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Most research on human fear conditioning and its generalization has focused on adults whereas only little is known about these processes in children. Direct comparisons between child and adult populations are needed to determine developmental risk markers of fear and anxiety. We compared 267 children and 285 adults in a differential fear conditioning paradigm and generalization test. Skin conductance responses (SCR) and ratings of valence and arousal were obtained to indicate fear learning. Both groups displayed robust and similar differential conditioning on subjective and physiological levels. However, children showed heightened fear generalization compared to adults as indexed by higher arousal ratings and SCR to the generalization stimuli. Results indicate overgeneralization of conditioned fear as a developmental correlate of fear learning. The developmental change from a shallow to a steeper generalization gradient is likely related to the maturation of brain structures that modulate efficient discrimination between danger and (ambiguous) safety cues.
This position paper is the second ESCMID Consensus Document on this subject and aims to provide intensivists, infectious disease specialists, and emergency physicians with a standardized approach to the management of serious travel-related infections in the intensive care unit (ICU) or the emergency department. This document is a cooperative effort between members of two European Society of Clinical Microbiology and Infectious Diseases (ESCMID) study groups and was coordinated by Hakan Leblebicioglu and Jordi Rello for ESGITM (ESCMID Study Group for Infections in Travellers and Migrants) and ESGCIP (ESCMID Study Group for Infections in Critically Ill Patients), respectively. A relevant expert on the subject of each section prepared the first draft which was then edited and approved by additional members from both ESCMID study groups. This article summarizes considerations regarding clinical syndromes requiring ICU admission in travellers, covering immunocompromised patients.
Der vorliegende Band dokumentiert die Erhebungsinstrumente, die im BilWiss-Forschungsprogramm in den Erhebungen der folgenden Projektphasen zum Einsatz kamen: BilWiss („Bildungswissenschaftliches Wissen und der Erwerb professioneller Kompetenz in der Lehramtsausbildung“; 2009–2013), gefördert vom Programm des Bundesministerium für Bildung und Forschung „Entwicklung von Professionalität des pädagogischen Personals in Bildungseinrichtungen (ProPäda)“ unter dem Förderkennzeichen 01 JH 0910, und BilWiss-Beruf („Die Bedeutung des bildungswissenschaftlichen Hochschulwissens für den Berufseinstieg von Lehrkräften“; 2013–2016), gefördert vom BMBF Förderprogramm „Kompetenzmodellierung und Kompetenzerfassung im Hochschulsektor (KoKoHs)“ unter dem Förderkennzeichen 01 PK1 1007. Das Forschungsprogramm ist ein Verbundprojekt der Goethe-Universität Frankfurt (M. Kunter), der Universität Duisburg-Essen (D. Leutner), der Westfälischen Wilhelms-Universität Münster (E. Terhart), des Max-Planck-Instituts für Bildungsforschung (J. Baumert, nur Projektphase BilWiss) und der Technischen Universität München (T. Seidel, nur Projektphase BilWiss-Beruf).
Das Forschungsprogramm zielt darauf ab, zu untersuchen, inwieweit angehende Lehrkräfte durch das Studium der Bildungswissenschaften unterstützt werden, mit den vielfältigen Herausforderungen ihres Berufs professionell umzugehen. Die zentrale Annahme dabei ist, dass konzeptuelles Wissen über bildungswissenschaftliche Inhalte die professionelle Entwicklung im Vorbereitungsdienst und im Berufseinstieg unterstützt. Die Grundhypothese des Projekts lautet:
Bildungswissenschaftliche Inhalte und Zusammenhänge stellen einen begrifflichen Rahmen dar, den Lehrkräfte benötigen, um Unterrichts- und Schulereignisse angemessen zu interpretieren, zu reflektieren und so für die eigene Kompetenzentwicklung zu nutzen.
