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Erstnachweis von Dryopteris affinis s. str. (Dryopteridaceae, Pteridophyta) für Nordrhein-Westfalen
(2013)
Neuerdings werden fünf Sippen des Dryopteris-affinis-Komplexes in Mitteleuropa als eigenständige Arten bewertet, wovon vier auch in Nordrhein-Westfalen (NRW) vorkommen. Dazu gehören die triploide D. bor - reri, die offenbar die mit Abstand häufigste Art repräsentiert, und zwei weitere triploide Arten, D. pseudodisjuncta und D. lacunosa. Letztere wurde erst vor kurzem neu beschrieben und ist in NRW bislang nur von einem Fundpunkt bekannt. Mit Hilfe der Flow-Cytometrie gelang es nun, eine auf Grund der kleinen Sporen verdächtig erscheinende Pflanze aus dem Schwalm- Nette-Gebiet als diploide D. affinis s. str. zu identifizieren. Die anfängliche Vermutung, diese Art sei auf Tiefland-Vorkommen im deutlich atlantisch getönten äußersten Nordwesten von NRW beschränkt, haben sich als unzutreffend erwiesen; die Art konnte nachfolgend auch mehrfach im Süderbergland gefunden werden. Ebenfalls mit Hilfe der Flow-Cytometrie wurden eine Reihe von Vorkommen von D. borreri bestätigt sowie tetra- und pentaploide Hybriden (D. ×complexa und D. ×critica) nachgewiesen, die durch Bastardbildung mit D. filix-mas entstehen. Während Vorkommen der pentaploiden D. ×critica bereits seit längerer Zeit aus NRW bekannt sind, handelt es sich bei denjenigen von D. ×complexa ebenfalls um Erstnachweise. Das nordrhein-westfälische Areal dieser Sippen wird in drei Fundortkarten dargestellt (für den D.-affinis-Komplex insgesamt sowie für cytologisch bzw. flow-cytometrisch bestätigte Vorkommen der beiden Arten D. affinis s. str. und D. borreri sowie der beiden Hybriden D. ×complexa und D. ×critica). Aus einer mit der räumlichen Verteilung der Jahresniederschläge kombinierten Verbreitungskarte wird die enge Bindung an niederschlagreichere Lagen (zumeist mehr als 800mm) deutlich. Dies und weitere standortökologische Besonderheiten weisen darauf hin, dass die Sippen des D.-affinis-Komplexes in größerem Maße von der Wasserversorgung abhängig sind als D. filix-mas. Zwar repräsentieren die D.-affinis-Sippen offenbar typische Waldfarne und zeigen eine Präferenz für bodensaure Buchenwald-Gesellschaften, vor allem D. affinis s. str. kommt aber auffallend häufig an anthropogen überformten Sekundärstandorten vor, so an Weg- und Grabenböschungen, in Abgrabungen sowie an einem künstlichen Steilhang und in einem Steinbruch.
An einem Beispiel wird demonstriert, dass es oft vom Erfassungsaufwand abhängt, ob ein Merkmal als qualitativ oder quantitativ (zähl- bzw. messbar) einzustufen ist. Es folgt ein Überblick über quantitative Merkmale, die von 1820 bis heute in der Literatur über mitteleuropäische Wildrosenarten (Rosaceae: Rosa) behandelt werden. Bei vielen dieser Merkmale erscheint eine Erfassung in Ordinalskalen sinnvoller als eine metrische. Zu 8 Merkmalen, bei denen das Sammeln von Messwerten und ihre statistische Aufbereitung Erfolg verheißt, werden eigene Beobachtungen und Untersuchungen mitgeteilt. Bei ihrer Erfassung gilt es, eine Reihe von Fehlerquellen zu beachten, die meist in den Objekten, in einem Fall im Beobachter liegen. Bei der Erfassung von Hagebuttenmerkmalen muss ein Dimorphismus zwischen End- und Seitenblüten der Blütenstände berücksichtigt werden. Die Beschränkung von Messungen auf solitäre Blüten verringert die Streuung der Messwerte ebenso wie die Ermittlung der Standardabweichung anstelle der von älteren Autoren verwendeten Variationsbreite. Aufgrund einer optischen Täuschung wird die relative Länge des Fruchtstiels in Bezug zur Hagebuttenlänge meist zu hoch eingeschätzt. Merkmale, deren quantitative Erfassung diagnostisch brauchbare Daten liefern kann, sind in erster Linie die relative Fruchtstiellänge und der Griffelkanaldurchmesser, in zweiter Linie die Endfiederlänge, der Längen-Breiten index der Endfiedern und die Kronblattlänge.
Nur wenige Differentialmerkmale erlauben eine sichere Unterscheidung der diploiden Stellaria pallida von der allotetraploiden S. media: die fehlenden oder rudimentären Kronblätter, die Staubblattanzahl sowie Größe und Masse der Samen. Nicht bewährt haben sich dagegen die Farbe der Laubblätter und der Samen sowie die Länge und die Behaarungsverhältnisse der Kelchblätter. Bestimmungsschwierigkeiten und die Tatsache, dass S. pallida oft übersehen wird, sind die Gründe, weshalb über Standort und Vergesellschaftung immer noch wenig bekannt ist. S. pallida bleibt nicht auf Sandgebiete und Tieflagen beschränkt, auch ist sie nicht in erster Linie eine Ruderalart (häufiger in Rasen-, Tritt- und Saumgesellschaften). Die Verbreitung ist überall erst unvollständig erfasst, sowohl innerhalb des als ursprünglich angesehenen Areals (Europa, Nordafrika, Westasien), als auch in Nord- und Südamerika, Südafrika, Ostasien und Australien, wo S. pallida als Neophyt angesehen wird. Fundierte Aussagen über eine Bestandsentwicklung sind bis jetzt nicht möglich. Ausbreitungsmöglichkeiten und Indigenat werden diskutiert. Strittig ist, ob der Name S. pallida (DUMORT.) PIRÉ 1863 als gültig veröffentlicht angesehen werden darf oder durch S. pallida (DUMORT.) CRÉPIN 1866 zu ersetzen ist. Der ältere Name S. apetala UCRIA 1793 hat Priorität vor S. pallida; ein Neotypus wird festgelegt.
Die Intention der hiermit fortgesetzten Reihe sowie die Kriterien zur Aufnahme der besprochenen Literatur und der nomenklatorischen Neuigkeiten sind in der Einführung zur ersten Folge in Kochia 1 erläutert. Uwe Amarell (Offenburg), Bernhard Dickore (München), Gerwin Kasperek (Frankfurt am Main) und Peter A. Schmidt (Tharandt) danken wir für Hinweise auf wichtige Neuerscheinungen.
Purpose: The aim of this official guideline coordinated and published by the German Society for Gynecology and Obstetrics (DGGG) and the German Cancer Society (DKG) was to optimize the screening, diagnosis, therapy and follow-up care of breast cancer.
Methods: The process of updating the S3 guideline dating from 2012 was based on the adaptation of identified source guidelines which were combined with reviews of evidence compiled using PICO (Patients/Interventions/Control/Outcome) questions and the results of a systematic search of literature databases and the selection and evaluation of the identified literature. The interdisciplinary working groups took the identified materials as their starting point to develop recommendations and statements which were modified and graded in a structured consensus procedure.
Recommendations: Part 1 of this short version of the guideline presents recommendations for the screening, diagnosis and follow-up care of breast cancer. The importance of mammography for screening is confirmed in this updated version of the guideline and forms the basis for all screening. In addition to the conventional methods used to diagnose breast cancer, computed tomography (CT) is recommended for staging in women with a higher risk of recurrence. The follow-up concept includes suggested intervals between physical, ultrasound and mammography examinations, additional high-tech diagnostic procedures, and the determination of tumor markers for the evaluation of metastatic disease.
Als Fortschreibung zu der in dieser Zeitschrift im Jahr 2006 erschienenen Zusammenstellung von Florenwerken und Verbreitungsatlanten der Gefäßpflanzen Deutschlands aus dem Zeitraum 1945 bis 2005 werden hier Ergänzungen aus den Jahren 2006 bis 2010 aufgeführt und mit Schlüsselinformationen versehen. Dabei handelt es sich um 29 neue Publikationen und zusätzlich 22 Neuauflagen, Ergänzungen oder Nachträge bereits in der ersten Zusammenstellung berücksichtigter Florenwerke.
Zwei neue Arten aus dem Ranunculus-auricomus-Komplex in Deutschland werden beschrieben und abgebildet: R. reichertii und R. mosellanus. Ihre bislang bekannte Verbreitung beschränkt sich auf Rheinland-Pfalz, dort im Saar-Nahe-Bergland (R. reichertii) und im Moseltal und Umgebung (R. mosellanus). R. reichertii zeichnet sich durch seine Größe und eine flache Basalbucht der Grundblätter aus, R. mosellanus weicht durch eine starke Blattspreitenteilung der Grundblätter mit überlappenden Seitenabschnitten morphologisch von allen bislang bekannten Arten ab.
Im Rahmen der botanischen Kartierung im baden- ürttembergischen Alpenvorland und dem angrenzenden bayerischen Allgäu wurden in den Jahren 2001 bis 2011 sechs Exemplare der seltenen Hybride Dryopteris ×brathaica (D. carthusiana × D. filix- mas) entdeckt. Molekulargenetische Untersuchungen an mitteleuropäischen Vertretern der Gattung Dryopteris zeigen sippendifferenzierende Längenunterschiede von DNA die in der vorliegenden Arbeit für einige hier interessierende Taxa in Form von Elektropherogrammen gezeigt werden. Für D. ×brathaica und D. ×deweveri wird die hybridogene Abstammung molekulargenetisch bestätigt. Nach einem Rückblick auf bisherige Funde von D. ×brathaica in England, Deutschland, Frankreich und Österreich werden von den Wuchsorten in Baden-württemberg und Bayern ökologische Aspekte und das Artenspektrum der begleitenden Farnpflanzen beschrieben. Die ausführliche morphologische Beschreibung von D. ×brathaica basiert auf Proben der neu aufgefundenen Pflanzen sowie auf uns vorliegenden Herbarbelegen englischer und österreichischer Herkunft. Ergänzt durch morphometrische Messungen wird die morphologische Mittelstellung von D. ×brathaica zu beiden Elternarten an verschiedenen Merkmalen verdeutlicht und die Hybride gegen D. remota abgegrenzt. An einer der neu aufgefundenen Pflanzen von D. ×brathaica wurde eine Chromosomenzählung durchgeführt.
Die taxonomische Umgrenzung und interpretation von Hieracium fallax war im 19. Jahrhundert sehr unklar und teilweise schwankend. Sie hat dann vor allem durch die Monographie von Nägeli & Peter (1889) eine starke Wandlung erfahren, die mit Beschreibung bei Willdenow (1809) und dem Typus-Material in B nicht mehr übereinstimmt. Die Geschichte dieses Bedeutungswandels wird kurz dargelegt. Der von Bräutigam & Greuter (2007) im Zuge der Ausgliederung von Pilosella aus Hieracium vorgenommene Namenswechsel zu P. setigera Fr. ist zu korrigieren, da für die betreffende „echioides-cymosum“- Zwischenart mit H. cymosiforme Froel. ein älterer Name aufgegriffen werden muss. Die Namen H. cymosiforme, H. fallax und Pilosella setigera werden lectotypisiert und die Neukombination P. cymosiformis vorgenommen.
