are often preceded by tensions over the uncomfortable co-existence of political, economic, social and cultural systems and relations of power as well as what is perceived as valuable, mobilisation for violence is driven by narratives of the legality and correctness of action such that notions of history, justice and memory are functions of narrative construction, power and authority. Narratives of violent conflict, such as happened in Kenya, are not absolute: they are contested, contradictory and incomplete. But they must be told so that the multiple voices from the citizens are heard.
To the Budding Creative Writer: A Handbook is designed to help young writers come to grips with questions and problems relative to their creative efforts. The authors discuss a range of topics, providing guidelines on such issues as style, technique, point of view, characterization, poetic diction, figurative language, denotation and connotation, etc. They equally offer useful critical comments on some of the works of accomplished African writers whom they cite as models for beginning writers, fusing literary creativity with literary criticism. All along the co-authors stress the centrality, in imaginative writing, of both the 'what' and the 'how' or matter and manner, and how to combine both to good effect.
The Lord of Anomy
(2009)
In 1875 the Rozvi Kingdom, now in present day Zimbabwe, is indistinctly besieged from within by the convergence of a missionary, Rev. Holbrook, a militant British bourgeoisie aspiring for knighthood, Sir Crowler, and an immorally amorous war emissary allegedly from King Cetshwayo of the feared Zulu Kingdom. The 'Zulu' ambassador uncompromisingly makes painstaking demands. While Rev. Holbrook is earnest in his endeavours, Sir Crowler is adamant the natives are enemies of both God and Britain meant for annihilation. The elders cannot consult the oracles; all diviners having fled before the arrival of the foreigners. An enigmatic and malicious hermit comes to the fore in the calamitous confusion that ensues. But nobody can tell with certainty if the hermit is messianic or anarchical.
The Wages of Corruption
(2009)
Corruption is endemic in Cameroon. Twice, Transparency International have accorded the country the infamous first place in corruption. As one of many concerned Cameroonians, Sammy Oke Akombi was moved and they realized that something was in fact wrong somewhere and something had to be done somehow. This collection of short stories is his contribution to the collective resolve by concerned Cameroonians to wage a war against this most unusual friend of fairness. The stories seek to elicit awareness about a social ill that is ironically championed by the very politicians, functionaries, educator, leaders and power elite whose duty it is to keep society healthy and on the rails. The stories are on corruption in different segments of society and about the people who perpetrate it. Almost everyone is immersed in it and so must make every effort to resurface from it. It takes only the will to stay alive because the wages of corruption like any other sin can only be death.
This meticulous and comprehensive documentation of Cameroonian Youth Day Messages and leadership discourse on youth from 1949 - 2009 is a gold mine for researchers, historians and anyone interested in studying youth, politics and society in Africa. The book presents and explores themes and content of Youth Day Messages: how these messages tied in with, or veered away from, key events and issues of the time; how they served as a platform for West Cameroon governments, and the Ahidjo and Biya regimes to articulate their political vision, justify their policies, sell their respective ideologies to the youth; and what lessons could be drawn from them on competing, conflicting and complementary perspectives on youth agency in Cameroon and Africa. Churchill links the Youth Day to ongoing discussions in Africa about the role and place of youths as agents of development in Africa. Most significantly, he finally puts Cameroon's controversial Youth Day in its appropriate historical context - not as a political device created by the Francophone politicians to distort Cameroonian history and erase 'plebiscite day' from the collective memory as Anglophone nationalists claim, but as a British Cameroons colonial legacy, successfully sold to the Ahidjo regime as a day to be commemorated throughout the federation, by leaders of the federated state of West Cameroon. Churchill Ewumbue-Monono, a senior career diplomat, is Minister Counsellor in the Cameroon Embassy in Moscow. A graduate of the International Higher School of Journalism, and the International Relations Institute of Cameroon in the University of Yaounde, he was a 1991-92 Fellow in Public Diplomacy in Boston University, USA. He has served in Cameroon in various professional capacities. Ewumbue-Monono has written extensively on Cameroon's political history, and his books include Men of Courage, published in 2005.
Wading the Tide
(2009)
Wading the Tide is an expression of profound emotions touching on a wide range of issues-personal and political-from the birth of the Cameroon nation, her political meandering, until the state of emergency declared on the North West Province in 1992. Accordingly, Doh complains, ridicules, and pays tribute, even as he instructs and guides on timeless matters of life, all in an effort to draw attention to his country's gradual, downward spiral into anomy.
