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Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Ajitanand, N. N. ; Alekseev, Igor G. ; Anderson, Derek M. ; Aoyama, Ryo ; Aparin, Alexey ; Arkhipkin, Dmitry A. ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Attri, Anjali ; Averichev, Georgy S. ; Bai, X. ; Bairathi, Vipul ; Barish, Kenneth ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bhattarai, P. ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Bouchet, J. ; Brandenburg, James D. ; Brandin, Andrei V. ; Brown, D. ; Bunzarov, Ivan ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Campbell, J. M. ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, X. ; Chen, J. H. ; Chen, X. ; Cheng, J. ; Cherney, Michael Gerard ; Christie, William ; Contin, Giacomo ; Crawford, Henry J. ; Das, Supriya ; De Silva, L. C. ; Dedovich, T. G. ; Deng, J. ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dilks, Christopher ; Dong, X. ; Drachenberg, James Lucus ; Draper, James E. ; Dunkelberger, L. E. ; Dunlop, James C. ; Efimov, Leonid G. ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, J. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Federicova, P. ; Fedorišin, Jan ; Feng, Z. ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Flores, C. E. ; Fujita, J. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Garand, D. ; Geurts, Frank ; Gibson, Adam ; Girard, M. ; Grosnick, David P. ; Gunarathne, D. S. ; Guo, Y. ; Gupta, Anik ; Gupta, S. ; Guryn, Włodzimierz ; Hamad, A. I. ; Hamed, Ahmed M. ; Harlenderova, Alena ; Harris, John W. ; He, L. ; Heppelmann, S. ; Heppelmann, S. ; Hirsch, Andrew S. ; Horvat, S. ; Huang, X. ; Huang, Bingchu ; Huang, T. ; Huang, Huan Zhong ; Humanic, Thomas J. ; Huo, P. ; Igo, George J. ; Jacobs, William W. ; Jentsch, Alexander ; Jia, Jiangyong ; Jiang, K. ; Jowzaee, S. ; Judd, Eleanor G. ; Kabana, Sonia ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Khan, Z. ; Kikoła, Daniel P. ; Kim, C. ; Kisel, Ivan ; Kisiel, Adam Ryszard ; Kočenda, L. M. ; Kocmanek, M. ; Kollegger, Thorsten ; Kosarzewski, Leszek Krzysztof ; Kraishan, A. F. ; Krauth, L. ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga, Nalinda ; Kumar, Lokesh ; Kvapil, Jakub ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Landgraf, Jeffery M. ; Landry, K. D. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J. H. ; Li, C. ; Li, X. ; Li, Y. ; Li, W. ; Lidrych, J. ; Lin, T. ; Lisa, Michael A. ; Liu, P. ; Liu, H. ; Liu, Y. ; Liu, F. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Lomnitz, M. ; Longacre, Ronald S. ; Luo, S. ; Luo, X. ; Ma, Yu-Gang ; Ma, L. ; Ma, R. ; Ma, G. L. ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Meehan, K. ; Mei, J. C. ; Miller, Z. W. ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mishra, Debadeepti ; Mizuno, S. ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Morozov, Dmitry A. ; Mustafa, M. K. ; Nasim, Md. ; Nayak, Tapan Kumar ; Nelson, John M. ; Nie, M. ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, K. ; Okorokov, Vitaly A. ; Olvitt, D. ; Page, Brian S. ; Pak, Robert ; Pandit, Y. ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pei, Hua ; Perkins, Chris ; Pile, P. ; Pluta, Jan Marian ; Poniatowska, K. ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qiu, H. ; Quintero, Amilkar ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Rehbein, M. J. ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Roth, J. D. ; Ruan, L. ; Rusnak, Jan ; Rusnakova, O. ; Sahoo, Nihar Ranjan ; Sahu, Pradip Kumar ; Salur, Sevil ; Sandweiss, Jack H. ; Saur, M. ; Schambach, Joachim ; Schmah, A. M. ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Sharma, A. ; Sharma, M. K. ; Shen, W. Q. ; Shi, Shusu ; Shi, Z. ; Shou, Q. Y. ; Sichtermann, Ernst P. ; Sikora, Rafał ; Šimko, Miroslav ; Singha, Subhash ; Skoby, Michael J. ; Smirnov, Nikolai ; Smirnov, Dmitri V. ; Solyst, William ; Song, L. ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, B. ; Stanislaus, T. D. Shirvel ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Sugiura, Tetsuro ; Šumbera, Michal ; Summa, Branden ; Sun, Y. ; Sun, X. M. ; Sun, X. ; Surrow, Bernd ; Svirida, Dmitry N. ; Tang, Zebo ; Tang, Aihong ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Tawfik, Abdel Nasser ; Thäder, Jochen ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; van Nieuwenhuizen, G. ; Vasiliev, Alexander Nikolaevich ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Vossen, A. ; Wang, G. ; Wang, Y. ; Wang, F. ; Wang, Y. ; Webb, Jason C. ; Webb, Grant ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xiao, Z. G. ; Xie, Guannan ; Xie, W. ; Xu, J. ; Xu, Z. ; Xu, Qinghua ; Xu, Y. F. ; Xu, N. ; Yang, S. ; Yang, Y. ; Yang, C. ; Yang, Q. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yoo, I. -K. ; Yu, N. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, Z. ; Zhang, J. B. ; Zhang, J. ; Zhang, S. ; Zhang, Y. ; Zhang, X. P. ; Zhang, J. ; Zhang, S. ; Zhao, J. ; Zhong, C. ; Zhou, C. ; Zhou, L. ; Zhu, X. ; Zhu, Z. ; Zyzak, Maksym
Rapidity-odd directed flow measurements at midrapidity are presented for Λ, Λ¯, K±, K0s and ϕ at sNN−−−−√= 7.7, 11.5, 14.5, 19.6, 27, 39, 62.4 and 200 GeV in Au+Au collisions recorded by the STAR detector at the Relativistic Heavy Ion Collider. These measurements greatly expand the scope of data available to constrain models with differing prescriptions for the equation of state of quantum chromodynamics. Results show good sensitivity for testing a picture where flow is assumed to be imposed before hadron formation and the observed particles are assumed to form via coalescence of constituent quarks. The pattern of departure from a coalescence-inspired sum-rule can be a valuable new tool for probing the collision dynamics.
Adamczyk, Leszek ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, Igor G. ; Alford, J. ; Aparin, Alexey ; Arkhipkin, Dmitry A. ; Aschenauer, Elke Caroline ; Averichev, Georgy S. ; Banerjee, A. ; Bellwied, Rene ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bhattarai, P. ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Bouchet, J. ; Brandin, Andrei V. ; Bunzarov, Ivan ; Burton, T.P. ; Butterworth, Joseph ; Caines, Helen Louise ; Calder’on de la Barca S’anchez, M. ; Campbell, J.M. ; Cebra, Daniel A. ; Cervantes, M.C. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chang, Z. ; Chattopadhyay, S. ; Chen, J.H. ; Chen, X. ; Cheng, J. ; Cherney, Michael Gerard ; Christie, William ; Codrington, M.J.M. ; Contin, Giacomo ; Crawford, Henry J. ; Das, Supriya ; De Silva, L.C. ; Debbe, R.R. ; Dedovič, Tatiana G. ; Deng, J. ; Derevschikov, Anatoly A. ; di Ruzza, Benedetto ; Didenko, Lidia ; Dilks, Christopher ; Dong, X. ; Drachenberg, James Lucus ; Draper, James E. ; Du, C.M. ; Dunkelberger, L.E. ; Dunlop, James C. ; Efimov, Leonid G. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Evdokimov, Olga Y. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Fedorišin, Jan ; Feng ; Filip, Peter ; Fisyak, Yuri V. ; Flores, C.E. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Garand, D. ; Geurts, Frank ; Gibson, Adam ; Girard, M. ; Greiner, Leo Clifford ; Grosnick, David P. ; Gunarathne, D.S. ; Guo, Y. ; Gupta, S. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Haque, R. ; Harris, John W. ; He, L. ; Heppelmann, S. ; Hirsch, Andrew S. ; Hoffmann, Gerald W. ; Hofman, D.J. ; Horvat, S. ; Huang, Huan Zhong ; Huang, X. ; Huang, Bingchu ; Huck, P. ; Humanic, Thomas J. ; Igo, George J. ; Jacobs, William W. ; Jang, H. ; Jiang, K. ; Judd, Eleanor G. ; Kabana, Sonia ; Kalinkin, Dmitry ; Kang, K. ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Khan, Z.H. ; Kikola, D.P. ; Kisel, Ivan ; Kisiel, Adam Ryszard ; Klein, Spencer Robert ; Koetke, Donald D. ; Kollegger, Thorsten ; Kosarzewski, Leszek Krzysztof ; Kotchenda, L. ; Kraishan, A.F. ; Kravtsov, Peter ; Krueger, Keith William ; Kulakov, Igor ; Kumar, Lokesh ; Kycia, R.A. ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; Landry, K.D. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Li, X. ; Li, X. ; Li, W. ; Li, Z.M. ; Li, Y. ; Li, C. ; Lisa, Michael A. ; Liu, F. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Lomnitz, M. ; Longacre, Ronald S. ; Luo, X. ; Ma, L. ; Ma, R. ; Ma, G.L. ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Manion, A. ; Margetis, Spyridon ; Markert, Christina ; Masui, H. ; Matis, Howard S. ; McDonald, Daniel ; Meehan, K. ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Morozov, Dmitry A. ; Mustafa, M.K. ; Nandi, Basanta Kumar ; Nasim, Md. ; Nayak, Tapan Kumar ; Nigmatkulov, Grigory A. ; Nogach, Larisa V. ; Noh, S.Y. ; Novak, J. ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, K. ; Okorokov, Vitaly A. ; Olvitt, D.L. ; Page, Brian S. ; Pan, Y.X. ; Pandit, Y. ; Panebratsev, Yuri ; Pawlak, Tomasz Jan ; Pawlik, Bogdan ; Pei, Hua ; Perkins, Chris ; Peterson, A. ; Pile, P. ; Planinic, Mirko ; Pluta, Jan Marian ; Poljak, Nikola ; Poniatowska, K. ; Porter, Jeffrey Brent ; Posik, Matthew ; Poskanzer, Arthur M. ; Pruthi, Navneet Kumar ; Putschke, Jörn H. ; Qiu, H. ; Quintero, Amilkar ; Ramachandran, Suvarna ; Raniwala, Rashmi ; Raniwala, Sudhir ; Ray, Robert L. ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Roy, Ankhi ; Ruan, L. ; Rusnak, Jan ; Rusnakova, O. ; Sahoo, Nihar Ranjan ; Sahu, Pradip Kumar ; Sakrejda, Iwona ; Salur, Sevil ; Sandacz, A. ; Sandweiss, Jack H. ; Sarkar, Amal ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmah, Alexander ; Schmidke, William B. ; Schmitz, Norbert ; Seger, Janet Elizabeth ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Sharma, M.K. ; Sharma, B. ; Shen, W.Q. ; Shi, Shusu ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Sikora, Rafał ; Šimko, Miroslav ; Skoby, Michael J. ; Smirnov, Nikolai ; Smirnov, Dmitri V. ; Solanki, D. ; Song, L. ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, B. ; Stanislaus, T. D. Shirvel ; Stock, Reinhard ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Šumbera, Michal ; Summa, B.J. ; Sun, Y. ; Sun, Z. ; Sun, X.M. ; Sun, X. ; Surrow, Bernd ; Svirida, Dmitry N. ; Szelezniak, M.A. ; Takahashi, Jun ; Tang, Aihong ; Tang, Zebo ; Tarnowsky, Terence J. ; Tawfik, Abdel Nasser ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Tokarev, Mikhail V. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; van Nieuwenhuizen, G. ; Vandenbroucke, M. ; Varma, Raghava ; Vasiliev, Alexander Nikolaevich ; Vértesi, Róbert ; Videbæk, Flemming ; Viyogi, Yogendra P. ; Vokal, Stanislav ; Voloshin, Sergei ; Vossen, A. ; Wang, Y. ; Wang, F. ; Wang, H. ; Wang, J.S. ; Wang, G. ; Wang, Y. ; Webb, Jason C. ; Webb, Grant ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y.F. ; Xiao, Z. ; Xie, W. ; Xin, K. ; Xu, Z. ; Xu, Qinghua ; Xu, N. ; Xu, H. ; Xu, Y.F. ; Yang, Y. ; Yang, C. ; Yang, S. ; Yang, Q. ; Yang, Y. ; Ye, Z. ; Yepes, Pablo P. ; Yi, L. ; Yip, K. ; Yoo, In-Kwon ; Yu, N. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, J.B. ; Zhang, X.P. ; Zhang, S. ; Zhang, J. ; Zhang, Z. ; Zhang, Y. ; Zhang, J.L. ; Zhao, F. ; Zhao, J. ; Zhong, C. ; Zhou, L. ; Zhu, X. ; Zoulkarneeva, Youlia ; Zyzak, Maksym
The acceptance-corrected dielectron excess mass spectra, where the known hadronic sources have been subtracted from the inclusive dielectron mass spectra, are reported for the first time at mid-rapidity |yee|<1 in minimum-bias Au+Au collisions at sNN−−−−√ = 19.6 and 200 GeV. The excess mass spectra are consistently described by a model calculation with a broadened ρ spectral function for Mee<1.1 GeV/c2. The integrated dielectron excess yield at sNN−−−−√ = 19.6 GeV for 0.4<Mee<0.75 GeV/c2, normalized to the charged particle multiplicity at mid-rapidity, has a value similar to that in In+In collisions at sNN−−−−√ = 17.3 GeV. For sNN−−−−√ = 200 GeV, the normalized excess yield in central collisions is higher than that at sNN−−−−√ = 17.3 GeV and increases from peripheral to central collisions. These measurements indicate that the lifetime of the hot, dense medium created in central Au+Au collisions at sNN−−−−√ = 200 GeV is longer than those in peripheral collisions and at lower energies.
Adamczyk, Leszek ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alakhverdyants, A. V. ; Alekseev, Igor G. ; Alford, J. ; Anderson, Bryon D. ; Anson, Christopher Daniel ; Arkhipkin, Dmitry A. ; Averichev, Georgy S. ; Balewski, Jan ; Banerjee, A. ; Barnovska, Z. ; Beavis, D. R. ; Bellwied, Rene ; Betancourt, M. J. ; Betts, R. R. ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bichsel, Hans ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Borowski, W. ; Bouchet, J. ; Brandin, Andrei V. ; Brovko, S. G. ; Bruna, Elena ; Bueltmann, S. ; Bunzarov, Ivan ; Burton, T. P. ; Butterworth, Joseph ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Cendejas, R. ; Cervantes, M. C. ; Chaloupka, Petr ; Chattopadhyay, S. ; Chen, H. F. ; Chen, J. H. ; Chen, J. Y. ; Chen, L. ; Cheng, J. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Christie, William ; Chung, P. ; Chwastowski, J. ; Codrington, M. J. M. ; Corliss, R. ; Cramer, John G. ; Crawford, Henry J. ; Cui, X. ; Davila Leyva, A. ; De Silva, L. C. ; Debbe, R. R. ; Dedovich, T. G. ; Deng, J. ; Souza, Rafael Derradi de ; Dhamija, S. ; Didenko, Lidia ; Ding, F. ; Djawotho, P. ; Dong, X. ; Drachenberg, James Lucus ; Draper, James E. ; Du, C. M. ; Dunkelberger, L. E. ; Dunlop, James C. ; Efimov, Leonid G. ; Elnimr, M. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Eun, L. ; Evdokimov, Olga Y. ; Fatemi, Renee H. ; Fedorišin, Jan ; Fersch, R. G. ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Gagliardi, Carl A. ; Gangadharan, Dhevan Raja ; Geurts, Frank ; Gliske, S. ; Gorbunov, Y. N. ; Grebenyuk, O. G. ; Grosnick, David P. ; Gupta, S. ; Guryn, Włodzimierz ; Haag, B. ; Hajkova, O. ; Hamed, Ahmed M. ; Han, L-X. ; Harris, John W. ; Hays-Wehle, J. P. ; Heppelmann, S. ; Hirsch, Andrew S. ; Hoffmann, Gerald W. ; Hofman, D. J. ; Horvat, S. ; Huang, Bingchu ; Huang, Huan Zhong ; Huck, P. ; Humanic, Thomas J. ; Huo, L. ; Igo, George J. ; Jacobs, William W. ; Jena, Chitrasen ; Joseph, J. ; Judd, Eleanor G. ; Kabana, Sonia ; Kang, K. ; Kapitan, J. ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kesich, A. ; Kettler, D. ; Kikola, D. P. ; Kiryluk, Joanna ; Kisiel, Adam Ryszard ; Kizka, V. ; Klein, Spencer Robert ; Koetke, Donald D. ; Kollegger, Thorsten ; Konzer, J. ; Koralt, I. ; Koroleva, L. ; Korsch, W. ; Kotchenda, L. ; Kravtsov, Peter ; Krueger, Keith William ; Kumar, Lokesh ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; LaPointe, S. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J. H. ; Leight, W. ; LeVine, Micheal J. ; Li, C. ; Li, L. ; Li, W. ; Li, X. ; Li, X. ; Li, Y. ; Li, Z. M. ; Lima, L. M. ; Lisa, Michael A. ; Liu, F. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Longacre, Ronald S. ; Lu, Y. ; Luo, X. ; Luszczak, A. ; Ma, G. L. ; Ma, Yu-Gang ; Mahapatra, Durga Prasad ; Majka, Richard Daniel ; Mall, O. I. ; Margetis, Spyridon ; Markert, Christina ; Masui, H. ; Matis, Howard S. ; McDonald, Daniel ; McShane, Tom S. ; Mioduszewski, Saskia ; Mitrovski, M. K. ; Mohammed, Y. ; Mohanty, Bedangadas ; Morozov, B. ; Munhoz, Marcelo Gameiro ; Mustafa, M. K. ; Naglis, M. ; Nandi, Basanta Kumar ; Nasim, Md. ; Nayak, Tapan Kumar ; Nogach, Larisa V. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, K. ; Ohlson, Alice ; Okorokov, Vitaly A. ; Oldag, E. W. ; Oliveira, R. A. N. ; Olson, Douglas L. ; Pachr, Miloš ; Page, Brian S. ; Pal, Susanta Kumar ; Pan, Y. X. ; Pandit, Y. ; Panebratsev, Yuri ; Pawlak, Tomasz Jan ; Pawlik, Bogdan ; Pei, Hua ; Perkins, Chris ; Peryt, Wiktor Stanislaw ; Pile, P. ; Planinic, Mirko ; Pluta, Jan Marian ; Plyku, D. ; Poljak, Nikola ; Porter, Jeffrey Brent ; Poskanzer, Arthur M. ; Powell, C. B. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Pujahari, P. R. ; Putschke, Jörn H. ; Qiu, H. ; Raniwala, Rashmi ; Raniwala, Sudhir ; Ray, Robert L. ; Redwine, R. ; Reed, Rosi Jan ; Riley, C. K. ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, L. ; Rusnak, Jan ; Sahoo, Nihar Ranjan ; Sakrejda, Iwona ; Salur, Sevil ; Sandweiss, Jack H. ; Sangaline, E. ; Sarkar, Amal ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmah, A. M. ; Schmitz, Norbert ; Schuster, T. R. ; Seele, J. ; Seger, Janet Elizabeth ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shao, M. ; Sharma, B. ; Sharma, M. ; Shi, Shusu ; Shou, Q. Y. ; Sichtermann, Ernst P. ; Singaraju, Rama Narayana ; Skoby, Michael J. ; Smirnov, Nikolai ; Solanki, D. ; Sorensen, Paul Richard ; deSouza, U. G. ; Spinka, Harold. M. ; Srivastava, B. ; Stanislaus, T. D. Shirvel ; Steadman, S. G. ; Stevens, J. R. ; Stock, Reinhard ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Suarez, M. C. ; Šumbera, Michal ; Sun, X. M. ; Sun, Y. ; Sun, Z. ; Surrow, Bernd ; Svirida, Dmitry N. ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Takahashi, Jun ; Tang, Aihong ; Tang, Zebo ; Tarini, L. H. ; Tarnowsky, Terence J. ; Thein, Dylan ; Thomas, James H. ; Tian, J. ; Timmins, Anthony Robert ; Tlusty, David ; Tokarev, Mikhail V. ; Trainor, Thomas A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Turnau, J. ; Ullrich, Thomas ; Underwood, David G. ; Van Buren, Gene ; van Nieuwenhuizen, G. ; Vanfossen, J. A. ; Varma, Raghava ; Vasconcelos, G. M. S. ; Videbæk, Flemming ; Viyogi, Yogendra P. ; Vokal, Stanislav ; Voloshin, Sergei ; Vossen, A. ; Wada, M. ; Wang, F. ; Wang, G. ; Wang, H. ; Wang, J. S. ; Wang, Q. ; Wang, X. L. ; Wang, Y. ; Webb, Grant ; Webb, Jason C. ; Westfall, Gary D. ; Whitten, Charles A. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Witzke, W. ; Wu, Y. F. ; Xiao, Z. ; Xie, W. ; Xin, K. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, W. ; Xu, Y. ; Xu, Z. ; Xue, L. ; Yang, Y. ; Yang, Y. ; Yepes, Pablo P. ; Yi, Y. ; Yip, K. ; Yoo, I-K. ; Zawisza, M. ; Zbroszczyk, Hanna Paulina ; Zhang, J. B. ; Zhang, S. ; Zhang, W. M. ; Zhang, X. P. ; Zhang, Y. ; Zhang, Z. P. ; Zhao, F. ; Zhao, J. ; Zhong, C. ; Zhu, X. ; Zhu, Y. H. ; Zoulkarneeva, Youlia
STAR's measurements of directed flow (v1) around midrapidity for π±, K±, K0S, p and p¯ in Au + Au collisions at $\sqrtsNN = 200$ GeV are presented. A negative v1(y) slope is observed for most of produced particles (π±, K±, K0S and p¯). The proton v1(y) slope is found to be much closer to zero compared to antiprotons. A sizable difference is seen between v1 of protons and antiprotons in 5-30% central collisions. The v1 excitation function is presented. Comparisons to model calculations (RQMD, UrQMD, AMPT, QGSM with parton recombination, and a hydrodynamics model with a tilted source) are made. Anti-flow alone cannot explain the centrality dependence of the difference between the v1(y) slopes of protons and antiprotons.