Acinetobacter baumannii is a nosocomial pathogen which can persist in the hospital environment not only due to the acquirement of multiple antibiotic resistances, but also because of its exceptional resistance against disinfectants and desiccation. A suitable desiccation assay was established in which A. baumannii ATCC 19606T survived for ca. 1 month. The growth medium slightly influenced survival after subsequent desiccation. A significant effect could be attributed to the growth phase in which bacteria were dried: In exponential phase, cells were much more desiccation sensitive. The main focus of the present study was the elucidation of the role of compatible solutes, which are known to protect many bacteria under low water activity conditions, in desiccation survival of A. baumannii. Exogenous trehalose was shown to efficiently protect A. baumannii on dry surfaces, in contrast to other compatible solutes tested such as mannitol or glycine betaine. To analyze the importance of intracellularly accumulated solutes, a double mutant lacking biosynthesis pathways for mannitol and trehalose was generated. This mutant accumulated glutamate as sole solute in the presence of high NaCl concentrations and showed severe growth defects under osmotic stress conditions. However, no effect on desiccation tolerance could be seen, neither when cells were dried in water nor in the presence of NaCl.
The centrosome linker proteins C-Nap1, rootletin, and CEP68 connect the two centrosomes of a cell during interphase into one microtubule-organizing center. This coupling is important for cell migration, cilia formation, and timing of mitotic spindle formation. Very little is known about the structure of the centrosome linker. Here, we used stimulated emission depletion (STED) microscopy to show that each C-Nap1 ring at the proximal end of the two centrioles organizes a rootletin ring and, in addition, multiple rootletin/CEP68 fibers. Rootletin/CEP68 fibers originating from the two centrosomes form a web-like, interdigitating network, explaining the flexible nature of the centrosome linker. The rootletin/CEP68 filaments are repetitive and highly ordered. Staggered rootletin molecules (N-to-N and C-to-C) within the filaments are 75 nm apart. Rootletin binds CEP68 via its C-terminal spectrin repeat-containing region in 75-nm intervals. The N-to-C distance of two rootletin molecules is ∼35 to 40 nm, leading to an estimated minimal rootletin length of ∼110 nm. CEP68 is important in forming rootletin filaments that branch off centrioles and to modulate the thickness of rootletin fibers. Thus, the centrosome linker consists of a vast network of repeating rootletin units with C-Nap1 as ring organizer and CEP68 as filament modulator.
Complex I (proton-pumping NADH:ubiquinone oxidoreductase) is the largest enzyme of the mitochondrial respiratory chain and a significant source of reactive oxygen species (ROS). We hypothesized that during energy conversion by complex I, electron transfer onto ubiquinone triggers the concerted rearrangement of three protein loops of subunits ND1, ND3, and 49-kDa thereby generating the power-stoke driving proton pumping. Here we show that fixing loop TMH1-2ND3 to the nearby subunit PSST via a disulfide bridge introduced by site-directed mutagenesis reversibly disengages proton pumping without impairing ubiquinone reduction, inhibitor binding or the Active/Deactive transition. The X-ray structure of mutant complex I indicates that the disulfide bridge immobilizes but does not displace the tip of loop TMH1-2ND3. We conclude that movement of loop TMH1-2ND3 located at the ubiquinone-binding pocket is required to drive proton pumping corroborating one of the central predictions of our model for the mechanism of energy conversion by complex I proposed earlier.
Light absorption of myoglobin triggers diatomic ligand photolysis and a spin crossover transition of iron(II) that initiate protein conformational change. The photolysis and spin crossover reactions happen concurrently on a femtosecond timescale. The microscopic origin of these reactions remains controversial. Here, we apply quantum wavepacket dynamics to elucidate the ultrafast photochemical mechanism for a heme–carbon monoxide (heme–CO) complex. We observe coherent oscillations of the Fe–CO bond distance with a period of 42 fs and an amplitude of ∼1 Å. These nuclear motions induce pronounced geometric reorganization, which makes the CO dissociation irreversible. The reaction is initially dominated by symmetry breaking vibrations inducing an electron transfer from porphyrin to iron. Subsequently, the wavepacket relaxes to the triplet manifold in ∼75 fs and to the quintet manifold in ∼430 fs. Our results highlight the central role of nuclear vibrations at the origin of the ultrafast photodynamics of organometallic complexes.
Previous magnetoencephalography (MEG) studies have revealed gamma-band activity at sensors over parietal and fronto-temporal cortex during the delay phase of auditory spatial and non-spatial match-to-sample tasks, respectively. While this activity was interpreted as reflecting the memory maintenance of sound features, we noted that task-related activation differences might have been present already prior to the onset of the sample stimulus. The present study focused on the interval between a visual cue indicating which sound feature was to be memorized (lateralization or pitch) and sample sound presentation to test for task-related activation differences preceding stimulus encoding. MEG spectral activity was analyzed with cluster randomization tests (N = 15). Whereas there were no differences in frequencies below 40 Hz, gamma-band spectral amplitude (about 50–65 and 90–100 Hz) was higher for the lateralization than the pitch task. This activity was localized at right posterior and central sensors and present for several hundred ms after task cue offset. Activity at 50–65 Hz was also increased throughout the delay phase for the lateralization compared with the pitch task. Apparently cortical networks related to auditory spatial processing were activated after participants had been informed about the task.
The ATP-binding cassette transporter TAPL translocates polypeptides from the cytosol into the lysosomal lumen. TAPL can be divided into two functional units: coreTAPL, active in ATP-dependent peptide translocation, and the N-terminal membrane spanning domain, TMD0, responsible for cellular localization and interaction with the lysosomal associated membrane proteins LAMP-1 and LAMP-2. Although the structure and function of ABC transporters were intensively analyzed in the past, the knowledge about accessory membrane embedded domains is limited. Therefore, we expressed the TMD0 of TAPL via a cell-free expression system and confirmed its correct folding by NMR and interaction studies. In cell as well as cell-free expressed TMD0 forms oligomers, which were assigned as dimers by PELDOR spectroscopy and static light scattering. By NMR spectroscopy of uniformly and selectively isotope labeled TMD0 we performed a complete backbone and partial side chain assignment. Accordingly, TMD0 has a four transmembrane helix topology with a short helical segment in a lysosomal loop. The topology of TMD0 was confirmed by paramagnetic relaxation enhancement with paramagnetic stearic acid as well as by nuclear Overhauser effects with c6-DHPC and cross-peaks with water.
Some students evidently find it difficult to paraphrase the content of a text (particularly a specialist or professional text) after reading it. This inability may have a negative impact on their performance when writing Bachelor theses or when studying in general. This paper therefore addresses the question of how to help students of German develop the important competency of paraphrasing and summarizing the content of texts. The starting point was a small-scale research project conducted among students at the Department of German Studies, Faculty of Arts, University of Ostrava; the results of the research were analyzed to identify the main problems encountered by students when carrying out these tasks. This analysis forms the basis for an overview of strategies and methods which can be practised by students when paraphrasing and summarizing the content of texts. The article systematizes the key processes and operations for paraphrasing and summarizing with reference to the theoretical literature. The article seeks to contribute to the discussion of a broad range of methods that can be used to help improve the quality of foreign language studies and the study of specialist and professional language
The recent recolonisation of the Central European lowland (CEL) by the grey wolf (Canis lupus) provides an excellent opportunity to study the effect of founder events on endoparasite diversity. Which role do prey and predator populations play in the re-establishment of endoparasite life cycles? Which intrinsic and extrinsic factors control individual endoparasite diversity in an expanding host population? In 53 individually known CEL wolves sampled in Germany, we revealed a community of four cestode, eight nematode, one trematode and 12 potential Sarcocystis species through molecular genetic techniques. Infections with zoonotic Echinococcus multilocularis, Trichinella britovi and T. spiralis occurred as single cases. Per capita endoparasite species richness and diversity significantly increased with population size and changed with age, whereas sex, microsatellite heterozygosity, and geographic origin had no effect. Tapeworm abundance (Taenia spp.) was significantly higher in immigrants than natives. Metacestode prevalence was slightly higher in ungulates from wolf territories than from control areas elsewhere. Even though alternative canid definitive hosts might also play a role within the investigated parasite life cycles, our findings indicate that (1) immigrated wolves increase parasite diversity in German packs, and (2) prevalence of wolf-associated parasites had declined during wolf absence and has now risen during recolonisation.
The endoplasmic reticulum (ER) forms a complex endomembrane network that reaches into the cellular compartments of a neuron, including dendritic spines. Recent work discloses that the spine ER is a dynamic structure that enters and leaves spines. While evidence exists that ER Ca2+ release is involved in synaptic plasticity, the role of spine ER morphology remains unknown. Combining a new 3D spine generator with 3D Ca2+ modeling, we addressed the relevance of ER positioning on spine-to-dendrite Ca2+ signaling. Our simulations, which account for Ca2+ exchange on the plasma membrane and ER, show that spine ER needs to be present in distinct morphological conformations in order to overcome a barrier between the spine and dendritic shaft. We demonstrate that RyR-carrying spine ER promotes spine-to-dendrite Ca2+ signals in a position-dependent manner. Our simulations indicate that RyR-carrying ER can initiate time-delayed Ca2+ reverberation, depending on the precise position of the spine ER. Upon spine growth, structural reorganization of the ER restores spine-to-dendrite Ca2+ communication, while maintaining aspects of Ca2+ homeostasis in the spine head. Our work emphasizes the relevance of precise positioning of RyR-containing spine ER in regulating the strength and timing of spine Ca2+ signaling, which could play an important role in tuning spine-to-dendrite Ca2+ communication and homeostasis.
Background: Vitamin D is required to maintain the integrity of the intestinal barrier and inhibits inflammatory signaling pathways.
Objective: Vitamin D deficiency might be involved in cirrhosis-associated systemic inflammation and risk of hepatic decompensation in patients with liver cirrhosis.
Methods: Outpatients of the Hepatology Unit of the University Hospital Frankfurt with advanced liver fibrosis and cirrhosis were prospectively enrolled. 25-hydroxyvitamin D (25(OH)D3) serum concentrations were quantified and associated with markers of systemic inflammation / intestinal bacterial translocation and hepatic decompensation.
Results: A total of 338 patients with advanced liver fibrosis or cirrhosis were included. Of those, 51 patients (15%) were hospitalized due to hepatic decompensation during follow-up. Overall, 72 patients (21%) had severe vitamin D deficiency. However, patients receiving vitamin D supplements had significantly higher 25(OH)D3 serum levels compared to patients without supplements (37 ng/mL vs. 16 ng/ml, P<0.0001). Uni- and multivariate analyses revealed an independent association of severe vitamin D deficiency with the risk of hepatic decompensation during follow-up (multivariate P = 0.012; OR = 3.25, 95% CI = 1.30–8.2), together with MELD score, low hemoglobin concentration, low coffee consumption, and presence of diabetes. Of note, serum levels of C-reactive protein, IL-6 and soluble CD14 were significantly higher in patients with versus without severe vitamin D deficiency, and serum levels of soluble CD14 levels declined in patients with de novo supplementation of vitamin D (median 2.15 vs. 1.87 ng/mL, P = 0.002).
Conclusions: In this prospective cohort study, baseline vitamin D levels were inversely associated with liver-cirrhosis related systemic inflammation and the risk of hepatic decompensation.