Twelve-year-old Bridget and her friends are excited when they get admitted into one of the most prestigious boarding secondary schools in Kumba, Cameroon. Passing exams is the least of their worries. But surviving the new academic and social culture with hormone driven adolescent boys and unscrupulous seniors remain a challenge. Can the ground rules for survival Bridget and her new girlfriends adopt protect them from the threats they face constantly from the seniors, teachers and the adults in the local community? Can they handle all the distractions in addition to the changes their pubescent bodies are undergoing?
The Wooden Bicycle and Other Stories is a compilation of eight compelling short stories which immediately engage the reader, regardless of which story is selected for reading. Just like the author's other collection of short stories, Cup Man and Other Stories, the book is a depiction of the joys and pains of everyday life in the typical African country or even in the West Indies. This dimension includes an in-depth look at life within the African community in the West - an experience which is, of course daunting as the immigrant struggles to adjust to the new dispensation. Azonga once again shows outstanding skill in narrative techniques by adopting a style that is at once simple and intricate, entertaining and instructive.
Tussles : Collected Plays
(2009)
This collection groups together four plays - The Bite, Things Fall in Place, The Will and The Imprisonment of Sende Ghandi - written between 1995 and 2006. The plays in this volume dramatize a comprehensive world view. Through characters and themes chosen for their power to articulate the intended message, the plays paint a convincing and at times funny picture of human beings tussling with daily life. With clearly non-reductionist purpose, the actions all eschew the narrow minority questions so dominant in Cameroon Anglophone drama and instead reach out to concerns of a broader nature. In these plays Nyamndi does more than entertain. He reaches into the psychology of human relations and individual drives, and intimates responses to occasioned challenges. His wide, penetrating mind meanders in society: detecting the drunk before he takes his first drop; uncovering the embezzler even before he lays his hands on the collective holding; steeling the masses before the calamities of misrule descend on them; hoisting the flag of freedom long before revolutionaries come anywhere near the mast. He uses the play for healing purposes.
In Cameroon and Africa, lakes are sacred and often secret places. They fascinate curiosity and have often served as repositories of local histories, memories and dreams. In Mystique, Bime offers the reader a rich and seductive menu of reflection on the significance of legends and myths on and around lakes in Cameroon, Ghana, Benin and Tanzania. She tells her stories with the talent and elegance of a writer who does not only have an ear for what others tell her but who also has the ability to transform what she hears into something uniquely hers and truly universal. Mystique is a must-read and an opportunity for progeny to keep alive a tested and cherished heritage of story-telling. This is truly innovative and culturally relevant entertainment that invites the reader to unchain her spirit to explore. Beatrice Fri Bime, an international management consultant, who enjoys humanitarian affairs, holds a Master of Business Administration (MBA) degree from the University of Wisconsin-Whitewater, USA. A Cameroonian, she has worked in Banking, government, national and international organizations and is author of Some Place, Some Where. She lives with her family in Yaounde.
Second Engagement
(2009)
Second Engagement is an enthralling tale of triangular love and the quest for fulfillment. Framed around Gabby and Lizzy, the narrative unravels the secrets surrounding relationships of love. Susan Nde explores the pleasures and tensions of how two individuals in love handle the obstacles on their path to being together. In an exceptionally lucid and graceful style, she weaves an enduring tapestry of great human interest, from divergent dreams, which converge at the point of acceptance and tolerance.
Oriki'badan
(2009)
ORIKI'BADAN, is an entertaining, revealing, and equally didactic poem in which Doh, through an enchanting metaphorical backdrop, recaptures a memorable era-rich, diverse, challenging, yet gratifying-in the life of a distinguished institution-the University of Ibadan, Nigeria. Characteristically bitter about those in power and the socio-political state of affairs on the African continent, this is a rare shot of Doh paying glaring tribute to his alma mater along with the distinguished faculty and student body that gave Ibadan its character during his days there as a student.
