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The rotation-vibration model and the hydrodynamic dipole-oscillation model are unified. A coupling between the dipole oscillations and the quadrupole vibrations is introduced in the adiabatic approximation. The dipole oscillations act as a "driving force" for the quadrupole vibrations and stabilize the intrinsic nucleus in a nonaxially symmetric equilibrium shape. The higher dipole resonance splits into two peaks separated by about 1.5-2 MeV. On top of the several giant resonances occur bands due to rotations and vibrations of the intrinsic nucleus. The dipole operator is established in terms of the collective coordinates and the γ-absorption cross section is derived. For the most important 1- levels the relative dipole excitation is estimated. It is found that some of the dipole strength of the higher giant resonance states is shared with those states in which one surface vibration quantum is excited in addition to the giant resonance.
The theory of Raman scattering is extended to include electric-quadrupole radiation. The results obtained are used to compute the elastic and Raman scattering cross sections of heavy deformed nuclei. The dipole and quadrupole resonances are described by a previously developed theory which includes surface vibrations and rotations. The computed cross sections are compared with experimental data for all those nuclei where both absorption and scattering cross sections are available. Some discrepances still exist in certain details; however, the over-all agreement between theory and experiment is very good.
The modes and frequencies of the giant quadrupole resonance of heavy deformed nuclei have been calculated. The quadrupole operator is computed and the absorption cross section is derived. The quadrupole sum rule is discussed, and the relevant oscillator strengths have been evaluated for various orientations of the nucleus. The giant quadrupole resonances have energies between 20 and 25 MeV. The total absorption cross section is about 20% of the giant dipole absorption cross section. Of particular interest is the occurrence of the quadrupole mode which is sensitive to the nuclear radius in a direction of approximately θ=(1/4)π from the symmetry axis. This may give information on the details of the nuclear shape.
A method is developed for the calculation of resonant nuclear states which preserves as many features of the shell model as possible. It is an extension of the R-matrix theory. The necessary formulas are derived and a detailed description of the computational procedure is given. The method is valid up to the two-particle emission threshold. With the assumption of consecutive decay of the nucleus, the two-particle emission process can also be described. The treatment is antisymmetrized in all particles.
In heavy nuclei the damping of the giant resonance is due to thermalization of the energy rather than to direct emission of particles; the latter process is strongly inhibited by the angular-momentum barrier. The thermalization proceeds via inelastic collisions leading from the particle-hole state to two-particle-two-hole states. In heavy nuclei, several hundred such states are available at the energy of the giant dipole resonance. The rather large width of the giant resonance arises from the addition of many small partial widths of channels leading to the different two-particle-two-hole states. Both the density of the two-particle-two-hole states and the mean value of the interaction matrix elements between the particle-hole and two-particle-two-hole states are evaluated in a simplified square-well shell model. In a given nucleus the energy dependence of the widths is determined mainly by the density of states; the A dependence is determined mainly by the size of the matrix elements. For A ~ 200, we find 0.5 <= Γ <=2.5 MeV. The uncertainty in this value comes mostly from the uncertainty in the strength of the interaction. Representing the energy dependence of the width by a power law we find for the exponent the value ~ 1.8.
The unified model and the collective giant-dipole-resonance model are unified. The resulting energy spectrum and the transition probabilities are derived. A new approximate selection rule involving the symmetry of the γ vibrations is established. It is verified that the main observable features in the photon-absorption cross section are not influenced by the odd particle, despite the considerably richer spectrum of states as compared to even-even nuclei.
Time dependent dirac equation with relativistic mean field dynamics applied to heavy ion scattering
(1986)
We treat the relativistic propagation of nucleons coupled to scalar- and vector-meson fields in a mean-field approximation. The time-dependent Dirac and mean-meson-field equations are solved numerically in three dimensions. Collisions of 16O(300, 600, and 1200 MeV/nucleon) + 16O are studied for various impact parameters. The results are compared to other recent theoretical approaches. The calculations predict spallation, large transverse-momentum transfer, and positive-angle sidewards flow, in qualitative agreement with the data in this energy regime.
The total particle-particle SJ matrix of O16 for spin J=1- and excitation energies between 15 and 27 MeV has been calculated in the eigenchannel reaction theory for several parameters of the Saxon-Woods potential and the two-body force. The many-body problem has been treated in the 1-particle-1-hole approximation. The photon channels have been included by perturbation theory. Surprisingly, the most important structure of the experimental cross sections is reproduced quite well in this simple approximation.