Festuca rhenana spec. nov. und Festuca heteropachys, zwei verkannte Schwingel der Flora Deutschlands
(2012)
Seit über vier Jahrzehnten werden kräftige Schwingel von Silikatfelsen des mittelrheinischen Raumes irrtümlich als Festuca heteropachys bezeichnet. Diese Pflanzen gehören zu keiner der bisher bekannten Sippen. Sie werden unter dem Namen F. rhenana als neue, in Deutschland endemische Art beschrieben. Im Nordpfälzer Bergland, im Nahe- , im Mittelrhein- und im Moseltal besiedelt F. rhenana extrem trocken-warme Felsstandorte auf ± basenreichen Silikatgesteinen (Rhyolith, Andesit, Oberrotliegendes, devonische Schiefer). Fast alle Fundorte liegen in Rheinland-Pfalz, zwei in Hessen. Die wahre F. heteropachys kommt ebenfalls in Deutschland vor, und zwar nur im südlichen Teil von Rheinland-Pfalz. F. heteropachys ist ein mesophiles bis schwach thermophiles, Halbschatten ertragendes Horstgras. Kennzeichnend sind die mit 30–50 cm oft sehr langen Grundblätter und die starke, deutlich bis über die Mitte der Halme reichende Beblätterung. Im Anschluss an die Vorkommen im Elsass findet sich F. heteropachys hauptsächlich im Pfälzer Wald auf ± sauren steinigen oder sandigen Böden über Buntsandstein. Unterscheidungsmerkmale von F. heteropachys, F. rhenana, F. lemanii und der häufigen F. guestfalica werden dargestellt.
Angegeben wird jeweils das Sammeldatum des für die Chromosomenzählung verwendeten Materials (Lebendpflanze, Samen) zuzüglich eines eventuell gesammelten Beleges sowie – getrennt durch einen Schrägstrich – Sammeldatum und Aufbewahrungsort eines Beleges der gezählten Pflanze. Wird nur ein Datum angegeben, ist allein die Wildaufsammlung dokumentiert. Die Abkürzungen der Herbarien richten sich nach Holmgren & al. (1990, sowie Online-Nachträge, für die neuerdings B. Thiers verantwortlich zeichnet). Taxonomie und Nomenklatur richten sich nach der aktuellen deutschen Standardliste (Buttler & Hand 2008) und den in dieser Zeitschrift publizierten Nachträgen. Die Abbildungen zeigen Metaphasen, die an Quetschpräparaten von Wurzelspitzen gewonnen wurden (zur Methodik siehe Vogt & Aparicio 2000). Ralf Hand dankt Michael Meyer und seinem Gärtnerteam sowie Monika Lüchow und Marion Cubr (alle Botanischer Garten und Botanisches Museum Berlin-Dahlem) für Kultur, Dokumentation und Hilfe bei der Zählung von Material.
Eine Hybride zwischen Asplenium septentrionale (L.) Hoffm. subsp. septentrionale und A. viride (L.) HUDS. wird beschrieben. Der Bastard wurde in einem Exemplar bei Bosco-Gurin im Schweizer Kanton Tessin gefunden. Die morphologische Mittelstellung sowie Sporen-, Cytologische und Molekulargenetische Untersuchungen bestätigten die vermutete Abstammung.
Schriftenschau
(2013)
Zwei Autoren botanischer Werke tragen den Namen Hermann Wagner. Sie sind beide 1824 geboren, der eine in Hadamar (Herzogtum Nassau, heute Hessen), der andere in Weißenfels (Preußen, Provinz Sachsen, heute Sachsen-Anhalt). Es war lange fraglich, welcher der beiden die Illustrierte deutsche Flora (1. Auflage 1869–1871) verfasst hat. Es ließ sich nachweisen, dass der Autor dieser Flora Hermann Wagner aus Weißenfels ist, der im übrigen vor allem zahlreiche populäre naturhistorische Schriften für die Jugend verfasst hat. In letzter Zeit wurde noch ein dritter als Autor genannt, der Geograph Hermann Wagner (1840–1929). Das ist sicher ein Irrtum.
Schriftenschau
(2007)
King Ottokar II and Záviš z Falkenštejna are often depicted in literary fiction as rivals – both in politics and in love. A similar representation can be found in the work of Franz Grillparzer, whose Zawisch incorporates both demonic and comic elements. He can be interpreted in various ways: as a sophisticated plotter of intrigues, a malicious poisoner, an arrogant figure who betrays his king and his country due to his wounded pride, or a seducer who eventually becomes subservient to an Amazon whom he had originally envisaged as his own puppet. Directors, viewers and readers usually do not see him as a great statesman. However, Jaroslav Hilbert depicted him in an entirely different manner. His Falkenštejn is a violent conspirator and usurper - but also a patriot, a statesman and a modern thinker. In Grillparzers work, the character of Zawisch is more reminiscent of his traditional rival Ottakar than of Hilbert's depiction. This study presents a comparison of both characters.
The article provides an insight into the Czech translations of the lecture 'Weihnachtsgeheimnis' by Edith Stein (1891-1942), which were published in 1991 and 2003. The analysis of the translations is based on Skopos theory, the ideas of Christiane Nord and hermeneutic approaches; the author points out the specific features and demands of translating religious texts.
Marie Luise Kaschnitz is not considered to be an experimental author in the usual sense. Her respectful use of traditional forms has been praised, but also criticized, and it was only in her later works that she loosened her strong links with tradition. The beginning of this change is marked by the short story Am Circeo [At Cape Circeo], placed exactly in the centre of her 1960 volume of short stories entitled Long Shadows. The present article examines the experimental elements of this text, attempting to determine what conditioned
them and seeking to reveal their influence on later works.
Die philosophische Erkenntnis in der 'Klage der Ceres' : Schillers Adaption des Proserpina-Mythos
(2018)
While Ceres behaves actively and energetically in the traditional myth, Friedrich von Schiller's poem 'Klage der Ceres' (1797) shows her within the same ancient plot but as a more emotional figure. This detailed analysis explains the poem's structure and the stylistic devices which lead to its philosophical impact. It also addresses the awareness that death is a part of life and discusses how art can help to reinvent traditional ideas.
This paper presents a contrastive analysis of auto- and hetero-stereotypes of Bosnians and Germans. The analysis is based on data collected from respondents choosing from a list of 140 characteristics. The anonymous online questionnaire asked respondents to identify those characteristics that they considered to be connected with their own culture or with the other culture, and to give their reasons for their choice (in the case of the most important characteristics). The analysis based on this data reveals how Germans and Bosnians perceive themselves and each other. It also enables the compilation of a list of stereotypes based on the most frequently identified characteristics, which can be used as a basis for further analysis and interpretation. This first analysis is intended as a foundation for future analyses of ethnic stereotypes among Germans and ethnic groups in the western Balkans: Bosnians, Serbs and Croats.
Although there are many dialect speakers in Bavaria, the dialect - mainly because of its non-standardized spelling - is usually not used in common print media or on nationwide television. Nevertheless, the Bavarian dialect appears on Bavarian television (BR) and in cinema films. However, the Bavarian used on television or in films is frequently not a genuine dialect; instead it is a synthetic language which resembles the German standard and merely refers to the dialect. This is mainly due to the needs of non-dialect speakers, who would definitely have comprehension problems with the genuine dialect. Furthermore, the Bavarian dialect is often used on online platforms, such as Facebook or YouTube. In these conversational situations, face-to-face communication is replaced by written texts. In the case of dialect speakers, these texts can appear as written dialect; due to the non-standardized spelling, the texts are strongly individualized.
This paper focuses on passages of interpreting/translation in four novels written by Bosnian novelists (Ivo Andrić, Dževad Karahasan, Saša Stanišić). It seeks to answer the following questions: How do the characters of the interpreters/translators represent their cultural background? Does the immediate situation (e.g. a situation of threat or violence) influence their verbal behaviour? Is the literary description a metaphorical one in order to symbolize the inadequacy and even the failure of interpreting/translation? How do the interpreters/translators in the novels attempt to bridge the gap between different cultures?
By juxtaposing parallel passages in Ernst Jünger's War Diary with those in his later works on World War I written during the 1920s, I aim to show that Jünger's concept of a soldier increasingly glorifies violence.
Flashmob, App, E-Bike, Gendermainstreaming, bloggen, skypen, gefaked/gefakt, geliked/gelikt, Coffee-to-go, Latte macchiato, Gnocchi, Yallah, Shisha oder Sushi – die beherrschenden Fremdwörter aus Wissenschaft und Alltag der Gegenwartssprache im 21. Jahrhundert sind englischen Ursprungs, im letzten Jahrzehnt auch zunehmend aus anderen modernen europäischen und außereuropäischen Sprachen entlehnt. Die Entlehnungsbedingungen dieser Wörter unterscheiden sich damit grundsätzlich von den Gegebenheiten, die für die Integrationsentwicklungen bei Gräzismen und Latinismen sowie für Gallizismen bestimmend waren. Während die Fremdwörter aus den drei bis ins 20. Jahrhundert hinein wesentlichen Gebersprachen über Jahrhunderte hinweg in mehreren Phasen schrittweise Eingang in die deutsche Sprache fanden und dabei durch einen kontinuierlichen, wenn auch nicht immer widerspruchsfreien Prozess orthografischer Normierung begleitet wurden, erfolgte die Übernahme einer Vielzahl von Anglizismen und anderer Neologismen erheblich schneller im Rahmen umfassender Internationalisierung und Globalisierung von Sprache und Gesellschaft. Die entlehnten Wörter bezeichnen zum allergrößten Teil neue Phänomene, Wortbedeutungen oder Sachverhalte, sie sind Indizien für fundamentale gesellschaftliche Veränderungen, die einen grundlegenden Sprach- und schließlich auch Schreibwandel zur Folge haben. Im Gegensatz zum Umfeld früherer Entlehnungen bieten normierende Texte wie Grammatiken oder Wörterbücher daher zunächst noch keine orthografische Orientierung. Stattdessen gewinnt das Internet, bestimmt von professionellen wie auch informellen Schreibern, sowohl als Bezugsquelle von Informationen als auch als Orientierungsrahmen für die Schreibung neuer Wörter eine immer stärkere Bedeutung. Anglizismen spielen dabei eine Sonderrolle: Sie werden sowohl von englischen als auch von deutschen Quelltexten aus rezipiert und zum Teil in ihrem gebersprachlichen graphemischen Status übernommen, zum Teil modifiziert.
Der Krieg von der Kanzel
(2016)
At the beginning of World War I a large number of war sermons ("Kriegspredigten") were published in Germany. The first part of this paper presents an overview of sermons given by my great-grandfather Karl König in August 1914. It elaborates on the general characteristics of war sermons as well as König's specific target audience and his linguistic means. The second part discusses König's usage of the term "Opfer" (victim vs. sacrifice).
The writer Lion Feuchtwanger makes an appeal against World War I with two dramatic adaptations of ancient texts: 'Die Perser des Aischylos' ('Aeschylus' Persians'), and – based on two works by Aristophanes – 'Friede' (‘Peace’). Feuchtwanger uses metaphors in various parts of these plays to express emotions concerning the war (across the spectrum of human emotions). These metaphors function as instruments for reinforcing the intended criticism of war in both works.