The Crown of Thorns
(2009)
Chief Nchindia held the Elders of his Council in total contempt, inwardly vowing to disagree with them at every point where disagreement was possible. What starts like a big joke develops into grim tragedy: the statue of the god of Nkokonoko Small Monje is discovered to have been stolen and sold to a white man! The tradition demands instant execution of the culprits. Was their Chief involved in the theft? What was worse, the crime or the punishment? Linus Asong was born in the South West Region of Cameroon in 1947. With a combined B.A honours in Education, in 1980 he entered the University of Windsor in Canada whence he graduated with a terminal degree in Creative Writing. He holds an M.A and a PhD in Comparative Literature from the University of Alberta, in Edmonton Canada, and is presently Associate Professor of Literature and Creative Writing at Ecole Normale Superieure Bambili (University of Yaounde 1). Asong is a stand-up humorist, a consummate portrait painter, an accomplished literary scholar, and a celebrated prolific writer with over a dozen novels to his credit.
A literary monument erected by a poet for poets with a vision for poetry as a special annunciation and the poet as a seer, spokesperson, recorder, analyst, adjudicator and advocate with poetic vision and poetic understanding. Bill Ndi, the poet has the rare gift of slipping into the self and psyche of his society to empty the dark depths where the treasures of burden and sadness are hidden. He empties and exposes them to the world to see how even personal repression of feelings by far outweighs those imposed throughout History by tyrants. It is above all, his greatest task of filling these depths with the joys and expectations of the society. This objective stance by the poet places him above the fanatic whose subjectivity pushes the world adrift and makes of the poet a universal man of peace.
Salvation Colony
(2009)
Dennis Nunqam Ndendemajem, the spectral social misfit of No Way To Die, having failed to die by suicide, is pursued by the hatred of friends and family relations. He seeks refuge in The Salvation Colony of the Angels of Limbo Church of Africa - a veritable paradise for all whom society has sidelined and whom chance or choice have led thereto. Refuge Dennis finds at the Salvation Colony, thanks to the kindly founding spiritual and material patron, the highly reputable but extremely devilish Pastor Sixtus Shrapnell, fondly referred to as Our Father. At the Colony, though completely dehumanized, Dennis maintains self-value and something to live for in life - God. In dispensing so completely and successfully with any authorial presence in this extremely rare but deeply psychological novel, Asong pushes the art of African fiction to a great new height. The novel shows his intellectual and perhaps formal vortex. His iridescent flushes of exquisite know-how in art, philosophy and psychology make the work worth a thinker's time.
Son of the Native Soil
(2009)
Son of the Native Soil is a work whose quiet maturity glows in both subject and style. Here, love heals but the force of hate is very real. The hero, Lucas Achamba, by charisma and love undertakes to unite Dudum clan which politicking and egotism have split. His quick success stirs bitter rivalry and heartless cruelty that decide his fate. Nature is jumpy and even hysterical at this, and Ambanasom exposes it with fine evocative mastery. The style is refined and honeyed by sonal devices and visual tropes that half conceal subtle slashes at human foibles.
The Bad Samaritan
(2009)
The Bad Samaritan is set in a kleptomaniac and highly corrupt imaginary African country called Ewawa. Due to mismanagement, financial institutions collapse. Salaries are slashed and there is unprecedented unemployment leading to country exodus. Professor Esole and his wife are not only aggrieved by the salary slashes, but also by the dubious closure of the Post Office Savings Bank with their savings. Desperate for money, they resort to borrowing from private sources at exorbitant interest rates. Esole toddles into politics with the aim of righting things. Will his nai͏̈ve approach to politics make or mar?
Perspectives on Translation and Interpretation in Cameroon is the first volume of a book series of the Advanced School of Translators and Interpreters (ASTI) of the University of Buea. It opens a window into the wide dynamic and interesting area of translation and interpretation in a multilingual Cameroon that had on the eve of independence and unification opted for official bilingualism in French and English. The book comprises contributions from scholars of translation in the broad area of translation, comprising: the concept of translation and its pedagogy, the history of translation and, the state of the art of translation as a discipline, profession and practice. The book also focuses on acquisition of translation competences through training, and chronicles the history of translation in Cameroon through the contributions of both Cameroonian and European actors from the German through the French and English colonial periods to the postcolonial present in their minutia. Rich, original and comprehensive, the book is a timely and invaluable contribution to the growing community of translators and interpreters in Africa and globally.