Adamczyk, Leszek ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alakhverdyants, A. V. ; Alekseev, Igor G. ; Alford, J. ; Anderson, Bryon D. ; Anson, Christopher Daniel ; Arkhipkin, Dmitry A. ; Averichev, Georgy S. ; Balewski, Jan ; Banerjee, A. ; Barnovska, Z. ; Beavis, D. R. ; Bellwied, Rene ; Betancourt, M. J. ; Betts, R. R. ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bichsel, Hans ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Borowski, W. ; Bouchet, J. ; Brandin, Andrei V. ; Brovko, S. G. ; Bruna, Elena ; Bueltmann, S. ; Bunzarov, Ivan ; Burton, T. P. ; Butterworth, Joseph ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Cendejas, R. ; Cervantes, M. C. ; Chaloupka, Petr ; Chattopadhyay, S. ; Chen, H. F. ; Chen, J. H. ; Chen, J. Y. ; Chen, L. ; Cheng, J. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Christie, William ; Chung, P. ; Chwastowski, J. ; Codrington, M. J. M. ; Corliss, R. ; Cramer, John G. ; Crawford, Henry J. ; Cui, X. ; Davila Leyva, A. ; De Silva, L. C. ; Debbe, R. R. ; Dedovich, T. G. ; Deng, J. ; Souza, Rafael Derradi de ; Dhamija, S. ; Didenko, Lidia ; Ding, F. ; Djawotho, P. ; Dong, X. ; Drachenberg, James Lucus ; Draper, James E. ; Du, C. M. ; Dunkelberger, L. E. ; Dunlop, James C. ; Efimov, Leonid G. ; Elnimr, M. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Eun, L. ; Evdokimov, Olga Y. ; Fatemi, Renee H. ; Fedorišin, Jan ; Fersch, R. G. ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Gagliardi, Carl A. ; Gangadharan, Dhevan Raja ; Geurts, Frank ; Gliske, S. ; Gorbunov, Y. N. ; Grebenyuk, O. G. ; Grosnick, David P. ; Gupta, S. ; Guryn, Włodzimierz ; Haag, B. ; Hajkova, O. ; Hamed, Ahmed M. ; Han, L-X. ; Harris, John W. ; Hays-Wehle, J. P. ; Heppelmann, S. ; Hirsch, Andrew S. ; Hoffmann, Gerald W. ; Hofman, D. J. ; Horvat, S. ; Huang, Bingchu ; Huang, Huan Zhong ; Huck, P. ; Humanic, Thomas J. ; Huo, L. ; Igo, George J. ; Jacobs, William W. ; Jena, Chitrasen ; Joseph, J. ; Judd, Eleanor G. ; Kabana, Sonia ; Kang, K. ; Kapitan, J. ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kesich, A. ; Kettler, D. ; Kikola, D. P. ; Kiryluk, Joanna ; Kisiel, Adam Ryszard ; Kizka, V. ; Klein, Spencer Robert ; Koetke, Donald D. ; Kollegger, Thorsten ; Konzer, J. ; Koralt, I. ; Koroleva, L. ; Korsch, W. ; Kotchenda, L. ; Kravtsov, Peter ; Krueger, Keith William ; Kumar, Lokesh ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; LaPointe, S. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J. H. ; Leight, W. ; LeVine, Micheal J. ; Li, C. ; Li, L. ; Li, W. ; Li, X. ; Li, X. ; Li, Y. ; Li, Z. M. ; Lima, L. M. ; Lisa, Michael A. ; Liu, F. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Longacre, Ronald S. ; Lu, Y. ; Luo, X. ; Luszczak, A. ; Ma, G. L. ; Ma, Yu-Gang ; Mahapatra, Durga Prasad ; Majka, Richard Daniel ; Mall, O. I. ; Margetis, Spyridon ; Markert, Christina ; Masui, H. ; Matis, Howard S. ; McDonald, Daniel ; McShane, Tom S. ; Mioduszewski, Saskia ; Mitrovski, M. K. ; Mohammed, Y. ; Mohanty, Bedangadas ; Morozov, B. ; Munhoz, Marcelo Gameiro ; Mustafa, M. K. ; Naglis, M. ; Nandi, Basanta Kumar ; Nasim, Md. ; Nayak, Tapan Kumar ; Nogach, Larisa V. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, K. ; Ohlson, Alice ; Okorokov, Vitaly A. ; Oldag, E. W. ; Oliveira, R. A. N. ; Olson, Douglas L. ; Pachr, Miloš ; Page, Brian S. ; Pal, Susanta Kumar ; Pan, Y. X. ; Pandit, Y. ; Panebratsev, Yuri ; Pawlak, Tomasz Jan ; Pawlik, Bogdan ; Pei, Hua ; Perkins, Chris ; Peryt, Wiktor Stanislaw ; Pile, P. ; Planinic, Mirko ; Pluta, Jan Marian ; Plyku, D. ; Poljak, Nikola ; Porter, Jeffrey Brent ; Poskanzer, Arthur M. ; Powell, C. B. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Pujahari, P. R. ; Putschke, Jörn H. ; Qiu, H. ; Raniwala, Rashmi ; Raniwala, Sudhir ; Ray, Robert L. ; Redwine, R. ; Reed, Rosi Jan ; Riley, C. K. ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, L. ; Rusnak, Jan ; Sahoo, Nihar Ranjan ; Sakrejda, Iwona ; Salur, Sevil ; Sandweiss, Jack H. ; Sangaline, E. ; Sarkar, Amal ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmah, A. M. ; Schmitz, Norbert ; Schuster, T. R. ; Seele, J. ; Seger, Janet Elizabeth ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shao, M. ; Sharma, B. ; Sharma, M. ; Shi, Shusu ; Shou, Q. Y. ; Sichtermann, Ernst P. ; Singaraju, Rama Narayana ; Skoby, Michael J. ; Smirnov, Nikolai ; Solanki, D. ; Sorensen, Paul Richard ; deSouza, U. G. ; Spinka, Harold. M. ; Srivastava, B. ; Stanislaus, T. D. Shirvel ; Steadman, S. G. ; Stevens, J. R. ; Stock, Reinhard ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Suarez, M. C. ; Šumbera, Michal ; Sun, X. M. ; Sun, Y. ; Sun, Z. ; Surrow, Bernd ; Svirida, Dmitry N. ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Takahashi, Jun ; Tang, Aihong ; Tang, Zebo ; Tarini, L. H. ; Tarnowsky, Terence J. ; Thein, Dylan ; Thomas, James H. ; Tian, J. ; Timmins, Anthony Robert ; Tlusty, David ; Tokarev, Mikhail V. ; Trainor, Thomas A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Turnau, J. ; Ullrich, Thomas ; Underwood, David G. ; Van Buren, Gene ; van Nieuwenhuizen, G. ; Vanfossen, J. A. ; Varma, Raghava ; Vasconcelos, G. M. S. ; Videbæk, Flemming ; Viyogi, Yogendra P. ; Vokal, Stanislav ; Voloshin, Sergei ; Vossen, A. ; Wada, M. ; Wang, F. ; Wang, G. ; Wang, H. ; Wang, J. S. ; Wang, Q. ; Wang, X. L. ; Wang, Y. ; Webb, Grant ; Webb, Jason C. ; Westfall, Gary D. ; Whitten, Charles A. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Witzke, W. ; Wu, Y. F. ; Xiao, Z. ; Xie, W. ; Xin, K. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, W. ; Xu, Y. ; Xu, Z. ; Xue, L. ; Yang, Y. ; Yang, Y. ; Yepes, Pablo P. ; Yi, Y. ; Yip, K. ; Yoo, I-K. ; Zawisza, M. ; Zbroszczyk, Hanna Paulina ; Zhang, J. B. ; Zhang, S. ; Zhang, W. M. ; Zhang, X. P. ; Zhang, Y. ; Zhang, Z. P. ; Zhao, F. ; Zhao, J. ; Zhong, C. ; Zhu, X. ; Zhu, Y. H. ; Zoulkarneeva, Youlia
STAR's measurements of directed flow (v1) around midrapidity for π±, K±, K0S, p and p¯ in Au + Au collisions at $\sqrtsNN = 200$ GeV are presented. A negative v1(y) slope is observed for most of produced particles (π±, K±, K0S and p¯). In 5-30% central collisions a sizable difference is present between the v1(y) slope of protons and antiprotons, with the former being consistent with zero within errors. The v1 excitation function is presented. Comparisons to model calculations (RQMD, UrQMD, AMPT, QGSM with parton recombination, and a hydrodynamics model with a tilted source) are made. For those models which have calculations of v1 for both pions and protons, none of them can describe v1(y) for pions and protons simultaneously. The hydrodynamics model with a tilted source as currently implemented cannot explain the centrality dependence of the difference between the v1(y) slopes of protons and antiprotons.