In a collective treatment the energies of the giant resonances are given by the boundary conditions at the nuclear surface, which is subject to vibration in spherical nuclei. The general form of the coupling between these two collective motions is given by angular-momentum and parity conservation. The coupling constants are completely determined within the hydrodynamical model. In the present treatment the influence of the surface vibrations on the total photon-absorption cross section is calculated. It turns out that in most of the spherical nuclei this interaction leads to a pronounced structure in the cross section. The agreement with the experiments in medium-heavy nuclei is striking; many of the experimental characteristics are reproduced by the present calculations. In some nuclei, however, there seem to be indications of single-particle excitations which are not yet contained in this work.
A first testing ground for QED in the combined presence of a strong Coulomb field and a strong magnetic field is provided by the precise measurement of the hyperfine structure splitting of hydrogenlike 209Bi. We present a complete calculation of the one-loop self-energy correction to the first-order hyperfine interaction for various nuclear charges. In the low-Z regime we almost perfectly agree with the Z alpha expansion, but for medium and high Z there is a substantial deviation.
We study the extrapolation of nuclear shell structure to the region of superheavy nuclei in self-consistent mean-field models—the Skyrme-Hartree-Fock approach and the relativistic mean-field model—using a large number of parametrizations which give similar results for stable nuclei but differ in detail. Results obtained with the folded-Yukawa potential which is widely used in macroscopic-macroscopic models are shown for comparison. We focus on differences in the isospin dependence of the spin-orbit interaction and the effective mass between the models and their influence on single-particle spectra. The predictive power of the mean-field models concerning single-particle spectra is discussed for the examples of 208Pb and the spin-orbit splittings of selected neutron and proton levels in 16O, 132Sn, and 208Pb. While all relativistic models give a reasonable description of spin-orbit splittings, all Skyrme interactions show a wrong trend with mass number. The spin-orbit splitting of heavy nuclei might be overestimated by 40%–80%, which exposes a fundamental deficiency of the current nonrelativistic models. In most cases the occurrence of spherical shell closures is found to be nucleon-number dependent. Spherical doubly magic superheavy nuclei are found at 184298114, 172292120, or 184310126 depending on the parametrization. The Z=114 proton shell closure, which is related to a large spin-orbit splitting of proton 2f states, is predicted only by forces which by far overestimate the proton spin-orbit splitting in 208Pb. The Z=120 and N=172 shell closures predicted by the relativistic models and some Skyrme interactions are found to be related to a central depression of the nuclear density distribution. This effect cannot appear in macroscopic-microscopic models or semiclassical approaches like the extended Thomas-Fermi-Strutinski integral approach which have a limited freedom for the density distribution only. In summary, our findings give a strong argument for 172292120 to be the next spherical doubly magic superheavy nucleus.
A fully gauge-invariant, Lorentz-covariant, nonlocal, and nonlinear theory, for coupled spin-½ fields, ψ, and vector fields, A, i.e., "electrons" and "photons," is constructed. The field theory is linear in the ψ fields. The nonlinearity in the A fields arises unambiguously from the requirement of gauge invariance. The coordinates are generalized to admit hypercomplex values, i.e., they are taken to be Clifford numbers. The nonlocality is limited to the hypercomplex component of the coordinates. As the size of the nonlocality is reduced toward zero, the theory goes over into the inhomogeneous Dirac theory. The nonlocality parameter corresponds to an inverse mass and induces self-regulatory properties of the propagators. It is argued that in a gauge-invariant theory a graph-by-graph convergence is impossible in principle, but it is possible that convergence may hold for the complete solution, or for sums over classes of graphs.
We investigate the production of heavy quarks in continuum and bound states in nuclear collisions. Creation rates for free bb and tt quark pairs and for bottomonium and toponium in the ground state are computed at energies of the BNL Relativistic Heavy Ion Collider, CERN Large Hadron Collider (LHC), and Superconducting Super Collider. Central and peripheral heavy-ion collisions are discussed. For top-quark creation we assumed a mass range of 90≤mt≤250 GeV. The creation rate for top quarks in peripheral collisions is estimated to be by a factor 40 to 130 smaller compared with corresponding central collisions. For mt=130 GeV we calculated a creation rate of about 4760 top-quark pairs per day at the LHC (3.5 TeV/nucleon) for Pb-Pb collisions.