Civil society and empowerment have become buzz words in neoliberal development discourse. Yet many unanswered questions remain on the actual nature and configuration assumed by civil society in specific contexts. Typically, while neoliberals perceive civil-society organisations as vital intermediary channels for the successful implementation of desired economic and political reforms, they are inclined to blame the current resurgence of the politics of belonging for the poor record of these reforms in Africa and elsewhere. This book rejects such notions and argues that the relationship between civil society and the politics of belonging is more complex in Africa than western donors and scholars are willing to admit. Konings argues that ethno-regional associations and movements are even more significant constituents of civil society in Africa than the conventional civil-society organisations that are often uncritically imposed or endorsed. He convincingly shows how the politics of belonging, so pervasive in Cameroon, and indeed much of Africa, during the current neoliberal economic and political reforms, has tended to penetrate the entire range of associational life. This calls for a critical re-appraisal of prevalent notions and assumptions about civil society in the interest of African reality. Hence the importance of this book!
Doughty human rights crusader, Albert Mukong was incarcerated for six years in some of Cameroon's worst detention centres under the despotic regime of late President Amadou Ahidjo. This book details his personal account of the discipline and punishment that the Cameroonian state has systematically dished out to dissidents who have dared to stand their ground. Until his death in 2004, Albert Mukong was without doubt, Anglophone Cameroon's most conspicuous political prisoner, spokesperson and champion human rights advocate. The particular detention he recounts in this book is evidence of how nationalists such as Ruben Um Nyobe, Ernest Ouandie, Bishop Ndongmo and others, have in their struggles sacrificed enormously so that freedom and democracy might see the light of day in their reluctant Cameroon.
Initially considered something of a black sheep within the Anglophone Cameroon literary genres, the Anglophone novel has gradually grown to carve out a respectable niche for itself in the Anglophone Cameroon sub-system, imposing itself in a way that makes it impossible for critics to ignore it. Now a vibrant genre, it even threatens to overtake drama and poetry, both of which have enjoyed more critical attention. This book is a study of how Anglophone Cameroon has contributed in extending the possibilities of the novel as a literary form, and of some of the established conventions necessary for a fruitful evaluation of the growing body of the Cameroonian novel in English. In this eclectic and compelling book, Ambanasom sets out to achieve three primary objectives: to introduce the reader to the extensive body of Cameroonian novels in English, to re-examine the distorting and limiting criteria upon which the critical assessment of the Cameroonian novel in English has so far been based, and to bridge the widening chasm between literary theory and actual critical practice. To achieve these objectives, Ambanasom begins by elaborating an alternative and flexible theoretical framework which he christens the 'Socio-Artistic Approach' and which, according to him, is 'concerned with both a text's thematic, moral, cultural or ideological issues, on the one hand, and its central literary analysis, on the other.' He then proceeds to use this new critical framework to examine twenty-seven major Cameroonian novels in English. There are critical voices, already emerging within the Anglophone Cameroonian literary circles, calling for rigorous teaching and practice of theory in the interpretation of literary works, setting in motion a critical discourse. Such a call is salutary, and welcome. Those university lecturers whose responsibility it is to teach theoretical courses should take this call very seriously, moving from theory to hands-on practice. This book is Ambanasom's contribution to that critical debate.
No Way to Die
(2009)
What happens when a young man of talent and visions of greatness falls victim to a cruel set of circumstances over which he has no control? No Way to Die is such a story. Dennis Nunqam Ndendemajem gives up! Even when he is given a second chance to start again, he refuses to gather the broken pieces of his life together. He refuses to rebuild, and refuses to live. But he also finds no way to die.
The Akroma File
(2009)
Faced with debts at home and threatened by poverty, Akroma a brilliant and well-educated Ghanaian, using unorthodox means, successfully gets into Cameroon. He is bent on making a fortune. Drawing on his tremendous presence of mind and, capitalising on the early discovery that in Cameroon there is no conscience that money cannot buy, this illegal alien, travelling under three criminal identities, builds up a great amount of wealth. But he cannot buy the entire police force. One police man, Inspector Kum Dangobert, will get even with him, even if it means death. The rest of this very readable novel is about what happens when the Ghanaian evil genius is pitted against the best Cameroonian police superintendent. It is the clash of giants that ends in a cataclysm.