The article starts by giving a brief survey of the current state of German-Czech and Czech-German lexicography in the field of learners' dictionaries. It then continues with a metalexicographic examination of two translational dictionaries published since 2000. Attention focuses on the ways in which each team of authors addresses some basic metalexicographic problems in the introductory texts. The article then explores the methods of description used for fixed lexical phrases, which are critically analyzed (using as an example the dictionary entry for the lemma Kopf (head).
The First World War brought devastating consequences for German linguistics. Formerly one of the most prestigious foreign languages taught at schools and universities outside Germany, after the war German disappeared from almost all curricula abroad. Furthermore, it proved impossible to establish a structuralist school (such as the Prague school) in Germany. The article suggests that this was neither due to the long tradition of the Jungian grammarians nor due to the Nazis' official condemnation of structuralism as being incompatible with the ideology of the state. It is shown that such a development should instead be attributed to the so-called "Krieg der Geister" ("war of the intellect"), which remained present even after the military peace (1918) amid a feeling of national insecurity. The article concludes that such a nationalistic social and political environment proved to be fertile ground for Whorfianism, and the influence of the so-called 'Sprachinhaltsforschung' prevailed towards structuralism.
The article deals with the representation of the life principles of Count Albert Joseph Hoditz as discussed in his literary work. The analysis places this work in its literary-historical and philosophical context and seeks to make an innovative contribution to literary-historical research of this topic.
The article describes the role of German as a working language and official language of the European Union. It also focuses on issues associated with the notion of an 'overarching' language of general use: especially in the field of law, each language reflects the specific legal and administrative traditions of the society in which it developed, meaning that different languages frequently lack precise one-to-one equivalents for particular legal concepts. Finally, the author assesses the 'economic value' of several European languages as proposed by Ulrich Ammons, demonstrating that German plays a leading role in this regard.
In 2015, the last work of Günter Grass appeared: Vonne Endlichkait (On Finiteness). This offers the opportunity to recall the highly personal style of this great German author. The whole book can be described as an artistic triad, consisting of short prose pieces, poems and drawings, most of them dealing with old age and death. The following linguistic and literary aspects are dealt with: genres and text types, the semiotic relations between prose, poetry and drawings, allusions to poets and philosophers, the representation of spoken and dialect German, syntactic constructions, semantics, and especially metaphorical processes. Finally, the article discusses some stylistic features which are typical of Grass's writing.
When becoming integrated into the German vocabulary, foreign words reflect paradigmatic changes regarding orthography, grammar as well as semantics. In this context, German orthography is also highly determined by orthographic codification, which continues to influence the development of spelling to the present day. This study compares digital linguistically annotated corpora containing texts written by professional as well as non-professional writers; these corpora contain several billion foreign words (of Greek, Latin and French origin, and in the second part of the study of English/American and Italian origin), studied over a period of 20 years following the German orthographic reform of 1996. The results may potentially help the official regulations to adapt to the spelling practices observed – either by describing the rules more precisely or by proposing possible spelling variants or eliminating those which are not in common use. The study may also help to support correct lexicographic codification in dictionaries.
The biography and cultural activities of Count Albert Josef Hodic has become a central theme of a whole series of publications on the history and cultural history, in which this nobleman is approached from the biographical as well as cultural and historical perspective. Although in the specialized literature Albert Joseph Hoditz is associated with the attributes oscillating between creativity, versatility, pacifist and cosmopolitan attitude, the pursuit of literary history to illuminate his numerous representations in European literature is rather marginal. The article aims to contribute to the approximation of the image of Count Hoditz in German literature.
The tragedy 'König Ottokars Glück und Ende' by the Austrian poet Franz Grillparzer is often viewed as an exclusively male drama. Nevertheless, it does contain female characters, including the two wives of the Přemyslid King Otakar I – Margaret of Austria and Kunigunda of Galicia. The first of these in particular is a somewhat ambiguous character, whose interpretation raises a number of questions. The aim of this study is to outline the problems associated with interpreting the character of Margaret and to find a character in Czech historical literature who is similar to Grillparzer's Margaret.
This paper attempts to apply the concepts of proximity and distance to a literary text – Arthur Schnitzler's "Fräulein Else". The analysis builds on five different proximity-distance relations: spatial, temporal, social, emotional and cognitive. The purpose is to show how linguistic devices are used to describe individual relations and what roles these relations play in the given text.
The article analyses three texts which address the same subject (the definition of the word Wort) and aims to demonstrate that it is not only the topic that plays a crucial role in creating the macrostructure and microstructure of a text, but also the communicative situation. The article explores what differences there are in the selection of linguistic means when the same content is being expressed in texts intended for communication at various levels of specialization, and which communication strategies the authors of the texts choose in connection with the text's genre, their intentions and (above all) the communicative situation.
This analysis of the literary comic 'der Spieler' seeks to identify similarities and differences between the text and its pre-text, exploring whether the comic manifests the intentions of Dostoyevsky's literary model 'The Gambler' and asking whether the stylistic tone of the novel is retained in the comic version. The analysis shows that the authors of the comic manage to retain both Dostoyevsky's intentions and his poetic/narrative techniques, while also creating their own verbal and graphic interpretations.
This study attempts to determine what methodological approach is suitable for studying speeches about Germanness that were written in Germany in the 1980s. The corpus of the speeches was chosen to cover multiple areas and disciplines. It includes literary, political and historiographical speeches authored by G. Grass ('Geschenkte Freiheit'), M. Walser ('Über Deutschland reden'), R. von Weizsäcker ('Der 8. Mai 1945'), E. Nolte ('Vergangenheit, die nicht vergehen will') and H. Lübbe ('Der Nationalsozialismus im Bewußtsein der deutschen Gegenwart'). The study illustrates the limitations of the ideological and purely disciplinary methodological approach. Instead it seeks a starting point for an analysis which proceeds in an intertextual and interdisciplinary manner.
Hlučín (formerly Hultschin) is now part of the Czech Republic, though the influence of the German language can be observed in the region's folk culture. Important names include August Scholtis, born in Bolatice, as well as other figures such as Hermann Janosch, Alfons Hayduk, Karl-Ernst Schellhammer, Richard Kühnau, Georg Hyckel, Ferdinand Minsberg and Elfrieda Moser-Rath. The oral folk tradition in the region has mostly been passed down via folk songs, fairy-tales, legends and other narratives. These genres reflect various themes, related primarily to local personalities, castles and manor houses or events in specific villages.
The article deals with Thomas Mann' s attitude to Stefan George and his work. The first part reproduces and comments on Mann's statements about George. It transpires that Thomas Mann's attitude to George was highly contradictory. This fact is mainly due to the self-searching of the North German author against the background of historical events. The article also contains an analysis of two short stories by Thomas Mann ('At the Prophet's' and 'Death in Venice') that have some relation to George (or his disciples) and thus clarify the issues in question.
Monologic dialogues and dialogue structures in Wedekind's 'Frühlings Erwachen' A drama presents a plot which is constituted through dialogues between the characters. This article therefore attempts to explore several instances of dialogue from Wedekind's 'Frühlings Erwachen' by conversationalanalytical means; such an approach facilitates a clear description of the characters' failures in their interactions. This in turn reveals the specific features of literary dialogues from this period, which are constituted in writing and thus precisely planned; an author not only imitates acts and actors via a play's dialogues, but fundamentally creates and moulds the characters through dialogue.
Bohemian and Moravian archives and libraries represent a rich resource of medieval texts on the plague. Advice, recommendations and recipes for avoiding the plague (prophylaxis), as well as instructions on how to treat it (therapy), can be found in many manuscripts from the 14th–16th centuries. An example of a varied approach to this topic can be found in the plague tractates contained in the Křivoklát manuscript I. b. 25 and the Olomouc manuscript M. I. 650. This article describes the origin and presentation of the information in the manuscripts, as well as the graphic arrangement of the text.
The article focuses on suffixoids based on titles of nobility and ecclesiastical titles. As an example, the study analyzes a total of 14 suffixoids with regard to the relation between the base word and the suffixoid. For this purpose, the author created a corpus of 200 tokens from online sources covering a 10-year period. The study presents suffixoids as active word-formation elements used as a result of linguistic expressivity and creativity. Moreover, it suggests an increasing tendency towards their use. This linguistic study can be seen as a new impetus to further investigations, especially in the field of translation studies – e.g. in the comparison of German and Czech with regard to this topic, which remains an uncharted field with no accurate studies yet available.
Background & Aims: Microvillus inclusion disease (MVID) is a congenital intestinal malabsorption disorder caused by defective apical vesicular transport. Existing cellular models do not fully recapitulate this heterogeneous pathology. The aim of this study was to characterize 3-dimensional intestinal organoids that continuously generate polarized absorptive cells as an accessible and relevant model to investigate MVID.
Methods: Intestinal organoids from Munc18-2/Stxbp2-null mice that are deficient for apical vesicular transport were subjected to enterocyte-specific differentiation protocols. Lentiviral rescue experiments were performed using human MUNC18-2 variants. Apical trafficking and microvillus formation were characterized by confocal and transmission electron microscopy. Spinning disc time-lapse microscopy was used to document the lifecycle of microvillus inclusions.
Results: Loss of Munc18-2/Stxbp2 recapitulated the pathologic features observed in patients with MUNC18-2 deficiency. The defects were fully restored by transgenic wild-type human MUNC18-2 protein, but not the patient variant (P477L). Importantly, we discovered that the MVID phenotype was correlated with the degree of enterocyte differentiation: secretory vesicles accumulated already in crypt progenitors, while differentiated enterocytes showed an apical tubulovesicular network and enlarged lysosomes. Upon prolonged enterocyte differentiation, cytoplasmic F-actin–positive foci were observed that further progressed into classic microvillus inclusions. Time-lapse microscopy showed their dynamic formation by intracellular maturation or invagination of the apical or basolateral plasma membrane.
Conclusions: We show that prolonged enterocyte-specific differentiation is required to recapitulate the entire spectrum of MVID. Primary organoids can provide a powerful model for this heterogeneous pathology. Formation of microvillus inclusions from multiple membrane sources showed an unexpected dynamic of the enterocyte brush border.
Emotional Competence (EC) is regarded as a fundamental skill for sports coaches. However, the applications of EC in football coaching are not well understood. This study analyzed the specific emotional processes football coaches experience. We interviewed 18 football coaches and analyzed the interview transcripts by using a systematic analysis process based on Grounded Theory principles. We derived a model from this analysis that comprises a four-phase process: emotional triggers, emotional experiences, emotion regulation strategies, and emotional consequences. In this model, we identified four categories which act as triggers of emotions in football coaches. These emotions can be positive or negative and are manifested at three levels. However, the coaches vary in their capability to perceive emotions. Our model also shows that coaches’ emotion regulation strategies influence the effect of emotional experiences. Experienced emotions promote consequences with psychological and social implications for coaches and may influence their perception of future situations. In short, the process seems to be circular. This finding suggests that the ability to deal with emotions is an important aspect for football coaches.
Increasing recognition of general practice is reflected in the growing number of university institutes devoted to the subject and Health Services Research (HSR) is flourishing as a result. In May 2015 the Institute of General Practice and Evidence-based Health Services Research, Medical University of Graz, initiated a survey of Styrian GPs. The aim of the survey was to determine the willingness to take part in HSR projects, to collect sociodemographic data from GPs who were interested and to identify factors affecting participation in research projects. Of the 1015 GPs who received the questionnaire, 142 (14%) responded and 135 (13%) were included in the analysis. Overall 106 (10%) GPs indicated their willingness to take part in research projects. Factors inhibiting participation were lack of time, administrative workload, and lack of assistance. Overall, 10% of Styrian GPs were willing to participate in research projects. Knowledge about the circumstances under which family doctors are prepared to participate in HSR projects will help in the planning of future projects.