The time dependent Hartree-Fock approximation is used to study the dynamical formation of long-lived superheavy nuclear complexes. The effects of long-range Coulomb polarization are treated in terms of a classical quadrupole polarization model. Our calculations show the existence of "resonantlike" structures over a narrow range of bombarding energies near the Coulomb barrier. Calculations of 238U + 238U are presented and the consequences of these results for supercritical positron emission are discussed. NUCLEAR REACTIONS 238U + 238U collisions as a function of bombarding energy, in the time-dependent Hartree-Fock approximation. Superheavy molecules and strongly damped collisions.
We investigate the structure of the potential energy surfaces of the superheavy nuclei 158258Fm100, 156264Hs108, 166278112, 184298114, and 172292120 within the framework of self-consistent nuclear models, i.e., the Skyrme-Hartree-Fock approach and the relativistic mean-field model. We compare results obtained with one representative parametrization of each model which is successful in describing superheavy nuclei. We find systematic changes as compared to the potential energy surfaces of heavy nuclei in the uranium region: there is no sufficiently stable fission isomer any more, the importance of triaxial configurations to lower the first barrier fades away, and asymmetric fission paths compete down to rather small deformation. Comparing the two models, it turns out that the relativistic mean-field model gives generally smaller fission barriers.
A calculation of the vacuum-polarization contribution to the hyperfine splitting for hydrogenlike atoms is presented. The extended nuclear charge distribution is taken into account. For the experimentally interesting case 209Bi82+ we predict a delta-lambda- -1.6 nm shift for the transition wavelength of the ground-state hyperfine splitting.
The aim of this clinical trial was to evaluate the impact of all-trans retinoic acid (ATRA) in combination with chemotherapy and to assess the NPM1 status as biomarker for ATRA therapy in younger adult patients (18-60 years) with acute myeloid leukemia (AML). Patients were randomized for intensive chemotherapy with or without open-label ATRA (45 mg/m2, days 6-8; 15 mg/m2, days 9-21). Two cycles of induction therapy were followed by risk-adapted consolidation with high-dose cytarabine or allogeneic hematopoietic cell transplantation. Due to the open label character of the study, analysis was performed on an intention-to-treat (ITT) and a per-protocol (PP) basis. One thousand one hundred patients were randomized (556, STANDARD; 544, ATRA) with 38 patients treated vice versa. Median follow-up for survival was 5.2 years. ITT analyses revealed no difference between ATRA and STANDARD for the total cohort and for the subset of NPM1-mutated AML with respect to event-free (EFS; p = 0.93, p = 0.17) and overall survival (OS; p = 0.24 and p = 0.32, respectively). Pre-specified PP analyses revealed better EFS in NPM1-mutated AML (p = 0.05) and better OS in the total cohort (p = 0.03). Explorative subgroup analyses on an ITT basis revealed better OS (p = 0.05) in ATRA for genetic low-risk patients according to ELN recommendations. The clinical trial is registered at clinicaltrialsregister.eu (EudraCT Number: 2004-004321-95).
Background and Aims: In patients with advanced liver cirrhosis due to chronic hepatitis C virus (HCV) infection antiviral therapy with peginterferon and ribavirin is feasible in selected cases only due to potentially life-threatening side effects. However, predictive factors associated with hepatic decompensation during antiviral therapy are poorly defined.
Methods: In a retrospective cohort study, 68 patients with HCV-associated liver cirrhosis (mean MELD score 9.18±2.72) were treated with peginterferon and ribavirin. Clinical events indicating hepatic decompensation (onset of ascites, hepatic encephalopathy, upper gastrointestinal bleeding, hospitalization) as well as laboratory data were recorded at baseline and during a follow up period of 72 weeks after initiation of antiviral therapy. To monitor long term sequelae of end stage liver disease an extended follow up for HCC development, transplantation and death was applied (240weeks, ±SD 136weeks).