Royalty and Politics is the fascinating autobiographical account of a life rich in controversy, leadership, service, achievement and innovation. Born 1925 into the prominent and influential royal family of Mankon in the Bamenda Grassfields of Cameroon, Solomon Anyeghamotü Ndefru least expected becoming king, only to find himself the chosen one following the death of his father in 1959. As Fo Angwafo III of Mankon, one of the most educated 'traditional rulers' at the dawn of independence, he succeeded into Parliament first as an independent, and subsequently as a member of the Cameroon National Union. He has served as First National Vice-President of Paul Biya's Cameroon People's Democratic Movement since 1990. In this unique, analytical and insightful reflection 50 years into his reign, Fo Angwafo III discusses growing up in colonial times; his surprise appointment as king; the 1961 Cameroon Plebiscite and his initiation into politics; being king and politician; coping with the hostility of the modern power elite towards his active involvement in politics; churches, schools and politics; life as an agriculturist; and investments in tending the Kingdom of Mankon. He argues that the best way of consolidating traditions is to make them modern, and that modernity can only make sense to the extent that it is firmly grounded in traditions. In many ways he feels his life encapsulates this negotiation and reconciliation of continuity and change.
Someplace, Somewhere
(2009)
Someplace, Somewhere is an exemplary piece of socio-political satire. It is a collection of short reflective stories that highlight the predicament of a people and exposes the ills of a society where neglect and decay are the nauseating lure and allure of everyday life. Carefully knit, this collection vividly provokes the nostalgia of the round-the-hearth rural evening story-telling atmosphere of yesteryears. Indeed, Bime has this knack for the fine details of story-telling, which blends so magically with her flare of crude humour, a combination that makes her social satire simply irresistible.
Shadows From The Abyss
(2009)
This is the first volume of a patriotic poet whose heart is on fire. The poems touch on a variety of issues, some personal and private, other public - past and current. They range from family, love and longing; friendship and marriage, to culture, politics, corruption and death. They are cadenced and vibrant with different emotions: nostalgia, regret and outrage; loss, pain and pathos tinged with a touch of wistfulness and irony. In style and themes, they reveal a keen observer, a budding poet struggling to find her stride; to mine the shallows and the deeps of human experience, to give a unique expressive voice to the human condition. With a wide range of emotions, Mbunda touches on a variety of turbulent issues muddying the waters. But she is not without hope; she believes the volcano will only erupt if her call is unheeded.
In the Shadow of my Country
(2009)
Growing up almost simultaneously with the independent Cameroon nation, it takes Tipoung'he a long time together with challenging experiences to realise that he has all along been living in the shadow of his country. His epic story is representative of the many whose untold stories are caught in the schematic confusion of independence, in which self-knowledge must rally back finally from the lethargic ideals of the Nation and the Patriot in a redeeming instance of identity. The story mirrors the growth of the hero as he gets used to his ever shifting environment. The complexity of experience, the burden of knowledge, and how to express these, confront Tipoung'he with prescriptive arrogance, and the more he gets entangled in the authoritative and patriotic mesh, the more he becomes aware of the need to withdraw from their osmotic consciousness. The moment of withdrawal, which coincides with self-knowledge, is a personal and symbolic rebirth.
This study analyses the effects of democratic transition in two African countries - Cameroon and South Africa - on chiefs and the institution of chieftainship. Based on ethnographic fieldwork, the monograph explores the cultural and socio-political conditions that enabled chiefs to reinvent themselves in the new era of democratic politics despite their status as 'old political actors'. It explores the kinds of legitimacies claimed by chiefs in the new era and the responses of their subjects to such claims, particularly with respect to chiefs' involvement in national politics. The monograph makes a case for the importance of comparative research on chiefs in the era of democracy and the predicaments they face therein. It contends that contrary to exhortations about the incompatibility of chiefs and democracy, the reality is that political transition in both South Africa and Cameroon produced contradictions, creating space and a role for chiefs in a fascinating and negotiated interplay of legitimacies and history.
Dispossession and Access to Land in South Africa. An African Perspective : An African Perspective
(2009)
This book deals with the conceptualization of access to land by the dispossessed in South Africa as a human right. Yanou examines the country's property model in the context of the post apartheid constitutional mandate to redress the skewed land distribution of the past. The book reviews the strengths and weaknesses of the land restitution process as well as the question of the payment of just and equitable compensation for land expropriated for restitution. It also reviews the phenomenon of land invasion and quality of access to land enjoyed by the South African black woman under the present dispensation. Yanou argues that the courts have, on occasions, construed just and equitable compensation generously. This approach has failed to reflect the fact that what is being paid for is land dispossessed from the forebears of indigenous inhabitants. In a South Africa that lost most of its ancestral land during colonialism and apartheid, access to land for the dispossessed should not be equated with the protection of property acquired under apartheid. Getting it right would entail truth and reconciliation with the collective dispossession suffered by South African blacks.