Thill, Marc ; Friedrich, Michael ; Kolberg-Liedtke, Cornelia ; Albert, Ute-Susann ; Banys-Paluchowski, Maggie ; Bauerfeind, Ingo ; Blohmer, Jens-Uwe ; Budach, Wilfried ; Dall, Peter ; Fallenberg, Eva Maria ; Fasching, Peter Andreas ; Fehm, Tanja ; Gerber, Bernd ; Gluz, Oleg ; Harbeck, Nadia ; Heil, Jörg ; Huober, Jens ; Jackisch, Christian ; Kreipe, Hans-H. ; Krug, David ; Kühn, Thorsten ; Kümmel, Sherko ; Loibl, Sibylle ; Lüftner, Diana ; Lux, Michael Patrick ; Maass, Nicolai ; Mundhenke, Christoph ; Nitz, Ulrike ; Park-Simon, Tjoung-Won ; Reimer, Toralf ; Rhiem, Kerstin ; Rody, Achim ; Schmidt, Marcus ; Schneeweiss, Andreas ; Schütz, Florian ; Sinn, Peter ; Solbach, Christine ; Solomayer, Erich-Franz ; Stickeler, Elmar ; Thomssen, Christoph ; Untch, Michael ; Witzel, Isabell ; Wöckel, Achim ; Müller, Volkmar ; Janni, Wolfgang ; Ditsch, Nina
O’Connell, Kevin S. ; Koromina, Maria ; van der Veen, Tracey ; Boltz, Toni ; David, Friederike S. ; Kay Yang, Jessica Mei ; Lin, Keng-Han ; Wang, Xin ; Coleman, Jonathan R. I. ; Mitchell, Brittany L. ; McGrouther, Caroline C. ; Rangan, Aaditya V. ; Lind, Penelope A. ; Koch, Elise ; Harder, Arvid ; Parker, Nadine ; Bendl, Jaroslav ; Adorjan, Kristina ; Agerbo, Esben ; Albani, Diego ; Alemany, Silvia ; Alliey-Rodriguez, Ney ; Als, Thomas D. ; Andlauer, Till F. M. ; Antoniou, Anastasia ; Ask, Helga ; Bass, Nicholas ; Bauer, Michael ; Beins, Eva C. ; Bigdeli, Tim B. ; Pedersen, Carsten Bøcker ; Boks, Marco P. ; Børte, Sigrid ; Bosch, Rosa ; Brum, Murielle ; Brumpton, Ben M. ; Brunkhorst-Kanaan, Nathalie ; Budde, Monika ; Bybjerg-Grauholm, Jonas ; Byerley, William ; Cabana-Domínguez, Judit ; Cairns, Murray J. ; Carpiniello, Bernardo ; Casas, Miquel ; Cervantes, Pablo ; Chatzinakos, Chris ; Chen, Hsi-Chung ; Clarence, Tereza ; Clarke, Toni-Kim ; Claus, Isabelle ; Coombes, Brandon ; Corfield, Elizabeth C. ; Cruceanu, Cristiana ; Cuellar-Barboza, Alfredo ; Czerski, Piotr M. ; Dafnas, Konstantinos ; Dale, Anders M. ; Dalkner, Nina ; Degenhardt, Franziska ; DePaulo, J. Raymond ; Djurovic, Srdjan ; Drange, Ole Kristian ; Escott-Price, Valentina ; Fanous, Ayman H. ; Fellendorf, Frederike T. ; Ferrier, I. Nicol ; Forty, Liz ; Frank, Josef ; Frei, Oleksandr ; Freimer, Nelson B. ; Fullard, John F. ; Garnham, Julie ; Gizer, Ian R. ; Gordon, Scott D. ; Gordon-Smith, Katherine ; Greenwood, Tiffany A. ; Grove, Jakob ; Guzman-Parra, José ; Ha, Tae Hyon ; Hahn, Tim ; Haraldsson, Magnus ; Hautzinger, Martin ; Havdahl, Alexandra ; Heilbronner, Urs ; Hellgren, Dennis ; Herms, Stefan ; Hickie, Ian B. ; Hoffmann, Per ; Holmans, Peter A. ; Huang, Ming-Chyi ; Ikeda, Masashi ; Jamain, Stéphane ; Johnson, Jessica S. ; Jonsson, Lina ; Kalman, Janos L. ; Kamatani, Yoichiro ; Kennedy, James L. ; Kim, Euitae ; Kim, Jaeyoung ; Kittel-Schneider, Sarah ; Knowles, James A. ; Kogevinas, Manolis ; Kranz, Thorsten M. ; Krebs, Kristi ; Kushner, Steven A. ; Lavebratt, Catharina ; Lawrence, Jacob ; Leber, Markus ; Lee, Heon-Jeong ; Liao, Calwing ; Lucae, Susanne ; Lundberg, Martin ; MacIntyre, Donald J. ; Maier, Wolfgang ; Maihofer, Adam X. ; Malaspina, Dolores ; Manchia, Mirko ; Maratou, Eirini ; Martinsson, Lina ; Mattheisen, Manuel ; McGregor, Nathaniel W. ; McInnis, Melvin G. ; McKay, James D. ; Medeiros, Helena ; Meyer-Lindenberg, Andreas ; Millischer, Vincent ; Morris, Derek W. ; Moutsatsou, Paraskevi ; Mühleisen, Thomas W. ; O’Donovan, Claire ; Olsen, Catherine M. ; Panagiotaropoulou, Georgia ; Papiol, Sergi ; Pardiñas, Antonio F. ; Park, Hye Youn ; Perry, Amy ; Pfennig, Andrea ; Pisanu, Claudia ; Potash, James B. ; Quested, Digby ; Rapaport, Mark H. ; Regeer, Eline J. ; Rice, John P. ; Rivera, Margarita ; Schulte, Eva C. ; Senner, Fanny ; Shadrin, Alexey ; Shilling, Paul D. ; Sigurdsson, Engilbert ; Sindermann, Lisa ; Sirignano, Lea ; Siskind, Dan ; Slaney, Claire ; Sloofman, Laura G. ; Smeland, Olav B. ; Smith, Daniel J. ; Sobell, Janet L. ; Soler Artigas, Maria ; Stein, Dan J. ; Stein, Frederike ; Su, Mei-Hsin ; Sung, Heejong ; Świątkowska, Beata ; Terao, Chikashi ; Tesfaye, Markos ; Tesli, Martin ; Thorgeirsson, Thorgeir E. ; Thorp, Jackson G. ; Toma, Claudio ; Tondo, Leonardo ; Tooney, Paul A. ; Tsai, Shih-Jen ; Tsermpini, Evangelia Eirini ; Vawter, Marquis P. ; Vedder, Helmut ; Vreeker, Annabel ; Walters, James T. R. ; Winsvold, Bendik S. ; Witt, Stephanie H. ; Won, Hong-Hee ; Ye, Robert ; Young, Allan H. ; Zandi, Peter P. ; Zillich, Lea ; Adolfsson, Rolf ; Alda, Martin ; Alfredsson, Lars ; Backlund, Lena ; Baune, Bernhard T. ; Bellivier, Frank ; Bengesser, Susanne ; Berrettini, Wade H. ; Biernacka, Joanna M. ; Boehnke, Michael ; Børglum, Anders D. ; Breen, Gerome ; Carr, Vaughan J. ; Catts, Stanley ; Cichon, Sven ; Corvin, Aiden ; Craddock, Nicholas ; Dannlowski, Udo ; Dikeos, Dimitris ; Etain, Bruno ; Ferentinos, Panagiotis ; Frye, Mark ; Fullerton, Janice M. ; Gawlik, Micha ; Gershon, Elliot S. ; Goes, Fernando S. ; Green, Melissa J. ; Grigoroiu-Serbanescu, Maria ; Hauser, Joanna ; Henskens, Frans A. ; Hjerling-Leffler, Jens ; Hougaard, David M. ; Hveem, Kristian ; Iwata, Nakao ; Jones, Ian ; Jones, Lisa A. ; Kahn, René S. ; Kelsoe, John R. ; Kircher, Tilo ; Kirov, George ; Kuo, Po-Hsiu ; Landén, Mikael ; Leboyer, Marion ; Li, Qingqin S. ; Lissowska, Jolanta ; Lochner, Christine ; Loughland, Carmel ; Luykx, Jurjen J. ; Martin, Nicholas G. ; Mathews, Carol A. ; Mayoral, Fermin ; McElroy, Susan L. ; McIntosh, Andrew M. ; McMahon, Francis J. ; Medland, Sarah E. ; Melle, Ingrid ; Milani, Lili ; Mitchell, Philip B. ; Morken, Gunnar ; Mors, Ole ; Mortensen, Preben Bo ; Müller-Myhsok, Bertram ; Myers, Richard M. ; Myung, Woojae ; Neale, Benjamin M. ; Nievergelt, Caroline M. ; Nordentoft, Merete ; Nöthen, Markus M. ; Nurnberger, John I. ; O’Donovan, Michael C. ; Oedegaard, Ketil J. ; Olsson, Tomas ; Owen, Michael J. ; Paciga, Sara A. ; Pantelis, Christos ; Pato, Carlos N. ; Pato, Michele T. ; Patrinos, George P. ; Pawlak, Joanna M. ; Ramos-Quiroga, Josep Antoni ; Reif, Andreas ; Reininghaus, Eva Z. ; Ribasés, Marta ; Rietschel, Marcella ; Ripke, Stephan ; Rouleau, Guy A. ; Roussos, Panos ; Saito, Takeo ; Schall, Ulrich ; Schalling, Martin ; Schofield, Peter R. ; Schulze, Thomas G. ; Scott, Laura J. ; Scott, Rodney J. ; Serretti, Alessandro ; Smoller, Jordan W. ; Squassina, Alessio ; Stahl, Eli A. ; Stefansson, Hreinn ; Stefansson, Kari ; Stordal, Eystein ; Streit, Fabian ; Sullivan, Patrick F. ; Turecki, Gustavo ; Vaaler, Arne E. ; Vieta, Eduard ; Vincent, John B. ; Waldman, Irwin D. ; Weickert, Cynthia S. ; Weickert, Thomas W. ; Werge, Thomas ; Whiteman, David C. ; Zwart, John-Anker ; Edenberg, Howard J. ; McQuillin, Andrew ; Forstner, Andreas J. ; Mullins, Niamh ; Di Florio, Arianna ; Ophoff, Roel A. ; Andreassen, Ole A.