Results: Eighteen patients (26.5%) achieved a sustained virologic response. During the observational period a hepatic decompensation was observed in 36.8%. Patients with hepatic decompensation had higher MELD scores (10.84 vs. 8.23, p<0.001) and higher mean bilirubin levels (26.74 vs. 14.63 µmol/l, p<0.001), as well as lower serum albumin levels (38.2 vs. 41.1 g/l, p = 0.015), mean platelets (102.64 vs. 138.95/nl, p = 0.014) and mean leukocytes (4.02 vs. 5.68/nl, p = 0.002) at baseline as compared to those without decompensation. In the multivariate analysis the MELD score remained independently associated with hepatic decompensation (OR 1.56, 1.18–2.07; p = 0.002). When the patients were grouped according to their baseline MELD scores, hepatic decompensation occurred in 22%, 59%, and 83% of patients with MELD scores of 6–9, 10–13, and >14, respectively. Baseline MELD score was significantly associated with the risk for transplantation/death (p<0.001).
Conclusions: Our data suggest that the baseline MELD score predicts the risk of hepatic decompensation during antiviral therapy and thus contributes to decision making when antiviral therapy is discussed in HCV patients with advanced liver cirrhosis.
Resilience has been defined as the maintenance or quick recovery of mental health during and after times of adversity. How to operationalize resilience and to determine the factors and processes that lead to good long-term mental health outcomes in stressor-exposed individuals is a matter of ongoing debate and of critical importance for the advancement of the field. One of the biggest challenges for implementing an outcome-based definition of resilience in longitudinal observational study designs lies in the fact that real-life adversity is usually unpredictable and that its substantial qualitative as well as temporal variability between subjects often precludes defining circumscribed time windows of inter-individually comparable stressor exposure relative to which the maintenance or recovery of mental health can be determined. To address this pertinent issue, we propose to frequently and regularly monitor stressor exposure (E) and mental health problems (P) throughout a study's observation period [Frequent Stressor and Mental Health Monitoring (FRESHMO)-paradigm]. On this basis, a subject's deviation at any single monitoring time point from the study sample's normative E–P relationship (the regression residual) can be used to calculate that subject's current mental health reactivity to stressor exposure (“stressor reactivity,” SR). The SR score takes into account the individual extent of experienced adversity and is comparable between and within subjects. Individual SR time courses across monitoring time points reflect intra-individual temporal variability in SR, where periods of under-reactivity (negative SR score) are associated with accumulation of fewer mental health problems than is normal for the sample. If FRESHMO is accompanied by regular measurement of potential resilience factors, temporal changes in resilience factors can be used to predict SR time courses. An increase in a resilience factor measurement explaining a lagged decrease in SR can then be considered to index a process of adaptation to stressor exposure that promotes a resilient outcome (an allostatic resilience process). This design principle allows resilience research to move beyond merely determining baseline predictors of resilience outcomes, which cannot inform about how individuals successfully adjust and adapt when confronted with adversity. Hence, FRESHMO plus regular resilience factor monitoring incorporates a dynamic-systems perspective into resilience research.
This paper reports on Monte Carlo simulation results for future measurements of the moduli of time-like proton electromagnetic form factors, |GE | and |GM|, using the ¯pp → μ+μ− reaction at PANDA (FAIR). The electromagnetic form factors are fundamental quantities parameterizing the electric and magnetic structure of hadrons. This work estimates the statistical and total accuracy with which the form factors can be measured at PANDA, using an analysis of simulated data within the PandaRoot software framework. The most crucial background channel is ¯pp → π+π−,due to the very similar behavior of muons and pions in the detector. The suppression factors are evaluated for this and all other relevant background channels at different values of antiproton beam momentum. The signal/background separation is based on a multivariate analysis, using the Boosted Decision Trees method. An expected background subtraction is included in this study, based on realistic angular distribuations of the background contribution. Systematic uncertainties are considered and the relative total uncertainties of the form factor measurements are presented.
Using a data sample of e+e− collision data corresponding to an integrated luminosity of 2.93 fb−1 collected with the BESIII detector at a center-of-mass energy of s=3.773GeV, we search for the singly Cabibbo-suppressed decays D0→π0π0π0, π0π0η, π0ηη and ηηη using the double tag method. The absolute branching fractions are measured to be B(D0→π0π0π0)=(2.0±0.4±0.3)×10−4, B(D0→π0π0η)=(3.8±1.1±0.7)×10−4 and B(D0→π0ηη)=(7.3±1.6±1.5)×10−4 with the statistical significances of 4.8σ, 3.8σ and 5.5σ, respectively, where the first uncertainties are statistical and the second ones systematic. No significant signal of D0→ηηη is found, and the upper limit on its decay branching fraction is set to be B(D0→ηηη)<1.3×10−4 at the 90% confidence level.