Um dies zu prüfen wurde im Rahmen des Forschungsprogramms ein standardisiertes Testinstrument zur Erfassung des bildungswissenschaftlichen Wissens entwickelt und in einer Vollerhebung von angehenden Lehrkräften zu Beginn des Vorbereitungsdienstes (n = 3298) an allen Studienseminaren in Nordrhein-Westfalen (NRW) eingesetzt. Um die Annahme zur Bedeutsamkeit des bildungswissenschaftlichen Wissens für die professionelle Entwicklung empirisch zu prüfen, wurde ein Teil dieser Lehramtsanwärter(innen) im Laufe des Vorbereitungsdienstes längsschnittlich begleitet, dabei wurden mehrfach das bildungswissenschaftliche Wissen und weitere Aspekte der professionellen Kompetenz sowie verschiedene Indikatoren des professionellen Verhaltens und beruflichen Erlebens erfasst. Die Erhebungszeitpunkte im Längsschnitt fanden ein Jahr nach dem Beginn des Vorbereitungsdienstes (n = 362), am Ende des Vorbereitungsdienstes (n = 284) und ca. zwei Jahre nach Berufseinstieg (n = 101) statt.
Die zeitliche Überschneidung des BilWiss-Projekts mit der Einführung eines reformierten Vorbereitungsdienstes im Rahmen der 2009 beschlossenen Neuerungen in der Lehrerbildung im Land NRW eröffnete zudem die Möglichkeit, die differenzielle Entwicklung der angehenden Lehrkräfte aufgrund unterschiedlicher Lerngelegenheiten in einer quasi-experimentellen Feldstudie empirisch zu untersuchen. Hierfür wurde zusätzlich zur oben bereits beschriebenen Kohorte, die sich im 24-monatigen Vorbereitungsdienst befand (Kohorte 1), eine weitere Kohorte in die Befragung einbezogen, die den reformierten verkürzten, 18-monatigen Vorbereitungsdienst absolviert (Kohorte 2). Die beiden Kohorten angehender Lehrkräfte stiegen zu verschiedenen Zeitpunkten in den Vorbereitungsdienst ein (Kohorte 1 = Anfang 2011; Kohorte 2 = Ende 2011), beendeten diesen jedoch durch die Verkürzung des Vorbereitungs-dienstes zu einem ähnlichen Zeitpunkt (Anfang 2013). Auch die Daten der Kohorte 2 wurde zu Beginn (n = 511) und Ende des Vorbereitungsdienstes (n = 386), sowie ca. zwei Jahre nach dem Berufseinstieg (n = 104) erhoben.
Weiterführende Informationen zum theoretischen Ansatz der Studie und Ergebnissen der Studie können der Internetseite http://www.bilwiss.uni-frankfurt.de sowie den unten aufgeführten Publikationen entnommen werden.
The fungal genus Pestalotiopsis s.l. contains approximately 300 described species and is globally distributed. The monotypic genus Pestalotia is considered the closest relative of Pestalotiopsis s.l. This study aims to investigate the diversity and systematics within Pestalotiopsis s.l. and its relation to Pestalotia. Therefore, an integrative approach is used considering molecular phylogeny methods as well as examination of morphological characters.
Recently, Pestalotiopsis s.l. was split into three genera with the addition of the newly erected Neopestalotiopsis and Pseudopestalotiopsis. The species of these genera are usually saprotrophic, phytoparasitic, or endophytic, and have been isolated from soil, air, and many kinds of anorganic material. The asexual fruiting bodies appear on infected plant material as black acervuli that release conidia. The conidia are important to examine for morphological taxon recognition. The number of conidial cells is the feature that distinguishes Pestalotiopsis s.l. spp. with five celled conidia, from Pestalotia pezizoides with six celled conidia. However, the significance of morphological characters is controversially discussed among mycologists. In recent years, 55 new species were described based on minor genetic distances and marginal or no morphological differences. Thus, the value of certain morphological characters and genetic markers need to be reconsidered.