Reifarth, René ; Altstadt, Sebastian ; Göbel, Kathrin ; Heftrich, Tanja ; Heil, Michael ; Koloczek, Alexander ; Langer, Christoph ; Plag, Ralf ; Pohl, M. ; Sonnabend, Kerstin ; Weigand, Mario ; Adachi, T. ; Aksouh, Farouk ; Al-Khalili, J. ; AlGarawi, M. ; AlGhamdi, S. ; Alkhazov, G. ; Alkhomashi, N. ; Alvarez-Pol, Héctor ; Alvarez-Rodriguez, R. ; Andreev, V. ; Andrei, B. ; Atar, Leyla ; Aumann, Thomas ; Avdeichikov, Vladimir ; Bacri, C. ; Bagchi, S. ; Barbieri, Carlo ; Beceiro, Saul ; Beck, C. ; Beinrucker, Clemens ; Belier, Gilbert ; Bemmerer, Daniel ; Bendel, M. ; Benlliure Anaya, Jose Fernando ; Benzoni, G. ; Berjillos, R. ; Bertini, D. ; Bertulani, Carlos A. ; Bishop, S. ; Blasi, N. ; Bloch, T. ; Blumenfeld, Y. ; Bonaccorso, A. ; Boretzky, Konstanze ; Botvina, Alexander ; Boudard, A. ; Boutachkov, P. ; Boztosun, I. ; Bracco, A. ; Brambilla, S. ; Monago, J.Briz ; Caamano, Manuel ; Caesar, Christoph ; Camera, F. ; Casarejos Ruiz, Enrique ; Catford, Wilton N. ; Cederkäll, Joakim ; Cederwall, B. ; Chartier, Marielle ; Chatillon, Audrey ; Cherciu, M. ; Chulkov, Leonid V. ; Coleman-Smith, P. ; Cortina Gil, Dolores ; Crespi, F. ; Crespo, Raquel ; Cresswell, J. ; Csatlós, Margit ; Déchery, F. ; Davids, B. ; Davinson, Thomas ; Derya, Vera ; Detistov, P. ; Díaz Fernández, Paloma ; DiJulio, D. ; Dmitry, S. ; Doré, D. ; Dueñas, J. ; Dupont, Emmeric ; Egelhof, Peter ; Egorova, I. ; Elekes, Zoltán ; Enders, Joachim ; Endres, Janis ; Ershov, S. ; Ershova, Olga ; Fernández Domínguez, Beatriz ; Fetisov, A. ; Fiori, Enrico ; Fomichev, A. ; Fonseca, M. ; Fraile, L. ; Freer, Martin ; Friese, Jürgen ; Garcia Borge, Maria José ; Galaviz Redondo, Daniel ; Gannon, S. ; Garg, U. ; Gašparić, Igor ; Gasques, L. ; Gastineau, B. ; Geissel, Hans ; Gernhäuser, Roman ; Ghosh, T. ; Gilbert, M. ; Glorius, Jan ; Golubev, Pavel ; Gorshkov, Alexander ; Gourishetty, A. ; Grigorenko, Leonid V. ; Gulyas, J. ; Haiduc, Maria ; Hammache, F. ; Harakeh, Muhsin N. ; Hass, M. ; Heine, Marcel ; Hennig, Andreas ; Henriques, Ana ; Herzberg, Rolf-Dietmar ; Holl, Matthias ; Ignatov, Alexander ; Ignatyuk, A. ; Ilieva, Stoyanka ; Ivanov, Marian ; Iwasa, N. ; Jakobsson, B. ; Johansson, Håkan T. ; Jonson, Björn ; Joshi, P. ; Junghans, Arnd Rudolf ; Jurado Apruzzese, Beatriz ; Körner, G. ; Kalantar, N. ; Kanungo, Rituparna ; Kelic-Heil, Aleksandra ; Kezzar, K. ; Khan, E. ; Khanzadeev, Alexei ; Kiselev, Oleg A. ; Kogimtzis, M. ; Körper, D. ; Kräckmann, S. ; Kröll, Thorsten ; Krücken, Reiner ; Krasznahorkay, Attila ; Kratz, Jens-Volker ; Kresan, Dmytro ; Krings, Thomas ; Krumbholz, A. ; Krupko, S. ; Kulessa, Reinhard ; Kumar, Shyam ; Kurz, Nikolaus ; Kuzmin, E. ; Labiche, Marc ; Langanke, Karlheinz ; Lazarus, I. ; Bleis, T.Le ; Lederer, Claudia ; Lemasson, A. ; Lemmon, Roy Crawford ; Liberati, V. ; Litvinov, Yuri A. ; Löher, Bastian ; Herraiz, J.Lopez ; Münzenberg, G. ; Machado, Jorge ; Maev, E. ; Mahata, Kripamay ; Mancusi, D. ; Marganiec, Justyna ; Perez, M.Martinez ; Marusov, V. ; Mengoni, D. ; Million, B. ; Morcelle, V. ; Moreno, O. ; Movsesyan, Alina ; Nácher González, Enrique ; Najafi, Mohammad Ali ; Nakamura, T. ; Naqvi, F. ; Nikolski, E. ; Nilsson, Thomas ; Nociforo, Chiara ; Nolan, P. ; Novatsky, B. ; Nyman, Göran Hugo ; Ornelas, A. ; Palit, R. ; Pandit, S. ; Panin, Valerii ; Paradela Dobarro, Carlos ; Parkar, V. ; Paschalis, Stefanos ; Pawłowski, P. ; Perea Martinez, Angel ; Pereira, J. ; Petrache, C. ; Petri, Marina ; Pickstone, Simon Glynn ; Pietralla, Norbert ; Pietri, Stephane ; Pivovarov, Y. ; Potlog, P. ; Prokofiev, Andrey ; Rastrepina, G. ; Rauscher, Thomas ; Ribeiro Jimenez, Guillermo ; Ricciardi, Maria Valentina ; Richter, Achim ; Rigollet, Catherine ; Riisager, Karsten ; Rios, A. ; Ritter, C. ; Rodríguez Frutos, Tomás Raúl ; Rodríguez Vignote, Javier ; Röder, Marko ; Romig, Christopher ; Rossi, Dominic M. ; Roussel-Chomaz, P. ; Rout, Prakash Chandra ; Roy, S. ; Söderström, P. ; Saha Sarkar, Maitreyee ; Sakuta, S. ; Salsac, M. ; Sampson, J. ; Sanchez, J. ; Saez, del Rio ; Rosado, J.Sanchez ; Sanjari, Mohammad Shahab ; Sarriguren, P. ; Sauerwein, Anne ; Savran, Deniz ; Scheidenberger, Christoph ; Scheit, Heiko ; Schmidt, Stefan ; Schmitt, C. ; Schnorrenberger, Linda ; Schrock, P. ; Schwengner, R. ; Seddon, D. ; Sherrill, B. ; Shrivastava, A. ; Sidorchuk, S. ; Silva, Joel ; Simon, Haik ; Simpson, E. ; Singh, P. ; Slobodan, D. ; Sohler, D. ; Spieker, Mark-Christoph ; Stach, D. ; Stan, E. ; Stanoiu, M. ; Stepantsov, S. ; Stevenson, P. ; Strieder, F. ; Stuhl, László ; Suda, T. ; Sümmerer, Klaus ; Streicher, Branislav ; Taieb, Julien ; Takechi, M. ; Tanihata, I. ; Taylor, J. ; Tengblad, Olof ; Ter-Akopian, G. ; Terashima, S. ; Teubig, P. ; Thies, Ronja ; Thoennessen, M. ; Thomas, T. ; Thornhill, J. ; Thungstrom, G. ; Timar, J. ; Togano, Yasuhiro ; Tomohiro, U. ; Tornyi, T. ; Tostevin, J. ; Townsley, C. ; Trautmann, Wolfgang ; Trivedi, T. ; Typel, Stefan ; Uberseder, E. ; Udias, J. ; Uesaka, T. ; Uvarov, L. ; Vajta, Z. ; Velho, Paulo ; Vikhrov, V. ; Volknandt, Meiko ; Volkov, Vasily ; Neumann-Cosel, Peter von ; Schmid, Mirko von ; Wagner, A. ; Wamers, Felix ; Weick, Helmut ; Wells, D. ; Westerberg, L. ; Wieland, Oliver ; Wiescher, Michael ; Wimmer, Christine ; Wimmer, K. ; Winfield, John S. ; Winkel, M. ; Woods, Philip John ; Wyss, R. ; Yakorev, Dmitry ; Yavor, M. ; Zamora Cardona, Juan Carlos ; Zartova, I. ; Zerguerras, T. ; Zgura, M. ; Zhdanov, A. ; Zhukov, Mikhail V. ; Zieblinski, M. ; Zilges, Andreas ; Zuber, Kai
The nucleosynthesis of elements beyond iron is dominated by neutron captures in the s and r processes. However, 32 stable, proton-rich isotopes cannot be formed during those processes, because they are shielded from the s-process flow and r-process β-decay chains. These nuclei are attributed to the p and rp process.