Dogs in the Sun
(2009)
This compelling narrative pits the legacies of two men in the village of Nwemba. Winjala the Crude, yardman to the English surveyor Pete Harrington, kills the latter's favourite animal, the big monkey called Stirrup, and runs to his village. Sama Gakoh, washerman to Harrington, also returns home when his services are terminated for age reasons. Both hold clashing views of the white man. They die shortly after their return but their sons pick up and sustain their conflicting philosophies. The drama culminates in the fishing contest where the village chief, Ndelu, takes an unprecedented decision charged with meaning and wisdom. The action is given piquancy by a strong undercurrent of human passion that flies in the face, so to speak, of artifices that divide and alienate. We are dealing here with a profound allegory that brings the classical stereotypes into pointed - and hopefully final - disrepute.
This book, slim as it looks, took Bernard Nsokikia Fonlon the best part of five laborious years to write 1965-9 inclusive. He writes 'I was penning away as students in France were up in arems against the academic Establishment, and their fury almost toppled a powerfful prestigious, political giant like General de Gaulle. In America students, arms in hand, besieeged and stormed the building of the University Administration, others blew up lecture halls in Canada - the student revolt, a very saeva indignatio, was in paroyysm. But in England (save in the London School of Economincs where students rioted for teh lame reason that the College gate looked like that of a jail0house) all was calm. 'Fonlon drew on these events to define the role of university education in this precious treasure of a book, which he dedicates to every African freshman and freshwoman. The book details his reflections and vision on the scientific and philosophical Nature, End and Purpose of university studies. He calls on African studens to harness the Scientific Method in their quest for Truth, and to put the specialised knowledge they acquire to the benefit of the commonwealth first, the, to themselves. To do this effectively, universities mus jealously protect academic freedom from all non-academic interferences. For any university that does not teach a student to think critically and in total freedom has taught him or her nothing of genuine worth. Universities are and must remain sacred places and spaces for the forging of genuine intellectuals imbued with skills and zeal to assume and promote social responsibiliti4es with self abnegation.
Foot Prints of Destiny
(2009)
The edifice of colonial Africa starts cracking as the Black experience with colonialism becomes intimately personal. There is Martin Paul Samba, whose adopted German aristocratic home as a student does not consider him material for a son-in-law. There are also Prince Rudolph Douala Manga Bell and Dr Bele who go to school with Samba in Germany. And then, of course, Princess Zara, the youthful Amazon warrior who is rescued from a slave ship on the shores of Kamerun. Supported by the Douala princes, Martin Paul Samba champions the cause of the exploited, in a central drama pitting Kamerunian nationalism against German colonialism. This is the story of youthful endeavours and loves, of some of Africa's best and brightest, immediately before and after the First World War.
This book deals with the important subject of governance and development. Even more significantly, the book has the merits of critically evaluating the concept of good governance in an African context, identifying the internal factors that impinge on good governance and development, and proposing solutions. It provides empirical evidence on the extent to which inappropriate governing strategies are the main internal obstacle to development in Cameroon. The authors discuss factors contributing to precarious and problematic governance from multidisciplinary perspectives, and demonstrate the extent to which such inadequacies impede positive social change. To promote effective development, the authors argue for the implementation of a good governance strategy that comprises, inter alia: adopting appropriate development strategies; decentralizing administration to make for popular participation and ensure accountability; taking the necessary steps to fight corruption; and ensuring the enforcement of property and cultural rights.
There is a growing body of literature on what was originally envisioned as a free political association of the French and British Cameroons and its dramatic effects on the 'British Cameroons' community. Anyangwe's new book is an attempt to write the history of the Southern Cameroons from a legal perspective. This authoritative work describes in great detail the story of La Republique du Cameroun's alleged annexation and colonization of the Southern Cameroons following the achievement of its independence, while highlighting the seeming complicity of the United Nations and the British Trusteeship Authority. In the process, Anyangwe unravels a number of myths created by the main actors to justify this injustice and, in the end, makes useful suggestions to reverse the situation and to restore statehood to the Southern Cameroons. The book is rich in archival research and informed by a global perspective. It convincingly shows the uniqueness of the Southern Cameroons case.