In this study, 102 herbarium specimens of 26 described species, with an emphasis on plant pathogenic species from North America, have been morphologically examined and documented through drawings and photographs. Morphological examination was complemented with a comprehensive molecular dataset obtained from 191 cultures representing the genera Neopestalotiopsis, Pestalotia, Pestalotiopsis, Pseudopestalotiopsis, and Truncatella. One novelty of this work is that, besides the well-established markers ITS, TEF1, and ß-tubulin, the protein-coding genes MCM7 and TSR1 were successfully sequenced and included in the analyses. Phylogenies using Maximum Likelihood and Bayesian inference methods of single loci and the combined dataset were calculated. By comparison of these phylogenies, MCM7 was identified as the most powerful one in terms of phylogenetic resolution and statistical support of nodes and is proposed as an additional barcoding marker in Pestalotiopsis s.l.
In Pestalotiopsis, species delimitation was tested using the Baysian Phylogenetics and Phylogeography (BP&P) program that tests an existing species scenario against Bayesian inference methods under a multispecies coalescent model. The program supported only ten species out of the predetermined 19 species scenario. Measurements of conidia for species detected by BP&P were explored using a TukeyHSD-Test in the program R to find means that are significantly different from each other. This test revealed that combinations of morphological characters are required to distinguish between the ten species found by BP&P.
Another purpose of this work was to clarify the status of Pestalotia with regard to Pestalotiopsis s.l. Therefore, fresh epitypic material of Pestalotia pezizoides, was collected, isolated, and cultivated. The molecular analysis of a combined dataset of the gene regions ITS and LSU for species of Amphisphaeriales nested P. pezizoides in the genus Seiridium. Thus, synonymy of Pestalotia with Seiridium is proposed here. This is supported by morphology of the conidia. Further, an epitype is proposed for the type species of Pestalotiopsis, P. maculans. On the other hand, the recently proposed epitype of P. adusta is rejected here as it conflicts with the taxonomic hypothesis obtained in this study and its introduction is inconsistent with the formal requirements for epitypification. A new topotypic specimen is proposed instead. Additionally, several nomenclatural changes become necessary in many species examined. These include three new combinations and six synonyms of species of Pestalotiopsis s.l.
The conclusion of this work is that morphological data have potential as a valuable, inexpensive and easy way to recognize species. However, it is not the best method for species discovery and delimitation bearing in mind that in microfungi and many other organisms, individual plasticity and analogous structures are inadequately investigated. By phylogenetic analyses of molecular sequence data, it is possible to compare a great amount of equivalent characters and to delimit species that are morphologically cryptic. This is especially important since species of Pestalotiopsis s.l. mostly lack sexual structures that are helpful for morphological species delimitation in other groups of fungi. Thus, the Genealogical Concordance Species Concept (GCSC) finds its application in many fungal taxa. Conflicts in the genealogy between phylogenetic trees of different markers are interpreted as recombination of the genetic material within a linage. Accordingly, the change from conflict to congruence in a set of different phylogenetic trees can be seen as the species limit. It can be expected that increased application of the GCSC will lead to further approximation of described species numbers to the real number of species, especially in complicated groups like asexual microfungi.
Mobilizations in defence of ‘companion animals’ have become major sites of contestation in Chinese society in recent years. They often reject the existing ambiguity between the use of these animals as pets and as meat, demanding unambiguous respect for and protection of dogs. However, in a society where inequalities are as significant as in China, where the level of poverty, sickness, and environmental and industrial tragedies appears overwhelming, one may ask how pets’ destinies have become such a symbolic focus and source of occasional fury – for both Chinese and foreign audiences. Taking this question seriously, this article aims to examine such mobilizations in China – demanding the protection of dogs – as a starting point to theoretically unwrap the more general problem of how the perception of certain beings as ‘weak’ and as deserving the protection of society is socially constructed, and what the related choices imply. I argue that to better understand these mobilizations to protect dogs, we should not separate the focus of the calls for protection from the social web of relationships and oppositions in which they are entrenched.