Low-frequency spike-field coherence is a fingerprint of periodicity coding in the auditory cortex
(2018)
The extraction of temporal information from sensory input streams is of paramount importance in the auditory system. In this study, amplitude-modulated sounds were used as stimuli to drive auditory cortex (AC) neurons of the bat species Carollia perspicillata, to assess the interactions between cortical spikes and local-field potentials (LFPs) for the processing of temporal acoustic cues. We observed that neurons in the AC capable of eliciting synchronized spiking to periodic acoustic envelopes were significantly more coherent to theta- and alpha-band LFPs than their non-synchronized counterparts. These differences occurred independently of the modulation rate tested and could not be explained by power or phase modulations of the field potentials. We argue that the coupling between neuronal spiking and the phase of low-frequency LFPs might be important for orchestrating the coding of temporal acoustic structures in the AC.
This article focuses on the 'Wegweiser zur Polnischen und Deutschen Sprache' [Guide to the Polish Language] by Michał Kuś, published in 1646. The Guide is made up of two parts – an extensive dictionary, and a guide to grammar and learning Polish that is more than a dozen pages long. The article's introduction gives information about the author of the Guide and describes the structure of the work. The author also focuses on issues related to the macrostructure of the text (the ordering and selection of the entries). Theoretical considerations are supported by numerous examples throughout the article. Special attention has been paid to making these examples typical of the Guide in order to ensure an objective analysis.
Background: Phobic patients avoid dental treatment impairing their oral health and making it challenging to offer them prosthetic rehabilitation. This study evaluated patients’ experience of implant-supported prosthetic treatment after implantation performed under general anaesthesia due to dental phobia and severe pharyngeal reflexes (SPR). The effect of gender, age and location of implantation on patient satisfaction was tested.
Methods: Two hundred five patients underwent implantation under general anesthesia both in maxilla and mandible, respectively. After a trans-gingival healing period of 6–8 weeks, fixed implant bridges were inserted. Patients completed oral health impact profile questionnaire (OHIP-14). An additional set of six special questions was also developed and considered. Analysis of the OHIP-14 total score was made using logistics regression. Wald chi-square test was used to analyse the effect of age, gender and location of implantation. Effect sizes were estimated as odds-ratios and associated 95% Wald confidence intervals.
Results: Eighty two of 205 patients were included after prosthetic treatment. After start, 38 patients were excluded (4 died and 34 couldn’t be reached). OHIP-14-analyses were made by 43 patients (30–90 years). 67% of patients were totally satisfied with the whole implant rehabilitation (scoring 0). Mean of total score was 2.5. Only age affected significantly (p = 0.014) patients satisfaction. The obtained data indicate that younger patients (30–64 years) especially women are less satisfied (4.95) than older patients (0.3) for age group (65–90 years).Special questions’ data showed that 94.5% were satisfied with their treatment. 77.3% continued regular check-up after treatment and 96.9% would undergo the same treatment again. 95.5% would recommend implants to a friend of colleague.
Conclusion: Gender and location of implantation have no significant influence on patient satisfaction. Younger patients especially women are less satisfied than older patients. Phobic patients are totally satisfied with implant rehabilitation under general anaesthesia which means that this treatment can be considered as a treatment of choice giving these patients the same opportunity like others to improve their oral health and well-being.
Between 28 June and 17 September 2018, 27 cases of human West Nile virus infections were recorded in Austria; four cases of West Nile neuroinvasive disease, 11 cases of West Nile fever, six infections detected by blood donation screening and six imported cases. In addition, 18 cases of human Usutu virus infections (all blood donors) were recorded. This is the highest number of annual infections recorded in Austria since the introduction of both viruses.
Upregulations of neuronal nitric oxide synthase (nNOS) in the rodent brain have been associated with neuronal aging. To address underlying mechanisms we generated SH-SY5Y neuronal cells constitutively expressing nNOS at a level similar to mouse brain (nNOS+ versus MOCK). Initial experiments revealed S-nitrosylations (SNO) of key players of protein homeostasis: heat shock cognate HSC70/HSPA8 within its nucleotide-binding site, and UBE2D ubiquitin conjugating enzymes at the catalytic site cysteine. HSPA8 is involved in protein folding, organelle import/export and chaperone-mediated LAMP2a-dependent autophagy (CMA). A set of deep redox and full proteome analyses, plus analysis of autophagy, CMA and ubiquitination with rapamycin and starvation as stimuli confirmed the initial observations and revealed a substantial increase of SNO modifications in nNOS+ cells, in particular targeting protein networks involved in protein catabolism, ubiquitination, carbohydrate metabolism and cell cycle control. Importantly, NO-independent reversible oxidations similarly occurred in both cell lines. Functionally, nNOS caused an accumulation of proteins, including CMA substrates and loss of LAMP2a. UBE2D activity and proteasome activity were impaired, resulting in dysregulations of cell cycle checkpoint proteins. The observed changes of protein degradation pathways caused an expansion of the cytoplasm, large lysosomes, slowing of the cell cycle and suppression of proliferation suggesting a switch of the phenotype towards aging, supported by downregulations of neuronal progenitor markers but increase of senescence-associated proteins. Hence, upregulation of nNOS in neuronal cells imposes aging by SNOing of key players of ubiquitination, chaperones and of substrate proteins leading to interference with crucial steps of protein homeostasis.
Research on the music-language interface has extensively investigated similarities and differences of poetic and musical meter, but largely disregarded melody. Using a measure of melodic structure in music––autocorrelations of sound sequences consisting of discrete pitch and duration values––, we show that individual poems feature distinct and text-driven pitch and duration contours, just like songs and other pieces of music. We conceptualize these recurrent melodic contours as an additional, hitherto unnoticed dimension of parallelistic patterning. Poetic speech melodies are higher order units beyond the level of individual syntactic phrases, and also beyond the levels of individual sentences and verse lines. Importantly, auto-correlation scores for pitch and duration recurrences across stanzas are predictive of how melodious naive listeners perceive the respective poems to be, and how likely these poems were to be set to music by professional composers. Experimentally removing classical parallelistic features characteristic of prototypical poems (rhyme, meter, and others) led to decreased autocorrelation scores of pitches, independent of spoken renditions, along with reduced ratings for perceived melodiousness. This suggests that the higher order parallelistic feature of poetic melody strongly interacts with the other parallelistic patterns of poems. Our discovery of a genuine poetic speech melody has great potential for deepening the understanding of the music-language interface.
Der von der GGR (Gesellschaft der Germanisten Rumäniens), von der Universität Oradea und von der Christlichen Universität Partium veranstaltete 11. Internationale Kongress der Germanisten Rumäniens fand zwischen 04.-07. Juni 2018 in Oradea statt. Neben den drei allgemeinen Forschungsgebieten (Sprach- und Literaturwissenschaft, Didaktik) erschienen weitere drei Forschungsgebiete mit spezieller Ausrichtung. Unter dem Schwerpunkt "Interkulturalität in Aktion" hat man Themen wie: 4.1. Interreferenţialităţi cultural-literare româno-germane. Geteilte, gemeinsame Welt: Nebeneinander und Miteinander in Rumänien; 4.2. Deutschungarische Kulturtransferprozesse im mitteleuropäischen Raum, behandelt. Das Forschungsgebiet "Übersetzungswissenschaft und Konferenzdolmetschen" wurde in die Sektion 5 zugeordnet. Schließlich haben sich NachwuchswissenschaftlerInnen in der Sektion 6 - "Forum junger ForscherInnen" versammelt.
Der Lehrstuhl für Fremdsprachen der Philosophischen Fakultät der Universität Pardubice veranstaltete schon zum siebtem Mal seine traditionelle "bienale" internationale Konferenz "Interkulturelle und transkulturelle Dimension im linguistischen, kulturellen und historischen Kontext" zum aktuellen Thema Multikulturalismus in allen möglichen Erscheinungen, Dimensionen, Engpässen sowie Konsequenzen. In Bezug auf die Tradition der vorherigen erfolgreichen Begegnungen hat man ein großes Interesse von Akademikern an der aktiven Teilnahme auch im Jahre 2017 erwartet, und zwar nicht nur aus der Tschechischen Republik, sondern auch vor allem aus dem Ausland.
Tahakküm, her ne kadar gözlemlenebilen bir olgu olsa da, teorik olarak yerini tam olarak belirlemek oldukça güçtür. Fakat Michel Foucault söz konusu tahakkümün sosyal mekânlara nüfuz ettiğini ileri sürmüş, böylelikle de geçici konfigürasyonlar ve söylem yapıları ile tahakkümün kendisini görünür kılabildiğini belirtmiştir (Srubar 2009: 201). Bu bağlamda söz konusu geçiciliğin önüne geçilebilmesi ve belleğin zamana direnmesi için mekânın önemli bir unsur olduğunun söylenilmesi yanlış olmaz. 20. yüzyılın en önemli düşünürlerinden biri olan Edmund Husserl'in öne sürmüş olduğu fikirler felsefe, sosyoloji ve psikoloji alanında analizlerin yapılmasına katkı sağlamıştır. Bu noktada çalışmanın amacı, Husserl'in temellerini atmış olduğu ve bir öz ontolojisi olan fenomenoloji yöntem olarak kullanılarak, 11 Eylül Müzesi'nin analizinin yapılmasıdır. Böylelikle de hafıza mekânı olarak kabul edilen müzenin Husserl referans alınarak göstergebilim üzerinden değerlendirilmesi amaçlanmaktadır
Önümüzdeki çalışma, Türkçe Çeviriler Bibliyografyası adlı çalışmada yer alan bilgiler ışığında Türkiye Cumhuriyeti’nin kuruluşundan 2016 yılına kadar Türkçeye çevrilmiş ve/ veya Türkiye’de yayımlanmış Alman edebi eserlerini raporlamayı amaçlamaktadır. Bu amaçla öncelikle, Türkçe Çeviriler Bibliyografyası kaynak kitabında da belirtildiği gibi çeşitli basılı ve elektronik kaynaklar (http://www.toplukatalog.gov.tr; https://kasif.mkutup.gov.tr ve http://koha.ekutuphane.gov.tr) taranarak bir veri tabanı oluşturulmuştur. Önümüzdeki çalışmada bu bilgilerden yola çıkılarak aşağıdaki soruların yanıtları aranmıştır: 1. Yıllara göre Almancadan Türkçeye çevrilen eserler belirlendiğinde karşımıza nasıl bir tablo çıkacaktır? 2. Her edebi türden toplam kaç kitap yayımlanmıştır? 3. En çok hangi yazarların eserleri Türkçeye çevrilmiştir? 4. Almancadan Türkçeye çevrilen eserler en çok hangi yayınevi tarafından basılmıştır? 5. En çok hangi çevirmenler Almancadan Türkçeye eserler kazandırmıştır? Bu soruların yanıtlarına istinaden niceliksel değerlere dayanan grafikler hazırlanmıştır. Daha sonra ise hazırlanan bu grafikler niteliksel olarak değerlendirilerek eserler Türkçeye çevrilirken hangi ölçütlerin esas alındığı, çeviri tercihlerinin- dönemine veya çevirmenine göre- nasıl yapıldığı tartışılmaktadır.