The densely populated Bamenda Highlands of Cameroon remains one of the regions with the greatest land degradation problems in the country. Factors responsible for this include climate change, the hilly nature or topographic layout of the land, and human interference through overgrazing, destructive agricultural practices and the impact of deforestation. This detailed study of resource management and its ecological challenges in the Bamenda Highlands, stresses an important link between falling food output and soil deterioration. While most areas in this predominantly agricultural region enjoy food abundance, the inhabitants of high-density infertile, rugged mountainous areas are forced to resort to double cropping and intensified land exploitation that leave little room for soil regeneration. The population problem in relation to land degradation is infinitely more complicated than the region's sheer ability to produce enough food supply. The authors make a strong case for a delicate balance between human agency and environmental protection in this highly populated and physically challenging region where land is a precious resource and land conflicts are common.
The celebrations that heralded democratic change in the 1990s in Africa have gradually faded into muffled cries of anger and attendant violence of despair. Almost everywhere on the continent so-called democratic leaders are openly subverting the people's will and disregarding national constitutions. Ordinary people find themselves removed from the centres of power, marginalized and reduced to helpless and hopeless onlookers as political leaders, their friends and families noisily enjoy the spoils of impunity. From Nigeria to Zimbabwe, Kenya to the Ivory Coast and Uganda to Cameroon, the writing is on the wall. The experiment with democracy has blatantly taken a dangerous nosedive. There is a crisis of honest, committed and democratic leadership, in spite of the advancements in education and intellectualism of the populace, and despite the influences of globalization and new understandings of governance. In this brief volume, Tatah Mentan makes an incisive diagnosis of how the 'security forces' brutally crush protests against bids to stay in power through corrupt electoral practices as well as how opposition voices have been hunted down and crushed or intimidated into graveyard silence. This is a clarion call for Africans to embrace the values of People Power in synch with the dictates of the current global imperatives. There is no place for visionless leadership. Africans need to raise their voices to recapture their freedom.
In this rich and compelling collection of poems the author explores the recesses of the imagination to reveal the different facets of contemporary experience. In doing this he highlights the social, the spiritual, and the metaphysical functions of poetry. The reader will find in the collection sincere expressions of feelings and penetrating thoughts, the genuine tone, spirit and taste of poetry and its ability to provide contemplative clues to prevailing circumstances. The preponderance of stimulating imagery and the overall display of ingenious poeticality reveal the poet as one imbued with a fertile imagination and prove as well that poetry remains the most noble of art through which one understands and comes to terms with the hidden secrets of the universe.
Imitation Whiteman
(2009)
This intriguing novel chronicles one migrant worker's experiences on a colonial plantation in West Africa. Martin Tebi cannot wait to board a truck to the south where he hopes to become a pioneer at a newly established oil palm plantation. Once he arrives, he realizes that becoming a 'Big man' in a new environment would not be as easy as he had thought. Set in the South West Region of Cameroon near the Bakassi region, this captivating story told in an authentic voice that fuses Pidgin and Standard English would keep readers spellbound as they follow Martin through his many struggles to become the first African manager. The experiences of Martin Tebi would resonate with economically displaced people in any part of the world.
This is a foundational text on the production and dissemination of Anglophone Cameroon literature. The Republic of Cameroon is a bilingual country with English and French as the official languages. Ashuntantang shows that the pattern of production and dissemination of Anglophone Cameroon literature is not only framed by the minority status of English and English-speaking Cameroonians within the Republic of Cameroon, but is also a reflection of a postcolonial reality in Africa where mostly African literary texts published by western multi-national corporations are assured wide international accessibility and readership. This book establishes that in spite of these setbacks, Anglophone Cameroon writers have produced a corpus of work that has enriched the genres of prose, poetry and drama, and that these texts deserve a wider readership.
Cup Man and Other Stories
(2009)
Cup Man and Other Stories is a collection of eight fictional short stories on themes such as the intrigues of the civil service, drunkenness, theft, matrimonial relations and living as an African immigrant in the West. The stories are a reflection of everyday life with all that goes with it. Each story is complete it itself, with all its humour, wit and figures of speech. Azonga's attention to detail and alert memory enable him to draw on memory and things past in a fascinating way. He excels in the craft of using simple and down-to-earth language, a factor which makes the collection an easy and compelling read.