For all those processes, current research in nuclear astrophysics addresses the need for more precise reaction data involving radioactive isotopes. Depending on the particular reaction, direct or inverse kinematics, forward or time-reversed direction are investigated to determine or at least to constrain the desired reaction cross sections.
The Facility for Antiproton and Ion Research (FAIR) will offer unique, unprecedented opportunities to investigate many of the important reactions. The high yield of radioactive isotopes, even far away from the valley of stability, allows the investigation of isotopes involved in processes as exotic as the r or rp processes.
Magunia, Harry ; Lederer, Simone ; Verbuecheln, Raphael ; Gilot, Bryant ; Köppen, Michael ; Häberle, Helene ; Mirakaj, Valbona ; Hofmann, Pascal ; Marx, Gernot ; Bickenbach, Johannes ; Nohe, Boris ; Lay, Michael ; Spies, Claudia D. ; Edel, Andreas ; Schiefenhövel, Fridtjof ; Rahmel, Tim ; Putensen, Christian ; Sellmann, Timur ; Koch, Thea ; Brandenburger, Timo ; Kindgen-Milles, Detlef ; Brenner, Thorsten ; Berger, Marc ; Zacharowski, Kai ; Adam, Elisabeth ; Posch, Matthias ; Mörer, Onnen ; Scheer, Christian S. ; Sedding, Daniel ; Weigand, Markus A. ; Fichtner, Falk ; Nau, Carla ; Prätsch, Florian ; Wiesmann, Thomas ; Koch, Christian ; Schneider, Gerhard ; Lahmer, Tobias ; Straub, Andreas ; Meiser, Andreas ; Weiß, Manfred ; Jungwirth, Bettina ; Wappler, Frank ; Meybohm, Patrick ; Herrmann, Johannes ; Malek, Nisar Peter ; Kohlbacher, Oliver ; Biergans, Stephanie ; Rosenberger, Peter
Background: Intensive Care Resources are heavily utilized during the COVID-19 pandemic. However, risk stratification and prediction of SARS-CoV-2 patient clinical outcomes upon ICU admission remain inadequate. This study aimed to develop a machine learning model, based on retrospective & prospective clinical data, to stratify patient risk and predict ICU survival and outcomes. Methods: A Germany-wide electronic registry was established to pseudonymously collect admission, therapeutic and discharge information of SARS-CoV-2 ICU patients retrospectively and prospectively. Machine learning approaches were evaluated for the accuracy and interpretability of predictions. The Explainable Boosting Machine approach was selected as the most suitable method. Individual, non-linear shape functions for predictive parameters and parameter interactions are reported. Results: 1039 patients were included in the Explainable Boosting Machine model, 596 patients retrospectively collected, and 443 patients prospectively collected. The model for prediction of general ICU outcome was shown to be more reliable to predict “survival”. Age, inflammatory and thrombotic activity, and severity of ARDS at ICU admission were shown to be predictive of ICU survival. Patients’ age, pulmonary dysfunction and transfer from an external institution were predictors for ECMO therapy. The interaction of patient age with D-dimer levels on admission and creatinine levels with SOFA score without GCS were predictors for renal replacement therapy. Conclusions: Using Explainable Boosting Machine analysis, we confirmed and weighed previously reported and identified novel predictors for outcome in critically ill COVID-19 patients. Using this strategy, predictive modeling of COVID-19 ICU patient outcomes can be performed overcoming the limitations of linear regression models. Trial registration “ClinicalTrials” (clinicaltrials.gov) under NCT04455451.
Abou Yassine, Rayane ; Adamczewski-Musch, Jörn ; Becker, Marten ; Bergmann, Philip ; Blanco, Alberto ; Blume, Christoph ; Chlad, Lukas ; Chudoba, Petr ; Ciepał, Izabela ; Cordts, Malte ; Dreyer, Jörn ; Esmail, Waleed Ahmed ; Firlej, Miroslaw ; Fiutowski, Tomasz ; Floersheimer, Henrik ; Fonte, Paulo ; Friese, Jürgen ; Fröhlich, Ingo ; Förtsch, Jörg ; Galatyuk, Tetyana ; Gniazdowski, Tomasz ; Greifenhagen, Robert ; Grunwald, Mateusz ; Grzonka, Dieter ; Gumberidze, Malgorzata ; Harabasz, Szymon ; Heinz, Thorsten ; Höhne, Claudia ; Hojeij, Fatima ; Holzmann, Romain ; Huck, Holger ; Idzik, Marek ; Kämpfer, Burkhard ; Kampert, Karl-Heinz ; Kardan, Behruz ; Kedych, Vadym ; Koenig, Ilse ; Koenig, Wolfgang ; Kohls, Marvin ; Kołaś, Jędrzej ; Korcyl, Grzegorz ; Kornakov, Georgy ; Kornas, Frédéric Julian ; Kotte, Roland ; Krueger, Wilhelm ; Kugler, Andrej ; Kulessa, Pawel ; Lalik, Rafał Tomasz ; Lebedev, Semen ; Linev, Sergey ; Lopes, Luis Alberto Vieira ; Lorenz, Manuel ; Malige, Akshay ; Markert, Jochen ; Matulewicz, Tomasz ; Messchendorp, Johannes Gerhardus ; Metag, Volker ; Michel, Jan ; Molenda, Aleksandra ; Moron, Jakub ; Müntz, Christian ; Nabroth, Marvin ; Naumann, Lothar ; Orliński, Jan ; Otto, Jan-Hendrik ; Parpottas, Yannis ; Parschau, Mirco ; Pauly, Christian ; Pechenov, Vladimir ; Pechenova, Olga ; Perez Andrade, Gabriela ; Pfeifer, Dennis ; Piasecki, Krzysztof ; Pietraszko, Jerzy ; Povar, Tetiana ; Prozorov, Alexandr ; Przygoda, Witold ; Pysz, Krzysztof ; Ramstein, Béatrice ; Rathod, Narendra ; Ritman, James Lambrecht ; Rost, Adrian ; Rustamov, Anar ; Salabura, Piotr ; Saraiva, Joao ; Schadmand, Susan ; Schild, Niklas ; Schwab, Erwin ; Seck, Florian ; Selyuzhenkov, Ilya ; Singh, Udai ; Skorpil, Leon ; Smyrski, Jerzy ; Sobiella, Manfred ; Spataro, Stefano ; Spies, Simon ; Stefaniak, Maria ; Ströbele, Herbert ; Stroth, Joachim ; Sumara, Konrad ; Svoboda, Ondřej ; Swientek, Krzysztof ; Szala, Melanie ; Tlusty, Pavel ; Traxler, Michael ; Tsertos, Haralabos ; Wagner, Vladimir ; Wasiluk, Mateusz ; Weber, Adrian Amatus ; Wendisch, Christian ; Wintz, Peter ; Zbroszczyk, Hanna Paulina ; Zherebtsova, Elizaveta S. ; Zielinski, Marcin ; Zumbruch, Peter W.
In March 2019 the HADES experiment recorded 14 billion Ag+Ag collisions at √sNN = 2.55 GeV as a part of the FAIR phase-0 physics program. In this contribution, we present and investigate our capabilities to reconstruct and analyze weakly decaying strange hadrons and hypernuclei emerging from these collisions. The focus is put on measuring the mean lifetimes of these particles.
Catalano, Antonella ; Adlesic, Mojca ; Kaltenbacher, Thorsten ; Klar, Rhena F. U. ; Albers, Joachim ; Seidel, Philipp ; Brandt, Laura P. ; Hejhal, Tomas ; Busenhart, Philipp ; Röhner, Niklas ; Zodel, Kyra ; Fritsch, Kornelia ; Wild, Peter Johannes ; Duyster, Justus ; Fritsch, Ralph ; Brummer, Tilman ; Frew, Ian
Simple Summary: Mutations in RAS-family genes frequently cause different types of human cancers. Inhibitors of the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) protein kinases that function downstream of RAS proteins have shown some clinical benefits when used for the treatment of these cancers, but drug resistance frequently emerges. Here we show that combined treatment with MEK and ERK inhibitors blocks the emergence of resistance to either drug alone. However, if cancer cells have already developed resistance to MEK inhibitors or to ERK inhibitors, the combined therapy is frequently ineffective. These findings imply that these inhibitors should be used together for cancer therapy. We also show that drug resistance involves complex patterns of rewiring of cellular kinase signaling networks that do not overlap between each different cancer cell line. Nonetheless, we show that MAP4K4 is required for efficient cell proliferation in several different MEK/ERK inhibitor resistant cancer cell lines, uncovering a potential new therapeutic target.