Çeviri faaliyeti, 18. yüzyılda Osmanlı Devleti'nin batılılaşması ve modernleşmesinde önemli bir yere sahipti. Bu amaca yönelik olarak çeviri eylemi, Osmanlı döneminde aydınlanma çağındaki fikirlerin yayılması ile birlikte siyasal ve bilimsel fikirlerin yerleşmesinde de çok etkili olmuştur. Bu durum Türkiye Cumhuriyeti'nin kuruluş yıllarında da devam etmiştir. Bu çeviri faaliyetini gerçekleştiren "gizli kahramanlar", yani çevirmenler, Türk diline ve edebiyatına yaptıkları katkılara nazaran pek tanınmazlar ve bilinmezler. Peki, bu çevirmenler kimlerdi? Kimlerin eserleri hangi dilden ve ne zaman çevrilip, hangi yayınevleri tarafından yayımlanmıştır? Türkçe Çevirmenler Sözlüğü'nde Türk edebiyatına katkıda bulunan ve Türk edebiyatının çeviri yoluyla zenginleşmesinde katkı sağlayan çevirmenlerin listelerini oluşturmak amaçlanmıştır. Ege Üniversitesi ile Johannes Gutenberg Üniversitesi Germersheim-Mainz (Almanya) mütercim tercümanlık bölümlerinin ortak yürüttükleri GIP (Germanistische Institutspartnerschaft) projesi bağlamında Türkçe Çeviriler Bibliyografyası kitap çalışması fikri de ortaya çıkmıştır. Uzun bir yöntem arayışından sonra başta Ege Üniversitesi Kütüphanesi, Hacettepe Üniversitesi Kütüphanesi, İstanbul Üniversitesi Kütüphanesi, Boğaziçi Üniversitesi Kütüphanesi ve Milli Kütüphane kayıtlarını barındıran ve T.C. Kültür ve Turizm Bakanlığı Kütüphaneler ve Yayımlar Genel Müdürlüğü ve TÜBİTAK ULAKBİM'in Ulusal Toplu Katalog veri tabanından yararlanılarak yabancı dilden Türkçeye aktarılan eserler ele alınmıştır. Çalışmada Cumhuriyetin ilk yıllarından 2016 yılına kadar Türkçeye aktarılan dil ve edebiyatların nesir, nazım ve tiyatro gibi edebi türlerine göre çevirileri incelenmiştir. Toplam 18.741 eser ve 6.006 çevirmen kaydına ulaşılmıştır.
Çeviri, birer eyleyen olarak çevirmenlerin yönlendirdiği bir eylemdir. Bu gerçek, bilgi teknolojilerinin bu uygulama sahasında varlıklarını yoğun biçimde hissettirdikleri günümüz çeviri dünyası içinde de geçerliliğini korumaktadır. İnsanın merkezde bulunduğu her uygulama sahasında olduğu gibi çeviri alanında da nesnel ölçütlerin bulunup uygulanabilmesi, beklenen ve arayışında olunan bir konu olagelmiştir.
Bugün özerk bir araştırma alanı olarak çeviribilim, salt araştırma alanında (pure research) çeviri olgusuna dâhil bütün boyutları betimlemeye ve buradan üst ilkelere ulaşmaya çalışırken, uygulamalı araştırma alanında (applied research) ise çeviri edimi ile ilgili nesnel ölçütler üretmeyi denemektedir. Bu yönüyle çeviribilimciler, çeviri eleştirisi, çeviri politikası, çeviri araçları alanlarında olduğu gibi akademik çeviri eğitiminde de nesnel ölçütleri aramaktadır.
Konu somut olarak çeviri uygulamalarının yaptırıldığı derslere indirgenirse, çeviri derslerinde metin seçiminin, bugün öznel gerekçelere dayandığı söylenebilir. Bu durum, bu çalışmada seçilen konunun sorunsallaştırılmasını önemli hale getirmektedir. Bu çalışmanın temel amacı, çeviri derslerinde metin seçiminin ölçütlerini saptamaya çalışmaktır.
Das Ziel dieses Beitrags besteht darin, am Beispiel der türkischen Germanistikstudenten an der Ege Universität die Merkmale und Entwicklung der pragmatisch-diskursiven Fähigkeit als eine Teilkompetenz der fremdsprachlichen Gesprächskompetenz zu untersuchen. Die Arbeit gliedert sich in zwei Abschnitte: Der erste Teil befasst sich mit der ausführlichen Beschreibung der Gesprächskompetenz als fremdsprachliche Kompetenz im Deutschen als Fremdsprache, der Bewertung der fremdsprachlichen Gesprächskompetenz als sprachproduktive Leistung und der Vorstellung von Subkategorien der pragmatisch-diskursiven Fähigkeit anhand der Beispiele aus dem Arbeitskorpus. Im zweiten Teil wird das Untersuchungsdesign und die Analyseergebnisse ausführlich dargestellt.
Are stereotypes possible pillars supporting the learning of a foreign language or are they possible sources of intercultural misunderstandings? In most coursebooks, intercultural materials are embedded in teaching units. The understanding of others is closely related to the understanding of someone's own culture as well as the target culture. Only when someone is aware of the own culture, then the target culture can be understood. In foreign language learning, it plays an important role, so that the knowledge of language structures alone is not enough to use the language successfully. At the same time, it requires cultural knowledge of the target language culture. This study focuses on the effects of culture-based fossilized prejudices on foreign language learning and to show the quantity of these stereotypes in given coursebooks. A coursebook analysis reveals to what extent stereotypes can be found in the respective GFL and TFL coursebooks. A compile of given stereotypes create an overall picture of foreign cultures. To what extent this overall picture reflects the reality has been handled at the end of this study
Her ne kadar Almanya politikası çeşitli fikirlerde de olsa; Almanya, tarihinde her zaman göç alan bir devlet olmuştur ve göçmenlere Almanca öğretimi konusunda oldukça köklü bir geçmişe, engin tecrübelere sahiptir. 60'lı yılların başlangıcında göçmenlere dil öğretimini gerekli görmeyen bu ülke 'dilsizliğin' getirdiği sosyal, siyasal ve ekonomik sorunlar sonrasında başarılı bir entegrasyon süreci için göçmenlere Alman dilinin öğretilmesinin gerekliliğini anlamış ve bu konuda çeşitli modeller denemiştir. Bu araştırmanın amacı; Almancanın ikinci dil olarak öğretimi alanındaki kuram ve modellerin, Türkçenin ikinci dil olarak öğretimine uyarlanabilirliğini göstermek ve Almanya'nın bu alandaki tecrübelerinden ikinci dil olarak Türkçe öğretimi alanında yararlanmaktır. Bu nedenle öncelikle 'yabancı dil' ve 'ikinci dil' kavramlarını birbirinden ayıran faktörler üzerinde durulacak ve böylece 'ikinci dil olarak Türkçe' kuramı incelenecektir. Sonrasında yine ikinci dil olarak Almanca öğretimi alanından çeşitli göçmen öğrenci tipleri ve bunlara Almanca öğretimi modelleri ortaya konacak, 'ikinci dil olarak Türkçe' kuramında karşılaşılacak öğrenci kavramının çeşitliliği değerlendirilecektir. Bu noktada okul çağında olan, okullara yatay geçiş yapması gereken ancak henüz Latin alfabesini bilmeyen, kurum olarak 'okul' kavramıyla hiç tanışmamış ve güncel Türkçenin dışında eğitim Türkçesi öğrenmesi gereken gençler üzerinde durulacaktır; çünkü toplumun birliği, bütünlüğü ve geleceği açısından özellikle bu gençlerin kazanılması büyük önem taşımaktadır. Aynı şekilde yetişkinlere Almanca öğretme modelleri tanıtılacak ve bu deneyimlerden 'ikinci dil olarak Türkçe' kuramı ve entegrasyon sürecinde nasıl yararlanılabileceği tartışılacaktır.
Bu araştırmada, 2016 yılında U. Ü. bilimsel araştırma projelerini destekleme birimi (BAP) desteğiyle başlatılan bir proje kapsamında yapılan yabancı dil öğretiminde dijital oyunlar ve oyunlaştırılmış uygulamalar geliştirme çalışmaları ele alınmıştır. Proje sürecinde yapılan alanyazın taraması ve öğretmenlerle yapılan anket çalışması sonucunda yabancı dil öğrenimi ve öğretimi süreçlerinde 3B dijital oyunların yeterince kullanılmadığı ve öğretmenlerin dijital oyun kullanma ve geliştirme konusunda yeterli kuramsal ve uygulamalı bilgiye sahip olmadıkları belirlenmiştir. Bu sonuç dikkate alınarak yapılan bu çalışmanın üçüncü bölümünde öğretmenlere ve materyal geliştiricilere yol göstermek amacıyla dijital oyun geliştirme süreci aşama aşama somut örneklerle ortaya konmuş, bu süreçte kullanılabilecek, materyal geliştirme araçları ayrıntılı olarak tanıtılmıştır. Söz konusu proje süreçlerinde elde edilen ve bu çalışmada ortaya konan bilgilerin yabancı dil öğretiminde dijital oyunların yaygınlaşmasına ve yabancı dil öğretmenlerinin kendi dersleri için dijital oyun materyallerini geliştirmelerine katkı sağlanması hedeflenmektedir.
Die Analyse und Bewertung der Sprachlernspiele in dem Lehrwerk 'MOMENT MAL 1' und 'MOMENT MAL 2'
(2018)
Das soziale und interaktive Lernen steht im Vordergrund des gesamten Lernprozesses. Auch der Erwerb einer Fremdsprache, egal in welchem Alter, verlangt soziale und interaktive Lernprozesse. Sprachlernspiele übernehmen in diesem Lernprozess eine wichtige Rolle. Diese Sprachlernspiele werden in dem kommunikativen, sowie interkulturellen Ansatz und in alternativen Methoden als Unterrichtsmaterial in den Lehrwerken benutzt. Obwohl Sprachlernspiele schon Mitte der 70er Jahre des zwanzigsten Jahrhunderts in kommunikativ orientierten Methoden ihren Höchstpunkt erreicht haben, ist das Interesse an ihrem Einsatz im Fremdsprachenunterricht bis heutzutage geblieben. Ziel dieser Studie ist, die Sprachlernspiele in den, im deutschen Sprachunterricht verwendeten Lehrwerk "Moment Mal 1" und "Moment Mal 2" zu analysieren, sie nach ihren Eigenschaften und Sprachfertigkeiten zu klassifizieren und die Bedeutung des Spielfaktors im Fremdsprachenlernen hervorzuheben. Diesbezüglich ist eine generelle Definition des Spiels behandelt und seine Eigenschaften, die zur Klassifikation der Sprachlernspiele einen Beitrag geleistet haben, hervorgehoben worden. Außerdem ist der Stellenwert der Sprachlernspiele im Fremdsprachenunterricht erforscht worden. In dieser Studie wurde die Lehrwerkanalyse als Methode verwendet. Die Sprachlernspiele in dem, im Deutschunterricht benutzten Lehrwerk "Moment Mal 1" und "Moment Mal 2" wurden nach dieser Methode analysiert. Von der allgemeinen Spieldefinition und den Zielen des Fremdsprachenunterrichts ausgehend wurden die Sprachlernspiele in diesem Lehrwerk sowohl nach ihren Eigenschaften, als auch bezüglich der Weiterförderung der Sprachfertigkeiten klassifiziert. Außerdem wurden die Sprachlernspiele aus diesem Lehrwerk in den Anadolu-Gymnasien, wo Deutsch als erste Fremdsprache gelehrt wird, ausgeübt.