Abstract: Oncogenic mutations in RAS family genes arise frequently in metastatic human cancers. Here we developed new mouse and cellular models of oncogenic HrasG12V-driven undifferentiated pleomorphic sarcoma metastasis and of KrasG12D-driven pancreatic ductal adenocarcinoma metastasis. Through analyses of these cells and of human oncogenic KRAS-, NRAS- and BRAF-driven cancer cell lines we identified that resistance to single MEK inhibitor and ERK inhibitor treatments arise rapidly but combination therapy completely blocks the emergence of resistance. The prior evolution of resistance to either single agent frequently leads to resistance to dual treatment. Dual MEK inhibitor plus ERK inhibitor therapy shows anti-tumor efficacy in an HrasG12V-driven autochthonous sarcoma model but features of drug resistance in vivo were also evident. Array-based kinome activity profiling revealed an absence of common patterns of signaling rewiring in single or double MEK and ERK inhibitor resistant cells, showing that the development of resistance to downstream signaling inhibition in oncogenic RAS-driven tumors represents a heterogeneous process. Nonetheless, in some single and double MEK and ERK inhibitor resistant cell lines we identified newly acquired drug sensitivities. These may represent additional therapeutic targets in oncogenic RAS-driven tumors and provide general proof-of-principle that therapeutic vulnerabilities of drug resistant cells can be identified.
Miehe, Susanne ; Crause, Peter ; Schmidt, Thorsten ; Löhn, Matthias ; Kleemann, Heinz-Werner ; Licher, Thomas ; Dittrich, Werner ; Rütten, Hartmut ; Strübing, Carsten
TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca2+ signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have been assigned to this class of ion channels. Despite their physiological relevance, few selective pharmacological tools are available to study TRPC channel function. We, therefore, screened a selection of pharmacologically active compounds for TRPC modulating activity. We found that the synthetic gestagen norgestimate inhibited diacylglycerol-sensitive TRPC3 and TRPC6 with IC50s of 3–5 µM, while half-maximal inhibition of TRPC5 required significantly higher compound concentrations (>10 µM). Norgestimate blocked TRPC-mediated vasopressin-induced cation currents in A7r5 smooth muscle cells and caused vasorelaxation of isolated rat aorta, indicating that norgestimate could be an interesting tool for the investigation of TRP channel function in native cells and tissues. The steroid hormone progesterone, which is structurally related to norgestimate, also inhibited TRPC channel activity with IC50s ranging from 6 to 18 µM but showed little subtype selectivity. Thus, TRPC channel inhibition by high gestational levels of progesterone may contribute to the physiological decrease of uterine contractility and immunosuppression during pregnancy.
Kashani, Kianoush ; Al-Khafaji, Ali ; Ardiles, Thomas ; Artigas, Antonio ; Bagshaw, Sean M. ; Bell, Max ; Bihorac, Azra ; Birkhahn, Robert ; Cely, Cynthia M. ; Chawla, Lakhmir S. ; Davison, Danielle L. ; Feldkamp, Thorsten ; Forni, Lui G. ; Gong, Michelle Ng ; Gunnerson, Kyle J. ; Haase, Michael ; Hackett, James ; Honore, Patrick M. ; Hoste, Eric A. J. ; Joannes-Boyau, Olivier ; Joannidis, Michael ; Kim, Patrick ; Koyner, Jay L. ; Laskowitz, Daniel T. ; Lissauer, Matthew E. ; Marx, Gernot ; McCullough, Peter A. ; Mullaney, Scott ; Ostermann, Marlies ; Rimmelé, Thomas ; Shapiro, Nathan I. ; Shaw, Andrew D. ; Shi, Jing ; Sprague, Amy M. ; Vincent, Jean-Louis ; Vinsonneau, Christophe ; Wagner, Ludwig ; Walker, Michael G. ; Wilkerson, R. Gentry ; Zacharowski, Kai ; Kellum, John A.
Introduction: Acute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely to provide benefit. Identifying early markers of kidney damage has been difficult due to the complex nature of human AKI, in which multiple etiologies exist. The objective of this study was to identify and validate novel biomarkers of AKI.
Methods: We performed two multicenter observational studies in critically ill patients at risk for AKI - discovery and validation. The top two markers from discovery were validated in a second study (Sapphire) and compared to a number of previously described biomarkers. In the discovery phase, we enrolled 522 adults in three distinct cohorts including patients with sepsis, shock, major surgery, and trauma and examined over 300 markers. In the Sapphire validation study, we enrolled 744 adult subjects with critical illness and without evidence of AKI at enrollment; the final analysis cohort was a heterogeneous sample of 728 critically ill patients. The primary endpoint was moderate to severe AKI (KDIGO stage 2 to 3) within 12 hours of sample collection.
Results: Moderate to severe AKI occurred in 14% of Sapphire subjects. The two top biomarkers from discovery were validated. Urine insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2), both inducers of G1 cell cycle arrest, a key mechanism implicated in AKI, together demonstrated an AUC of 0.80 (0.76 and 0.79 alone). Urine [TIMP-2].[IGFBP7] was significantly superior to all previously described markers of AKI (P <0.002), none of which achieved an AUC >0.72. Furthermore, [TIMP-2].[IGFBP7] significantly improved risk stratification when added to a nine-variable clinical model when analyzed using Cox proportional hazards model, generalized estimating equation, integrated discrimination improvement or net reclassification improvement. Finally, in sensitivity analyses [TIMP-2].[IGFBP7] remained significant and superior to all other markers regardless of changes in reference creatinine method.
Conclusions: Two novel markers for AKI have been identified and validated in independent multicenter cohorts. Both markers are superior to existing markers, provide additional information over clinical variables and add mechanistic insight into AKI. Trial registration: ClinicalTrials.gov number NCT01209169.
Sarabhai, Theresia ; Peter, Christoph ; Bär, Anne-Kathrin ; Windolf, Joachim ; Relja, Borna ; Wesselborg, Sebastian ; Wahlers, Thorsten ; Paunel-Görgülü, Adnana-Nicoleta
Excessive neutrophil activation accompanied by delayed apoptotic cell death in inflammatory conditions causes progressive damage of cells and tissues, leading to life-threatening multiple organ dysfunction syndrome. Previous work suggested that circulating serum factors during inflammation are critically involved in the suppression of neutrophil cell death although the identity of these antiapoptotic mediators remained elusive. In this study, we identified the acute phase protein α-1 Antitrypsin (AAT) as a potent suppressor of staurosporine (STS)-induced apoptosis in human neutrophils through a mechanism implicating caspases-independent pathways. We show here that serum levels of AAT, potentially in part released by stimulated neutrophils, are markedly elevated in major trauma patients suffering from systemic inflammatory response syndrome (SIRS). Notably, AAT depletion from serum increased sensitivity of human neutrophils for STS-induced cell death. In fact, AAT was demonstrated to confer intrinsic apoptosis resistance by preventing PKC/Akt inactivation and subsequent proteasomal degradation of antiapoptotic Mcl-1 protein in response to STS treatment. Neither MAP kinase ERK1/2 nor caspases were found to be involved in AAT-triggered antiapoptotic pathways in neutrophils. In summary, these results establish a novel pivotal role of circulating AAT in mediating survival by antagonizing the proapoptotic action of the PKC inhibitor STS and should be considered for AAT augmentation therapies in future.
Banys-Paluchowski, Maggie ; Gasparri, Maria Luisa ; de Boniface, Jana ; Gentilini, Oreste ; Stickeler, Elmar ; Hartmann, Steffi ; Thill, Marc ; Rubio, Isabel T. ; Di Micco, Rosa ; Bonci, Eduard-Alexandru ; Niinikoski, Laura ; Kontos, Michalis ; Cakmak, Guldeniz Karadeniz ; Hauptmann, Michael ; Peintinger, Florentia ; Pinto, David ; Matrai, Zoltan ; Murawa, Dawid ; Kadayaprath, Geeta ; Dostalek, Lukas ; Nina, Helidon ; Krivorotko, Petr ; Classe, Jean-Marc ; Schlichting, Ellen ; Appelgren, Matilda ; Paluchowski, Peter ; Solbach, Christine ; Blohmer, Jens-Uwe ; Kühn, Thorsten
Simple Summary: Currently, it is unclear which kind of axillary staging surgery breast cancer patients with lymph node metastasis should receive after neoadjuvant chemotherapy. For decades, these patients have been treated with a full axillary lymph node dissection, even if they converted to clinical node negativity. However, the removal of a large number of lymph nodes during the procedure can increase arm morbidity and impact quality of life. Therefore, several studies investigated less radical surgical strategies in this setting, such as sentinel lymph node biopsy or targeted axillary dissection, i.e., removal of a previously marked node combined with sentinel node removal. In this review, we summarize current evidence on the different surgical techniques and compare national and international recommendations. We show that many questions regarding oncological safety of different surgery types and the optimal marking technique remain unanswered and present the multinational prospective cohort study AXSANA that will address these open issues.
Abstract: In the last two decades, surgical methods for axillary staging in breast cancer patients have become less extensive, and full axillary lymph node dissection (ALND) is confined to selected patients. In initially node-positive patients undergoing neoadjuvant chemotherapy, however, the optimal management remains unclear. Current guidelines vary widely, endorsing different strategies. We performed a literature review on axillary staging strategies and their place in international recommendations. This overview defines knowledge gaps associated with specific procedures, summarizes currently ongoing clinical trials that address these unsolved issues, and provides the rationale for further research. While some guidelines have already implemented surgical de-escalation, replacing ALND with, e.g., sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD) in cN+ patients converting to clinical node negativity, others recommend ALND. Numerous techniques are in use for tagging lymph node metastasis, but many questions regarding the marking technique, i.e., the optimal time for marker placement and the number of marked nodes, remain unanswered. The optimal number of SLNs to be excised also remains a matter of debate. Data on oncological safety and quality of life following different staging procedures are lacking. These results provide the rationale for the multinational prospective cohort study AXSANA initiated by EUBREAST, which started enrollment in June 2020 and aims at recruiting 3000 patients in 20 countries (NCT04373655; Funded by AGO-B, Claudia von Schilling Foundation for Breast Cancer Research, AWOgyn, EndoMag, Mammotome, and MeritMedical).
Jeltsch, Florian ; Bonte, Dries ; Pe'er, Guy ; Reineking, Björn ; Leimgruber, Peter ; Balkenhol, Niko ; Schröder, Boris ; Buchmann, Carsten M. ; Mueller, Thomas ; Blaum, Niels ; Zurell, Damaris ; Böhning-Gaese, Katrin ; Wiegand, Thorsten ; Eccard, Jana A. ; Hofer, Heribert ; Reeg, Jette ; Eggers, Ute ; Bauer, Silke
Movement of organisms is one of the key mechanisms shaping biodiversity, e.g. the distribution of genes, individuals and species in space and time. Recent technological and conceptual advances have improved our ability to assess the causes and consequences of individual movement, and led to the emergence of the new field of ‘movement ecology’. Here, we outline how movement ecology can contribute to the broad field of biodiversity research, i.e. the study of processes and patterns of life among and across different scales, from genes to ecosystems, and we propose a conceptual framework linking these hitherto largely separated fields of research. Our framework builds on the concept of movement ecology for individuals, and demonstrates its importance for linking individual organismal movement with biodiversity. First, organismal movements can provide ‘mobile links’ between habitats or ecosystems, thereby connecting resources, genes, and processes among otherwise separate locations. Understanding these mobile links and their impact on biodiversity will be facilitated by movement ecology, because mobile links can be created by different modes of movement (i.e., foraging, dispersal, migration) that relate to different spatiotemporal scales and have differential effects on biodiversity. Second, organismal movements can also mediate coexistence in communities, through ‘equalizing’ and ‘stabilizing’ mechanisms. This novel integrated framework provides a conceptual starting point for a better understanding of biodiversity dynamics in light of individual movement and space-use behavior across spatiotemporal scales. By illustrating this framework with examples, we argue that the integration of movement ecology and biodiversity research will also enhance our ability to conserve diversity at the genetic, species, and ecosystem levels.
Tombach, Bernd ; Bohndorf, Klaus ; Brodtrager, Wolfgang ; Claussen, Claus D. ; Düber, Christoph ; Galanski, Michael ; Grabbe, Eckhardt ; Gortenuti, Giacomo ; Kuhn, Michael ; Gross-Fengels, Walter ; Hammerstingl, Renate Maria ; Happel, Brigitte ; Heinz-Peer, Gertraud ; Jung, Gregor ; Kittner, Thomas ; Lagalla, Roberto ; Lengsfeld, Philipp ; Loose, Reinhard ; Oyen, Raymond H. G. ; Pavlica, Pietro ; Pering, Christiane ; Pozzi-Mucelli, Roberto ; Persigehl, Thorsten ; Reimer, Peter ; Renken, Nomdo S. ; Richter, Götz M. ; Rummeny, Ernst J. ; Schäfer, Fritz ; Szczerbo-Trojanowska, Malgorzata ; Urbanik, Andrzej ; Vogl, Thomas J. ; Hajek, Paul
The purpose of this phase III clinical trial was to compare two different extracellular contrast agents, 1.0 M gadobutrol and 0.5 M gadopentate dimeglumine, for magnetic resonance imaging (MRI) in patients with known or suspected focal renal lesions. Using a multicenter, single-blind, interindividual, randomized study design, both contrast agents were compared in a total of 471 patients regarding their diagnostic accuracy, sensitivity, and specificity to correctly classify focal lesions of the kidney. To test for noninferiority the diagnostic accuracy rates for both contrast agents were compared with CT results based on a blinded reading. The average diagnostic accuracy across the three blinded readers (‘average reader’) was 83.7% for gadobutrol and 87.3% for gadopentate dimeglumine. The increase in accuracy from precontrast to combined precontrast and postcontrast MRI was 8.0% for gadobutrol and 6.9% for gadopentate dimeglumine. Sensitivity of the average reader was 85.2% for gadobutrol and 88.7% for gadopentate dimeglumine. Specificity of the average reader was 82.1% for gadobutrol and 86.1% for gadopentate dimeglumine. In conclusion, this study documents evidence for the noninferiority of a single i.v. bolus injection of 1.0 M gadobutrol compared with 0.5 M gadopentate dimeglumine in the diagnostic assessment of renal lesions with CE-MRI.
Grimm, Oliver ; Weber, Heike ; Kittel-Schneider, Sarah ; Kranz, Thorsten Manfred ; Jacob, Christian P. ; Lesch, Klaus-Peter J. ; Reif, Andreas
While impulsivity is a basic feature of attention-deficit / hyperactivity disorder (ADHD), no study explored the effect of different components of the Impulsiveness (Imp) and Venturesomeness (Vent) scale (IV7) on psychiatric comorbidities and an ADHD polygenic risk score (PRS). We used the IV7 self-report scale in an adult ADHD sample of 903 patients, 70% suffering from additional comorbid disorders, and in a subsample of 435 genotyped patients. Venturesomeness, unlike immediate Impulsivity, is not specific to ADHD. We consequently analyzed the influence of Imp and Vent also in the context of a PRS on psychiatric comorbidities of ADHD. Vent shows a distinctly different distribution of comorbidities, e.g., less anxiety and depression. PRS showed no effect on different ADHD comorbidities, but correlated with childhood hyperactivity. In a complementary analysis using principal component analysis with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition ADHD criteria, revised NEO Personality Inventory, Imp, Vent, and PRS, we identified three ADHD subtypes. These are an impulsive–neurotic type, an adventurous–hyperactive type with a stronger genetic component, and an anxious–inattentive type. Our study thus suggests the importance of adventurousness and the differential consideration of impulsivity in ADHD. The genetic risk is distributed differently between these subtypes, which underlines the importance of clinically motivated subtyping. Impulsivity subtyping might give insights into the organization of comorbid disorders in ADHD and different genetic background.
Heidler, Juliana ; Fysikopoulos, Athanasios ; Wempe, Frank ; Seimetz, Michael ; Bangsow, Thorsten ; Tomasovic, Ana ; Veit, Florian ; Scheibe, Susan ; Pichl, Alexandra ; Weisel, Friederike ; Lloyd, K. C. Kent ; Jaksch, Peter ; Klepetko, Walter ; Weißmann, Norbert ; Melchner, Harald von
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD is caused by chronic exposure to cigarette smoke and/or other environmental pollutants that are believed to induce reactive oxygen species (ROS) that gradually disrupt signalling pathways responsible for maintaining lung integrity. Here we identify the antioxidant protein sestrin-2 (SESN2) as a repressor of PDGFRβ signalling, and PDGFRβ signalling as an upstream regulator of alveolar maintenance programmes. In mice, the mutational inactivation of Sesn2 prevents the development of cigarette-smoke-induced pulmonary emphysema by upregulating PDGFRβ expression via a selective accumulation of intracellular superoxide anions (O2−). We also show that SESN2 is overexpressed and PDGFRβ downregulated in the emphysematous lungs of individuals with COPD and to a lesser extent in human lungs of habitual smokers without COPD, implicating a negative SESN2-PDGFRβ interrelationship in the pathogenesis of COPD. Taken together, our results imply that SESN2 could serve as both a biomarker and as a drug target in the clinical management of COPD.
Heidler, Juliana ; Fysikopoulos, Athanasios ; Wempe, Frank ; Seimetz, Michael ; Bangsow, Thorsten ; Tomasovic, Ana ; Veit, Florian ; Scheibe, Susan ; Pichl, Alexandra ; Weisel, Friederike ; Lloyd, K. C. Kent ; Jaksch, Peter ; Klepetko, Walter ; Weißmann, Norbert ; Melchner, Harald von
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD is caused by chronic exposure to cigarette smoke and/or other environmental pollutants that are believed to induce reactive oxygen species (ROS) that gradually disrupt signalling pathways responsible for maintaining lung integrity. Here we identify the antioxidant protein Sestrin 2 (Sesn2) as a repressor of PDGFRβ signalling and PDGFRβ signalling as an upstream regulator of alveolar maintenance programs. In mice, the mutational inactivation of Sesn2 prevents the development of cigarette-smoke induced pulmonary emphysema by upregulating PDGFRβ expression via a selective accumulation of intracellular superoxide anions (O2-). We also show that SESN2 is overexpressed and PDGFRβ downregulated in the emphysematous lungs of patients with COPD and to a lesser extent in human lungs of habitual smokers without COPD, implicating a negative SESN2/PDGFRβ interrelationship in the pathogenesis of COPD. Taken together, our results imply that SESN2 could serve as both a biomarker and as a drug target in the clinical management of COPD.
Richter, Martin ; Peter, Thorsten ; Rüttermann, Stefan ; Sader, Robert Alexander ; Seifert, Lukas Benedikt
Introduction: The treatment of carious lesions is one of the most fundamental competencies in daily dental practice. However, many commercially available training models lack in reality regarding the simulation of pathologies such as carious lesions. 3D printed models could provide a more realistic simulation. This study provides an exemplary description of the fabrication of 3D printed dental models with carious lesions and assesses their educational value compared to commercially available models in conservative dentistry.
Materials and Methods: A single-stage, controlled cohort study was conducted within the context of a curricular course. A stereolithographic model was obtained from an intraoral scan and then printed using fused deposition modelling. These models were first piloted by experts and then implemented and compared against commercial models in a conservative dentistry course. Experts and students evaluated both models using a validated questionnaire. Additionally, a cost analysis for both models was carried out.
Results: Thirteen dentists and twenty-seven 5th year dental students participated in the study. The 3D printed models were rated significantly more realistic in many test areas. In particular, the different tactility and the distinction in colour was rated positively in the 3D printed models. At 28.29€ (compared to 112.36€), the 3D printed models were exceptionally cost-efficient.
Conclusions: 3D printed dental models present a more realistic and cost-efficient alternative to commercial models in the undergraduate training of conservative dentistry.