Eine Studie zur fehleranalytischen Kompetenz der Studierenden in der Deutschlehrendenausbildung
(2018)
Die Fehleranalyse gilt seit langem als eine wertvolle Hilfe beim Fremdsprachenunterricht, weil sowohl Lernende als auch Lehrende dadurch wichtige Informationen über den Spracherwerbsprozess bekommen können. Auch die vorliegende Arbeit beabsichtigt mit Hilfe der Fehleranalyse zu Erkenntnissen über die fehleranalytische Kompetenz der künftigen Deutschlehrer zu gelangen. Ausgangspunkt dieser Studie war die Frage, ob es eine direkte Verbindung zwischen dem Sprachniveau und der fehleranalytischen Kompetenz der Studierenden gebe. An der Untersuchung haben 37 Studierenden der Gazi Universität teilgenommen, von denen sieben Rückkehrende aus Deutschland waren und über gute Sprachkenntnisse verfügten. Alle Probanden befanden sich im sechsten Semester und hatten sich im Rahmen der angewandten Linguistik ein semesterlang mit der Fehleranalyse befasst. Den Probanden wurden zwei Texte vorgelegt, deren Fehler sie identifizieren und anhand eines Rasters klassifizieren mussten. Es hat sich herausgestellt, dass bei der Fehleridentifizierung die Fremdsprachenkenntnisse ein entscheidender Faktor waren. Bei der Fehlerklassifizierung dagegen, schienen die Fremdsprachenkenntnisse eher eine untergeordnete Rolle zu spielen.
Im Bereich des Deutschen als Fremdsprache bietet etwa das Goethe-Institut Prüfungen auf allen Niveaus (A1-C2) an und entwickelt entsprechende Vorbereitungsmaterialien. Dazu gehören neben Modellprüfungen auch Wortlisten A1, A2 und B1 (vgl. z. B. Goethe-Institut 2016). Zur Arbeit mit den Wortlisten im DaF-Unterricht liegen nach Auskunft des Informationszentrums für Fremdsprachenforschung der Philipps-Universität Marburg vom 01.12.2017 weder wissenschaftliche Untersuchungen noch Praxisberichte vor. Mit der vorliegenden Arbeit soll versucht werden, zum Beheben dieses Desiderats beizutragen. Der Untersuchungsfokus liegt dabei auf den Erfahrungen der DaF-Studierenden mit dem Einsatz der Wortliste im Unterricht sowie ihren persönlichen Speicherstrategien beim Vokabellernen.
Die Anzahl der Werke zum Thema Antikriegsliteratur, vor allem im Zusammenhang mit dem Ersten Weltkrieg, ist im literarischen Bereich reichlich vorhanden. Die deutsche Literatur bietet durch ihre umfangreiche Anzahl Möglichkeiten diese Werke zu untersuchen. Die Darstellung des Krieges in dem Roman "Im Westen nichts Neues" ist deshalb bemerkenswert, weil es viele Beispiele zum Thema Kriegstrauma enthält. Wie wird Kriegstrauma im Roman "Im Westen nichts Neues" in der Gegenwartsliteratur geschildert bzw. thematisiert? Um diese Frage zu beantworten, soll das Motiv, "Kriegstrauma" und dessen Darstellungen, die im Roman vorkommen, gelöst werden. Der Ausdruck auf der ersten Seite der Einführung des Romans "Die Schrecken des Ersten Weltkrieges sind die Schrecken aller Kriege", deutet auf das Hauptthema im Roman. Dieser Roman wird auch heute 100 Jahre nach dem Ersten Weltkrieg als ein Zeitzeugen-Dokument angesehen. Der Roman schildert die Erfahrungen eines einfachen Frontsoldaten im Ersten Weltkrieg, den Erich Maria Remarque im Jahre 1927 als er an der Westfront Dienst war geschrieben hat. Im Roman "Im Westen nichts Neues" wird die Geschichte des deutschen Soldaten Paul Bäumer und seiner Kameraden im Ersten Weltkrieg erzählt. Traumata / Kriegstraumata / Kriegserlebnisse der Soldaten an der Front sind ein zentrales Thema des Romans.
'Leutnant Gustl' als eine repräsentative Figur für die
Identitätsdefizite in der Gesellschaft
(2018)
In vorliegender Arbeit haben wir den Versuch unternommen, die Novelle mit dem Titel "Leutnant Gustl" von Arthur Schnitzler im Lichte der wissenschaftlichen Literatur mit dem deskriptiven Verfahren zu analysieren. Es geht darin um einen Konflikt zwischen der inneren Welt des kleinbürgerlichen Protagonisten der k.u.k. Monarchie der Jahrhundertwende, und der Gesellschaft, in der er lebt. Hier wird vorwiegend die Identitätskrise der Figur Leutnant Gustl, die mit seiner Umgebung zu tun hat, und die sich mit der Überwindung derselben auseinandergesetzt. Bei der Analyse wird nicht zuletzt auf die Fragen eingegangen, worin die Identitätsprobleme liegen, wie der Protagonist aus diesen Problemen herauszukommen versucht.
Rolf Schneider gehörte zu jenen DDR-Schriftstellern, deren Romane um 1970 überwiegend in der Bundesrepublik herauskamen. Auch war er Teil der Gruppe von Autoren, die von 1978 bis 1981 langfristige Visa erhielten und zwischen Ost- und Westdeutschland hin- und herpendelten. Es ist anzunehmen, dass der Umstand, gleichsam zwischen den Stühlen zu sitzen, Schneiders Autorschaft in hohem Maß bedingte. Damit ist zugleich die Frage aufgeworfen, in welcher Weise dies der Fall war. Im Beitrag soll dem anhand der 1965 erschienenen Erzählung Metamorphosen nachgegangen werden. Sie bietet sich hier deshalb als Textgrundlage an, da sie eine intertextuelle Relation zu Die Verwandlung von Franz Kafka aufweist, dessen Werk von den Kulturfunktionären der DDR bis in die 70er Jahre hinein abgelehnt und aus dem offiziellen "Erbe"-Kanon ausgeschlossen wurde. Vor diesem Hintergrund ist davon auszugehen, dass die in Metamorphosen enthaltenen Anspielungen auf den Kafka-Text Schneider zur Inszenierung seiner regimekritischen Autorschaft dienten. Wie dies im Einzelnen aussah, ist Gegenstand der Untersuchung, die sich den intertextuellen Bezügen von verschiedenen Seiten annähern wird, um so die Aspekte zu beleuchten, die für die literarische Selbstdarstellung Schneiders maßgeblich sind.
Der vorliegende Beitrag beschäftigt sich mit einer Frage, die aufmerksame Leser von Wolfgang Hilbigs Texten vor Fragen stellt, der Frage nach den Störungen in der Libido seiner Protagonisten, die zugleich Alter-Ego-Figuren im Werk sind. Dass sich diese Störungen über viele verschiedenen Texte und in einer konstant wiederkehrenden Dauer zeigen, wird durch Beispiele nachgewiesen. Es wird eine Erklärung dieses Phänomens am Schluss des Beitrags zur Diskussion gestellt. Dabei geht der Diskurs von den Protagonisten Hilbigs bis in den Diskurs um die Problematik des Autors über.
All linguistics should be media linguistics, but it is not. This thesis is presented by using linguistic landscapes as an example. LL research does not belong to the traditional core of either mainstream linguistics or media linguistics. This is why not everything within power has been done yet to make full use of their thematic, conceptual and methodological possibilities. Visible signs in public space, however, are an everyday phenomenon. You have to pull out all the stops to research them extensively. The distinction between linguistics and media linguistics turns out to be counterproductive. But this does not only apply to the case of linguistic landscapes. It also stands for any comprehensive investigation of language and language use. (Exceptions may be very narrow questions for specific purposes.) The above thoughts are supported by a database of the project „Metropolenzeichen“ with more than 25.000 systematically collected, geocoded and tagged photographs.
Mitochondrial derived reactive oxygen species (mtROS) are known for their signaling qualities in both physiology and pathology. To elucidate mitochondrial complex I-dependent ROS-signaling after lipopolysaccharide (LPS)-stimulation THP-1 macrophages with a knockdown of the transmembrane protein TMEM126B were generated. TMEM knockdown cells (sh126B) showed a reduced assembly of complex I and attenuated mtROS production. In these cells we identified protein oxidization by mtROS upon LPS-treatment using the BIAM switch assay coupled to liquid chromatography and mass spectrometry. One of the identified targets of mtROS was succinate dehydrogenase (SDH) flavoprotein subunit A (SDHA). Oxidation of SDHA decreased its enzymatic activity and pharmacological inhibition of SDH in turn stabilized hypoxia inducible factor (HIF)-1α and caused the subsequent, sustained expression of interleukin-1β (IL-1β). Oxidation of SDHA in sh126B cells was attenuated, while pharmacological inhibition of SDH by atpenin A5 restored IL-1β expression in sh126B cells upon LPS-treatment. Conclusively, oxidation of SDH by mtROS links an altered metabolism, i.e. succinate accumulation to HIF-1-driven, inflammatory changes in macrophages.
Recent research indicates that attentional stimulus selection could be a rhythmic process. In monkey, neurons in V4 and IT exhibit rhythmic spiking activity in the theta range in response to a stimulus. When two stimuli are presented together, the rhythmic neuronal responses to each occur in anti-phase, a result indicative of competitive interactions. In addition, it was recently demonstrated that these alternating oscillations in monkey V4 modulate the speed of saccadic responses to a target flashed on one of the two competing stimuli. Here, we replicate a similar behavioral task in humans (7 participants, each performed 4000 trials) and report a pattern of results consistent with the monkey findings: saccadic response times fluctuate in the theta range (6 Hz), with opposite phase for targets flashed on distinct competing stimuli.
An information-theoretic approach to numerically determine the Markov order of discrete stochastic processes defined over a finite state space is introduced. To measure statistical dependencies between different time points of symbolic time series, two information-theoretic measures are proposed. The first measure is time-lagged mutual information between the random variables Xn and Xn+k, representing the values of the process at time points n and n + k, respectively. The measure will be termed autoinformation, in analogy to the autocorrelation function for metric time series, but using Shannon entropy rather than linear correlation. This measure is complemented by the conditional mutual information between Xn and Xn+k, removing the influence of the intermediate values Xn+k−1, …, Xn+1. The second measure is termed partial autoinformation, in analogy to the partial autocorrelation function (PACF) in metric time series analysis. Mathematical relations with known quantities such as the entropy rate and active information storage are established. Both measures are applied to a number of examples, ranging from theoretical Markov and non-Markov processes with known stochastic properties, to models from statistical physics, and finally, to a discrete transform of an EEG data set. The combination of autoinformation and partial autoinformation yields important insights into the temporal structure of the data in all test cases. For first- and higher-order Markov processes, partial autoinformation correctly identifies the order parameter, but also suggests extended, non-Markovian effects in the examples that lack the Markov property. For three hidden Markov models (HMMs), the underlying Markov order is found. The combination of both quantities may be used as an early step in the analysis of experimental, non-metric time series and can be employed to discover higher-order Markov dependencies, non-Markovianity and periodicities in symbolic time series.
Macrophages are highly versatile cells, which acquire, depending on their microenvironment, pro- (M1-like), or antiinflammatory (M2-like) phenotypes. Here, we studied the role of the G-protein coupled receptor G2A (GPR132), in chemotactic migration and polarization of macrophages, using the zymosan-model of acute inflammation. G2A-deficient mice showed a reduced zymosan-induced thermal hyperalgesia, which was reversed after macrophage depletion. Fittingly, the number of M1-like macrophages was reduced in the inflamed tissue in G2A-deficient mice. However, G2A activation was not sufficient to promote M1-polarization in bone marrow-derived macrophages. While the number of monocyte-derived macrophages in the inflamed paw was not altered, G2A-deficient mice had less macrophages in the direct vicinity of the origin of inflammation, an area marked by the presence of zymosan, neutrophil accumulation and proinflammatory cytokines. Fittingly neutrophil efferocytosis was decreased in G2A-deficient mice and several lipids, which are released by neutrophils and promote G2A-mediated chemotaxis, were increased in the inflamed tissue. Taken together, G2A is necessary to position macrophages in the proinflammatory microenvironment surrounding the center of inflammation. In absence of G2A the macrophages are localized in an antiinflammatory microenvironment and macrophage polarization is shifted toward M2-like macrophages.
Mandelic acid is an important aromatic fine chemical and is currently mainly produced via chemical synthesis. Recently, mandelic acid production was achieved by microbial fermentations using engineered Escherichia coli and Saccharomyces cerevisiae expressing heterologous hydroxymandelate synthases (hmaS). The best-performing strains carried a deletion of the gene encoding the first enzyme of the tyrosine biosynthetic pathway and therefore were auxotrophic for tyrosine. This was necessary to avoid formation of the competing intermediate hydroxyphenylpyruvate, the preferred substrate for HmaS, which would have resulted in the predominant production of hydroxymandelic acid. However, feeding tyrosine to the medium would increase fermentation costs. In order to engineer a tyrosine prototrophic mandelic acid-producing S. cerevisiae strain, we tested three strategies: (1) rational engineering of the HmaS active site for reduced binding of hydroxyphenylpyruvate, (2) compartmentalization of the mandelic acid biosynthesis pathway by relocating HmaS together with the two upstream enzymes chorismate mutase Aro7 and prephenate dehydratase Pha2 into mitochondria or peroxisomes, and (3) utilizing a feedback-resistant version of the bifunctional E. coli enzyme PheA (PheAfbr) in an aro7 deletion strain. PheA has both chorismate mutase and prephenate dehydratase activity. Whereas the enzyme engineering approaches were only successful in respect to reducing the preference of HmaS for hydroxyphenylpyruvate but not in increasing mandelic acid titers, we could show that strategies (2) and (3) significantly reduced hydroxymandelic acid production in favor of increased mandelic acid production, without causing tyrosine auxotrophy. Using the bifunctional enzyme PheAfbr turned out to be the most promising strategy, and mandelic acid production could be increased 12-fold, yielding titers up to 120 mg/L. Moreover, our results indicate that utilizing PheAfbr also shows promise for other industrial applications with S. cerevisiae that depend on a strong flux into the phenylalanine biosynthetic pathway.
Background: Protective effects of vitamin D have been reported in autoimmune and malignant thyroid diseases, though little is known about the underlying mechanism. Sirtuin 1 histon deacethylase (SIRT1) links the vitamin D pathway with regulation of transcription factor FOXO3a, a key player in cell cycle regulation and apoptosis. Aim of the present study was to investigate common single nucleotide polymorphisms (SNP's) in FOXO3a gene in respect to thyroid diseases, as well as to evaluate the hypothesis of Sirtuin1-FOXO3a interaction being a mediator of anti-proliferative vitamin D effects.
Methods: The SNP's FOXO3a rs4946936/rs4945816/rs9400239 were genotyped in 257 patients with differentiated thyroid carcinoma (DTC), 139 patients with Hashimoto thyroiditis (HT) and 463 healthy controls (HC). Moreover, T-helper cells of HC and papillary thyroid cancer cell line BCPAP were incubated with 1,25(OH)2D3 and/or SIRT1 inhibitor Ex-527 in order to elucidate SIRT1- dependent vitamin D effects on cell proliferation and FOXO3a gene expression in vitro.
Results: Patients with DTC tended to carry more often allele C in FOXO3a rs4946936 in comparison to HC (pcorrected = pc = 0.08). FOXO3a rs9400239T and rs4945816C was more frequent in HT in comparison to HC (pc = 0.02 and pc = 0.01, respectively). In both DTC and HT, we could not find a correlation of FOXO3a SNP's with vitamin D status. However, on in vitro level, 1,25(OH)2D3 showed an anti-proliferative effect in both T-helper cells and BCPAP, that was blocked by SIRT1 inhibition (T-helper cells: p = 0.0059, BCPAP: p = 0.04) and accompanied by elevated FOXO3a gene expression in T-helper cells (p = 0.05).
Conclusions: FOXO3a rs9400239T and rs4945816C may constitute risk factors for HT, independent of the vitamin D status.This indicates the implication of FOXO3a in pathogenesis of autoimmune thyroid diseases. The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects.
Bipolar disorder (BD) is a major psychiatric illness affecting around 1% of the global population. BD is characterized by recurrent manic and depressive episodes, and has an estimated heritability of around 70%. Research has identified the first BD susceptibility genes. However, the underlying pathways and regulatory networks remain largely unknown. Research suggests that the cumulative impact of common alleles with small effects explains only around 25–38% of the phenotypic variance for BD. A plausible hypothesis therefore is that rare, high penetrance variants may contribute to BD risk. The present study investigated the role of rare, nonsynonymous, and potentially functional variants via whole exome sequencing in 15 BD cases from two large, multiply affected families from Cuba. The high prevalence of BD in these pedigrees renders them promising in terms of the identification of genetic risk variants with large effect sizes. In addition, SNP array data were used to calculate polygenic risk scores for affected and unaffected family members. After correction for multiple testing, no significant increase in polygenic risk scores for common, BD-associated genetic variants was found in BD cases compared to healthy relatives. Exome sequencing identified a total of 17 rare and potentially damaging variants in 17 genes. The identified variants were shared by all investigated BD cases in the respective pedigree. The most promising variant was located in the gene SERPING1 (p.L349F), which has been reported previously as a genome-wide significant risk gene for schizophrenia. The present data suggest novel candidate genes for BD susceptibility, and may facilitate the discovery of disease-relevant pathways and regulatory networks.
Scholars have debated the taxonomic identity of isolated primate teeth from the Asian Pleistocene for over a century, which is complicated by morphological and metric convergence between orangutan (Pongo) and hominin (Homo) molariform teeth. Like Homo erectus, Pongo once showed considerable dental variation and a wide distribution throughout mainland and insular Asia. In order to clarify the utility of isolated dental remains to document the presence of hominins during Asian prehistory, we examined enamel thickness, enamel-dentine junction shape, and crown development in 33 molars from G. H. R. von Koenigswald's Chinese Apothecary collection (11 Sinanthropus officinalis [= Homo erectus], 21 “Hemanthropus peii,” and 1 “Hemanthropus peii” or Pongo) and 7 molars from Sangiran dome (either Homo erectus or Pongo). All fossil teeth were imaged with non-destructive conventional and/or synchrotron micro-computed tomography. These were compared to H. erectus teeth from Zhoukoudian, Sangiran and Trinil, and a large comparative sample of fossil Pongo, recent Pongo, and recent human teeth. We find that Homo and Pongo molars overlap substantially in relative enamel thickness; molar enamel-dentine junction shape is more distinctive, with Pongo showing relatively shorter dentine horns and wider crowns than Homo. Long-period line periodicity values are significantly greater in Pongo than in H. erectus, leading to longer crown formation times in the former. Most of the sample originally assigned to S. officinalis and H. erectus shows greater affinity to Pongo than to the hominin comparative sample. Moreover, enamel thickness, enamel-dentine junction shape, and a long-period line periodicity value in the “Hemanthropus peii” sample are indistinguishable from fossil Pongo. These results underscore the need for additional recovery and study of associated dentitions prior to erecting new taxa from isolated teeth.
Angegeben wird jeweils das Sammeldatum des für die Chromosomenzählung verwendeten Materials (Lebendpflanze, Samen) zuzüglich eines eventuell gesammelten Beleges sowie –
getrennt durch einen Schrägstrich – Sammeldatum und Aufbewahrungsort eines Beleges der gezählten Pflanze. Wird nur ein Datum angegeben, ist allein die Wildaufsammlung dokumentiert. Die Abkürzungen der Herbarien richten sich nach Holmgren & al. (1990, sowie Onlinenachträge, für die neuerdings B. Thiers verantwortlich zeichnet). Taxonomie und Nomenklatur richten sich nach der aktuellen deutschen Standardliste (BUTTLER & HAND 2008). Die Abbildungen zeigen Metaphasen, die an Quetschpräparaten von Wurzelspitzen gewonnen wurden (zur Methodik siehe VOGT & APARICIO 2000). Ralf Hand dankt Michael Meyer und seinem Gärtnerteam sowie Monika Lüchow und Monika Cubr (alle Botanischer Garten und Botanisches Museum Berlin-Dahlem) für Kultur, Dokumentation und Hilfe bei der Zählung von Material.
Soweit bisher noch nicht geschehen, werden für Sippen der Potentillacollina- Gruppe mit Zackenhaaren, die mutmaßlich aus Kreuzungen zwischen P. argentea l. und P. incana G. Gaertn., B. mey. & Scherb. hervorgegangen sind, und für mit der P.-collina- Gruppe in Verbindung gebrachte Sippen Lecto- oder Neotypen ausgewählt.
In dem Beitrag sind weitere Nachträge und Korrekturen zur 2008 veröffentlichten „Liste der Gefäßpflanzen Deutschlands“ zusammengestellt und kommentiert. 3 Taxa, darunter 1 eingebürgerter Neophyt, müssen der Liste hinzugefügt, 2 Taxa müssen gestrichen werden. die Nomenklatur von ×Triticosecale rimpaui wird besprochen.
Schriftenschau
(2009)
Die Nelke Dianthus carthusianorum wurde nach dem Kartäuserorden benannt. Nach den derzeit geltenden deutschen Rechtschreibregeln ist nur die Schreibweise „Kartäusernelke“ ohne h korrekt. Der tatsächliche Gebrauch (Literatur, Internet) ist jedoch nicht einheitlich. Für die Form ohne h sprechen die etymologische Herkunft und die Übereinstimmung mit anderen europäischen Sprachen, für die Form mit h eine mehr als 500jährige Tradition im deutschen Sprachraum.
Es gibt in der botanischen Taxonomie (bisher) nur einen Autor wissenschaftlicher Pflanzennamen namens Medikus oder Medicus ohne gleichnamige Nomenklatoren neben ihm. Die in BRUMMITT & POWELL (1992) angeführten Standardautoren „L.W.MEDICUS“ und „W.MEDICUS“ sind als nomenklatorisch irrelevant zu ignorieren. Die Autorbezeichnung „MEDIK.“ gilt ausnahmslos für alle infrage kommenden Taxa. Autorbezeichnungen wie „MED.“, „MEDIC.“ oder „MEDICUS“ sind entsprechend zu standardisieren.